Details of the Target

General Information of Target

Target ID LDTP03787
Target Name Choline kinase alpha (CHKA)
Gene Name CHKA
Gene ID 1119
Synonyms
CHK; CKI; Choline kinase alpha; CK; EC 2.7.1.32; CHETK-alpha; Ethanolamine kinase; EK; EC 2.7.1.82
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPP
PPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGL
SNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAMVLE
SVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKM
PFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPV
VFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYP
FFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLW
GLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Choline/ethanolamine kinase family
Subcellular location
Cytoplasm, cytosol; Lipid droplet
Function
Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis. Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis. Has higher activity with choline. May contribute to tumor cell growth.; [Isoform 1]: This isoform plays a key role in lipolysis of lipid droplets following glucose deprivation. In response to glucose deprivation, phosphorylated by AMPK, promoting localization to lipid droplets. Phosphorylation is followed by acetylation by KAT5, leading to dissociation of the homodimer into a monomer. Monomeric CHKA isoform 1 is converted into a tyrosine-protein kinase, which phosphorylates lipid droplet structural proteins PLIN2 and PLIN3, leading to lipolysis of lipid droplets.
TTD ID
T55709
Uniprot ID
P35790
DrugMap ID
TT10AWB
Ensemble ID
ENST00000265689.9
HGNC ID
HGNC:1937
ChEMBL ID
CHEMBL3117

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.G32D .
HEC1B SNV: p.P130S .
HT115 SNV: p.K429N .
KASUMI2 SNV: p.S416P .
MFE319 SNV: p.M183V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K372(10.00)  LDD0277  [1]
AHL-Pu-1
 Probe Info  		C22(2.12)  LDD0170  [2]
DBIA
 Probe Info  		C95(28.94)  LDD0209  [3]
IPM
 Probe Info  		C95(2.00)  LDD1702  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0149  [5]
VSF
 Probe Info  		C6(0.00); C22(0.00)  LDD0007  [6]
PAL-AfBPP Probe
Click To Hide/Show 72 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ILS-1 PP
 Probe Info  		3.82  LDD0417  [7]
C022
 Probe Info  		8.57  LDD1728  [8]
C041
 Probe Info  		10.48  LDD1741  [8]
C059
 Probe Info  		19.84  LDD1756  [8]
C060
 Probe Info  		5.06  LDD1757  [8]
C063
 Probe Info  		10.93  LDD1760  [8]
C064
 Probe Info  		18.51  LDD1761  [8]
C070
 Probe Info  		10.93  LDD1766  [8]
C085
 Probe Info  		14.52  LDD1777  [8]
C087
 Probe Info  		10.85  LDD1779  [8]
C089
 Probe Info  		14.72  LDD1781  [8]
C139
 Probe Info  		11.16  LDD1821  [8]
C140
 Probe Info  		8.00  LDD1822  [8]
C150
 Probe Info  		6.87  LDD1831  [8]
C160
 Probe Info  		10.13  LDD1840  [8]
C161
 Probe Info  		12.64  LDD1841  [8]
C164
 Probe Info  		7.16  LDD1844  [8]
C165
 Probe Info  		13.55  LDD1845  [8]
C170
 Probe Info  		8.46  LDD1850  [8]
C173
 Probe Info  		12.04  LDD1853  [8]
C186
 Probe Info  		9.99  LDD1864  [8]
C187
 Probe Info  		16.11  LDD1865  [8]
C193
 Probe Info  		5.24  LDD1869  [8]
C194
 Probe Info  		49.52  LDD1870  [8]
C196
 Probe Info  		12.38  LDD1872  [8]
C198
 Probe Info  		20.97  LDD1874  [8]
C201
 Probe Info  		44.02  LDD1877  [8]
C205
 Probe Info  		7.62  LDD1880  [8]
C206
 Probe Info  		16.80  LDD1881  [8]
C211
 Probe Info  		8.57  LDD1885  [8]
C212
 Probe Info  		14.03  LDD1886  [8]
C213
 Probe Info  		17.51  LDD1887  [8]
C222
 Probe Info  		12.82  LDD1896  [8]
C226
 Probe Info  		7.67  LDD1899  [8]
C228
 Probe Info  		41.07  LDD1901  [8]
C249
 Probe Info  		12.21  LDD1922  [8]
C252
 Probe Info  		9.78  LDD1925  [8]
C255
 Probe Info  		13.55  LDD1928  [8]
C256
 Probe Info  		10.48  LDD1929  [8]
C264
 Probe Info  		18.77  LDD1935  [8]
C269
 Probe Info  		5.86  LDD1939  [8]
C274
 Probe Info  		5.66  LDD1944  [8]
C277
 Probe Info  		19.03  LDD1947  [8]
C288
 Probe Info  		7.01  LDD1958  [8]
C296
 Probe Info  		15.03  LDD1966  [8]
C299
 Probe Info  		7.62  LDD1968  [8]
C305
 Probe Info  		11.47  LDD1974  [8]
C310
 Probe Info  		12.47  LDD1977  [8]
C313
 Probe Info  		13.64  LDD1980  [8]
C320
 Probe Info  		7.06  LDD1986  [8]
C322
 Probe Info  		9.65  LDD1988  [8]
C338
 Probe Info  		15.78  LDD2001  [8]
C347
 Probe Info  		4.99  LDD2008  [8]
C355
 Probe Info  		36.25  LDD2016  [8]
C361
 Probe Info  		21.41  LDD2022  [8]
C363
 Probe Info  		17.75  LDD2024  [8]
C364
 Probe Info  		22.01  LDD2025  [8]
C367
 Probe Info  		9.38  LDD2028  [8]
C376
 Probe Info  		6.82  LDD2036  [8]
C378
 Probe Info  		7.84  LDD2037  [8]
C380
 Probe Info  		8.40  LDD2039  [8]
C382
 Probe Info  		9.71  LDD2041  [8]
C386
 Probe Info  		8.11  LDD2045  [8]
C390
 Probe Info  		32.90  LDD2049  [8]
C391
 Probe Info  		17.88  LDD2050  [8]
C392
 Probe Info  		11.55  LDD2051  [8]
C393
 Probe Info  		42.52  LDD2052  [8]
C396
 Probe Info  		5.94  LDD2055  [8]
C399
 Probe Info  		16.91  LDD2058  [8]
C419
 Probe Info  		18.90  LDD2074  [8]
C420
 Probe Info  		13.83  LDD2075  [8]
VE-P
 Probe Info  		N.A.  LDD0396  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C22(2.12)  LDD0170  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C22(2.03)  LDD0171  [2]
 LDCM0214  AC1 HCT 116 C22(0.99); C6(0.99)  LDD0531  [10]
 LDCM0215  AC10 PaTu 8988t C22(1.67); C6(1.67)  LDD1094  [10]
 LDCM0216  AC100 HCT 116 C22(0.88); C6(0.88)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C22(0.92); C6(0.92)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C22(0.89); C6(0.89)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C22(1.22); C6(1.22)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C22(1.25); C6(1.25)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C22(1.16); C6(1.16)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C22(1.10); C6(1.10)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C22(1.30); C6(1.14)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C22(0.84); C6(0.90)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C22(0.87); C6(0.89)  LDD0542  [10]
 LDCM0226  AC11 PaTu 8988t C22(1.71); C6(1.71)  LDD1105  [10]
 LDCM0227  AC110 HCT 116 C22(0.92); C6(1.00)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C22(0.94); C6(1.07)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C22(1.00); C6(1.00)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C22(1.14); C6(1.14)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C22(1.52); C6(1.52)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C22(1.50); C6(1.50)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C22(1.47); C6(1.47)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C22(1.75); C6(1.75)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C22(1.20); C6(1.20)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C22(1.58); C6(1.58)  LDD0553  [10]
 LDCM0237  AC12 PaTu 8988t C22(1.78); C6(1.78)  LDD1116  [10]
 LDCM0238  AC120 HCT 116 C22(1.26); C6(1.26)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C22(1.36); C6(1.36)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C22(1.34); C6(1.34)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C22(1.01); C6(1.01)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C22(1.29); C6(1.29)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C22(1.37); C6(1.37)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C22(1.96); C6(1.96)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C22(1.81); C6(1.81)  LDD0562  [10]
 LDCM0246  AC128 PaTu 8988t C303(0.51); C307(0.51); C22(1.09); C6(1.09)  LDD1125  [10]
 LDCM0247  AC129 PaTu 8988t C303(0.90); C307(0.90); C22(1.44); C6(1.44)  LDD1126  [10]
 LDCM0249  AC130 PaTu 8988t C303(1.13); C307(1.13); C22(1.44); C6(1.44)  LDD1128  [10]
 LDCM0250  AC131 PaTu 8988t C303(0.65); C307(0.65); C22(1.21); C6(1.21)  LDD1129  [10]
 LDCM0251  AC132 PaTu 8988t C303(0.98); C307(0.98); C22(1.30); C6(1.30)  LDD1130  [10]
 LDCM0252  AC133 PaTu 8988t C303(0.45); C307(0.45); C22(1.42); C6(1.42)  LDD1131  [10]
 LDCM0253  AC134 PaTu 8988t C303(0.63); C307(0.63); C22(1.34); C6(1.34)  LDD1132  [10]
 LDCM0254  AC135 PaTu 8988t C303(0.55); C307(0.55); C22(1.78); C6(1.78)  LDD1133  [10]
 LDCM0255  AC136 PaTu 8988t C303(0.50); C307(0.50); C22(1.43); C6(1.43)  LDD1134  [10]
 LDCM0256  AC137 PaTu 8988t C303(0.36); C307(0.36); C22(1.70); C6(1.70)  LDD1135  [10]
 LDCM0257  AC138 PaTu 8988t C303(0.89); C307(0.89); C22(1.31); C6(1.31)  LDD1136  [10]
 LDCM0258  AC139 PaTu 8988t C303(0.63); C307(0.63); C22(1.25); C6(1.25)  LDD1137  [10]
 LDCM0259  AC14 PaTu 8988t C22(1.25); C6(1.25)  LDD1138  [10]
 LDCM0260  AC140 PaTu 8988t C303(0.86); C307(0.86); C22(1.53); C6(1.53)  LDD1139  [10]
 LDCM0261  AC141 PaTu 8988t C303(1.53); C307(1.53); C22(1.36); C6(1.36)  LDD1140  [10]
 LDCM0262  AC142 PaTu 8988t C303(0.71); C307(0.71); C22(1.28); C6(1.28)  LDD1141  [10]
 LDCM0263  AC143 HCT 116 C22(1.23); C6(1.23)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C22(1.82); C6(1.82)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C22(1.09); C6(1.09)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C22(1.48); C6(1.48)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C22(1.59); C6(1.59)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C22(2.45); C6(2.45)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C22(2.03); C6(2.03)  LDD0586  [10]
 LDCM0270  AC15 PaTu 8988t C22(1.45); C6(1.45)  LDD1149  [10]
 LDCM0271  AC150 HCT 116 C22(1.09); C6(1.09)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C22(1.27); C6(1.27)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C22(1.59); C6(1.59)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C22(2.39); C6(2.39)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C22(1.80); C6(1.80)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C22(2.33); C6(2.33)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C22(1.14); C6(1.14)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C22(1.68); C6(1.68)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C22(1.83); C6(1.83)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C22(1.79); C6(1.79)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C22(2.14); C6(2.14)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C22(0.79); C6(0.79)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C22(2.27); C6(2.27)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C22(2.58); C6(2.58)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C22(1.54); C6(1.54)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C22(1.36); C6(1.36)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C22(1.56); C6(1.56)  LDD0601  [10]
 LDCM0285  AC25 PaTu 8988t C22(0.91); C6(0.91)  LDD1164  [10]
 LDCM0286  AC26 PaTu 8988t C22(1.05); C6(1.05)  LDD1165  [10]
 LDCM0287  AC27 PaTu 8988t C22(1.08); C6(1.08)  LDD1166  [10]
 LDCM0288  AC28 PaTu 8988t C22(1.29); C6(1.29)  LDD1167  [10]
 LDCM0289  AC29 PaTu 8988t C22(1.00); C6(1.00)  LDD1168  [10]
 LDCM0290  AC3 HCT 116 C22(1.05); C6(1.05)  LDD0607  [10]
 LDCM0291  AC30 PaTu 8988t C22(1.00); C6(1.00)  LDD1170  [10]
 LDCM0292  AC31 PaTu 8988t C22(0.86); C6(0.86)  LDD1171  [10]
 LDCM0293  AC32 PaTu 8988t C22(1.18); C6(1.18)  LDD1172  [10]
 LDCM0294  AC33 PaTu 8988t C22(1.82); C6(1.82)  LDD1173  [10]
 LDCM0295  AC34 PaTu 8988t C22(1.46); C6(1.46)  LDD1174  [10]
 LDCM0296  AC35 HCT 116 C22(1.01); C6(1.01)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C22(0.96); C6(0.96)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C22(0.93); C6(0.93)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C22(1.18); C6(1.18)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C22(0.82); C6(0.82)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C22(1.14); C6(1.14)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C22(1.65); C6(1.65)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C22(0.95); C6(0.95)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C22(0.97); C6(0.97)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C22(1.09); C6(1.09)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C22(0.83); C6(0.83)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C22(0.90); C6(0.90)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C22(1.17); C6(1.17)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C22(1.12); C6(1.12)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C22(0.77); C6(0.77)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C22(1.74); C6(1.74)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C22(1.02); C6(1.02)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C22(2.03); C6(2.03)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C22(0.99); C6(0.99)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C22(1.11); C6(1.11)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C22(1.82); C6(1.82)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C22(1.38); C6(1.38)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C22(1.98); C6(1.98)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C22(3.01); C6(3.01)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C22(1.11); C6(1.11)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C22(1.56); C6(1.56)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C22(1.63); C6(1.63)  LDD0639  [10]
 LDCM0323  AC6 PaTu 8988t C22(1.19); C6(1.19)  LDD1202  [10]
 LDCM0324  AC60 HCT 116 C22(1.33); C6(1.33)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C22(1.37); C6(1.37)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C22(1.71); C6(1.71)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C22(1.89); C6(1.89)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C22(1.39); C6(1.39)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C22(0.67); C6(0.67)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C22(0.70); C6(0.70)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C22(0.79); C6(0.79)  LDD0648  [10]
 LDCM0332  AC68 PaTu 8988t C22(0.86); C6(0.86)  LDD1211  [10]
 LDCM0333  AC69 PaTu 8988t C22(1.21); C6(1.21)  LDD1212  [10]
 LDCM0334  AC7 PaTu 8988t C22(1.04); C6(1.04)  LDD1213  [10]
 LDCM0335  AC70 PaTu 8988t C22(0.90); C6(0.90)  LDD1214  [10]
 LDCM0336  AC71 PaTu 8988t C22(0.83); C6(0.83)  LDD1215  [10]
 LDCM0337  AC72 PaTu 8988t C22(0.83); C6(0.83)  LDD1216  [10]
 LDCM0338  AC73 PaTu 8988t C22(0.87); C6(0.87)  LDD1217  [10]
 LDCM0339  AC74 PaTu 8988t C22(0.93); C6(0.93)  LDD1218  [10]
 LDCM0340  AC75 PaTu 8988t C22(1.07); C6(1.07)  LDD1219  [10]
 LDCM0341  AC76 PaTu 8988t C22(1.07); C6(1.07)  LDD1220  [10]
 LDCM0342  AC77 PaTu 8988t C22(0.95); C6(0.95)  LDD1221  [10]
 LDCM0343  AC78 PaTu 8988t C22(1.00); C6(1.00)  LDD1222  [10]
 LDCM0344  AC79 PaTu 8988t C22(1.20); C6(1.20)  LDD1223  [10]
 LDCM0345  AC8 PaTu 8988t C22(1.36); C6(1.36)  LDD1224  [10]
 LDCM0346  AC80 PaTu 8988t C22(1.08); C6(1.08)  LDD1225  [10]
 LDCM0347  AC81 PaTu 8988t C22(1.17); C6(1.17)  LDD1226  [10]
 LDCM0348  AC82 PaTu 8988t C22(1.19); C6(1.19)  LDD1227  [10]
 LDCM0349  AC83 HCT 116 C22(2.04); C6(2.04)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C22(1.91); C6(1.91)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C22(1.36); C6(1.36)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C22(1.30); C6(1.30)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C22(1.22); C6(1.22)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C22(1.37); C6(1.37)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C22(2.01); C6(2.01)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C22(1.24); C6(1.24)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C22(2.21); C6(2.21)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C22(2.10); C6(2.10)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C22(1.57); C6(1.57)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C22(1.54); C6(1.54)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C22(1.38); C6(1.38)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C22(1.81); C6(1.81)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C22(1.83); C6(1.83)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C22(1.48); C6(1.48)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C22(0.79); C6(0.79)  LDD0683  [10]
 LDCM0248  AKOS034007472 PaTu 8988t C22(1.55); C6(1.55)  LDD1127  [10]
 LDCM0356  AKOS034007680 PaTu 8988t C22(1.64); C6(1.64)  LDD1235  [10]
 LDCM0275  AKOS034007705 PaTu 8988t C22(1.42); C6(1.42)  LDD1154  [10]
 LDCM0367  CL1 HCT 116 C22(1.07); C6(1.07)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C22(3.43); C6(3.43)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C22(1.56); C6(1.56)  LDD0686  [10]
 LDCM0370  CL101 PaTu 8988t C22(1.40); C6(1.40)  LDD1249  [10]
 LDCM0371  CL102 PaTu 8988t C22(1.46); C6(1.46)  LDD1250  [10]
 LDCM0372  CL103 PaTu 8988t C22(1.94); C6(1.94)  LDD1251  [10]
 LDCM0373  CL104 PaTu 8988t C22(1.56); C6(1.56)  LDD1252  [10]
 LDCM0374  CL105 HCT 116 C22(1.81); C6(1.81)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C22(2.14); C6(2.14)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C22(1.58); C6(1.58)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C22(1.73); C6(1.73)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C22(1.90); C6(1.90)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C22(2.45); C6(2.45)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C22(4.23); C6(4.23)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C22(2.79); C6(2.79)  LDD0698  [10]
 LDCM0382  CL112 PaTu 8988t C22(1.11); C6(1.11)  LDD1261  [10]
 LDCM0383  CL113 PaTu 8988t C22(0.99); C6(0.99)  LDD1262  [10]
 LDCM0384  CL114 PaTu 8988t C22(1.24); C6(1.24)  LDD1263  [10]
 LDCM0385  CL115 PaTu 8988t C22(1.10); C6(1.10)  LDD1264  [10]
 LDCM0386  CL116 PaTu 8988t C22(1.15); C6(1.15)  LDD1265  [10]
 LDCM0387  CL117 HCT 116 C22(2.53); C6(2.53)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C22(0.84); C6(0.84)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C22(1.55); C6(1.55)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C22(2.57); C6(2.57)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C22(0.89); C6(0.89)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C22(4.84); C6(4.84)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C22(1.16); C6(1.16)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C22(1.78); C6(1.78)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C22(2.06); C6(2.06)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C22(1.13); C6(1.13)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C22(1.28); C6(1.28)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C22(1.14); C6(1.14)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C22(1.64); C6(1.64)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C22(1.98); C6(1.98)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C22(1.37); C6(1.37)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C22(2.22); C6(2.22)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C22(1.05); C6(1.05)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C22(1.03); C6(1.03)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C22(1.51); C6(1.51)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C22(1.70); C6(1.70)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C22(1.06); C6(1.06)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C22(1.77); C6(1.77)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C22(2.43); C6(2.43)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C22(3.37); C6(3.37)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C22(1.67); C6(1.67)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C22(3.15); C6(3.15)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C22(2.66); C6(2.66)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C22(1.76); C6(1.76)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C22(1.68); C6(1.68)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C22(1.97); C6(1.97)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C22(1.85); C6(1.85)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C22(1.10); C6(1.10)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C22(1.32); C6(1.32)  LDD0736  [10]
 LDCM0420  CL31 PaTu 8988t C22(1.15); C6(1.15)  LDD1299  [10]
 LDCM0421  CL32 PaTu 8988t C22(1.40); C6(1.40)  LDD1300  [10]
 LDCM0422  CL33 PaTu 8988t C22(2.04); C6(2.04)  LDD1301  [10]
 LDCM0423  CL34 PaTu 8988t C22(1.90); C6(1.90)  LDD1302  [10]
 LDCM0424  CL35 PaTu 8988t C22(1.71); C6(1.71)  LDD1303  [10]
 LDCM0425  CL36 PaTu 8988t C22(1.40); C6(1.40)  LDD1304  [10]
 LDCM0426  CL37 PaTu 8988t C22(1.67); C6(1.67)  LDD1305  [10]
 LDCM0428  CL39 PaTu 8988t C22(1.89); C6(1.89)  LDD1307  [10]
 LDCM0429  CL4 HCT 116 C22(1.23); C6(1.23)  LDD0746  [10]
 LDCM0430  CL40 PaTu 8988t C22(1.39); C6(1.39)  LDD1309  [10]
 LDCM0431  CL41 PaTu 8988t C22(1.84); C6(1.84)  LDD1310  [10]
 LDCM0432  CL42 PaTu 8988t C22(2.21); C6(2.21)  LDD1311  [10]
 LDCM0433  CL43 PaTu 8988t C22(2.64); C6(2.64)  LDD1312  [10]
 LDCM0434  CL44 PaTu 8988t C22(1.76); C6(1.76)  LDD1313  [10]
 LDCM0435  CL45 PaTu 8988t C22(2.09); C6(2.09)  LDD1314  [10]
 LDCM0436  CL46 PaTu 8988t C22(1.26); C6(1.26)  LDD1315  [10]
 LDCM0437  CL47 PaTu 8988t C22(1.33); C6(1.33)  LDD1316  [10]
 LDCM0438  CL48 PaTu 8988t C22(1.61); C6(1.61)  LDD1317  [10]
 LDCM0439  CL49 PaTu 8988t C22(1.35); C6(1.35)  LDD1318  [10]
 LDCM0440  CL5 HCT 116 C22(1.26); C6(1.26)  LDD0757  [10]
 LDCM0441  CL50 PaTu 8988t C22(1.61); C6(1.61)  LDD1320  [10]
 LDCM0442  CL51 PaTu 8988t C22(1.72); C6(1.72)  LDD1321  [10]
 LDCM0443  CL52 PaTu 8988t C22(1.57); C6(1.57)  LDD1322  [10]
 LDCM0444  CL53 PaTu 8988t C22(1.87); C6(1.87)  LDD1323  [10]
 LDCM0445  CL54 PaTu 8988t C22(1.28); C6(1.28)  LDD1324  [10]
 LDCM0446  CL55 PaTu 8988t C22(1.57); C6(1.57)  LDD1325  [10]
 LDCM0447  CL56 PaTu 8988t C22(1.28); C6(1.28)  LDD1326  [10]
 LDCM0448  CL57 PaTu 8988t C22(2.93); C6(2.93)  LDD1327  [10]
 LDCM0449  CL58 PaTu 8988t C22(1.53); C6(1.53)  LDD1328  [10]
 LDCM0450  CL59 PaTu 8988t C22(2.91); C6(2.91)  LDD1329  [10]
 LDCM0451  CL6 HCT 116 C22(1.54); C6(1.54)  LDD0768  [10]
 LDCM0452  CL60 PaTu 8988t C22(2.39); C6(2.39)  LDD1331  [10]
 LDCM0453  CL61 HCT 116 C22(1.23); C6(1.23)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C22(1.70); C6(1.70)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C22(1.73); C6(1.73)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C22(1.49); C6(1.49)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C22(0.88); C6(0.88)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C22(1.69); C6(1.69)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C22(1.75); C6(1.75)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C22(1.16); C6(1.16)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C22(1.30); C6(1.30)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C22(2.26); C6(2.26)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C22(1.65); C6(1.65)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C22(1.44); C6(1.44)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C22(1.22); C6(1.22)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C22(1.44); C6(1.44)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C22(1.79); C6(1.79)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C22(1.29); C6(1.29)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C22(1.04); C6(1.04)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C22(0.50); C6(0.50)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C22(0.60); C6(0.60)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C22(3.07); C6(3.07)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C22(0.38); C6(0.38)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C22(0.58); C6(0.58)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C22(1.05); C6(1.05)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C22(0.72); C6(0.72)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C22(0.72); C6(0.72)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C22(0.39); C6(0.39)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C22(0.28); C6(0.28)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C22(0.66); C6(0.66)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C22(0.61); C6(0.61)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C22(0.56); C6(0.56)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C22(1.73); C6(1.73)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C22(0.30); C6(0.30)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C22(1.07); C6(1.07)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C22(0.88); C6(0.88)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C22(1.11); C6(1.11)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C22(3.10); C6(3.10)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C22(1.22); C6(1.22)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C22(1.42); C6(1.42)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C22(0.90); C6(0.90)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C22(0.90); C6(0.90)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C22(1.74); C6(1.74)  LDD0811  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C95(2.00)  LDD1702  [4]
 LDCM0578  Fragment27 Ramos C157(1.85)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C157(0.43)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C157(1.68)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C157(0.65)  LDD2200  [11]
 LDCM0468  Fragment33 HCT 116 C22(1.45); C6(1.45)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C157(1.10)  LDD2203  [11]
 LDCM0427  Fragment51 PaTu 8988t C22(2.16); C6(2.16)  LDD1306  [10]
 LDCM0614  Fragment56 Ramos C157(1.76)  LDD2205  [11]
 LDCM0022  KB02 T cell-activated C6, C22(5.96)  LDD1708  [12]
 LDCM0023  KB03 Jurkat C95(28.94)  LDD0209  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Choline Small molecular drug DB00122
Choline Salicylate Small molecular drug DB14006
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tcd-717 . D0G2XR

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.