General Information of Target

Target ID LDTP08926
Target Name Solute carrier family 15 member 4 (SLC15A4)
Gene Name SLC15A4
Gene ID 121260
Synonyms
PHT1; PTR4; Solute carrier family 15 member 4; Peptide transporter 4; Peptide/histidine transporter 1; hPHT1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGSGGGAGERAPLLGARRAAAAAAAAGAFAGRRAACGAVLLTELLERAAFYGITSNLVL
FLNGAPFCWEGAQASEALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGMLAF
PLLAAPATRAALCGSARLLNCTAPGPDAAARCCSPATFAGLVLVGLGVATVKANITPFGA
DQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQQNVSFVTGYAIPTVCVGLAFVVF
LCGQSVFITKPPDGSAFTDMFKILTYSCCSQKRSGERQSNGEGIGVFQQSSKQSLFDSCK
MSHGGPFTEEKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYVLQSLHLRIPEISNITTT
PHTLPAAWLTMFDAVLILLLIPLKDKLVDPILRRHGLLPSSLKRIAVGMFFVMCSAFAAG
ILESKRLNLVKEKTINQTIGNVVYHAADLSLWWQVPQYLLIGISEIFASIAGLEFAYSAA
PKSMQSAIMGLFFFFSGVGSFVGSGLLALVSIKAIGWMSSHTDFGNINGCYLNYYFFLLA
AIQGATLLLFLIISVKYDHHRDHQRSRANGVPTSRRA
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Major facilitator superfamily, Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family
Subcellular location
Lysosome membrane
Function
Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response. Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans. Transporter activity is pH-dependent and maximized in the acidic lysosomal environment. Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand. Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5. Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation. Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses.
TTD ID
T09063
Uniprot ID
Q8N697
DrugMap ID
TTG2XRE
Ensemble ID
ENST00000266771.10
HGNC ID
HGNC:23090

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A471T .
CMK SNV: p.G38V; p.T43M .
FADU SNV: p.G116C .
HCT15 SNV: p.M518I .
HT115 SNV: p.L295M .
LNCaP clone FGC SNV: p.C232Ter .
SNGM SNV: p.W94Ter DBIA    Probe Info 
SNU5 SNV: p.C141S DBIA    Probe Info 
YSCCC SNV: p.I439M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P13
 Probe Info 
20.00  LDD0203  [1]
BTD
 Probe Info 
C133(0.87)  LDD2099  [2]
DBIA
 Probe Info 
C133(1.49)  LDD0531  [3]
IA-alkyne
 Probe Info 
N.A.  LDD0036  [4]
WYneN
 Probe Info 
N.A.  LDD0021  [5]
WYneO
 Probe Info 
N.A.  LDD0022  [5]
IPM
 Probe Info 
N.A.  LDD0005  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C133(0.55)  LDD2117  [2]
 LDCM0214  AC1 HCT 116 C133(1.49)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C133(0.53)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C133(0.91)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C133(0.96)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C133(1.10)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C133(1.24)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C133(0.98)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C133(1.21)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C133(0.95)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C133(0.86)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C133(1.30)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C133(0.82)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C133(1.34)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C133(1.15)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C133(0.86)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C133(1.24)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C133(1.24); C299(0.96)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C133(1.20); C299(0.93)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C133(1.17); C299(1.00)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C133(1.25); C299(1.01)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C133(1.39); C299(1.24)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C133(1.32); C299(1.19)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C133(1.49); C299(1.19)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C133(0.59)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C133(1.27); C299(0.97)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C133(1.50); C299(1.31)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C133(1.43); C299(0.91)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C133(1.06); C299(1.57)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C133(1.72); C299(1.19)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C133(1.22); C299(0.82)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C133(1.22); C299(0.85)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C133(1.28); C299(1.30)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C299(1.03)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C299(0.85)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C299(1.00)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C299(0.68)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C299(0.77)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C299(0.90)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C299(1.18)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C299(0.78)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C299(0.83)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C299(0.77)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C299(0.89)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C299(1.08)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C133(0.54)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C299(1.04)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C299(0.96)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C299(1.04)  LDD0579  [3]
 LDCM0270  AC15 HCT 116 C133(0.70)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C299(1.00)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C299(0.85)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C299(1.07)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C133(1.20)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C299(0.99)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C299(0.92)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C299(0.94)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C299(0.94)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C299(0.96)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C299(0.93)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C299(0.92)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C299(1.04)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C299(1.03)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C299(0.91)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C133(1.47)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C299(1.05)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C299(1.05)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C299(0.76)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C299(0.66)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C299(0.85)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C133(0.54)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C133(0.60)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C133(0.57)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C133(0.62)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C133(0.53)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C133(1.39)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C133(0.64)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C133(0.48)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C133(0.44)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C133(0.70)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C133(0.42)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C133(0.47)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C133(1.19)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C133(1.27)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C133(1.21)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C133(1.09)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C133(1.87)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C133(1.30)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C133(1.27)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C133(1.04)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C133(1.06)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C133(1.45)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C133(1.32)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C133(1.14)  LDD0636  [3]
 LDCM0320  AC57 PaTu 8988t C37(1.07)  LDD1199  [3]
 LDCM0321  AC58 PaTu 8988t C37(1.16)  LDD1200  [3]
 LDCM0322  AC59 PaTu 8988t C37(1.06)  LDD1201  [3]
 LDCM0323  AC6 HCT 116 C133(0.68)  LDD0640  [3]
 LDCM0324  AC60 PaTu 8988t C37(0.95)  LDD1203  [3]
 LDCM0325  AC61 PaTu 8988t C37(1.06)  LDD1204  [3]
 LDCM0326  AC62 PaTu 8988t C37(1.01)  LDD1205  [3]
 LDCM0327  AC63 PaTu 8988t C37(1.00)  LDD1206  [3]
 LDCM0328  AC64 PaTu 8988t C37(1.54)  LDD1207  [3]
 LDCM0329  AC65 PaTu 8988t C37(1.23)  LDD1208  [3]
 LDCM0330  AC66 PaTu 8988t C37(1.16)  LDD1209  [3]
 LDCM0331  AC67 PaTu 8988t C37(1.13)  LDD1210  [3]
 LDCM0332  AC68 HCT 116 C299(1.00); C133(1.11)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C133(0.98); C299(1.09)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C133(0.50)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C133(1.02); C299(1.18)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C299(1.11); C133(1.29)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C133(0.99); C299(1.15)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C133(0.95); C299(1.10)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C299(1.10); C133(1.15)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C133(1.00); C299(1.08)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C133(0.96); C299(1.04)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C133(0.89); C299(0.93)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C299(0.83); C133(0.95)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C299(0.89); C133(1.09)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C133(0.79)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C299(1.10); C133(1.11)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C133(0.97); C299(1.03)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C133(0.85); C299(1.06)  LDD0665  [3]
 LDCM0349  AC83 HEK-293T C133(0.76)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C133(1.22)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C133(0.85)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C133(0.64)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C133(0.67)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C133(0.85)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C133(0.73)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C133(0.99)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C133(0.45)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C133(0.72)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C133(0.55)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C133(0.65)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C133(0.62)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C133(0.54)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C133(0.48)  LDD0962  [3]
 LDCM0365  AC98 HCT 116 C133(1.05)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C133(1.53)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C133(0.61)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C133(0.77)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C133(0.81)  LDD0592  [3]
 LDCM0088  C45 HEK-293T 20.00  LDD0203  [1]
 LDCM0367  CL1 HCT 116 C299(1.08); C133(1.11)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C133(0.77); C299(1.17)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C133(1.44)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C133(0.47)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C133(0.73)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C133(0.61)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C133(0.59)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C299(1.05)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C299(1.11)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C299(0.96)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C299(0.96)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C299(1.06)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C133(0.72); C299(1.48)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C299(1.05)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C299(1.07)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C299(0.80)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C299(0.81)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C299(0.81)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C299(0.85)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C299(0.79)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C133(0.73)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C133(0.47)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C133(0.44)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C133(0.69); C299(1.33)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C133(0.49)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C133(1.07)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C133(1.32)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C133(0.88)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C133(1.14)  LDD0712  [3]
 LDCM0396  CL125 PaTu 8988t C37(1.26)  LDD1275  [3]
 LDCM0397  CL126 PaTu 8988t C37(1.37)  LDD1276  [3]
 LDCM0398  CL127 PaTu 8988t C37(1.06)  LDD1277  [3]
 LDCM0399  CL128 PaTu 8988t C37(0.97)  LDD1278  [3]
 LDCM0400  CL13 HCT 116 C133(0.85); C299(1.28)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C133(1.01); C299(1.08)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C133(0.72); C299(1.28)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C133(1.12)  LDD0720  [3]
 LDCM0404  CL17 HEK-293T C37(1.54); C133(1.26); C299(1.27); C141(1.50)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C37(1.07); C133(0.90); C299(1.05); C141(0.90)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C37(1.18); C133(0.94); C299(1.04)  LDD1610  [6]
 LDCM0407  CL2 HCT 116 C133(0.92); C299(1.06)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C37(1.34); C133(0.94); C299(1.01)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C37(1.50); C133(1.15); C299(1.09); C141(1.13)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C37(1.31); C133(0.95); C299(0.93)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C37(1.58); C133(0.92); C299(1.01); C141(0.90)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C37(1.65); C133(0.93); C299(0.93)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C37(1.34); C133(1.15); C299(1.12)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C37(0.96); C133(0.94); C299(0.97); C141(0.96)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C37(1.08); C133(0.86); C299(0.98)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C37(0.96); C133(0.96); C299(1.05); C141(0.90)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C37(0.98); C133(0.96); C299(1.05); C141(1.04)  LDD1621  [6]
 LDCM0418  CL3 HCT 116 C133(0.86); C299(1.07)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C37(0.90); C133(1.00); C299(1.01); C141(0.91)  LDD1623  [6]
 LDCM0420  CL31 PaTu 8988t C37(1.15)  LDD1299  [3]
 LDCM0421  CL32 HCT 116 C133(1.55)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C133(1.35)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C133(1.14)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C133(1.45)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C133(1.12)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C133(1.59)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C133(1.01)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C133(0.92); C299(0.95)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C133(1.22)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C133(1.43)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C133(1.00)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C133(1.33)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C133(1.20)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C133(1.45)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C133(0.65); C299(0.83)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C133(0.64); C299(0.83)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C133(0.71); C299(0.79)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C133(0.80); C299(0.88)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C133(1.03); C299(1.05)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C133(0.46); C299(0.63)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C133(0.80); C299(0.79)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C133(1.01); C299(1.07)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C133(0.98); C299(1.01)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C133(0.53); C299(0.68)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C133(0.68); C299(0.78)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C133(0.98); C299(1.01)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C133(0.48); C299(0.78)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C133(0.74); C299(0.85)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C133(0.66); C299(0.80)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C133(0.92); C299(0.95)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C133(0.55); C299(0.69)  LDD1050  [3]
 LDCM0453  CL61 HCT 116 C133(0.81)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C133(0.69)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C133(1.51)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C133(1.36)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C133(1.07)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C133(1.06)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C133(0.79)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C133(0.98)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C133(0.83)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C133(1.01); C299(1.38)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C133(0.82)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C133(1.04)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C133(0.56)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C133(0.88)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C133(0.90)  LDD0784  [3]
 LDCM0469  CL76 PaTu 8988t C37(1.48)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C37(1.00)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C37(1.03)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C37(1.18)  LDD1351  [3]
 LDCM0473  CL8 HCT 116 C133(0.83); C299(1.04)  LDD0790  [3]
 LDCM0474  CL80 PaTu 8988t C37(0.90)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C37(1.28)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C37(0.87)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C37(1.04)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C37(1.29)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C37(1.12)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C37(1.30)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C37(1.01)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C37(1.26)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C37(1.07)  LDD1362  [3]
 LDCM0484  CL9 HCT 116 C133(0.72); C299(1.07)  LDD0801  [3]
 LDCM0485  CL90 PaTu 8988t C37(1.25)  LDD1364  [3]
 LDCM0486  CL91 HCT 116 C133(1.04)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C133(0.95)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C133(0.95)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C133(0.61)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C133(0.80)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C133(0.98)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C133(1.10)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C133(1.20)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C133(1.33)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C37(1.00); C133(0.85); C299(1.03)  LDD1698  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C133(2.89); C299(2.52)  LDD1702  [2]
 LDCM0625  F8 Ramos C133(1.34)  LDD2187  [7]
 LDCM0573  Fragment11 Ramos C133(0.58)  LDD2190  [7]
 LDCM0575  Fragment13 Ramos C133(1.17)  LDD2192  [7]
 LDCM0580  Fragment21 Ramos C133(1.30)  LDD2195  [7]
 LDCM0582  Fragment23 Ramos C133(0.97)  LDD2196  [7]
 LDCM0578  Fragment27 Ramos C133(0.80)  LDD2197  [7]
 LDCM0586  Fragment28 Ramos C133(1.12)  LDD2198  [7]
 LDCM0588  Fragment30 Ramos C133(1.27)  LDD2199  [7]
 LDCM0589  Fragment31 Ramos C133(1.66)  LDD2200  [7]
 LDCM0590  Fragment32 Ramos C133(3.65)  LDD2201  [7]
 LDCM0468  Fragment33 HCT 116 C133(0.64)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C133(3.32)  LDD2203  [7]
 LDCM0566  Fragment4 Ramos C133(4.52)  LDD2184  [7]
 LDCM0427  Fragment51 HCT 116 C133(1.21)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C133(2.02)  LDD2204  [7]
 LDCM0614  Fragment56 Ramos C133(1.30)  LDD2205  [7]
 LDCM0569  Fragment7 Ramos C133(2.81)  LDD2186  [7]
 LDCM0022  KB02 HEK-293T C133(0.95); C37(0.85)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C133(0.98); C37(0.95)  LDD1497  [6]
 LDCM0024  KB05 G361 C133(8.90)  LDD3311  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C133(0.87)  LDD2099  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C133(0.93)  LDD2107  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C133(0.72)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C133(0.67)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C133(0.77)  LDD2127  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C133(0.95)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C133(1.11)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C133(0.72); C299(1.01)  LDD2137  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C133(0.55)  LDD2146  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C299(0.46)  LDD2207  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Solute carrier family 15 member 3 (SLC15A3) Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family Q8IY34
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) . Q9HC29
TLR adapter interacting with SLC15A4 on the lysosome (TASL) . Q9HAI6

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
[14c]Histidine Small molecular drug D0XT2X
[3h]Histidine Small molecular drug D07UTZ

References

1 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.