Details of the Probe

General Information of Probe

Probe ID
LDPC0608
Probe Name
C389
Synonyms
Z3462083520
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 287.34
Lipid-water partition coefficient (xlogp) 2.7
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C13H13N5OS
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]imidazo[2,1-b][1,3]thiazole-2-carboxamide
Canonical SMILES
C#CCCC1(N=N1)CCNC(=O)C2=CN3C=CN=C3S2
InChI
InChI=1S/C13H13N5OS/c1-2-3-4-13(16-17-13)5-6-14-11(19)10-9-18-8-7-15-12(18)20-10/h1,7-9H,3-6H2,(H,14,19)
InChIKey
LBVICNYRCFFNHS-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

35 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) LDTP06325 5.98  LDD2048 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 10.06  LDD2048 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 7.78  LDD2048 
Adenosine deaminase (ADA) LDTP01803 10.13  LDD2048 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 15.24  LDD2048 
Dehydrogenase/reductase SDR family member 13 (DHRS13) LDTP15154 5.06  LDD2048 
Deoxyhypusine hydroxylase (DOHH) LDTP11225 5.78  LDD2048 
Dihydrofolate reductase (DHFR) LDTP01769 5.35  LDD2048 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 7.89  LDD2048 
Ferrochelatase, mitochondrial (FECH) LDTP03198 20.68  LDD2048 
Heme oxygenase 2 (HMOX2) LDTP03540 6.73  LDD2048 
Inactive C-alpha-formylglycine-generating enzyme 2 (SUMF2) LDTP09056 6.50  LDD2048 
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) LDTP03084 6.19  LDD2048 
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASDHPPT) LDTP12524 8.82  LDD2048 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 8.28  LDD2048 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 6.41  LDD2048 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 6.59  LDD2048 
Macrophage migration inhibitory factor (MIF) LDTP02713 5.03  LDD2048 
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) LDTP12227 21.86  LDD2048 
NAD-capped RNA hydrolase NUDT12 (NUDT12) LDTP11081 9.38  LDD2048 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 7.73  LDD2048 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 5.94  LDD2048 
Polyamine-transporting ATPase 13A2 (ATP13A2) LDTP12386 6.96  LDD2048 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 11.16  LDD2048 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 7.36  LDD2048 
Prolyl endopeptidase-like (PREPL) LDTP06849 6.19  LDD2048 
Proteasome subunit alpha type-2 (PSMA2) LDTP03331 5.58  LDD2048 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 9.13  LDD2048 
RAC-alpha serine/threonine-protein kinase (AKT1) LDTP03607 5.06  LDD2048 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 12.82  LDD2048 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 5.21  LDD2048 
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) LDTP02067 6.19  LDD2048 
TLC domain-containing protein 1 (TLCD1) LDTP10182 10.41  LDD2048 
Ubiquitin carboxyl-terminal hydrolase 47 (USP47) LDTP10495 5.70  LDD2048 
X-ray repair cross-complementing protein 6 (XRCC6) LDTP02640 9.19  LDD2048 
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⏷ Show the Full List of 35 Enzyme
10 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 11.00  LDD2048 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 11.55  LDD2048 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 13.93  LDD2048 
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) LDTP14099 5.54  LDD2048 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 5.70  LDD2048 
Mpv17-like protein 2 (MPV17L2) LDTP14952 10.63  LDD2048 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 9.00  LDD2048 
Solute carrier family 25 member 44 (SLC25A44) LDTP15733 5.58  LDD2048 
Solute carrier family 35 member F1 (SLC35F1) LDTP15000 5.86  LDD2048 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 5.46  LDD2048 
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⏷ Show the Full List of 10 Transporter and channel
1 GPCR Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Membrane progestin receptor alpha (PAQR7) LDTP15303 6.59  LDD2048 
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1 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
HLA class I histocompatibility antigen, alpha chain F (HLA-F) LDTP03538 6.68  LDD2048 
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26 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Apolipoprotein L2 (APOL2) LDTP11076 7.11  LDD2048 
Cell cycle and apoptosis regulator protein 2 (CCAR2) LDTP08760 9.19  LDD2048 
Centrosomal protein 43 (CEP43) LDTP01652 7.31  LDD2048 
Clustered mitochondria protein homolog (CLUH) LDTP14486 5.17  LDD2048 
Coiled-coil domain-containing protein 97 (CCDC97) LDTP19860 5.54  LDD2048 
Cold-inducible RNA-binding protein (CIRBP) LDTP06022 5.70  LDD2048 
Elongation factor 1-delta (EEF1D) LDTP03499 12.64  LDD2048 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 6.02  LDD2048 
Intraflagellar transport protein 52 homolog (IFT52) LDTP13952 5.78  LDD2048 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 5.39  LDD2048 
Large proline-rich protein BAG6 (BAG6) LDTP04094 5.94  LDD2048 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 5.24  LDD2048 
Microtubule nucleation factor SSNA1 (SSNA1) LDTP00871 5.43  LDD2048 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 4.92  LDD2048 
Neuferricin (CYB5D2) LDTP15623 15.45  LDD2048 
Nuclear cap-binding protein subunit 3 (NCBP3) LDTP06887 5.78  LDD2048 
Nucleobindin-2 (NUCB2) LDTP05160 6.82  LDD2048 
Oxysterol-binding protein-related protein 6 (OSBPL6) LDTP11533 14.93  LDD2048 
p53 and DNA damage-regulated protein 1 (PDRG1) LDTP16099 5.70  LDD2048 
Protein CutA (CUTA) LDTP01075 8.06  LDD2048 
Reticulocalbin-2 (RCN2) LDTP06097 6.54  LDD2048 
Reticulophagy regulator 2 (RETREG2) LDTP09080 5.13  LDD2048 
Testis-expressed protein 264 (TEX264) LDTP14259 6.06  LDD2048 
Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) LDTP15634 8.82  LDD2048 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 10.20  LDD2048 
Zinc finger CCCH domain-containing protein 7B (ZC3H7B) LDTP13245 5.17  LDD2048 
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⏷ Show the Full List of 26 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD2048 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587