Details of the Probe-central Interaction Altas
General Information of Experiment
| Probe Name | C039 | Probe Info | ||||
|---|---|---|---|---|---|---|
| Probe concentration | Probe:50uM; negative probe:50uM | |||||
| Criteria | Quantification: AfBPP Probe vs Negative Probe | |||||
| Quantitative Method |
TMT
|
|||||
| In Vivo Experiment Model | Model Type |
|
Living cell | |||
| Derived Tissue |
|
Peripheral blood | ||||
| Disease Model | Normal | |||||
| Model Name | Human normal cells (HEK-293T) | |||||
| Note | Negative probe:C#CCCC1(CCC(NC)=O)N=N1 | |||||
Interaction Altas of This Experiment [1]
Enzyme
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP12013 | dCTP pyrophosphatase 1 (DCTPP1) | 26.2 | ||||
| LDTP02359 | Heme oxygenase 1 (HMOX1) | 14.4 | ||||
| LDTP03540 | Heme oxygenase 2 (HMOX2) | 13.2 | ||||
| LDTP16032 | Retinoid-inducible serine carboxypeptidase (SCPEP1) | 11.8 | ||||
| LDTP13620 | Lysosomal thioesterase PPT2 (PPT2) | 10.9 | ||||
| LDTP16007 | Lipid droplet-associated hydrolase (LDAH) | 10.0 | ||||
| LDTP00832 | NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) | 9.8 | ||||
| LDTP03394 | Ceramide synthase 1 (CERS1) | 9.2 | ||||
| LDTP12679 | Trimethyllysine dioxygenase, mitochondrial (TMLHE) | 8.9 | ||||
| LDTP14218 | Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) | 8.8 | ||||
| LDTP04506 | Diacylglycerol kinase epsilon (DGKE) | 8.8 | ||||
| LDTP06375 | Delta(24)-sterol reductase (DHCR24) | 7.6 | ||||
| LDTP08728 | Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) | 7.6 | ||||
| LDTP04008 | Endothelin-converting enzyme 1 (ECE1) | 7.4 | ||||
| LDTP14030 | V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) | 7.4 | ||||
| LDTP13282 | Prenylcysteine oxidase 1 (PCYOX1) | 7.2 | ||||
| LDTP06618 | ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) | 7.0 | ||||
| LDTP04712 | Puromycin-sensitive aminopeptidase (NPEPPS) | 7.0 | ||||
| LDTP10032 | 7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) | 7.0 | ||||
| LDTP09096 | Carbohydrate sulfotransferase 14 (CHST14) | 7.0 | ||||
| LDTP13358 | Leucyl-cystinyl aminopeptidase (LNPEP) | 7.0 | ||||
| LDTP05758 | S-methyl-5'-thioadenosine phosphorylase (MTAP) | 6.9 | ||||
| LDTP04388 | Palmitoyl-protein thioesterase 1 (PPT1) | 6.8 | ||||
| LDTP01241 | Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) | 6.6 | ||||
| LDTP17410 | Cytochrome P450 20A1 (CYP20A1) | 6.5 | ||||
| LDTP06477 | Methylsterol monooxygenase 1 (MSMO1) | 6.2 | ||||
| LDTP01328 | CAAX prenyl protease 1 homolog (ZMPSTE24) | 6.1 | ||||
| LDTP04051 | Nicotinamide phosphoribosyltransferase (NAMPT) | 6.1 | ||||
| LDTP12279 | Endoplasmic reticulum transmembrane helix translocase (ATP13A1) | 5.9 | ||||
| LDTP06325 | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) | 5.9 | ||||
| LDTP02175 | Epoxide hydrolase 1 (EPHX1) | 5.9 | ||||
| LDTP02837 | Beta-galactosidase (GLB1) | 5.8 | ||||
| LDTP02721 | Farnesyl pyrophosphate synthase (FDPS) | 5.7 | ||||
| LDTP04285 | Proteasome subunit beta type-2 (PSMB2) | 5.7 | ||||
| LDTP15422 | Prostaglandin reductase 3 (PTGR3) | 5.7 | ||||
| LDTP05066 | Signal peptidase complex catalytic subunit SEC11A (SEC11A) | 5.4 | ||||
| LDTP12524 | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASDHPPT) | 5.4 | ||||
| LDTP03145 | Catechol O-methyltransferase (COMT) | 5.3 | ||||
| LDTP00486 | Cytochrome b-c1 complex subunit 8 (UQCRQ) | 5.3 | ||||
| LDTP00697 | Cytochrome b5 type B (CYB5B) | 5.2 | ||||
| LDTP04211 | Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) | 5.0 | ||||
| LDTP12959 | NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) | 5.0 | ||||
| LDTP09256 | Putative phospholipase B-like 2 (PLBD2) | 5.0 | ||||
| LDTP12363 | Lysophosphatidic acid phosphatase type 6 (ACP6) | 5.0 | ||||
| LDTP05862 | NAD(P) transhydrogenase, mitochondrial (NNT) | 4.9 | ||||
| LDTP09088 | Phospholipase A2 group XV (PLA2G15) | 4.9 | ||||
Transporter and channel
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP02724 | Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) | 32.2 | ||||
| LDTP09968 | V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) | 12.7 | ||||
| LDTP10913 | Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) | 12.5 | ||||
| LDTP01059 | Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) | 12.4 | ||||
| LDTP03546 | Translocator protein (TSPO) | 12.0 | ||||
| LDTP04033 | Translocon-associated protein subunit alpha (SSR1) | 12.0 | ||||
| LDTP14511 | ATP synthase subunit g, mitochondrial (ATP5MG) | 10.9 | ||||
| LDTP06426 | Translocating chain-associated membrane protein 1 (TRAM1) | 10.1 | ||||
| LDTP03277 | ER lumen protein-retaining receptor 1 (KDELR1) | 9.9 | ||||
| LDTP07885 | Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) | 9.7 | ||||
| LDTP11813 | Solute carrier family 25 member 32 (SLC25A32) | 8.9 | ||||
| LDTP06034 | Lysosome membrane protein 2 (SCARB2) | 8.9 | ||||
| LDTP03132 | Voltage-dependent anion-selective channel protein 1 (VDAC1) | 7.9 | ||||
| LDTP00865 | Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) | 7.8 | ||||
| LDTP15733 | Solute carrier family 25 member 44 (SLC25A44) | 7.6 | ||||
| LDTP08881 | Transmembrane protein 199 (TMEM199) | 7.2 | ||||
| LDTP07236 | Protein GPR107 (GPR107) | 7.2 | ||||
| LDTP09547 | Scavenger receptor class B member 1 (SCARB1) | 6.8 | ||||
| LDTP04071 | Voltage-dependent anion-selective channel protein 2 (VDAC2) | 6.6 | ||||
| LDTP20002 | Transmembrane protein 160 (TMEM160) | 6.5 | ||||
| LDTP14099 | Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) | 6.4 | ||||
| LDTP13983 | Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) | 5.7 | ||||
| LDTP15948 | Transmembrane protein 126A (TMEM126A) | 5.6 | ||||
| LDTP18448 | Transmembrane 9 superfamily member 3 (TM9SF3) | 5.5 | ||||
| LDTP17641 | Solute carrier family 35 member F2 (SLC35F2) | 5.4 | ||||
| LDTP14952 | Mpv17-like protein 2 (MPV17L2) | 5.0 | ||||
| LDTP01671 | STARD3 N-terminal-like protein (STARD3NL) | 5.0 | ||||
| LDTP11213 | Nucleoporin NDC1 (NDC1) | 4.9 | ||||
Other
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP03678 | ER lumen protein-retaining receptor 2 (KDELR2) | 18.6 | ||||
| LDTP12565 | Mitochondrial import receptor subunit TOM22 homolog (TOMM22) | 15.9 | ||||
| LDTP11076 | Apolipoprotein L2 (APOL2) | 15.0 | ||||
| LDTP15420 | Mitochondrial import receptor subunit TOM5 homolog (TOMM5) | 13.6 | ||||
| LDTP19859 | Small integral membrane protein 12 (SMIM12) | 11.8 | ||||
| LDTP05160 | Nucleobindin-2 (NUCB2) | 11.6 | ||||
| LDTP00850 | ER lumen protein-retaining receptor 3 (KDELR3) | 8.9 | ||||
| LDTP05375 | Nucleobindin-1 (NUCB1) | 8.6 | ||||
| LDTP06391 | Protein transport protein Sec23B (SEC23B) | 8.3 | ||||
| LDTP15623 | Neuferricin (CYB5D2) | 7.7 | ||||
| LDTP07368 | Tetratricopeptide repeat protein 19, mitochondrial (TTC19) | 6.7 | ||||
| LDTP10056 | Protein FAM162A (FAM162A) | 5.9 | ||||
| LDTP19780 | Keratinocyte-associated transmembrane protein 2 (KCT2) | 5.8 | ||||
| LDTP13311 | Poly(U)-binding-splicing factor PUF60 (PUF60) | 5.8 | ||||
| LDTP14486 | Clustered mitochondria protein homolog (CLUH) | 5.4 | ||||
| LDTP13797 | HIG1 domain family member 1A, mitochondrial (HIGD1A) | 5.4 | ||||
| LDTP06097 | Reticulocalbin-2 (RCN2) | 5.4 | ||||
| LDTP00281 | Golgi integral membrane protein 4 (GOLIM4) | 5.2 | ||||
| LDTP09881 | TATA-binding protein-associated factor 2N (TAF15) | 5.2 | ||||
| LDTP00500 | Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) | 5.1 | ||||
| LDTP06390 | Protein transport protein Sec23A (SEC23A) | 5.0 | ||||
| LDTP16006 | Optic atrophy 3 protein (OPA3) | 5.0 | ||||
| LDTP13828 | Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) | 5.0 | ||||
| LDTP18373 | Thioredoxin-related transmembrane protein 4 (TMX4) | 5.0 | ||||