Details of the Target

General Information of Target

Target ID LDTP12679
Target Name Trimethyllysine dioxygenase, mitochondrial (TMLHE)
Gene Name TMLHE
Gene ID 55217
Synonyms
TMLH; Trimethyllysine dioxygenase, mitochondrial; EC 1.14.11.8; Epsilon-trimethyllysine 2-oxoglutarate dioxygenase; Epsilon-trimethyllysine hydroxylase; TML hydroxylase; TML-alpha-ketoglutarate dioxygenase; TML dioxygenase; TMLD
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPIL
INSAFLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRIFSVIHSNDPVARA
ITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSKDFAVGICNKI
SEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLLQQLVTSYPSTKMVIVSLHTFTL
LAASSLVDTPKQIQLLLQYLKNDPRKAVKRLAIQDLKLLANKTPHTWSRENIQALCECAL
QTPYDSLKLGMLSVLSTLSGTIAIKHYFSIVPGNVSSSPRSSDLVKLAQECCYHNNRGIA
AHGVRVLTNITVSCQEKDLLALEQDAVFGLESLLVLCSQDDSPGAQATLKIALNCMVKLA
KGRPHLSQSVVETLLTQLHSAQDAARILMCHCLAAIAMQLPVLGDGMLGDLMELYKVIGR
SATDKQQELLVSLATVIFVASQKALSVESKAVIKQQLESVSNGWTVYRIARQASRMGNHD
MAKELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEENYSSALSCIAESLKFYHKG
IASLTAASTPLNPLSFQCEFVKLRIDLLQAFSQLICTCNSLKTSPPPAIATTIAMTLGND
LQRCGRISNQMKQSMEEFRSLASRYGDLYQASFDADSATLRNVELQQQSCLLISHAIEAL
ILDPESASFQEYGSTGTAHADSEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLCNA
IIALLKVPLSFQRYFFQKLQSTSIKLALSPSPRNPAEPIAVQNNQQLALKVEGVVQHGSK
PGLFRKIQSVCLNVSSTLQSKSGQDYKIPIDNMTNEMEQRVEPHNDYFSTQFLLNFAILG
THNITVESSVKDANGIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQAQQPLQQQQQRNAYT
RF
Target Bioclass
Enzyme
Family
Gamma-BBH/TMLD family
Subcellular location
Mitochondrion matrix
Function Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
Uniprot ID
Q9NVH6
Ensemble ID
ENST00000334398.8
HGNC ID
HGNC:18308

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT SNV: p.N183D .
IGROV1 Insertion: p.T119HfsTer9 DBIA    Probe Info 
MCC13 SNV: p.E288K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Alkylaryl probe 3
 Probe Info  		15.11  LDD0381  [2]
P13
 Probe Info  		11.79  LDD0203  [3]
Curcusone 37
 Probe Info  		2.22  LDD0188  [4]
DBIA
 Probe Info  		C393(31.27)  LDD0209  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
Compound 11
 Probe Info  		N.A.  LDD2213  [9]
IPM
 Probe Info  		N.A.  LDD0005  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Phosphinate-6
 Probe Info  		C259(0.00); C103(0.00); C393(0.00); C308(0.00)  LDD0018  [11]
AOyne
 Probe Info  		8.70  LDD0443  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
TER-AC
 Probe Info  		N.A.  LDD0426  [14]
PAL-AfBPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.63  LDD1714  [15]
C039
 Probe Info  		8.94  LDD1739  [15]
C064
 Probe Info  		5.94  LDD1761  [15]
C070
 Probe Info  		8.75  LDD1766  [15]
C087
 Probe Info  		10.70  LDD1779  [15]
C129
 Probe Info  		17.03  LDD1811  [15]
C169
 Probe Info  		25.46  LDD1849  [15]
C173
 Probe Info  		5.86  LDD1853  [15]
C201
 Probe Info  		25.81  LDD1877  [15]
C203
 Probe Info  		10.56  LDD1878  [15]
C204
 Probe Info  		7.11  LDD1879  [15]
C206
 Probe Info  		20.25  LDD1881  [15]
C211
 Probe Info  		8.88  LDD1885  [15]
C225
 Probe Info  		5.58  LDD1898  [15]
C226
 Probe Info  		5.90  LDD1899  [15]
C228
 Probe Info  		19.43  LDD1901  [15]
C249
 Probe Info  		19.43  LDD1922  [15]
C265
 Probe Info  		23.59  LDD1936  [15]
C280
 Probe Info  		11.63  LDD1950  [15]
C293
 Probe Info  		17.51  LDD1963  [15]
C296
 Probe Info  		13.64  LDD1966  [15]
C376
 Probe Info  		17.03  LDD2036  [15]
C378
 Probe Info  		6.32  LDD2037  [15]
C380
 Probe Info  		15.24  LDD2039  [15]
C382
 Probe Info  		17.15  LDD2041  [15]
C390
 Probe Info  		21.71  LDD2049  [15]
C397
 Probe Info  		21.56  LDD2056  [15]
C403
 Probe Info  		18.64  LDD2061  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C103(1.08); C85(1.17); C393(1.01); C51(0.83)  LDD1507  [16]
 LDCM0215  AC10 HEK-293T C103(1.10); C85(1.10); C393(0.96); C308(0.99)  LDD1508  [16]
 LDCM0226  AC11 HEK-293T C103(0.89); C85(1.17); C393(1.12); C308(1.17)  LDD1509  [16]
 LDCM0237  AC12 HEK-293T C103(1.06); C85(1.07); C393(0.92); C308(0.91)  LDD1510  [16]
 LDCM0259  AC14 HEK-293T C103(1.07); C393(1.01); C308(1.09); C252(0.86)  LDD1512  [16]
 LDCM0270  AC15 HEK-293T C103(1.06); C393(0.92); C308(0.98); C167(1.06)  LDD1513  [16]
 LDCM0276  AC17 HEK-293T C103(1.04); C85(1.06); C393(1.05); C51(0.94)  LDD1515  [16]
 LDCM0277  AC18 HEK-293T C103(1.00); C85(1.02); C393(0.97); C308(1.05)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C103(1.01); C85(1.64); C393(0.93); C308(1.02)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C103(1.13); C85(1.05); C393(0.94); C308(0.99)  LDD1518  [16]
 LDCM0280  AC20 HEK-293T C103(1.15); C85(1.08); C393(0.94); C308(1.01)  LDD1519  [16]
 LDCM0281  AC21 HEK-293T C103(1.03); C393(1.05); C308(1.02); C403(1.08)  LDD1520  [16]
 LDCM0282  AC22 HEK-293T C103(1.04); C393(0.94); C308(1.04); C252(0.81)  LDD1521  [16]
 LDCM0283  AC23 HEK-293T C103(1.04); C393(1.00); C308(0.97); C167(0.95)  LDD1522  [16]
 LDCM0284  AC24 HEK-293T C103(1.03); C393(1.05); C308(1.03); C167(0.93)  LDD1523  [16]
 LDCM0285  AC25 HEK-293T C103(1.06); C85(1.03); C393(1.03); C51(1.16)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C103(1.02); C85(1.07); C393(1.00); C308(1.03)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C103(0.89); C85(1.09); C393(1.02); C308(0.98)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C103(1.11); C85(0.98); C393(0.94); C308(1.00)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C103(0.97); C393(0.94); C308(1.01); C403(0.96)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C103(0.90); C85(1.15); C393(1.07); C308(1.15)  LDD1529  [16]
 LDCM0291  AC30 HEK-293T C103(1.08); C393(1.05); C308(1.00); C252(0.97)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C103(1.02); C393(0.91); C308(1.04); C167(1.00)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C103(0.92); C393(1.04); C308(0.89); C167(1.01)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C103(1.07); C85(1.08); C393(0.98); C51(0.99)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C103(1.09); C85(0.98); C393(1.01); C308(1.11)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C103(0.85); C85(1.16); C393(1.11); C308(1.02)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C103(1.10); C85(1.00); C393(0.97); C308(0.99)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C103(0.94); C393(0.89); C308(1.00); C403(1.36)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C103(0.97); C393(1.05); C308(1.01); C252(0.93)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C103(1.08); C393(0.98); C308(1.03); C167(0.85)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C103(1.06); C85(1.05); C393(0.95); C308(1.03)  LDD1540  [16]
 LDCM0302  AC40 HEK-293T C103(0.93); C393(0.96); C308(1.08); C167(0.96)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C103(1.04); C85(1.18); C393(1.12); C51(0.93)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C103(1.07); C85(1.08); C393(1.97); C308(1.18)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C103(0.88); C85(1.15); C393(1.14); C308(1.10)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C103(1.00); C85(1.20); C393(0.93); C308(1.02)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C103(0.95); C393(0.99); C308(1.06); C403(1.00)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C103(1.00); C393(1.07); C308(1.08); C252(0.94)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C103(1.08); C393(1.02); C308(1.07); C167(1.05)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C103(0.95); C393(1.05); C308(1.06); C167(1.25)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C103(1.05); C85(1.07); C393(1.04); C51(1.23)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C103(0.98); C393(0.93); C308(1.00); C403(0.99)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C103(1.10); C85(1.24); C393(1.07); C308(0.99)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C103(0.91); C85(1.16); C393(1.03); C308(1.15)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C103(1.02); C85(1.10); C393(0.94); C308(0.98)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C103(0.91); C393(0.97); C308(0.96); C403(0.95)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C103(1.02); C393(0.91); C308(1.05); C252(0.98)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C103(1.09); C393(0.84); C308(1.09); C167(0.91)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C103(0.91); C393(1.03); C308(1.02); C167(1.13)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C103(1.04); C85(1.06); C393(0.95); C51(0.92)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C103(1.05); C85(1.06); C393(0.95); C308(1.07)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C103(0.89); C85(1.07); C393(1.00); C308(1.10)  LDD1561  [16]
 LDCM0323  AC6 HEK-293T C103(1.05); C393(1.02); C308(1.04); C252(1.03)  LDD1562  [16]
 LDCM0324  AC60 HEK-293T C103(1.13); C85(0.91); C393(0.97); C308(1.02)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C103(1.01); C393(0.94); C308(0.93); C403(1.31)  LDD1564  [16]
 LDCM0326  AC62 HEK-293T C103(1.05); C393(0.99); C308(1.05); C252(1.06)  LDD1565  [16]
 LDCM0327  AC63 HEK-293T C103(1.08); C393(0.90); C308(1.05); C167(0.87)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C103(0.96); C393(0.96); C308(1.09); C167(1.15)  LDD1567  [16]
 LDCM0334  AC7 HEK-293T C103(1.07); C393(0.99); C308(1.04); C167(0.94)  LDD1568  [16]
 LDCM0345  AC8 HEK-293T C103(0.90); C393(1.00); C308(0.98); C167(1.27)  LDD1569  [16]
 LDCM0248  AKOS034007472 HEK-293T C103(0.96); C393(0.92); C308(0.91); C403(0.87)  LDD1511  [16]
 LDCM0356  AKOS034007680 HEK-293T C103(1.09); C85(1.14); C393(1.09); C51(0.95)  LDD1570  [16]
 LDCM0275  AKOS034007705 HEK-293T C103(0.92); C393(0.99); C308(1.01); C167(1.20)  LDD1514  [16]
 LDCM0156  Aniline NCI-H1299 11.92  LDD0403  [1]
 LDCM0088  C45 HEK-293T 11.79  LDD0203  [3]
 LDCM0632  CL-Sc Hep-G2 C103(0.96)  LDD2227  [13]
 LDCM0367  CL1 HEK-293T C103(1.10); C85(1.19); C393(0.90); C51(1.59)  LDD1571  [16]
 LDCM0368  CL10 HEK-293T C103(0.75); C393(0.95); C308(0.80); C252(0.83)  LDD1572  [16]
 LDCM0369  CL100 HEK-293T C103(1.00); C393(1.01); C308(1.00); C167(0.99)  LDD1573  [16]
 LDCM0370  CL101 HEK-293T C103(1.11); C85(1.21); C393(0.94); C51(1.53)  LDD1574  [16]
 LDCM0371  CL102 HEK-293T C103(0.89); C85(1.12); C393(0.98); C308(0.99)  LDD1575  [16]
 LDCM0372  CL103 HEK-293T C103(0.91); C393(1.02); C308(1.01); C252(0.92)  LDD1576  [16]
 LDCM0373  CL104 HEK-293T C103(0.98); C393(0.91); C308(0.96); C167(1.09)  LDD1577  [16]
 LDCM0374  CL105 HEK-293T C103(1.03); C85(1.13); C393(0.94); C51(1.41)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C103(0.92); C85(1.09); C393(0.97); C308(1.00)  LDD1579  [16]
 LDCM0376  CL107 HEK-293T C103(0.98); C393(1.10); C308(1.03); C252(0.89)  LDD1580  [16]
 LDCM0377  CL108 HEK-293T C103(0.94); C393(0.95); C308(0.88); C167(1.16)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C103(1.04); C85(0.99); C393(0.92); C51(1.48)  LDD1582  [16]
 LDCM0379  CL11 HEK-293T C103(0.89); C393(0.93); C308(0.91); C167(1.08)  LDD1583  [16]
 LDCM0380  CL110 HEK-293T C103(0.84); C85(0.99); C393(0.95); C308(0.92)  LDD1584  [16]
 LDCM0381  CL111 HEK-293T C103(0.83); C393(1.15); C308(1.00); C252(1.01)  LDD1585  [16]
 LDCM0382  CL112 HEK-293T C103(0.96); C393(1.17); C308(0.97); C167(1.08)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C103(1.19); C85(1.10); C393(0.97); C51(1.43)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C103(0.90); C85(1.06); C393(0.96); C308(0.91)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C103(0.84); C393(1.11); C308(1.07); C252(1.04)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C103(0.96); C393(0.96); C308(0.94); C167(1.26)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C103(1.09); C85(1.05); C393(0.85); C51(0.88)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C103(0.96); C85(1.11); C393(0.92); C308(1.01)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C103(0.88); C393(1.09); C308(1.04); C252(1.02)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C103(0.95); C393(1.09); C308(0.88); C167(1.01)  LDD1594  [16]
 LDCM0391  CL120 HEK-293T C103(0.95); C393(0.90); C308(0.99); C167(1.02)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C103(1.16); C85(1.15); C393(0.88); C51(1.47)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C103(0.93); C85(1.00); C393(0.95); C308(1.11)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C103(0.80); C393(0.97); C308(0.99); C252(0.88)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C103(0.92); C393(0.91); C308(0.93); C167(0.96)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C103(1.15); C85(1.04); C393(0.91); C51(1.01)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C103(0.92); C85(1.06); C393(1.03); C308(1.06)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C103(0.91); C393(1.17); C308(1.01); C252(0.94)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C103(0.96); C393(0.95); C308(0.99); C167(0.97)  LDD1603  [16]
 LDCM0400  CL13 HEK-293T C103(1.15); C85(1.25); C393(1.00); C51(1.52)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C103(1.02); C85(0.98); C393(1.02); C308(0.98)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C103(0.87); C393(0.96); C308(0.93); C252(0.89)  LDD1606  [16]
 LDCM0403  CL16 HEK-293T C103(1.02); C393(0.92); C308(1.05); C167(1.13)  LDD1607  [16]
 LDCM0404  CL17 HEK-293T C103(0.98); C85(1.11); C393(1.02); C51(1.21)  LDD1608  [16]
 LDCM0405  CL18 HEK-293T C103(0.94); C85(1.28); C393(0.98); C308(1.13)  LDD1609  [16]
 LDCM0406  CL19 HEK-293T C103(1.07); C85(1.13); C393(1.18); C308(1.01)  LDD1610  [16]
 LDCM0407  CL2 HEK-293T C103(1.03); C85(1.22); C393(1.05); C308(0.93)  LDD1611  [16]
 LDCM0408  CL20 HEK-293T C103(0.78); C85(1.16); C393(0.95); C308(0.98)  LDD1612  [16]
 LDCM0409  CL21 HEK-293T C103(0.86); C393(1.00); C308(0.88); C403(0.92)  LDD1613  [16]
 LDCM0410  CL22 HEK-293T C103(0.83); C393(1.03); C308(0.96); C252(1.16)  LDD1614  [16]
 LDCM0411  CL23 HEK-293T C103(0.89); C393(1.02); C308(0.90); C167(1.19)  LDD1615  [16]
 LDCM0412  CL24 HEK-293T C103(1.07); C393(1.01); C308(1.03); C167(1.17)  LDD1616  [16]
 LDCM0413  CL25 HEK-293T C103(1.00); C85(1.11); C393(0.89); C51(1.54)  LDD1617  [16]
 LDCM0414  CL26 HEK-293T C103(0.94); C85(1.01); C393(0.88); C308(0.98)  LDD1618  [16]
 LDCM0415  CL27 HEK-293T C103(0.91); C393(0.88); C308(0.98); C252(0.90)  LDD1619  [16]
 LDCM0416  CL28 HEK-293T C103(1.02); C393(1.00); C308(0.91); C167(1.19)  LDD1620  [16]
 LDCM0417  CL29 HEK-293T C103(1.11); C85(1.13); C393(0.92); C51(0.93)  LDD1621  [16]
 LDCM0418  CL3 HEK-293T C103(1.00); C393(1.10); C308(1.02); C252(0.96)  LDD1622  [16]
 LDCM0419  CL30 HEK-293T C103(0.89); C85(1.12); C393(1.01); C308(0.96)  LDD1623  [16]
 LDCM0420  CL31 HEK-293T C103(1.05); C85(1.12); C393(1.15); C308(1.06)  LDD1624  [16]
 LDCM0421  CL32 HEK-293T C103(0.79); C85(1.13); C393(0.94); C308(0.96)  LDD1625  [16]
 LDCM0422  CL33 HEK-293T C103(0.77); C393(0.88); C308(0.81); C403(1.21)  LDD1626  [16]
 LDCM0423  CL34 HEK-293T C103(0.84); C393(0.92); C308(0.85); C252(0.89)  LDD1627  [16]
 LDCM0424  CL35 HEK-293T C103(0.79); C393(1.03); C308(0.90); C167(1.02)  LDD1628  [16]
 LDCM0425  CL36 HEK-293T C103(1.12); C393(1.02); C308(0.91); C167(1.08)  LDD1629  [16]
 LDCM0426  CL37 HEK-293T C103(1.06); C85(1.00); C393(0.85); C51(1.56)  LDD1630  [16]
 LDCM0428  CL39 HEK-293T C103(0.86); C393(1.07); C308(1.01); C252(0.87)  LDD1632  [16]
 LDCM0429  CL4 HEK-293T C103(1.01); C393(0.96); C308(0.93); C167(1.09)  LDD1633  [16]
 LDCM0430  CL40 HEK-293T C103(1.02); C393(0.98); C308(0.96); C167(1.04)  LDD1634  [16]
 LDCM0431  CL41 HEK-293T C103(1.02); C85(0.99); C393(0.97); C51(0.97)  LDD1635  [16]
 LDCM0432  CL42 HEK-293T C103(0.88); C85(0.96); C393(1.11); C308(0.96)  LDD1636  [16]
 LDCM0433  CL43 HEK-293T C103(1.05); C85(1.06); C393(1.03); C308(0.96)  LDD1637  [16]
 LDCM0434  CL44 HEK-293T C103(0.83); C85(1.11); C393(1.01); C308(0.94)  LDD1638  [16]
 LDCM0435  CL45 HEK-293T C103(0.88); C393(1.05); C308(0.92); C403(0.98)  LDD1639  [16]
 LDCM0436  CL46 HEK-293T C103(0.86); C393(1.01); C308(0.84); C252(0.80)  LDD1640  [16]
 LDCM0437  CL47 HEK-293T C103(0.81); C393(1.20); C308(0.88); C167(1.07)  LDD1641  [16]
 LDCM0438  CL48 HEK-293T C103(1.09); C393(1.00); C308(0.99); C167(1.14)  LDD1642  [16]
 LDCM0439  CL49 HEK-293T C103(1.09); C85(1.15); C393(0.83); C51(1.74)  LDD1643  [16]
 LDCM0440  CL5 HEK-293T C103(1.10); C85(1.10); C393(1.04); C51(1.06)  LDD1644  [16]
 LDCM0441  CL50 HEK-293T C103(1.01); C85(1.06); C393(1.10); C308(1.02)  LDD1645  [16]
 LDCM0443  CL52 HEK-293T C103(1.02); C393(1.01); C308(1.04); C167(1.06)  LDD1646  [16]
 LDCM0444  CL53 HEK-293T C103(1.02); C85(1.01); C393(1.02); C51(1.23)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C103(0.88); C85(1.06); C393(0.97); C308(0.94)  LDD1648  [16]
 LDCM0446  CL55 HEK-293T C103(1.16); C85(1.11); C393(1.19); C308(1.01)  LDD1649  [16]
 LDCM0447  CL56 HEK-293T C103(0.77); C85(1.09); C393(0.96); C308(0.97)  LDD1650  [16]
 LDCM0448  CL57 HEK-293T C103(0.79); C393(0.94); C308(0.85); C403(0.86)  LDD1651  [16]
 LDCM0449  CL58 HEK-293T C103(0.78); C393(0.96); C308(0.91); C252(0.94)  LDD1652  [16]
 LDCM0450  CL59 HEK-293T C103(0.94); C393(0.96); C308(0.90); C167(1.06)  LDD1653  [16]
 LDCM0451  CL6 HEK-293T C103(0.91); C85(1.12); C393(0.96); C308(0.99)  LDD1654  [16]
 LDCM0452  CL60 HEK-293T C103(0.89); C393(1.03); C308(0.87); C167(1.07)  LDD1655  [16]
 LDCM0453  CL61 HEK-293T C103(1.09); C85(1.18); C393(0.98); C51(1.60)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C103(0.92); C85(1.15); C393(1.04); C308(1.11)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C103(0.86); C393(1.15); C308(0.96); C252(0.87)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C103(0.93); C393(0.94); C308(0.97); C167(1.18)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C103(1.09); C85(1.13); C393(1.07); C51(0.92)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C103(0.90); C85(1.09); C393(1.00); C308(1.06)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C103(1.02); C85(1.06); C393(1.21); C308(1.15)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C103(0.74); C85(0.99); C393(0.93); C308(0.90)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C103(0.90); C393(1.00); C308(0.89); C403(1.03)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C103(1.05); C85(1.15); C393(1.18); C308(1.02)  LDD1665  [16]
 LDCM0463  CL70 HEK-293T C103(0.85); C393(1.06); C308(0.94); C252(0.82)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C103(0.90); C393(0.89); C308(0.88); C167(1.05)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C103(0.99); C393(1.16); C308(0.94); C167(1.10)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C103(1.07); C85(1.06); C393(0.87); C51(1.69)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C103(0.96); C85(0.95); C393(1.05); C308(1.12)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C103(1.00); C393(0.99); C308(0.96); C167(1.02)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C103(1.04); C85(1.29); C393(1.10); C51(1.05)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C103(0.96); C85(1.03); C393(1.06); C308(0.98)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C103(1.09); C85(1.21); C393(1.09); C308(1.08)  LDD1675  [16]
 LDCM0473  CL8 HEK-293T C103(0.60); C85(1.16); C393(0.79); C308(0.67)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C103(0.78); C85(1.08); C393(0.90); C308(1.01)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C103(0.94); C393(0.97); C308(0.96); C403(1.47)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C103(0.93); C393(1.00); C308(0.89); C252(1.02)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C103(0.85); C393(0.91); C308(0.89); C167(0.88)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C103(0.92); C393(1.00); C308(0.91); C167(0.93)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C103(1.18); C85(1.22); C393(0.84); C51(1.60)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C103(0.87); C85(1.07); C393(1.01); C308(1.07)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C103(0.88); C393(1.12); C308(1.05); C252(1.05)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C103(0.97); C393(1.00); C308(1.04); C167(1.09)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C103(1.08); C85(1.15); C393(1.02); C51(1.05)  LDD1686  [16]
 LDCM0484  CL9 HEK-293T C103(0.91); C393(1.02); C308(0.86); C403(1.21)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C103(0.81); C85(1.20); C393(0.89); C308(0.84)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C103(0.96); C85(1.29); C393(1.16); C308(1.01)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C103(0.81); C85(1.18); C393(0.88); C308(0.89)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C103(0.86); C393(1.04); C308(0.85); C403(0.64)  LDD1691  [16]
 LDCM0489  CL94 HEK-293T C103(0.89); C393(1.07); C308(1.01); C252(0.81)  LDD1692  [16]
 LDCM0490  CL95 HEK-293T C103(0.88); C393(1.04); C308(0.83); C167(1.15)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C103(0.88); C393(0.96); C308(0.80); C167(1.14)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C103(1.04); C85(1.04); C393(0.96); C51(1.56)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C103(0.96); C85(0.93); C393(0.96); C308(0.99)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C103(0.91); C393(1.07); C308(0.98); C252(1.08)  LDD1697  [16]
 LDCM0033  Curcusone1d MCF-7 2.22  LDD0188  [4]
 LDCM0495  E2913 HEK-293T C103(0.81); C393(1.27); C308(1.00); C252(0.93)  LDD1698  [16]
 LDCM0573  Fragment11 Ramos C103(20.00)  LDD2190  [17]
 LDCM0576  Fragment14 Ramos C103(0.84)  LDD2193  [17]
 LDCM0468  Fragment33 HEK-293T C103(0.92); C393(0.94); C308(1.04); C252(0.94)  LDD1671  [16]
 LDCM0566  Fragment4 Ramos C103(2.41)  LDD2184  [17]
 LDCM0427  Fragment51 HEK-293T C103(1.01); C85(1.03); C393(1.00); C308(1.00)  LDD1631  [16]
 LDCM0569  Fragment7 Ramos C103(0.97)  LDD2186  [17]
 LDCM0022  KB02 HEK-293T C85(0.98); C103(0.98); C308(1.07)  LDD1492  [16]
 LDCM0023  KB03 Jurkat C393(31.27)  LDD0209  [5]
 LDCM0024  KB05 COLO792 C96(2.24)  LDD3310  [18]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ascorbic Acid Small molecular drug DB00126

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
4 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840