Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C089  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 26 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 26.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 16.2
 LDTP03787  Choline kinase alpha (CHKA) 14.7
 LDTP12105  L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) 13.2
 LDTP02713  Macrophage migration inhibitory factor (MIF) 12.7
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 11.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 10.5
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 9.7
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 9.7
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 8.8
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 8.8
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 8.7
 LDTP01803  Adenosine deaminase (ADA) 8.5
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 8.1
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 7.5
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 7.4
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 7.3
 LDTP01769  Dihydrofolate reductase (DHFR) 6.5
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 6.4
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 5.9
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 5.7
 LDTP13751  Exonuclease 1 (EXO1) 5.6
 LDTP02359  Heme oxygenase 1 (HMOX1) 5.2
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 5.1
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 5.0
 LDTP00758  Thioredoxin-like protein 1 (TXNL1) 4.9
Transporter and channel
Click to Show/Hide to Show 14 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 10.5
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 8.9
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 7.7
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 7.4
 LDTP16813  Tetraspanin-3 (TSPAN3) 7.3
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 7.1
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 6.5
 LDTP05900  Metaxin-1 (MTX1) 5.9
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 5.7
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 5.5
 LDTP11844  Protein spinster homolog 1 (SPNS1) 5.5
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.5
 LDTP07236  Protein GPR107 (GPR107) 5.4
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 5.0
Other
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 13.4
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 10.7
 LDTP15623  Neuferricin (CYB5D2) 10.3
 LDTP14458  Tetraspanin-6 (TSPAN6) 8.1
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 7.7
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 7.6
 LDTP01075  Protein CutA (CUTA) 6.9
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 5.8
 LDTP05160  Nucleobindin-2 (NUCB2) 5.0
 LDTP05375  Nucleobindin-1 (NUCB1) 4.9

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587