Details of the Target

General Information of Target

Target ID	LDTP02713
Target Name	Macrophage migration inhibitory factor (MIF)
Gene Name	MIF
Gene ID	4282
Synonyms	GLIF; MMIF; Macrophage migration inhibitory factor; MIF; EC 5.3.2.1; Glycosylation-inhibiting factor; GIF; L-dopachrome isomerase; L-dopachrome tautomerase; EC 5.3.3.12; Phenylpyruvate tautomerase
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALC SLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
Target Type	Clinical trial
Target Bioclass	Enzyme
Family	MIF family
Subcellular location	Secreted
Function	Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
TTD ID	T39977
Uniprot ID	P14174
DrugMap ID	TT2AST1
Ensemble ID	ENST00000215754.8
HGNC ID	HGNC:7097
ChEMBL ID	CHEMBL2085

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 35 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
P3 Probe Info	10.00	LDD0450	[1]
TH211 Probe Info	Y76(7.87)	LDD0257	[2]
TH214 Probe Info	Y76(20.00)	LDD0258	[2]
TH216 Probe Info	Y76(20.00)	LDD0259	[2]
YN-1 Probe Info	100.00	LDD0444	[3]
JZ128-DTB Probe Info	N.A.	LDD0462	[4]
THZ1-DTB Probe Info	C81(1.10)	LDD0460	[4]
BTD Probe Info	C60(1.39)	LDD1700	[5]
Sulforaphane-probe2 Probe Info	2.64	LDD0160	[6]
HHS-482 Probe Info	Y100(0.93); Y76(1.31); Y96(1.22); Y99(0.93)	LDD0285	[7]
HHS-475 Probe Info	Y76(0.82)	LDD0264	[8]
HHS-465 Probe Info	Y99(10.00)	LDD2237	[9]
DBIA Probe Info	C81(1.13)	LDD0080	[10]
AMP probe Probe Info	N.A.	LDD0200	[11]
ATP probe Probe Info	N.A.	LDD0199	[11]
m-APA Probe Info	N.A.	LDD2233	[12]
CY-1 Probe Info	N.A.	LDD0246	[13]
N1 Probe Info	N.A.	LDD0245	[13]
4-Iodoacetamidophenylacetylene Probe Info	N.A.	LDD0038	[14]
IA-alkyne Probe Info	N.A.	LDD0032	[15]
IPIAA_H Probe Info	C81(0.00); C57(0.00)	LDD0030	[16]
IPIAA_L Probe Info	C81(0.00); C57(0.00); C60(0.00)	LDD0031	[16]
Lodoacetamide azide Probe Info	N.A.	LDD0037	[14]
AZ-9 Probe Info	N.A.	LDD0395	[17]
JW-RF-010 Probe Info	N.A.	LDD0026	[18]
NAIA_4 Probe Info	N.A.	LDD2226	[19]
TFBX Probe Info	N.A.	LDD0027	[18]
WYneN Probe Info	N.A.	LDD0021	[20]
IPM Probe Info	N.A.	LDD0005	[20]
SF Probe Info	N.A.	LDD0028	[21]
STPyne Probe Info	N.A.	LDD0009	[20]
Phosphinate-6 Probe Info	C57(0.00); C81(0.00)	LDD0018	[22]
Acrolein Probe Info	N.A.	LDD0217	[23]
W1 Probe Info	N.A.	LDD0236	[24]
NAIA_5 Probe Info	N.A.	LDD2223	[19]

PAL-AfBPP Probe

Click To Hide/Show 37 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C017 Probe Info	6.50	LDD1725	[25]
C027 Probe Info	22.01	LDD1733	[25]
C056 Probe Info	23.92	LDD1753	[25]
C070 Probe Info	11.71	LDD1766	[25]
C087 Probe Info	8.40	LDD1779	[25]
C089 Probe Info	12.73	LDD1781	[25]
C145 Probe Info	12.64	LDD1827	[25]
C170 Probe Info	7.62	LDD1850	[25]
C174 Probe Info	5.74	LDD1854	[25]
C216 Probe Info	11.24	LDD1890	[25]
C220 Probe Info	11.71	LDD1894	[25]
C232 Probe Info	69.55	LDD1905	[25]
C235 Probe Info	18.13	LDD1908	[25]
C239 Probe Info	11.96	LDD1912	[25]
C249 Probe Info	30.48	LDD1922	[25]
C252 Probe Info	8.51	LDD1925	[25]
C280 Probe Info	12.47	LDD1950	[25]
C284 Probe Info	36.25	LDD1954	[25]
C285 Probe Info	20.68	LDD1955	[25]
C286 Probe Info	23.75	LDD1956	[25]
C294 Probe Info	5.21	LDD1964	[25]
C296 Probe Info	22.78	LDD1966	[25]
C305 Probe Info	23.92	LDD1974	[25]
C314 Probe Info	26.91	LDD1981	[25]
C326 Probe Info	11.08	LDD1990	[25]
C346 Probe Info	30.70	LDD2007	[25]
C362 Probe Info	32.45	LDD2023	[25]
C363 Probe Info	43.71	LDD2024	[25]
C364 Probe Info	50.91	LDD2025	[25]
C374 Probe Info	5.58	LDD2034	[25]
C378 Probe Info	7.89	LDD2037	[25]
C383 Probe Info	11.71	LDD2042	[25]
C389 Probe Info	5.03	LDD2048	[25]
C420 Probe Info	14.93	LDD2075	[25]
STS-1 Probe Info	1.13	LDD0137	[26]
STS-2 Probe Info	N.A.	LDD0138	[26]
OEA-DA Probe Info	7.10	LDD0046	[27]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0548	1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one	MDA-MB-231	C57(0.51); C60(0.51)	LDD2142	[5]
LDCM0519	1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one	MDA-MB-231	C57(0.55); C60(0.46)	LDD2112	[5]
LDCM0524	2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide	MDA-MB-231	C60(0.89)	LDD2117	[5]
LDCM0558	2-Cyano-N-phenylacetamide	MDA-MB-231	C57(1.10); C60(0.98)	LDD2152	[5]
LDCM0214	AC1	HCT 116	C81(1.37)	LDD0531	[10]
LDCM0215	AC10	HCT 116	C81(1.11)	LDD0532	[10]
LDCM0216	AC100	HCT 116	C81(0.88)	LDD0533	[10]
LDCM0217	AC101	HCT 116	C81(0.88)	LDD0534	[10]
LDCM0218	AC102	HCT 116	C81(0.96)	LDD0535	[10]
LDCM0219	AC103	HCT 116	C81(0.90)	LDD0536	[10]
LDCM0220	AC104	HCT 116	C81(1.01)	LDD0537	[10]
LDCM0221	AC105	HCT 116	C81(1.14)	LDD0538	[10]
LDCM0222	AC106	HCT 116	C81(0.94)	LDD0539	[10]
LDCM0223	AC107	HCT 116	C81(1.00)	LDD0540	[10]
LDCM0224	AC108	HCT 116	C81(0.77)	LDD0541	[10]
LDCM0225	AC109	HCT 116	C81(1.18)	LDD0542	[10]
LDCM0226	AC11	HCT 116	C81(0.94)	LDD0543	[10]
LDCM0227	AC110	HCT 116	C81(0.81)	LDD0544	[10]
LDCM0228	AC111	HCT 116	C81(0.85)	LDD0545	[10]
LDCM0229	AC112	HCT 116	C81(0.89)	LDD0546	[10]
LDCM0230	AC113	HCT 116	C81(2.30)	LDD0547	[10]
LDCM0231	AC114	HCT 116	C81(3.39)	LDD0548	[10]
LDCM0232	AC115	HCT 116	C81(2.87)	LDD0549	[10]
LDCM0233	AC116	HCT 116	C81(2.94)	LDD0550	[10]
LDCM0234	AC117	HCT 116	C81(2.88)	LDD0551	[10]
LDCM0235	AC118	HCT 116	C81(3.50)	LDD0552	[10]
LDCM0236	AC119	HCT 116	C81(3.48)	LDD0553	[10]
LDCM0237	AC12	HCT 116	C81(1.15)	LDD0554	[10]
LDCM0238	AC120	HCT 116	C81(3.87)	LDD0555	[10]
LDCM0239	AC121	HCT 116	C81(2.53)	LDD0556	[10]
LDCM0240	AC122	HCT 116	C81(3.59)	LDD0557	[10]
LDCM0241	AC123	HCT 116	C81(3.61)	LDD0558	[10]
LDCM0242	AC124	HCT 116	C81(3.43)	LDD0559	[10]
LDCM0243	AC125	HCT 116	C81(2.82)	LDD0560	[10]
LDCM0244	AC126	HCT 116	C81(2.29)	LDD0561	[10]
LDCM0245	AC127	HCT 116	C81(3.27)	LDD0562	[10]
LDCM0246	AC128	HCT 116	C81(0.95)	LDD0563	[10]
LDCM0247	AC129	HCT 116	C81(1.14)	LDD0564	[10]
LDCM0249	AC130	HCT 116	C81(1.12)	LDD0566	[10]
LDCM0250	AC131	HCT 116	C81(0.90)	LDD0567	[10]
LDCM0251	AC132	HCT 116	C81(1.14)	LDD0568	[10]
LDCM0252	AC133	HCT 116	C81(1.06)	LDD0569	[10]
LDCM0253	AC134	HCT 116	C81(1.20)	LDD0570	[10]
LDCM0254	AC135	HCT 116	C81(0.86)	LDD0571	[10]
LDCM0255	AC136	HCT 116	C81(1.13)	LDD0572	[10]
LDCM0256	AC137	HCT 116	C81(0.97)	LDD0573	[10]
LDCM0257	AC138	HCT 116	C81(1.07)	LDD0574	[10]
LDCM0258	AC139	HCT 116	C81(1.05)	LDD0575	[10]
LDCM0259	AC14	HCT 116	C81(1.06)	LDD0576	[10]
LDCM0260	AC140	HCT 116	C81(1.38)	LDD0577	[10]
LDCM0261	AC141	HCT 116	C81(0.96)	LDD0578	[10]
LDCM0262	AC142	HCT 116	C81(1.04)	LDD0579	[10]
LDCM0263	AC143	HCT 116	C81(0.89)	LDD0580	[10]
LDCM0264	AC144	HCT 116	C81(0.88)	LDD0581	[10]
LDCM0265	AC145	HCT 116	C81(0.88)	LDD0582	[10]
LDCM0266	AC146	HCT 116	C81(0.87)	LDD0583	[10]
LDCM0267	AC147	HCT 116	C81(0.93)	LDD0584	[10]
LDCM0268	AC148	HCT 116	C81(0.65)	LDD0585	[10]
LDCM0269	AC149	HCT 116	C81(0.78)	LDD0586	[10]
LDCM0270	AC15	HCT 116	C81(1.10)	LDD0587	[10]
LDCM0271	AC150	HCT 116	C81(0.91)	LDD0588	[10]
LDCM0272	AC151	HCT 116	C81(0.79)	LDD0589	[10]
LDCM0273	AC152	HCT 116	C81(0.80)	LDD0590	[10]
LDCM0274	AC153	HCT 116	C81(0.64)	LDD0591	[10]
LDCM0621	AC154	HCT 116	C81(0.91)	LDD2158	[10]
LDCM0622	AC155	HCT 116	C81(0.91)	LDD2159	[10]
LDCM0623	AC156	HCT 116	C81(0.83)	LDD2160	[10]
LDCM0624	AC157	HCT 116	C81(0.92)	LDD2161	[10]
LDCM0276	AC17	HCT 116	C81(1.01)	LDD0593	[10]
LDCM0277	AC18	HCT 116	C81(0.96)	LDD0594	[10]
LDCM0278	AC19	HCT 116	C81(1.03)	LDD0595	[10]
LDCM0279	AC2	HCT 116	C81(1.23)	LDD0596	[10]
LDCM0280	AC20	HCT 116	C81(0.98)	LDD0597	[10]
LDCM0281	AC21	HCT 116	C81(0.91)	LDD0598	[10]
LDCM0282	AC22	HCT 116	C81(0.97)	LDD0599	[10]
LDCM0283	AC23	HCT 116	C81(0.85)	LDD0600	[10]
LDCM0284	AC24	HCT 116	C81(1.00)	LDD0601	[10]
LDCM0285	AC25	HCT 116	C81(1.19)	LDD0602	[10]
LDCM0286	AC26	HCT 116	C81(1.08)	LDD0603	[10]
LDCM0287	AC27	HCT 116	C81(1.12)	LDD0604	[10]
LDCM0288	AC28	HCT 116	C81(1.16)	LDD0605	[10]
LDCM0289	AC29	HCT 116	C81(1.10)	LDD0606	[10]
LDCM0290	AC3	HCT 116	C81(0.99)	LDD0607	[10]
LDCM0291	AC30	HCT 116	C81(0.77)	LDD0608	[10]
LDCM0292	AC31	HCT 116	C81(1.03)	LDD0609	[10]
LDCM0293	AC32	HCT 116	C81(1.17)	LDD0610	[10]
LDCM0294	AC33	HCT 116	C81(1.07)	LDD0611	[10]
LDCM0295	AC34	HCT 116	C81(1.05)	LDD0612	[10]
LDCM0296	AC35	HCT 116	C81(1.14)	LDD0613	[10]
LDCM0297	AC36	HCT 116	C81(1.10)	LDD0614	[10]
LDCM0298	AC37	HCT 116	C81(1.12)	LDD0615	[10]
LDCM0299	AC38	HCT 116	C81(1.17)	LDD0616	[10]
LDCM0300	AC39	HCT 116	C81(1.02)	LDD0617	[10]
LDCM0301	AC4	HCT 116	C81(1.30)	LDD0618	[10]
LDCM0302	AC40	HCT 116	C81(1.02)	LDD0619	[10]
LDCM0303	AC41	HCT 116	C81(0.75)	LDD0620	[10]
LDCM0304	AC42	HCT 116	C81(1.09)	LDD0621	[10]
LDCM0305	AC43	HCT 116	C81(1.01)	LDD0622	[10]
LDCM0306	AC44	HCT 116	C81(0.71)	LDD0623	[10]
LDCM0307	AC45	HCT 116	C81(1.02)	LDD0624	[10]
LDCM0308	AC46	HCT 116	C81(0.98)	LDD0625	[10]
LDCM0309	AC47	HCT 116	C81(1.05)	LDD0626	[10]
LDCM0310	AC48	HCT 116	C81(1.07)	LDD0627	[10]
LDCM0311	AC49	HCT 116	C81(1.23)	LDD0628	[10]
LDCM0312	AC5	HCT 116	C81(1.24)	LDD0629	[10]
LDCM0313	AC50	HCT 116	C81(1.22)	LDD0630	[10]
LDCM0314	AC51	HCT 116	C81(1.22)	LDD0631	[10]
LDCM0315	AC52	HCT 116	C81(1.25)	LDD0632	[10]
LDCM0316	AC53	HCT 116	C81(1.23)	LDD0633	[10]
LDCM0317	AC54	HCT 116	C81(1.10)	LDD0634	[10]
LDCM0318	AC55	HCT 116	C81(1.23)	LDD0635	[10]
LDCM0319	AC56	HCT 116	C81(0.99)	LDD0636	[10]
LDCM0320	AC57	HCT 116	C81(1.67)	LDD0637	[10]
LDCM0321	AC58	HCT 116	C81(1.60)	LDD0638	[10]
LDCM0322	AC59	HCT 116	C81(1.57)	LDD0639	[10]
LDCM0323	AC6	HCT 116	C81(1.09)	LDD0640	[10]
LDCM0324	AC60	HCT 116	C81(1.69)	LDD0641	[10]
LDCM0325	AC61	HCT 116	C81(1.71)	LDD0642	[10]
LDCM0326	AC62	HCT 116	C81(1.63)	LDD0643	[10]
LDCM0327	AC63	HCT 116	C81(1.57)	LDD0644	[10]
LDCM0328	AC64	HCT 116	C81(1.88)	LDD0645	[10]
LDCM0329	AC65	HCT 116	C81(1.95)	LDD0646	[10]
LDCM0330	AC66	HCT 116	C81(2.16)	LDD0647	[10]
LDCM0331	AC67	HCT 116	C81(1.63)	LDD0648	[10]
LDCM0332	AC68	HCT 116	C81(1.16)	LDD0649	[10]
LDCM0333	AC69	HCT 116	C81(1.00)	LDD0650	[10]
LDCM0334	AC7	HCT 116	C81(1.03)	LDD0651	[10]
LDCM0335	AC70	HCT 116	C81(1.02)	LDD0652	[10]
LDCM0336	AC71	HCT 116	C81(1.10)	LDD0653	[10]
LDCM0337	AC72	HCT 116	C81(1.00)	LDD0654	[10]
LDCM0338	AC73	HCT 116	C81(0.95)	LDD0655	[10]
LDCM0339	AC74	HCT 116	C81(0.89)	LDD0656	[10]
LDCM0340	AC75	HCT 116	C81(0.96)	LDD0657	[10]
LDCM0341	AC76	HCT 116	C81(1.08)	LDD0658	[10]
LDCM0342	AC77	HCT 116	C81(0.89)	LDD0659	[10]
LDCM0343	AC78	HCT 116	C81(1.08)	LDD0660	[10]
LDCM0344	AC79	HCT 116	C81(1.14)	LDD0661	[10]
LDCM0345	AC8	HCT 116	C81(0.96)	LDD0662	[10]
LDCM0346	AC80	HCT 116	C81(1.16)	LDD0663	[10]
LDCM0347	AC81	HCT 116	C81(1.09)	LDD0664	[10]
LDCM0348	AC82	HCT 116	C81(0.68)	LDD0665	[10]
LDCM0349	AC83	HCT 116	C81(1.15)	LDD0666	[10]
LDCM0350	AC84	HCT 116	C81(1.10)	LDD0667	[10]
LDCM0351	AC85	HCT 116	C81(1.29)	LDD0668	[10]
LDCM0352	AC86	HCT 116	C81(1.27)	LDD0669	[10]
LDCM0353	AC87	HCT 116	C81(1.11)	LDD0670	[10]
LDCM0354	AC88	HCT 116	C81(1.07)	LDD0671	[10]
LDCM0355	AC89	HCT 116	C81(1.03)	LDD0672	[10]
LDCM0357	AC90	HCT 116	C81(1.19)	LDD0674	[10]
LDCM0358	AC91	HCT 116	C81(1.15)	LDD0675	[10]
LDCM0359	AC92	HCT 116	C81(1.13)	LDD0676	[10]
LDCM0360	AC93	HCT 116	C81(1.07)	LDD0677	[10]
LDCM0361	AC94	HCT 116	C81(1.29)	LDD0678	[10]
LDCM0362	AC95	HCT 116	C81(1.21)	LDD0679	[10]
LDCM0363	AC96	HCT 116	C81(1.21)	LDD0680	[10]
LDCM0364	AC97	HCT 116	C81(1.27)	LDD0681	[10]
LDCM0365	AC98	HCT 116	C81(0.56)	LDD0682	[10]
LDCM0366	AC99	HCT 116	C81(0.88)	LDD0683	[10]
LDCM0520	AKOS000195272	MDA-MB-231	C57(0.75); C60(1.04)	LDD2113	[5]
LDCM0248	AKOS034007472	HCT 116	C81(1.11)	LDD0565	[10]
LDCM0356	AKOS034007680	HCT 116	C81(1.09)	LDD0673	[10]
LDCM0275	AKOS034007705	HCT 116	C81(1.13)	LDD0592	[10]
LDCM0020	ARS-1620	HCC44	C81(1.02)	LDD2171	[10]
LDCM0498	BS-3668	MDA-MB-231	C57(0.68)	LDD2091	[5]
LDCM0108	Chloroacetamide	HeLa	C57(0.00); H63(0.00); C60(0.00)	LDD0222	[23]
LDCM0632	CL-Sc	Hep-G2	C81(0.77)	LDD2227	[19]
LDCM0367	CL1	HCT 116	C81(0.90)	LDD0684	[10]
LDCM0368	CL10	HCT 116	C81(0.90)	LDD0685	[10]
LDCM0369	CL100	HCT 116	C81(1.28)	LDD0686	[10]
LDCM0370	CL101	HCT 116	C81(1.00)	LDD0687	[10]
LDCM0371	CL102	HCT 116	C81(1.01)	LDD0688	[10]
LDCM0372	CL103	HCT 116	C81(1.13)	LDD0689	[10]
LDCM0373	CL104	HCT 116	C81(1.03)	LDD0690	[10]
LDCM0374	CL105	HCT 116	C81(0.89)	LDD0691	[10]
LDCM0375	CL106	HCT 116	C81(0.74)	LDD0692	[10]
LDCM0376	CL107	HCT 116	C81(0.93)	LDD0693	[10]
LDCM0377	CL108	HCT 116	C81(0.91)	LDD0694	[10]
LDCM0378	CL109	HCT 116	C81(0.61)	LDD0695	[10]
LDCM0379	CL11	HCT 116	C81(0.88)	LDD0696	[10]
LDCM0380	CL110	HCT 116	C81(0.81)	LDD0697	[10]
LDCM0381	CL111	HCT 116	C81(0.83)	LDD0698	[10]
LDCM0382	CL112	HCT 116	C81(1.03)	LDD0699	[10]
LDCM0383	CL113	HCT 116	C81(1.11)	LDD0700	[10]
LDCM0384	CL114	HCT 116	C81(1.00)	LDD0701	[10]
LDCM0385	CL115	HCT 116	C81(1.03)	LDD0702	[10]
LDCM0386	CL116	HCT 116	C81(1.12)	LDD0703	[10]
LDCM0387	CL117	HCT 116	C81(0.95)	LDD0704	[10]
LDCM0388	CL118	HCT 116	C81(1.05)	LDD0705	[10]
LDCM0389	CL119	HCT 116	C81(0.99)	LDD0706	[10]
LDCM0390	CL12	HCT 116	C81(0.92)	LDD0707	[10]
LDCM0391	CL120	HCT 116	C81(1.17)	LDD0708	[10]
LDCM0392	CL121	HCT 116	C81(1.03)	LDD0709	[10]
LDCM0393	CL122	HCT 116	C81(1.10)	LDD0710	[10]
LDCM0394	CL123	HCT 116	C81(0.82)	LDD0711	[10]
LDCM0395	CL124	HCT 116	C81(1.23)	LDD0712	[10]
LDCM0396	CL125	HCT 116	C81(1.75)	LDD0713	[10]
LDCM0397	CL126	HCT 116	C81(1.53)	LDD0714	[10]
LDCM0398	CL127	HCT 116	C81(1.52)	LDD0715	[10]
LDCM0399	CL128	HCT 116	C81(1.59)	LDD0716	[10]
LDCM0400	CL13	HCT 116	C81(0.97)	LDD0717	[10]
LDCM0401	CL14	HCT 116	C81(1.05)	LDD0718	[10]
LDCM0402	CL15	HCT 116	C81(0.39)	LDD0719	[10]
LDCM0403	CL16	HCT 116	C81(0.91)	LDD0720	[10]
LDCM0404	CL17	HCT 116	C81(0.85)	LDD0721	[10]
LDCM0405	CL18	HCT 116	C81(1.02)	LDD0722	[10]
LDCM0406	CL19	HCT 116	C81(0.98)	LDD0723	[10]
LDCM0407	CL2	HCT 116	C81(0.97)	LDD0724	[10]
LDCM0408	CL20	HCT 116	C81(1.03)	LDD0725	[10]
LDCM0409	CL21	HCT 116	C81(0.16)	LDD0726	[10]
LDCM0410	CL22	HCT 116	C81(0.96)	LDD0727	[10]
LDCM0411	CL23	HCT 116	C81(1.35)	LDD0728	[10]
LDCM0412	CL24	HCT 116	C81(1.07)	LDD0729	[10]
LDCM0413	CL25	HCT 116	C81(0.98)	LDD0730	[10]
LDCM0414	CL26	HCT 116	C81(0.90)	LDD0731	[10]
LDCM0415	CL27	HCT 116	C81(1.05)	LDD0732	[10]
LDCM0416	CL28	HCT 116	C81(0.80)	LDD0733	[10]
LDCM0417	CL29	HCT 116	C81(1.00)	LDD0734	[10]
LDCM0418	CL3	HCT 116	C81(0.94)	LDD0735	[10]
LDCM0419	CL30	HCT 116	C81(1.11)	LDD0736	[10]
LDCM0420	CL31	HCT 116	C81(0.99)	LDD0737	[10]
LDCM0421	CL32	HCT 116	C81(0.81)	LDD0738	[10]
LDCM0422	CL33	HCT 116	C81(0.77)	LDD0739	[10]
LDCM0423	CL34	HCT 116	C81(0.86)	LDD0740	[10]
LDCM0424	CL35	HCT 116	C81(0.78)	LDD0741	[10]
LDCM0425	CL36	HCT 116	C81(0.85)	LDD0742	[10]
LDCM0426	CL37	HCT 116	C81(0.83)	LDD0743	[10]
LDCM0428	CL39	HCT 116	C81(0.85)	LDD0745	[10]
LDCM0429	CL4	HCT 116	C81(1.07)	LDD0746	[10]
LDCM0430	CL40	HCT 116	C81(0.86)	LDD0747	[10]
LDCM0431	CL41	HCT 116	C81(1.05)	LDD0748	[10]
LDCM0432	CL42	HCT 116	C81(0.85)	LDD0749	[10]
LDCM0433	CL43	HCT 116	C81(0.87)	LDD0750	[10]
LDCM0434	CL44	HCT 116	C81(0.89)	LDD0751	[10]
LDCM0435	CL45	HCT 116	C81(0.86)	LDD0752	[10]
LDCM0436	CL46	HCT 116	C81(0.91)	LDD0753	[10]
LDCM0437	CL47	HCT 116	C81(0.79)	LDD0754	[10]
LDCM0438	CL48	HCT 116	C81(1.07)	LDD0755	[10]
LDCM0439	CL49	HCT 116	C81(0.92)	LDD0756	[10]
LDCM0440	CL5	HCT 116	C81(1.15)	LDD0757	[10]
LDCM0441	CL50	HCT 116	C81(0.99)	LDD0758	[10]
LDCM0442	CL51	HCT 116	C81(0.86)	LDD0759	[10]
LDCM0443	CL52	HCT 116	C81(0.71)	LDD0760	[10]
LDCM0444	CL53	HCT 116	C81(0.72)	LDD0761	[10]
LDCM0445	CL54	HCT 116	C81(0.63)	LDD0762	[10]
LDCM0446	CL55	HCT 116	C81(1.06)	LDD0763	[10]
LDCM0447	CL56	HCT 116	C81(0.74)	LDD0764	[10]
LDCM0448	CL57	HCT 116	C81(1.05)	LDD0765	[10]
LDCM0449	CL58	HCT 116	C81(1.01)	LDD0766	[10]
LDCM0450	CL59	HCT 116	C81(1.04)	LDD0767	[10]
LDCM0451	CL6	HCT 116	C81(0.83)	LDD0768	[10]
LDCM0452	CL60	HCT 116	C81(1.04)	LDD0769	[10]
LDCM0453	CL61	HCT 116	C81(1.11)	LDD0770	[10]
LDCM0454	CL62	HCT 116	C81(1.06)	LDD0771	[10]
LDCM0455	CL63	HCT 116	C81(1.02)	LDD0772	[10]
LDCM0456	CL64	HCT 116	C81(1.09)	LDD0773	[10]
LDCM0457	CL65	HCT 116	C81(1.11)	LDD0774	[10]
LDCM0458	CL66	HCT 116	C81(1.21)	LDD0775	[10]
LDCM0459	CL67	HCT 116	C81(1.28)	LDD0776	[10]
LDCM0460	CL68	HCT 116	C81(0.94)	LDD0777	[10]
LDCM0461	CL69	HCT 116	C81(0.83)	LDD0778	[10]
LDCM0462	CL7	HCT 116	C81(1.22)	LDD0779	[10]
LDCM0463	CL70	HCT 116	C81(1.21)	LDD0780	[10]
LDCM0464	CL71	HCT 116	C81(0.78)	LDD0781	[10]
LDCM0465	CL72	HCT 116	C81(0.96)	LDD0782	[10]
LDCM0466	CL73	HCT 116	C81(0.91)	LDD0783	[10]
LDCM0467	CL74	HCT 116	C81(1.10)	LDD0784	[10]
LDCM0469	CL76	HCT 116	C81(0.98)	LDD0786	[10]
LDCM0470	CL77	HCT 116	C81(0.48)	LDD0787	[10]
LDCM0471	CL78	HCT 116	C81(1.02)	LDD0788	[10]
LDCM0472	CL79	HCT 116	C81(1.06)	LDD0789	[10]
LDCM0473	CL8	HCT 116	C81(1.00)	LDD0790	[10]
LDCM0474	CL80	HCT 116	C81(1.02)	LDD0791	[10]
LDCM0475	CL81	HCT 116	C81(0.93)	LDD0792	[10]
LDCM0476	CL82	HCT 116	C81(0.99)	LDD0793	[10]
LDCM0477	CL83	HCT 116	C81(0.85)	LDD0794	[10]
LDCM0478	CL84	HCT 116	C81(0.76)	LDD0795	[10]
LDCM0479	CL85	HCT 116	C81(0.96)	LDD0796	[10]
LDCM0480	CL86	HCT 116	C81(0.90)	LDD0797	[10]
LDCM0481	CL87	HCT 116	C81(0.85)	LDD0798	[10]
LDCM0482	CL88	HCT 116	C81(0.95)	LDD0799	[10]
LDCM0483	CL89	HCT 116	C81(0.78)	LDD0800	[10]
LDCM0484	CL9	HCT 116	C81(1.08)	LDD0801	[10]
LDCM0485	CL90	HCT 116	C81(0.79)	LDD0802	[10]
LDCM0486	CL91	HCT 116	C81(1.07)	LDD0803	[10]
LDCM0487	CL92	HCT 116	C81(1.04)	LDD0804	[10]
LDCM0488	CL93	HCT 116	C81(0.92)	LDD0805	[10]
LDCM0489	CL94	HCT 116	C81(1.14)	LDD0806	[10]
LDCM0490	CL95	HCT 116	C81(1.13)	LDD0807	[10]
LDCM0491	CL96	HCT 116	C81(1.21)	LDD0808	[10]
LDCM0492	CL97	HCT 116	C81(0.67)	LDD0809	[10]
LDCM0493	CL98	HCT 116	C81(1.24)	LDD0810	[10]
LDCM0494	CL99	HCT 116	C81(1.32)	LDD0811	[10]
LDCM0495	E2913	HEK-293T	C81(0.72)	LDD1698	[28]
LDCM0625	F8	Ramos	C81(0.40)	LDD2187	[29]
LDCM0572	Fragment10	Ramos	C81(0.46)	LDD2189	[29]
LDCM0573	Fragment11	Ramos	C81(0.00)	LDD2190	[29]
LDCM0574	Fragment12	Ramos	C81(0.47)	LDD2191	[29]
LDCM0575	Fragment13	Ramos	C81(1.24)	LDD2192	[29]
LDCM0576	Fragment14	Ramos	C81(0.55)	LDD2193	[29]
LDCM0579	Fragment20	Ramos	C81(0.37)	LDD2194	[29]
LDCM0580	Fragment21	Ramos	C81(1.12)	LDD2195	[29]
LDCM0582	Fragment23	Ramos	C81(1.02)	LDD2196	[29]
LDCM0578	Fragment27	Ramos	C81(1.34)	LDD2197	[29]
LDCM0586	Fragment28	Ramos	C81(1.19)	LDD2198	[29]
LDCM0588	Fragment30	Ramos	C81(0.73)	LDD2199	[29]
LDCM0589	Fragment31	Ramos	C81(1.54)	LDD2200	[29]
LDCM0590	Fragment32	Ramos	C81(0.42)	LDD2201	[29]
LDCM0468	Fragment33	HCT 116	C81(1.12)	LDD0785	[10]
LDCM0596	Fragment38	Ramos	C81(1.43)	LDD2203	[29]
LDCM0566	Fragment4	Ramos	C81(0.42)	LDD2184	[29]
LDCM0427	Fragment51	HCT 116	C81(0.87)	LDD0744	[10]
LDCM0610	Fragment52	Ramos	C81(0.65)	LDD2204	[29]
LDCM0614	Fragment56	Ramos	C81(0.77)	LDD2205	[29]
LDCM0569	Fragment7	Ramos	C81(0.38)	LDD2186	[29]
LDCM0571	Fragment9	Ramos	C81(0.37)	LDD2188	[29]
LDCM0116	HHS-0101	DM93	Y76(0.82)	LDD0264	[8]
LDCM0117	HHS-0201	DM93	Y76(0.73)	LDD0265	[8]
LDCM0118	HHS-0301	DM93	Y76(0.65)	LDD0266	[8]
LDCM0119	HHS-0401	DM93	Y76(0.84)	LDD0267	[8]
LDCM0120	HHS-0701	DM93	Y76(0.90)	LDD0268	[8]
LDCM0107	IAA	HeLa	H63(0.00); C60(0.00)	LDD0221	[23]
LDCM0123	JWB131	DM93	Y100(0.93); Y76(1.31); Y96(1.22); Y99(0.93)	LDD0285	[7]
LDCM0124	JWB142	DM93	Y100(0.34); Y96(0.30); Y99(0.25)	LDD0286	[7]
LDCM0125	JWB146	DM93	Y100(1.10); Y76(0.96); Y96(1.17); Y99(1.22)	LDD0287	[7]
LDCM0126	JWB150	DM93	Y100(2.93); Y76(5.21); Y96(4.38); Y99(3.33)	LDD0288	[7]
LDCM0127	JWB152	DM93	Y100(1.65); Y76(2.83); Y96(1.52); Y99(1.84)	LDD0289	[7]
LDCM0128	JWB198	DM93	Y100(0.74); Y76(1.85); Y96(0.68); Y99(1.34)	LDD0290	[7]
LDCM0129	JWB202	DM93	Y100(0.41); Y76(1.98); Y96(0.41); Y99(0.41)	LDD0291	[7]
LDCM0130	JWB211	DM93	Y100(0.71); Y76(1.20); Y96(0.57); Y99(0.75)	LDD0292	[7]
LDCM0179	JZ128	PC-3	N.A.	LDD0462	[4]
LDCM0022	KB02	HCT 116	C81(1.13)	LDD0080	[10]
LDCM0023	KB03	HCT 116	C81(2.00)	LDD0081	[10]
LDCM0024	KB05	HCT 116	C81(2.46)	LDD0082	[10]
LDCM0509	N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide	MDA-MB-231	C60(0.97)	LDD2102	[5]
LDCM0109	NEM	HeLa	N.A.	LDD0223	[23]
LDCM0497	Nucleophilic fragment 11b	MDA-MB-231	C57(0.99)	LDD2090	[5]
LDCM0499	Nucleophilic fragment 12b	MDA-MB-231	C57(0.88); C60(1.36)	LDD2092	[5]
LDCM0500	Nucleophilic fragment 13a	MDA-MB-231	C60(0.93)	LDD2093	[5]
LDCM0501	Nucleophilic fragment 13b	MDA-MB-231	C60(2.31)	LDD2094	[5]
LDCM0503	Nucleophilic fragment 14b	MDA-MB-231	C57(1.41)	LDD2096	[5]
LDCM0504	Nucleophilic fragment 15a	MDA-MB-231	C57(0.93); C60(1.10)	LDD2097	[5]
LDCM0505	Nucleophilic fragment 15b	MDA-MB-231	C60(1.21)	LDD2098	[5]
LDCM0506	Nucleophilic fragment 16a	MDA-MB-231	C57(0.86); C60(0.99)	LDD2099	[5]
LDCM0507	Nucleophilic fragment 16b	MDA-MB-231	C60(0.53)	LDD2100	[5]
LDCM0508	Nucleophilic fragment 17a	MDA-MB-231	C57(0.53); C60(1.33)	LDD2101	[5]
LDCM0511	Nucleophilic fragment 18b	MDA-MB-231	C57(0.42); C60(0.60)	LDD2104	[5]
LDCM0512	Nucleophilic fragment 19a	MDA-MB-231	C60(1.20)	LDD2105	[5]
LDCM0513	Nucleophilic fragment 19b	MDA-MB-231	C57(0.36)	LDD2106	[5]
LDCM0514	Nucleophilic fragment 20a	MDA-MB-231	C57(0.93); C60(0.84)	LDD2107	[5]
LDCM0515	Nucleophilic fragment 20b	MDA-MB-231	C60(0.69)	LDD2108	[5]
LDCM0516	Nucleophilic fragment 21a	MDA-MB-231	C57(0.74); C60(0.93)	LDD2109	[5]
LDCM0517	Nucleophilic fragment 21b	MDA-MB-231	C57(0.27); C60(0.20)	LDD2110	[5]
LDCM0518	Nucleophilic fragment 22a	MDA-MB-231	C57(1.25); C60(1.00)	LDD2111	[5]
LDCM0521	Nucleophilic fragment 23b	MDA-MB-231	C60(0.54)	LDD2114	[5]
LDCM0522	Nucleophilic fragment 24a	MDA-MB-231	C57(0.40); C60(0.52)	LDD2115	[5]
LDCM0525	Nucleophilic fragment 25b	MDA-MB-231	C57(2.82)	LDD2118	[5]
LDCM0526	Nucleophilic fragment 26a	MDA-MB-231	C60(1.08)	LDD2119	[5]
LDCM0527	Nucleophilic fragment 26b	MDA-MB-231	C57(0.74); C60(0.97)	LDD2120	[5]
LDCM0529	Nucleophilic fragment 27b	MDA-MB-231	C57(2.31); C60(3.08)	LDD2122	[5]
LDCM0530	Nucleophilic fragment 28a	MDA-MB-231	C57(0.82); C60(0.91)	LDD2123	[5]
LDCM0531	Nucleophilic fragment 28b	MDA-MB-231	C57(1.10)	LDD2124	[5]
LDCM0532	Nucleophilic fragment 29a	MDA-MB-231	C57(0.90); C60(0.87)	LDD2125	[5]
LDCM0534	Nucleophilic fragment 30a	MDA-MB-231	C57(0.95); C60(1.06)	LDD2127	[5]
LDCM0535	Nucleophilic fragment 30b	MDA-MB-231	C57(1.41); C60(1.46)	LDD2128	[5]
LDCM0536	Nucleophilic fragment 31	MDA-MB-231	C57(0.99); C60(0.74)	LDD2129	[5]
LDCM0540	Nucleophilic fragment 35	MDA-MB-231	C57(0.60)	LDD2133	[5]
LDCM0541	Nucleophilic fragment 36	MDA-MB-231	C57(0.57)	LDD2134	[5]
LDCM0542	Nucleophilic fragment 37	MDA-MB-231	C60(0.95)	LDD2135	[5]
LDCM0543	Nucleophilic fragment 38	MDA-MB-231	C60(1.25)	LDD2136	[5]
LDCM0544	Nucleophilic fragment 39	MDA-MB-231	C57(0.66); C60(0.91)	LDD2137	[5]
LDCM0211	Nucleophilic fragment 3b	MDA-MB-231	C60(1.39)	LDD1700	[5]
LDCM0546	Nucleophilic fragment 40	MDA-MB-231	C60(1.11)	LDD2140	[5]
LDCM0547	Nucleophilic fragment 41	MDA-MB-231	C60(1.07)	LDD2141	[5]
LDCM0549	Nucleophilic fragment 43	MDA-MB-231	C57(1.37); C60(0.97)	LDD2143	[5]
LDCM0550	Nucleophilic fragment 5a	MDA-MB-231	C60(1.28)	LDD2144	[5]
LDCM0551	Nucleophilic fragment 5b	MDA-MB-231	C57(0.38); C60(0.30)	LDD2145	[5]
LDCM0552	Nucleophilic fragment 6a	MDA-MB-231	C57(0.93); C60(0.81)	LDD2146	[5]
LDCM0553	Nucleophilic fragment 6b	MDA-MB-231	C57(3.22); C60(2.65)	LDD2147	[5]
LDCM0554	Nucleophilic fragment 7a	MDA-MB-231	C57(0.51)	LDD2148	[5]
LDCM0557	Nucleophilic fragment 8b	MDA-MB-231	C57(2.42)	LDD2151	[5]
LDCM0559	Nucleophilic fragment 9b	MDA-MB-231	C57(1.77)	LDD2153	[5]
LDCM0628	OTUB2-COV-1	HEK-293T	C81(0.60)	LDD2207	[30]
LDCM0131	RA190	MM1.R	C81(1.24)	LDD0304	[31]
LDCM0003	Sulforaphane	MDA-MB-231	2.64	LDD0160	[6]
LDCM0021	THZ1	HeLa S3	C81(1.10)	LDD0460	[4]
LDCM0110	W12	Hep-G2	N7(13.62)	LDD0237	[24]
LDCM0112	W16	Hep-G2	N7(0.54)	LDD0239	[24]
LDCM0113	W17	Hep-G2	N7(8.49)	LDD0240	[24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 4 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Macrophage migration inhibitory factor (MIF)	MIF family	P14174
Protein N-terminal glutamine amidohydrolase (NTAQ1)	NTAQ1 family	Q96HA8
Serine protease HTRA1 (HTRA1)	Peptidase S1C family	Q92743
Epidermal growth factor receptor (EGFR)	Tyr protein kinase family	P00533

The Drug(s) Related To This Target

Phase 4

Click To Hide/Show 2 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
3,4-dihydroxycinnamic Acid				Small molecular drug	D0V9EN
Anti-mif Antibodies				.	D0O7IZ

Phase 1

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Iso-1				Small molecular drug	D04KKT

Preclinical

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Cor100140				Small molecular drug	D0F3II

Investigative

Click To Hide/Show 13 Drug(s) Interacting with This Target

Drug Name	Drug Type	External ID
34-dihydroxycinnamic Acid	Small molecular drug	DB01880
4-hydroxybenzaldehyde O-(Cyclohexylcarbonyl)Oxime	Small molecular drug	D0NN3G
4-hydroxyphenylpyruvic Acid	Small molecular drug	D0G6RI
4-hydroxyphenylpyruvic Acid	Small molecular drug	DB07718
6-hydroxy-1,3-benzothiazole-2-sulfonamide	Small molecular drug	D0A6HS
6-hydroxy-13-benzothiazole-2-sulfonamide	Small molecular drug	DB08765
7-hydroxy-2-oxo-chromene-3-carboxylic Acid Ethyl Ester	Small molecular drug	DB02728
Napqi	Small molecular drug	D0W1JY
3-(4-hydroxyphenyl)-45-dihydro-5-isoxazole-acetic Acid Methyl Ester	.	DB07888
3-fluoro-4-hydroxybenzaldehyde O-(Cyclohexylcarbonyl)Oxime	.	DB08334
4-hydroxybenzaldehyde O-(33-dimethylbutanoyl)Oxime	.	DB08335
Avp-13546	.	D00YTS
Avp-13748	.	D01SWJ

References

1	Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3	Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4	A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
6	Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c. Mass spectrometry data entry: PXD006279
7	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8	Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9	Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11	Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12	Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print. Mass spectrometry data entry: PXD042377
13	Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
14	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
15	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16	SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25. Mass spectrometry data entry: PXD029500 , PXD031647
17	2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
18	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
19	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
20	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21	Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022. Mass spectrometry data entry: PXD039931
22	DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22. Mass spectrometry data entry: PXD033004
23	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
26	Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
27	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
28	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
29	Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7. Mass spectrometry data entry: PXD027578
30	Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
31	Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.

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Prof. Feng Zhu

Prof. Feng Ni