Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C059  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 36 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 99.7
 LDTP01769  Dihydrofolate reductase (DHFR) 74.0
 LDTP03787  Choline kinase alpha (CHKA) 19.8
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 16.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 15.7
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 14.9
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 13.2
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 12.7
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 10.5
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 10.3
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 9.7
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 9.6
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 9.1
 LDTP08352  Histone-arginine methyltransferase CARM1 (CARM1) 8.3
 LDTP08859  Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) 8.3
 LDTP00575  Glutathione S-transferase A4 (GSTA4) 7.9
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 7.7
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 7.4
 LDTP07620  Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX) 7.1
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 7.0
 LDTP08455  Palmitoyltransferase ZDHHC13 (ZDHHC13) 7.0
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 6.8
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 6.8
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 6.8
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 6.5
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 6.4
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 6.2
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 6.0
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 5.9
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 5.8
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 5.7
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 5.6
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 5.4
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 5.2
 LDTP03060  Proteasome subunit beta type-1 (PSMB1) 5.1
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 5.1
Transporter and channel
Click to Show/Hide to Show 21 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 28.6
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 21.7
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 21.3
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 19.3
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 13.9
 LDTP12383  Protein GPR108 (GPR108) 10.1
 LDTP07236  Protein GPR107 (GPR107) 7.3
 LDTP20002  Transmembrane protein 160 (TMEM160) 7.3
 LDTP01804  ATP synthase subunit a (MT-ATP6) 7.2
 LDTP08881  Transmembrane protein 199 (TMEM199) 7.0
 LDTP15481  Transmembrane protein 87A (TMEM87A) 6.4
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 6.3
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 6.3
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 5.9
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 5.7
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 5.7
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 5.5
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 5.4
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 5.3
 LDTP15948  Transmembrane protein 126A (TMEM126A) 5.2
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 5.0
Other
Click to Show/Hide to Show 31 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07906  Mediator of RNA polymerase II transcription subunit 25 (MED25) 36.0
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 25.8
 LDTP05160  Nucleobindin-2 (NUCB2) 23.6
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 22.2
 LDTP15269  Large ribosomal subunit protein mL55 (MRPL55) 18.1
 LDTP05375  Nucleobindin-1 (NUCB1) 15.1
 LDTP02345  Retinol-binding protein 1 (RBP1) 12.3
 LDTP15623  Neuferricin (CYB5D2) 11.7
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 11.2
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 10.9
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 10.2
 LDTP10276  SAGA-associated factor 29 (SGF29) 9.4
 LDTP11076  Apolipoprotein L2 (APOL2) 8.2
 LDTP17580  FHF complex subunit HOOK-interacting protein 2B (FHIP2B) 8.1
 LDTP07476  RAD50-interacting protein 1 (RINT1) 8.0
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 7.9
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 7.7
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 7.6
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 7.6
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) 6.0
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 5.8
 LDTP16099  p53 and DNA damage-regulated protein 1 (PDRG1) 5.8
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 5.4
 LDTP02960  Negative elongation factor E (NELFE) 5.4
 LDTP03612  Bifunctional purine biosynthesis protein ATIC (ATIC) 5.4
 LDTP13630  Neudesin (NENF) 5.3
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 5.1
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 5.1
 LDTP18494  Tropomodulin-3 (TMOD3) 5.1
 LDTP05277  Protein SET (SET) 5.0
 LDTP16080  Protein FAM114A2 (FAM114A2) 4.9

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587