Details of the Target

General Information of Target

Target ID LDTP19859
Target Name Small integral membrane protein 12 (SMIM12)
Gene Name SMIM12
Gene ID 113444
Synonyms
C1orf212; Small integral membrane protein 12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLVVFCGLPYSGKSRRAEELRVALAAEGRAVYVVDDAAVLGAEDPAVYGDSAREKALRG
ALRASVERRLSRHDVVILDSLNYIKGFRYELYCLARAARTPLCLVYCVRPGGPIAGPQVA
GANENPGRNVSVSWRPRAEEDGRAQAAGSSVLRELHTADSVVNGSAQADVPKELEREESG
AAESPALVTPDSEKSAKHGSGAFYSPELLEALTLRFEAPDSRNRWDRPLFTLVGLEEPLP
LAGIRSALFENRAPPPHQSTQSQPLASGSFLHQLDQVTSQVLAGLMEAQKSAVPGDLLTL
PGTTEHLRFTRPLTMAELSRLRRQFISYTKMHPNNENLPQLANMFLQYLSQSLH
Target Bioclass
Other
Family
SMIM12 family
Subcellular location
Membrane
Uniprot ID
Q96EX1
Ensemble ID
ENST00000417239.1
HGNC ID
HGNC:25154

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K81(10.00)  LDD0277  [1]
HPAP
 Probe Info  		3.10  LDD0062  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
PAL-AfBPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C039
 Probe Info  		11.79  LDD1739  [5]
C040
 Probe Info  		82.71  LDD1740  [5]
C041
 Probe Info  		9.13  LDD1741  [5]
C055
 Probe Info  		76.64  LDD1752  [5]
C056
 Probe Info  		30.48  LDD1753  [5]
C063
 Probe Info  		15.35  LDD1760  [5]
C106
 Probe Info  		28.44  LDD1793  [5]
C107
 Probe Info  		5.66  LDD1794  [5]
C108
 Probe Info  		10.20  LDD1795  [5]
C178
 Probe Info  		15.35  LDD1857  [5]
C186
 Probe Info  		22.63  LDD1864  [5]
C210
 Probe Info  		53.82  LDD1884  [5]
C231
 Probe Info  		18.38  LDD1904  [5]
C238
 Probe Info  		23.59  LDD1911  [5]
C240
 Probe Info  		9.71  LDD1913  [5]
C264
 Probe Info  		19.29  LDD1935  [5]
C265
 Probe Info  		16.91  LDD1936  [5]
C270
 Probe Info  		7.36  LDD1940  [5]
C278
 Probe Info  		54.57  LDD1948  [5]
C282
 Probe Info  		18.13  LDD1952  [5]
C289
 Probe Info  		36.50  LDD1959  [5]
C293
 Probe Info  		33.59  LDD1963  [5]
C388
 Probe Info  		99.73  LDD2047  [5]
C403
 Probe Info  		18.51  LDD2061  [5]
C407
 Probe Info  		74.03  LDD2064  [5]
C429
 Probe Info  		25.28  LDD2084  [5]
C431
 Probe Info  		32.90  LDD2086  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0109  NEM HeLa N.A.  LDD0224  [3]
 LDCM0014  Panhematin HEK-293T 3.10  LDD0062  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587