Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C389  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 35 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12227  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) 21.9
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 20.7
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 15.2
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 12.8
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 11.2
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 10.4
 LDTP01803  Adenosine deaminase (ADA) 10.1
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) 10.1
 LDTP11081  NAD-capped RNA hydrolase NUDT12 (NUDT12) 9.4
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) 9.2
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 9.1
 LDTP12524  L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASDHPPT) 8.8
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 8.3
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 7.9
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 7.8
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 7.7
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 7.4
 LDTP12386  Polyamine-transporting ATPase 13A2 (ATP13A2) 7.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 6.7
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 6.6
 LDTP09056  Inactive C-alpha-formylglycine-generating enzyme 2 (SUMF2) 6.5
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 6.4
 LDTP03084  Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) 6.2
 LDTP06849  Prolyl endopeptidase-like (PREPL) 6.2
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) 6.2
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 6.0
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 5.9
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 5.8
 LDTP10495  Ubiquitin carboxyl-terminal hydrolase 47 (USP47) 5.7
 LDTP03331  Proteasome subunit alpha type-2 (PSMA2) 5.6
 LDTP01769  Dihydrofolate reductase (DHFR) 5.4
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 5.2
 LDTP15154  Dehydrogenase/reductase SDR family member 13 (DHRS13) 5.1
 LDTP03607  RAC-alpha serine/threonine-protein kinase (AKT1) 5.1
 LDTP02713  Macrophage migration inhibitory factor (MIF) 5.0
Transporter and channel
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 13.9
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 11.6
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 11.0
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 10.6
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 9.0
 LDTP15000  Solute carrier family 35 member F1 (SLC35F1) 5.9
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 5.7
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 5.6
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 5.5
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.5
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15303  Membrane progestin receptor alpha (PAQR7) 6.6
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03538  HLA class I histocompatibility antigen, alpha chain F (HLA-F) 6.7
Other
Click to Show/Hide to Show 26 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15623  Neuferricin (CYB5D2) 15.5
 LDTP11533  Oxysterol-binding protein-related protein 6 (OSBPL6) 14.9
 LDTP03499  Elongation factor 1-delta (EEF1D) 12.6
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 10.2
 LDTP08760  Cell cycle and apoptosis regulator protein 2 (CCAR2) 9.2
 LDTP15634  Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) 8.8
 LDTP01075  Protein CutA (CUTA) 8.1
 LDTP01652  Centrosomal protein 43 (CEP43) 7.3
 LDTP11076  Apolipoprotein L2 (APOL2) 7.1
 LDTP05160  Nucleobindin-2 (NUCB2) 6.8
 LDTP06097  Reticulocalbin-2 (RCN2) 6.5
 LDTP14259  Testis-expressed protein 264 (TEX264) 6.1
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 6.0
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 5.9
 LDTP13952  Intraflagellar transport protein 52 homolog (IFT52) 5.8
 LDTP06887  Nuclear cap-binding protein subunit 3 (NCBP3) 5.8
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 5.7
 LDTP16099  p53 and DNA damage-regulated protein 1 (PDRG1) 5.7
 LDTP19860  Coiled-coil domain-containing protein 97 (CCDC97) 5.5
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 5.4
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 5.4
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 5.2
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 5.2
 LDTP13245  Zinc finger CCCH domain-containing protein 7B (ZC3H7B) 5.2
 LDTP09080  Reticulophagy regulator 2 (RETREG2) 5.1
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 4.9

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587