Details of the Target

General Information of Target

Target ID LDTP09096
Target Name Carbohydrate sulfotransferase 14 (CHST14)
Gene Name CHST14
Gene ID 113189
Synonyms
D4ST1; Carbohydrate sulfotransferase 14; EC 2.8.2.35; Dermatan 4-sulfotransferase 1; D4ST-1; hD4ST1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MFPRPLTPLAAPNGAEPLGRALRRAPLGRARAGLGGPPLLLPSMLMFAVIVASSGLLLMI
ERGILAEMKPLPLHPPGREGTAWRGKAPKPGGLSLRAGDADLQVRQDVRNRTLRAVCGQP
GMPRDPWDLPVGQRRTLLRHILVSDRYRFLYCYVPKVACSNWKRVMKVLAGVLDSVDVRL
KMDHRSDLVFLADLRPEEIRYRLQHYFKFLFVREPLERLLSAYRNKFGEIREYQQRYGAE
IVRRYRAGAGPSPAGDDVTFPEFLRYLVDEDPERMNEHWMPVYHLCQPCAVHYDFVGSYE
RLEADANQVLEWVRAPPHVRFPARQAWYRPASPESLHYHLCSAPRALLQDVLPKYILDFS
LFAYPLPNVTKEACQQ
Target Bioclass
Enzyme
Family
Sulfotransferase 2 family
Subcellular location
Golgi apparatus membrane
Function
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development.
Uniprot ID
Q8NCH0
Ensemble ID
ENST00000306243.7
HGNC ID
HGNC:24464

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.30  LDD0402  [1]
FBPP2
 Probe Info  		6.42  LDD0318  [2]
STPyne
 Probe Info  		K226(10.00)  LDD0277  [3]
OPA-S-S-alkyne
 Probe Info  		K226(1.37)  LDD3494  [4]
BTD
 Probe Info  		C341(1.14)  LDD2094  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
DBIA
 Probe Info  		C117(1.43); C159(0.95)  LDD0531  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
AOyne
 Probe Info  		13.60  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 126 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		6.82  LDD1725  [10]
C022
 Probe Info  		18.25  LDD1728  [10]
C027
 Probe Info  		6.68  LDD1733  [10]
C039
 Probe Info  		6.96  LDD1739  [10]
C040
 Probe Info  		33.36  LDD1740  [10]
C041
 Probe Info  		14.03  LDD1741  [10]
C055
 Probe Info  		29.24  LDD1752  [10]
C056
 Probe Info  		46.85  LDD1753  [10]
C059
 Probe Info  		5.06  LDD1756  [10]
C063
 Probe Info  		20.25  LDD1760  [10]
C064
 Probe Info  		8.40  LDD1761  [10]
C070
 Probe Info  		14.32  LDD1766  [10]
C072
 Probe Info  		7.57  LDD1768  [10]
C082
 Probe Info  		7.21  LDD1774  [10]
C085
 Probe Info  		5.10  LDD1777  [10]
C087
 Probe Info  		11.24  LDD1779  [10]
C091
 Probe Info  		32.22  LDD1782  [10]
C092
 Probe Info  		43.41  LDD1783  [10]
C094
 Probe Info  		43.41  LDD1785  [10]
C095
 Probe Info  		6.50  LDD1786  [10]
C100
 Probe Info  		5.82  LDD1789  [10]
C106
 Probe Info  		25.11  LDD1793  [10]
C107
 Probe Info  		7.73  LDD1794  [10]
C108
 Probe Info  		10.20  LDD1795  [10]
C112
 Probe Info  		23.43  LDD1799  [10]
C129
 Probe Info  		9.32  LDD1811  [10]
C130
 Probe Info  		8.22  LDD1812  [10]
C134
 Probe Info  		58.49  LDD1816  [10]
C135
 Probe Info  		27.10  LDD1817  [10]
C139
 Probe Info  		19.16  LDD1821  [10]
C140
 Probe Info  		11.79  LDD1822  [10]
C141
 Probe Info  		17.88  LDD1823  [10]
C143
 Probe Info  		36.00  LDD1825  [10]
C147
 Probe Info  		7.46  LDD1829  [10]
C153
 Probe Info  		30.48  LDD1834  [10]
C159
 Probe Info  		14.52  LDD1839  [10]
C160
 Probe Info  		12.82  LDD1840  [10]
C161
 Probe Info  		23.59  LDD1841  [10]
C163
 Probe Info  		7.57  LDD1843  [10]
C166
 Probe Info  		7.46  LDD1846  [10]
C169
 Probe Info  		40.50  LDD1849  [10]
C170
 Probe Info  		8.94  LDD1850  [10]
C177
 Probe Info  		7.94  LDD1856  [10]
C178
 Probe Info  		31.12  LDD1857  [10]
C183
 Probe Info  		7.46  LDD1861  [10]
C186
 Probe Info  		16.22  LDD1864  [10]
C187
 Probe Info  		22.94  LDD1865  [10]
C191
 Probe Info  		9.92  LDD1868  [10]
C196
 Probe Info  		12.55  LDD1872  [10]
C198
 Probe Info  		12.55  LDD1874  [10]
C201
 Probe Info  		50.21  LDD1877  [10]
C206
 Probe Info  		24.93  LDD1881  [10]
C218
 Probe Info  		19.84  LDD1892  [10]
C219
 Probe Info  		6.54  LDD1893  [10]
C220
 Probe Info  		20.53  LDD1894  [10]
C225
 Probe Info  		5.24  LDD1898  [10]
C226
 Probe Info  		5.46  LDD1899  [10]
C228
 Probe Info  		25.28  LDD1901  [10]
C229
 Probe Info  		8.82  LDD1902  [10]
C231
 Probe Info  		32.67  LDD1904  [10]
C232
 Probe Info  		51.63  LDD1905  [10]
C233
 Probe Info  		14.62  LDD1906  [10]
C234
 Probe Info  		8.69  LDD1907  [10]
C235
 Probe Info  		43.71  LDD1908  [10]
C238
 Probe Info  		29.24  LDD1911  [10]
C240
 Probe Info  		14.93  LDD1913  [10]
C243
 Probe Info  		18.90  LDD1916  [10]
C244
 Probe Info  		18.51  LDD1917  [10]
C246
 Probe Info  		25.28  LDD1919  [10]
C249
 Probe Info  		20.25  LDD1922  [10]
C252
 Probe Info  		19.56  LDD1925  [10]
C264
 Probe Info  		32.67  LDD1935  [10]
C265
 Probe Info  		22.32  LDD1936  [10]
C269
 Probe Info  		6.92  LDD1939  [10]
C270
 Probe Info  		9.65  LDD1940  [10]
C273
 Probe Info  		7.46  LDD1943  [10]
C277
 Probe Info  		19.97  LDD1947  [10]
C278
 Probe Info  		99.73  LDD1948  [10]
C280
 Probe Info  		21.41  LDD1950  [10]
C282
 Probe Info  		70.03  LDD1952  [10]
C284
 Probe Info  		64.45  LDD1954  [10]
C285
 Probe Info  		53.82  LDD1955  [10]
C286
 Probe Info  		6.50  LDD1956  [10]
C287
 Probe Info  		26.17  LDD1957  [10]
C288
 Probe Info  		17.63  LDD1958  [10]
C289
 Probe Info  		80.45  LDD1959  [10]
C290
 Probe Info  		8.94  LDD1960  [10]
C293
 Probe Info  		42.81  LDD1963  [10]
C296
 Probe Info  		43.71  LDD1966  [10]
C299
 Probe Info  		8.06  LDD1968  [10]
C305
 Probe Info  		11.39  LDD1974  [10]
C313
 Probe Info  		18.38  LDD1980  [10]
C314
 Probe Info  		23.59  LDD1981  [10]
C317
 Probe Info  		7.41  LDD1983  [10]
C326
 Probe Info  		8.11  LDD1990  [10]
C339
 Probe Info  		8.40  LDD2002  [10]
C343
 Probe Info  		25.63  LDD2005  [10]
C346
 Probe Info  		13.83  LDD2007  [10]
C348
 Probe Info  		25.63  LDD2009  [10]
C349
 Probe Info  		39.95  LDD2010  [10]
C350
 Probe Info  		98.36  LDD2011  [10]
C353
 Probe Info  		8.22  LDD2014  [10]
C354
 Probe Info  		8.17  LDD2015  [10]
C355
 Probe Info  		40.50  LDD2016  [10]
C356
 Probe Info  		14.52  LDD2017  [10]
C357
 Probe Info  		7.01  LDD2018  [10]
C362
 Probe Info  		99.73  LDD2023  [10]
C363
 Probe Info  		38.59  LDD2024  [10]
C364
 Probe Info  		41.64  LDD2025  [10]
C366
 Probe Info  		17.15  LDD2027  [10]
C367
 Probe Info  		9.58  LDD2028  [10]
C373
 Probe Info  		6.73  LDD2033  [10]
C376
 Probe Info  		12.55  LDD2036  [10]
C378
 Probe Info  		8.22  LDD2037  [10]
C380
 Probe Info  		6.06  LDD2039  [10]
C382
 Probe Info  		17.88  LDD2041  [10]
C383
 Probe Info  		16.45  LDD2042  [10]
C386
 Probe Info  		8.34  LDD2045  [10]
C388
 Probe Info  		88.65  LDD2047  [10]
C390
 Probe Info  		86.82  LDD2049  [10]
C391
 Probe Info  		18.77  LDD2050  [10]
C399
 Probe Info  		17.15  LDD2058  [10]
C403
 Probe Info  		44.02  LDD2061  [10]
C407
 Probe Info  		30.27  LDD2064  [10]
C413
 Probe Info  		30.06  LDD2069  [10]
OEA-DA
 Probe Info  		20.00  LDD0046  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C117(1.43); C159(0.95)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C159(1.09)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C159(0.98)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C159(0.90)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C159(0.95)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C159(1.11)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C159(1.04)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C159(0.95)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C159(1.22)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C159(1.19)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C159(0.99)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C159(1.01)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C159(1.11)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C159(0.91)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C159(0.91)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C159(0.98)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C159(1.14)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C159(1.19)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C159(1.17)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C159(1.29)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C159(1.19)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C159(1.17)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C159(1.25)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C159(1.16)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C159(1.34)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C159(1.17)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C159(1.11)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C159(1.12)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C159(1.06)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C159(1.08)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C159(1.29)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C159(1.30)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C159(1.07)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C159(1.16)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C159(1.11)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C159(1.01)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C159(0.96)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C159(0.99)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C159(0.97)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C159(0.98)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C159(0.87)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C159(0.93)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C159(0.82)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C159(0.78)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C159(1.01)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C159(0.69)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C159(0.66)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C159(0.89)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C159(1.00)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C159(1.04)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C159(1.03)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C159(0.96)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C159(0.95)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C159(1.01)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C159(0.97)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C159(1.01)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C159(1.13)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C159(1.04)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C159(0.96)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C159(0.95)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C159(1.03)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C159(1.09)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C159(0.98)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C159(0.83)  LDD2161  [7]
 LDCM0276  AC17 HEK-293T C117(1.15)  LDD1515  [12]
 LDCM0278  AC19 HEK-293T C117(1.29)  LDD1517  [12]
 LDCM0279  AC2 HCT 116 C159(1.04); C117(1.50)  LDD0596  [7]
 LDCM0280  AC20 HEK-293T C117(0.84)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C117(1.19)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C117(1.03)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C117(0.99)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C117(1.01)  LDD1523  [12]
 LDCM0285  AC25 HCT 116 C159(0.98)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C159(1.07)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C159(1.07)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C159(1.01)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C159(0.92)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C159(1.00); C117(1.57)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C159(1.07)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C159(1.08)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C159(1.09)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C159(1.11)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C159(1.13)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C159(1.08)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C159(1.02)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C159(1.07)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C159(0.97)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C159(0.97)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C159(0.96); C117(1.19)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C159(0.99)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C159(1.01)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C159(0.97)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C159(0.90)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C159(0.99)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C159(0.99)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C159(1.10)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C159(1.06)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C159(0.86)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C159(0.98)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C159(0.98); C117(1.10)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C159(0.93)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C159(0.93)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C159(0.98)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C159(0.98)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C159(0.95)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C159(1.11)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C159(1.12)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C117(0.69); C159(1.30)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C117(0.68); C159(1.38)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C117(0.74); C159(1.34)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C159(1.01)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C117(1.21); C159(1.32)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C117(1.03); C159(1.21)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C117(0.71); C159(1.32)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C117(0.64); C159(1.20)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C117(1.25); C159(1.47)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C117(1.60); C159(1.70)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C117(1.18); C159(1.30)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C117(1.18); C159(1.46)  LDD0648  [7]
 LDCM0332  AC68 HEK-293T C159(0.93)  LDD0930  [7]
 LDCM0333  AC69 HEK-293T C159(0.89)  LDD0931  [7]
 LDCM0334  AC7 HCT 116 C159(1.09)  LDD0651  [7]
 LDCM0335  AC70 HEK-293T C159(1.00)  LDD0933  [7]
 LDCM0336  AC71 HEK-293T C159(1.07)  LDD0934  [7]
 LDCM0337  AC72 HEK-293T C159(1.02)  LDD0935  [7]
 LDCM0338  AC73 HEK-293T C159(1.12)  LDD0936  [7]
 LDCM0339  AC74 HEK-293T C159(0.92)  LDD0937  [7]
 LDCM0340  AC75 HEK-293T C159(1.16)  LDD0938  [7]
 LDCM0341  AC76 HEK-293T C159(0.94)  LDD0939  [7]
 LDCM0342  AC77 HEK-293T C159(0.98)  LDD0940  [7]
 LDCM0343  AC78 HEK-293T C159(0.93)  LDD0941  [7]
 LDCM0344  AC79 HEK-293T C159(0.85)  LDD0942  [7]
 LDCM0345  AC8 HCT 116 C159(0.93)  LDD0662  [7]
 LDCM0346  AC80 HEK-293T C159(0.95)  LDD0944  [7]
 LDCM0347  AC81 HEK-293T C159(0.79)  LDD0945  [7]
 LDCM0348  AC82 HEK-293T C159(0.95)  LDD0946  [7]
 LDCM0349  AC83 HCT 116 C159(1.81)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C159(1.36)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C159(1.40)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C159(1.81)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C159(0.94)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C159(1.06)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C159(1.41)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C159(1.20)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C159(1.49)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C159(1.73)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C159(1.09)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C159(1.42)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C159(1.26)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C159(1.13)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C159(1.66)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C159(1.18)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C159(1.10)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C159(1.10)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C159(1.00)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C159(1.03)  LDD0592  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HCT 116 C159(1.05); C117(1.16)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C117(1.31); C159(1.60)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C159(1.01); C117(1.73)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C159(1.18)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C159(1.24)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C159(1.23)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C159(1.19)  LDD0690  [7]
 LDCM0375  CL106 HEK-293T C117(1.07)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C117(0.88)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C117(1.14)  LDD1581  [12]
 LDCM0379  CL11 HCT 116 C117(1.32); C159(1.58)  LDD0696  [7]
 LDCM0380  CL110 HEK-293T C117(1.05)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C117(0.94)  LDD1585  [12]
 LDCM0382  CL112 HCT 116 C159(1.00)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C159(1.10)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C159(1.16)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C159(1.09)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C159(1.17)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C159(1.04)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C159(1.01)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C159(0.99)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C117(1.42); C159(1.81)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C159(0.98)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C159(1.07)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C159(1.05)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C159(1.17)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C159(1.08)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C159(1.09); C117(1.32)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C159(1.08); C117(1.24)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C159(1.11); C117(2.08)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C117(1.09); C159(1.23)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C159(1.33); C117(1.61)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C159(1.14); C117(1.34)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C159(1.35); C117(1.51)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C159(1.16)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C117(1.07); C159(1.15)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C117(0.85); C159(1.23)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C117(0.85); C159(1.20)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C159(1.05); C117(1.64)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C117(0.98); C159(1.14)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C117(0.98); C159(1.30)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C117(0.75); C159(1.95)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C117(1.07); C159(1.18)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C117(0.99); C159(1.26)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C117(1.04); C159(1.57)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C117(1.04); C159(1.21)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C117(0.93); C159(1.37)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C117(1.30); C159(1.30)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C117(1.04); C159(1.24)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C117(1.86); C159(1.05)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C117(0.89); C159(1.04)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C117(0.82)  LDD0737  [7]
 LDCM0421  CL32 PaTu 8988t C159(1.36)  LDD1300  [7]
 LDCM0422  CL33 PaTu 8988t C159(1.67)  LDD1301  [7]
 LDCM0423  CL34 PaTu 8988t C159(1.33)  LDD1302  [7]
 LDCM0424  CL35 PaTu 8988t C159(1.39)  LDD1303  [7]
 LDCM0425  CL36 PaTu 8988t C159(1.32)  LDD1304  [7]
 LDCM0426  CL37 PaTu 8988t C159(1.78)  LDD1305  [7]
 LDCM0428  CL39 PaTu 8988t C159(1.17)  LDD1307  [7]
 LDCM0429  CL4 HCT 116 C117(1.24); C159(1.12)  LDD0746  [7]
 LDCM0430  CL40 PaTu 8988t C159(1.16)  LDD1309  [7]
 LDCM0431  CL41 PaTu 8988t C159(1.51)  LDD1310  [7]
 LDCM0432  CL42 PaTu 8988t C159(1.78)  LDD1311  [7]
 LDCM0433  CL43 PaTu 8988t C159(2.27)  LDD1312  [7]
 LDCM0434  CL44 PaTu 8988t C159(1.54)  LDD1313  [7]
 LDCM0435  CL45 PaTu 8988t C159(1.26)  LDD1314  [7]
 LDCM0436  CL46 HCT 116 C159(0.92)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C159(0.99)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C159(0.91)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C159(0.94)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C117(1.10); C159(1.22)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C159(0.97)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C159(0.93)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C159(0.92)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C159(0.94)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C159(0.87)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C159(0.92)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C159(1.05)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C159(0.90)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C159(1.05)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C159(0.92)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C117(1.72); C159(1.38)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C159(1.07)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C117(0.81); C159(1.04)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C117(0.59); C159(1.11)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C117(0.56); C159(1.13)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C117(0.68); C159(1.36)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C117(0.75); C159(1.20)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C117(0.69); C159(1.19)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C117(1.04); C159(1.14)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C117(0.66); C159(1.22)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C117(0.49); C159(1.00)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C117(1.78); C159(1.51)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C117(0.64); C159(1.14)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C117(0.75); C159(1.29)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C117(0.59); C159(1.12)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C117(0.66); C159(1.17)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C117(0.73); C159(1.19)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C159(1.06)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C159(0.94)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C159(1.08)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C159(0.99)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C117(1.10); C159(1.97)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C159(0.99)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C159(1.09)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C159(1.14)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C159(0.92)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C159(1.12)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C159(1.01)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C159(1.07)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C159(1.05)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C159(1.02)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C159(1.06)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C117(1.63); C159(1.33)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C159(1.26)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C117(1.28); C159(0.99)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C117(1.00); C159(1.07)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C117(1.03); C159(1.02)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C117(1.09); C159(0.99)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C117(1.03); C159(1.14)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C117(1.21); C159(0.97)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C117(1.24); C159(1.06)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C117(1.25); C159(1.10)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C117(1.35); C159(1.03)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C117(1.04)  LDD1698  [12]
 LDCM0468  Fragment33 HCT 116 C117(0.56); C159(1.32)  LDD0785  [7]
 LDCM0427  Fragment51 PaTu 8988t C159(1.43)  LDD1306  [7]
 LDCM0022  KB02 22RV1 C117(2.70)  LDD2243  [13]
 LDCM0023  KB03 MDA-MB-231 C117(3.39)  LDD1701  [5]
 LDCM0024  KB05 G361 C117(4.06)  LDD3311  [13]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C341(1.14)  LDD2094  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C341(0.88)  LDD2099  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C117(0.78)  LDD2109  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C341(1.52)  LDD2119  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C341(1.22)  LDD2123  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C117(0.90)  LDD2127  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C117(0.72)  LDD2137  [5]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840