Details of the Target

General Information of Target

Target ID LDTP02918
Target Name S-adenosylmethionine decarboxylase proenzyme (AMD1)
Gene Name AMD1
Gene ID 262
Synonyms
AMD; S-adenosylmethionine decarboxylase proenzyme; AdoMetDC; SAMDC; EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQ
EAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKP
SHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEIL
MSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYW
TIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQ
KIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
Target Type
Successful
Target Bioclass
Enzyme
Family
Eukaryotic AdoMetDC family
Function Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
TTD ID
T55922
Uniprot ID
P17707
DrugMap ID
TTBFROQ
Ensemble ID
ENST00000368882.8
HGNC ID
HGNC:457
ChEMBL ID
CHEMBL4181

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.P36L .
MCC13 Substitution: p.V217A .
MOLT4 SNV: p.G30W IA-alkyne    Probe Info 
NCIH82 SNV: p.V203I .
P31FUJ Deletion: p.E135VfsTer3 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		20.00  LDD0385  [1]
Alkylaryl probe 2
 Probe Info  		20.00  LDD0389  [1]
P13
 Probe Info  		10.01  LDD0203  [2]
IPM
 Probe Info  		C82(3.69)  LDD1701  [3]
DBIA
 Probe Info  		C156(0.96)  LDD0531  [4]
IA-alkyne
 Probe Info  		C310(0.00); C82(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C156(0.96)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C156(1.20)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C156(0.94)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C156(0.86)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C156(1.02)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C156(0.97)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C156(0.88)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C156(0.84)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C156(0.81)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C156(0.98)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C156(0.80)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C156(1.25)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C156(1.19)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C156(1.26)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C156(1.10)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C156(1.01)  LDD0546  [4]
 LDCM0230  AC113 HEK-293T C156(0.75)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C156(0.57)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C156(0.77)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C156(0.90)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C156(0.84)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C156(0.81)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C156(0.64)  LDD0834  [4]
 LDCM0237  AC12 HCT 116 C156(1.02)  LDD0554  [4]
 LDCM0238  AC120 HEK-293T C156(0.78)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C156(0.69)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C156(0.59)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C156(0.69)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C156(0.86)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C156(0.58)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C156(0.44)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C156(0.34)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C156(1.42)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C156(1.29)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C156(1.26)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C156(1.51)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C156(1.67)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C156(1.51)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C156(1.69)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C156(1.35)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C156(1.25)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C156(1.25)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C156(1.11)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C156(1.19)  LDD0856  [4]
 LDCM0259  AC14 HCT 116 C156(1.51)  LDD0576  [4]
 LDCM0260  AC140 HEK-293T C156(1.69)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C156(1.20)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C156(1.57)  LDD0860  [4]
 LDCM0263  AC143 PaTu 8988t C156(1.48)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C156(1.21)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C156(1.08)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C156(2.13)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C156(1.18)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C156(1.50)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C156(1.13)  LDD1148  [4]
 LDCM0270  AC15 HCT 116 C156(1.36)  LDD0587  [4]
 LDCM0271  AC150 PaTu 8988t C156(1.40)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C156(1.61)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C156(1.31)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C156(1.67)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C156(1.29)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C156(1.45)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C156(1.56)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C156(1.28)  LDD2169  [4]
 LDCM0276  AC17 HCT 116 C156(1.40)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C156(1.39)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C156(1.35)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C156(1.10)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C156(1.19)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C156(1.21)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C156(1.15)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C156(1.19)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C156(1.25)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C156(0.95)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C156(1.02)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C156(1.05)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C156(0.83)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C156(0.96)  LDD0887  [4]
 LDCM0290  AC3 HCT 116 C156(0.95)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C156(1.07)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C156(0.90)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C156(0.95)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C156(0.99)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C156(1.03)  LDD0893  [4]
 LDCM0296  AC35 HEK-293T C156(0.83)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C156(0.97)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C156(0.83)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C156(1.24)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C156(1.05)  LDD0898  [4]
 LDCM0301  AC4 HCT 116 C156(0.94)  LDD0618  [4]
 LDCM0302  AC40 HEK-293T C156(0.84)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C156(1.29)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C156(0.80)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C156(0.87)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C156(0.98)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C156(1.11)  LDD0905  [4]
 LDCM0308  AC46 HCT 116 C156(1.22)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C156(0.87)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C156(0.83)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C156(1.23)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C156(1.01)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C156(1.17)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C156(0.85)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C156(1.00)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C156(1.55)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C156(0.99)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C156(1.17)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C156(1.35)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C156(0.99)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C156(1.33)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C156(1.17)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C156(1.25)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C156(0.95)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C156(1.04)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C156(1.24)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C156(0.89)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C156(1.06)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C156(1.33)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C156(1.32)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C156(1.10)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C156(1.05)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C156(0.98)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C156(1.60)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C156(0.96)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C156(0.96)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C156(1.09)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C156(1.07)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C156(0.96)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C156(1.14)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C156(1.04)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C156(0.97)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C156(0.95)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C156(0.83)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C156(1.06)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C156(0.87)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C156(0.72)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C156(0.90)  LDD0665  [4]
 LDCM0349  AC83 HEK-293T C156(0.89)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C156(0.82)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C156(0.82)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C156(0.82)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C156(0.98)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C156(1.07)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C156(1.02)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C156(0.93)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C156(0.87)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C156(0.89)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C156(0.34)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C156(1.06)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C156(1.16)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C156(0.70)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C156(0.60)  LDD0962  [4]
 LDCM0365  AC98 HCT 116 C156(1.05)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C156(0.87)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C156(1.10)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C156(1.34)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C156(1.55)  LDD0592  [4]
 LDCM0088  C45 HEK-293T 10.01  LDD0203  [2]
 LDCM0367  CL1 HCT 116 C156(0.95)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C156(1.22)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C156(0.98)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C156(1.62)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C156(1.14)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C156(0.97)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C156(1.22)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C156(1.52)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C156(2.01)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C156(1.55)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C156(2.06)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C156(1.33)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C156(1.21)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C156(1.57)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C156(1.19)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C156(0.88)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C156(0.90)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C156(0.61)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C156(0.95)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C156(1.13)  LDD0984  [4]
 LDCM0387  CL117 HEK-293T C156(1.18)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C156(1.47)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C156(1.22)  LDD0987  [4]
 LDCM0390  CL12 HCT 116 C156(1.53)  LDD0707  [4]
 LDCM0391  CL120 HEK-293T C156(1.10)  LDD0989  [4]
 LDCM0392  CL121 HCT 116 C156(0.95)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C156(0.82)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C156(1.05)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C156(0.97)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C156(1.03)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C156(0.95)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C156(1.16)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C156(1.18)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C156(1.26)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C156(1.25)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C156(1.39)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C156(0.91)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C156(0.90)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C156(1.36)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C156(1.08)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C156(1.01)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C156(1.25)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C156(1.34)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C156(1.60)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C156(1.45)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C156(1.48)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C156(1.09)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C156(1.19)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C156(1.03)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C156(1.27)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C156(1.37)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C156(1.05)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C156(1.35)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C156(1.17)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C156(1.29)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C156(0.97)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C156(1.42)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C156(1.31)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C156(1.20)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C156(1.51)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C156(1.25)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C156(1.06)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C156(1.41)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C156(1.31)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C156(1.49)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C156(1.48)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C156(1.57)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C156(1.63)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C156(1.06)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C156(1.04)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C156(1.32)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C156(1.30)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C156(1.21)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C156(1.15)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C156(1.00)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C156(1.46)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C156(1.21)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C156(1.42)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C156(1.59)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C156(1.07)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C156(0.99)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C156(1.20)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C156(1.41)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C156(1.38)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C156(1.24)  LDD0769  [4]
 LDCM0453  CL61 PaTu 8988t C156(1.27)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C156(0.98)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C156(0.79)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C156(1.03)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C156(1.01)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C156(0.92)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C156(1.22)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C156(1.70)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C156(1.22)  LDD1340  [4]
 LDCM0462  CL7 HCT 116 C156(1.42)  LDD0779  [4]
 LDCM0463  CL70 PaTu 8988t C156(1.43)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C156(1.01)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C156(0.75)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C156(1.35)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C156(1.13)  LDD1346  [4]
 LDCM0469  CL76 HCT 116 C156(1.40)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C156(4.51)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C156(1.29)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C156(1.15)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C156(1.22)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C156(1.17)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C156(0.88)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C156(1.43)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C156(1.62)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C156(1.82)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C156(0.98)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C156(1.01)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C156(1.00)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C156(1.41)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C156(1.44)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C156(1.25)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C156(0.68)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C156(0.85)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C156(0.67)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C156(0.97)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C156(1.11)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C156(0.93)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C156(0.82)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C156(0.91)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C156(0.86)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C156(0.91)  LDD0811  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C82(1.43)  LDD1702  [3]
 LDCM0468  Fragment33 PaTu 8988t C156(1.67)  LDD1347  [4]
 LDCM0427  Fragment51 HCT 116 C156(1.59)  LDD0744  [4]
 LDCM0022  KB02 769-P C82(1.54)  LDD2246  [6]
 LDCM0023  KB03 MDA-MB-231 C82(3.69)  LDD1701  [3]
 LDCM0024  KB05 MKN-1 C82(1.99)  LDD3331  [6]
 LDCM0099  Phenelzine HEK-293T 5.00  LDD0386  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
S-adenosylmethionine decarboxylase proenzyme (AMD1) Eukaryotic AdoMetDC family P17707
Peroxynitrite isomerase THAP4 (THAP4) Nitrobindin family Q8WY91

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ademetionine Small molecular drug DB00118
Tromethamine Small molecular drug D03ZFN
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Org 34517/34850 Small molecular drug D0E2WF
Investigative
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
5'-([(Z)-4-amino-2-butenyl]Methylamino)-5'-deoxyadenosine Small molecular drug D0Y7YL
5'-deoxy-5'-(N,N-dimethylamino)-8-methyladenosine Small molecular drug D0YM6B
5'-deoxy-5'-(N,N-dimethylamino)Adenosine Small molecular drug D03OLX
5'-deoxy-5'-dimethylsulfonioadenosine Chloride Small molecular drug D0I7IA
5'-deoxy-5'-[(3-hydrazinopropyl)Methylamino]Adenosine Small molecular drug D0V2QF
[(2-aminooxyethyl)Methylamino]-5'-deoxyadenosine Small molecular drug D0P5YR
5'-{[4-(Aminooxy)Butyl](Methyl)Amino}-5'-deoxy-8-ethenyladenosine . DB08163
Hydroxyalanine . D0BI4H
Discontinued
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cgp-40215a Small molecular drug D0S6VX
Mgbg Small molecular drug D05FFR
Putrescine Small molecular drug D00FMV

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840