Details of the Target

General Information of Target

Target ID LDTP12227
Target Name Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2)
Gene Name MCCC2
Gene ID 64087
Synonyms
MCCB; Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; MCCase subunit beta; EC 6.4.1.4; 3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLSPAPLKLSRTPALLALALPLAAALAFSDETLDKVPKSEGYCSRILRAQGTRREGYTE
FSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALRENREGDKEEDHAGTFQIIDEE
ETQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCVILKASIVQKRIIYFQDEGSLTKK
LCEQDSTFDGVTDKPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHS
KNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPLNVRAA
PSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSG
VTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPD
NVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPC
PDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTL
PTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETS
QAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKC
MLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKC
LRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMT
VKKRFKSSQFTSCKDKKEIRACNVHPC
Target Bioclass
Enzyme
Family
AccD/PCCB family
Subcellular location
Mitochondrion matrix
Function
Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.
Uniprot ID
Q9HCC0
Ensemble ID
ENST00000340941.11
HGNC ID
HGNC:6937

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.F312C DBIA    Probe Info 
KASUMI1 SNV: p.E476G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 40 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CHEMBL5175495
 Probe Info  		6.06  LDD0196  [2]
N1
 Probe Info  		100.00  LDD0242  [3]
W1
 Probe Info  		35.02  LDD0235  [4]
TH211
 Probe Info  		Y413(14.83)  LDD0260  [5]
TH214
 Probe Info  		Y413(11.33)  LDD0258  [5]
TH216
 Probe Info  		Y413(6.41)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
STPyne
 Probe Info  		K235(9.14); K512(10.00); K70(8.33)  LDD0277  [7]
Probe 1
 Probe Info  		Y145(69.19); Y146(10.17); Y196(31.72); Y296(121.31)  LDD3495  [8]
Alkylaryl probe 3
 Probe Info  		4.81  LDD0384  [9]
BTD
 Probe Info  		C267(0.77)  LDD2089  [10]
AHL-Pu-1
 Probe Info  		C267(2.31); C167(2.33)  LDD0168  [11]
EA-probe
 Probe Info  		N.A.  LDD0440  [12]
HHS-482
 Probe Info  		Y413(2.35)  LDD0285  [13]
DBIA
 Probe Info  		C392(0.97); C267(0.94)  LDD0078  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C267(0.00); C431(0.00); C167(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [16]
Lodoacetamide azide
 Probe Info  		C267(0.00); C167(0.00); C431(0.00); C391(0.00)  LDD0037  [15]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
NAIA_4
 Probe Info  		C216(0.00); C267(0.00); C453(0.00)  LDD2226  [18]
TFBX
 Probe Info  		C431(0.00); C267(0.00)  LDD0027  [17]
WYneN
 Probe Info  		C267(0.00); C392(0.00)  LDD0021  [19]
WYneO
 Probe Info  		N.A.  LDD0022  [19]
Compound 10
 Probe Info  		N.A.  LDD2216  [20]
Compound 11
 Probe Info  		N.A.  LDD2213  [20]
ENE
 Probe Info  		N.A.  LDD0006  [19]
IPM
 Probe Info  		C267(0.00); C392(0.00)  LDD0005  [19]
SF
 Probe Info  		N.A.  LDD0028  [21]
VSF
 Probe Info  		N.A.  LDD0007  [19]
Phosphinate-6
 Probe Info  		C431(0.00); C453(0.00); C216(0.00); C267(0.00)  LDD0018  [22]
Ox-W18
 Probe Info  		N.A.  LDD2175  [23]
1d-yne
 Probe Info  		N.A.  LDD0357  [24]
Acrolein
 Probe Info  		C267(0.00); C431(0.00); C131(0.00)  LDD0217  [25]
Crotonaldehyde
 Probe Info  		C267(0.00); C131(0.00); C431(0.00)  LDD0219  [25]
Methacrolein
 Probe Info  		C131(0.00); C267(0.00)  LDD0218  [25]
AOyne
 Probe Info  		14.00  LDD0443  [26]
NAIA_5
 Probe Info  		C267(0.00); C167(0.00); C431(0.00); C131(0.00)  LDD2223  [18]
TPP-AC
 Probe Info  		N.A.  LDD0427  [27]
HHS-465
 Probe Info  		Y177(0.00); Y413(0.00)  LDD2240  [28]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C145
 Probe Info  		18.38  LDD1827  [29]
C158
 Probe Info  		12.55  LDD1838  [29]
C165
 Probe Info  		15.24  LDD1845  [29]
C193
 Probe Info  		5.24  LDD1869  [29]
C220
 Probe Info  		12.13  LDD1894  [29]
C278
 Probe Info  		52.71  LDD1948  [29]
C350
 Probe Info  		28.05  LDD2011  [29]
C361
 Probe Info  		17.39  LDD2022  [29]
C389
 Probe Info  		21.86  LDD2048  [29]
FFF probe11
 Probe Info  		20.00  LDD0471  [30]
FFF probe13
 Probe Info  		14.86  LDD0475  [30]
FFF probe14
 Probe Info  		20.00  LDD0477  [30]
FFF probe2
 Probe Info  		20.00  LDD0463  [30]
FFF probe3
 Probe Info  		12.63  LDD0464  [30]
FFF probe4
 Probe Info  		8.16  LDD0466  [30]
JN0003
 Probe Info  		20.00  LDD0469  [30]
STS-2
 Probe Info  		N.A.  LDD0139  [31]
DA-2
 Probe Info  		N.A.  LDD0072  [32]
OEA-DA
 Probe Info  		3.47  LDD0046  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C267(0.87)  LDD2112  [10]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C431(0.98)  LDD2117  [10]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C391(1.31)  LDD2152  [10]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C392(1.30)  LDD2103  [10]
 LDCM0025  4SU-RNA HEK-293T C267(2.31); C167(2.33)  LDD0168  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C216(2.09)  LDD0169  [11]
 LDCM0214  AC1 HCT 116 C391(0.96); C392(1.13); C453(0.91); C167(0.74)  LDD0531  [14]
 LDCM0215  AC10 HCT 116 C391(1.13); C392(1.09); C267(1.23)  LDD0532  [14]
 LDCM0216  AC100 HCT 116 C391(0.94); C392(0.94); C267(0.95)  LDD0533  [14]
 LDCM0217  AC101 HCT 116 C391(0.93); C392(0.93); C267(1.09)  LDD0534  [14]
 LDCM0218  AC102 HCT 116 C391(1.07); C392(1.07); C267(0.99)  LDD0535  [14]
 LDCM0219  AC103 HCT 116 C391(1.02); C392(1.02); C267(1.20)  LDD0536  [14]
 LDCM0220  AC104 HCT 116 C391(0.94); C392(0.94); C267(1.00)  LDD0537  [14]
 LDCM0221  AC105 HCT 116 C391(1.00); C392(1.00); C267(1.16)  LDD0538  [14]
 LDCM0222  AC106 HCT 116 C391(0.91); C392(0.91); C267(1.14)  LDD0539  [14]
 LDCM0223  AC107 HCT 116 C391(0.95); C392(0.95); C267(0.96)  LDD0540  [14]
 LDCM0224  AC108 HCT 116 C391(1.12); C392(1.12); C267(1.06)  LDD0541  [14]
 LDCM0225  AC109 HCT 116 C391(0.85); C392(0.85); C267(0.86)  LDD0542  [14]
 LDCM0226  AC11 HCT 116 C391(1.14); C392(1.08); C267(1.25)  LDD0543  [14]
 LDCM0227  AC110 HCT 116 C391(0.95); C392(0.95); C267(1.02)  LDD0544  [14]
 LDCM0228  AC111 HCT 116 C391(0.96); C392(0.96); C267(1.11)  LDD0545  [14]
 LDCM0229  AC112 HCT 116 C391(0.94); C392(0.94); C267(1.06)  LDD0546  [14]
 LDCM0230  AC113 HCT 116 C391(1.12); C392(1.10); C267(1.10)  LDD0547  [14]
 LDCM0231  AC114 HCT 116 C391(0.96); C392(1.22); C267(1.42)  LDD0548  [14]
 LDCM0232  AC115 HCT 116 C391(0.88); C392(1.05); C267(1.56)  LDD0549  [14]
 LDCM0233  AC116 HCT 116 C391(1.12); C392(1.07); C267(1.62)  LDD0550  [14]
 LDCM0234  AC117 HCT 116 C391(1.27); C392(1.02); C267(1.28)  LDD0551  [14]
 LDCM0235  AC118 HCT 116 C391(1.08); C392(1.07); C267(1.26)  LDD0552  [14]
 LDCM0236  AC119 HCT 116 C391(1.21); C392(1.03); C267(1.51)  LDD0553  [14]
 LDCM0237  AC12 HCT 116 C391(1.14); C392(1.03); C267(1.09)  LDD0554  [14]
 LDCM0238  AC120 HCT 116 C391(0.92); C392(1.23); C267(1.21)  LDD0555  [14]
 LDCM0239  AC121 HCT 116 C391(1.20); C392(1.09); C267(1.25)  LDD0556  [14]
 LDCM0240  AC122 HCT 116 C391(1.09); C392(1.14); C267(1.21)  LDD0557  [14]
 LDCM0241  AC123 HCT 116 C391(0.90); C392(1.06); C267(1.26)  LDD0558  [14]
 LDCM0242  AC124 HCT 116 C391(1.21); C392(1.16); C267(1.27)  LDD0559  [14]
 LDCM0243  AC125 HCT 116 C391(0.91); C392(1.08); C267(1.36)  LDD0560  [14]
 LDCM0244  AC126 HCT 116 C391(0.91); C392(1.13); C267(1.31)  LDD0561  [14]
 LDCM0245  AC127 HCT 116 C391(1.14); C392(1.17); C267(1.37)  LDD0562  [14]
 LDCM0246  AC128 HCT 116 C391(1.11); C392(1.11); C167(0.62); C267(0.96)  LDD0563  [14]
 LDCM0247  AC129 HCT 116 C391(1.17); C392(1.17); C167(1.33); C267(0.79)  LDD0564  [14]
 LDCM0249  AC130 HCT 116 C391(1.18); C392(1.18); C167(0.66); C267(1.03)  LDD0566  [14]
 LDCM0250  AC131 HCT 116 C391(1.32); C392(1.32); C167(1.33); C267(0.82)  LDD0567  [14]
 LDCM0251  AC132 HCT 116 C391(1.60); C392(1.60); C167(1.36); C267(0.92)  LDD0568  [14]
 LDCM0252  AC133 HCT 116 C391(1.11); C392(1.11); C167(0.80); C267(1.01)  LDD0569  [14]
 LDCM0253  AC134 HCT 116 C391(1.19); C392(1.19); C167(0.71); C267(1.07)  LDD0570  [14]
 LDCM0254  AC135 HCT 116 C391(1.30); C392(1.30); C167(0.72); C267(1.11)  LDD0571  [14]
 LDCM0255  AC136 HCT 116 C391(1.09); C392(1.09); C167(0.89); C267(1.01)  LDD0572  [14]
 LDCM0256  AC137 HCT 116 C391(1.23); C392(1.23); C167(1.19); C267(0.97)  LDD0573  [14]
 LDCM0257  AC138 HCT 116 C391(1.16); C392(1.16); C167(0.76); C267(1.16)  LDD0574  [14]
 LDCM0258  AC139 HCT 116 C391(1.02); C392(1.02); C167(0.96); C267(1.05)  LDD0575  [14]
 LDCM0259  AC14 HCT 116 C391(1.21); C392(1.18); C267(1.13)  LDD0576  [14]
 LDCM0260  AC140 HCT 116 C391(1.01); C392(1.01); C167(0.77); C267(1.17)  LDD0577  [14]
 LDCM0261  AC141 HCT 116 C391(1.04); C392(1.04); C167(0.96); C267(1.22)  LDD0578  [14]
 LDCM0262  AC142 HCT 116 C391(1.21); C392(1.21); C167(1.42); C267(0.94)  LDD0579  [14]
 LDCM0263  AC143 HCT 116 C391(1.02); C392(1.00); C267(1.23); C167(1.25)  LDD0580  [14]
 LDCM0264  AC144 HCT 116 C167(0.57); C391(0.80); C392(0.88); C267(1.25)  LDD0581  [14]
 LDCM0265  AC145 HCT 116 C392(0.76); C167(0.83); C391(0.99); C267(1.04)  LDD0582  [14]
 LDCM0266  AC146 HCT 116 C392(0.86); C391(0.91); C167(0.92); C267(1.35)  LDD0583  [14]
 LDCM0267  AC147 HCT 116 C167(0.54); C392(0.80); C391(0.91); C267(1.29)  LDD0584  [14]
 LDCM0268  AC148 HCT 116 C167(0.45); C392(0.77); C391(0.97); C267(1.36)  LDD0585  [14]
 LDCM0269  AC149 HCT 116 C167(0.46); C392(0.82); C391(1.05); C267(1.44)  LDD0586  [14]
 LDCM0270  AC15 HCT 116 C391(1.05); C392(1.09); C267(1.28)  LDD0587  [14]
 LDCM0271  AC150 HCT 116 C392(0.89); C391(0.99); C167(1.03); C267(1.16)  LDD0588  [14]
 LDCM0272  AC151 HCT 116 C167(0.92); C392(0.93); C391(1.06); C267(1.29)  LDD0589  [14]
 LDCM0273  AC152 HCT 116 C167(0.43); C392(0.86); C391(0.96); C267(1.21)  LDD0590  [14]
 LDCM0274  AC153 HCT 116 C167(0.46); C392(0.79); C391(1.04); C267(1.56)  LDD0591  [14]
 LDCM0621  AC154 HCT 116 C391(0.92); C392(0.75); C167(0.72); C267(1.29)  LDD2158  [14]
 LDCM0622  AC155 HCT 116 C391(0.99); C392(0.83); C167(0.64); C267(1.12)  LDD2159  [14]
 LDCM0623  AC156 HCT 116 C391(0.87); C392(0.87); C167(1.18); C267(1.02)  LDD2160  [14]
 LDCM0624  AC157 HCT 116 C391(0.79); C392(0.80); C167(1.46); C267(1.00)  LDD2161  [14]
 LDCM0276  AC17 HCT 116 C267(1.02); C392(1.03); C391(1.09)  LDD0593  [14]
 LDCM0277  AC18 HCT 116 C392(1.03); C391(1.11); C267(1.25)  LDD0594  [14]
 LDCM0278  AC19 HCT 116 C392(1.05); C267(1.10); C391(1.12)  LDD0595  [14]
 LDCM0279  AC2 HCT 116 C453(0.88); C167(0.90); C267(1.05); C391(1.11)  LDD0596  [14]
 LDCM0280  AC20 HCT 116 C267(1.09); C391(1.10); C392(1.15)  LDD0597  [14]
 LDCM0281  AC21 HCT 116 C392(0.95); C391(1.03); C267(1.28)  LDD0598  [14]
 LDCM0282  AC22 HCT 116 C392(0.98); C391(1.04); C267(1.04)  LDD0599  [14]
 LDCM0283  AC23 HCT 116 C267(0.95); C392(1.09); C391(1.18)  LDD0600  [14]
 LDCM0284  AC24 HCT 116 C267(0.88); C391(1.06); C392(1.21)  LDD0601  [14]
 LDCM0285  AC25 HCT 116 C453(0.67); C392(0.80); C391(0.94); C267(1.19)  LDD0602  [14]
 LDCM0286  AC26 HCT 116 C453(0.57); C392(0.85); C391(0.92); C267(1.27)  LDD0603  [14]
 LDCM0287  AC27 HCT 116 C392(0.76); C391(0.79); C453(0.89); C267(1.39)  LDD0604  [14]
 LDCM0288  AC28 HCT 116 C453(0.78); C392(0.89); C391(0.97); C267(1.28)  LDD0605  [14]
 LDCM0289  AC29 HCT 116 C453(0.67); C391(0.84); C392(0.86); C267(1.31)  LDD0606  [14]
 LDCM0290  AC3 HCT 116 C167(0.80); C453(0.86); C391(1.00); C267(1.08)  LDD0607  [14]
 LDCM0291  AC30 HCT 116 C453(0.89); C392(0.92); C391(0.95); C267(1.38)  LDD0608  [14]
 LDCM0292  AC31 HCT 116 C453(0.78); C392(0.80); C391(0.81); C267(1.26)  LDD0609  [14]
 LDCM0293  AC32 HCT 116 C391(0.86); C453(0.88); C392(0.90); C267(1.41)  LDD0610  [14]
 LDCM0294  AC33 HCT 116 C453(0.80); C391(0.89); C392(0.90); C267(1.46)  LDD0611  [14]
 LDCM0295  AC34 HCT 116 C392(0.84); C391(0.85); C453(0.92); C267(1.45)  LDD0612  [14]
 LDCM0296  AC35 HCT 116 C391(0.97); C267(0.98); C392(1.05); C167(1.22)  LDD0613  [14]
 LDCM0297  AC36 HCT 116 C267(0.91); C391(1.06); C392(1.10); C167(1.47)  LDD0614  [14]
 LDCM0298  AC37 HCT 116 C267(0.98); C392(1.15); C391(1.16); C167(1.31)  LDD0615  [14]
 LDCM0299  AC38 HCT 116 C391(1.04); C392(1.05); C267(1.08); C167(1.29)  LDD0616  [14]
 LDCM0300  AC39 HCT 116 C391(1.00); C267(1.04); C392(1.09); C167(1.11)  LDD0617  [14]
 LDCM0301  AC4 HCT 116 C167(0.47); C391(1.01); C392(1.09); C453(1.11)  LDD0618  [14]
 LDCM0302  AC40 HCT 116 C167(0.71); C267(1.00); C391(1.04); C392(1.18)  LDD0619  [14]
 LDCM0303  AC41 HCT 116 C267(1.04); C167(1.04); C392(1.12); C391(1.13)  LDD0620  [14]
 LDCM0304  AC42 HCT 116 C167(0.94); C392(1.05); C267(1.07); C391(1.07)  LDD0621  [14]
 LDCM0305  AC43 HCT 116 C267(1.12); C167(1.13); C392(1.14); C391(1.15)  LDD0622  [14]
 LDCM0306  AC44 HCT 116 C167(0.87); C391(1.03); C392(1.07); C267(1.08)  LDD0623  [14]
 LDCM0307  AC45 HCT 116 C167(0.71); C267(0.95); C391(1.09); C392(1.10)  LDD0624  [14]
 LDCM0308  AC46 HCT 116 C391(1.06); C267(1.07); C392(1.12); C167(1.23)  LDD0625  [14]
 LDCM0309  AC47 HCT 116 C167(0.86); C267(1.01); C392(1.07); C391(1.11)  LDD0626  [14]
 LDCM0310  AC48 HCT 116 C391(1.02); C392(1.02); C267(1.10); C167(1.40)  LDD0627  [14]
 LDCM0311  AC49 HCT 116 C167(0.66); C267(1.17); C391(1.23); C392(1.25)  LDD0628  [14]
 LDCM0312  AC5 HCT 116 C167(0.58); C391(0.91); C453(1.05); C392(1.15)  LDD0629  [14]
 LDCM0313  AC50 HCT 116 C167(0.65); C391(1.06); C392(1.10); C267(1.20)  LDD0630  [14]
 LDCM0314  AC51 HCT 116 C267(0.86); C391(1.07); C392(1.10); C167(1.68)  LDD0631  [14]
 LDCM0315  AC52 HCT 116 C167(0.89); C267(1.04); C392(1.05); C391(1.09)  LDD0632  [14]
 LDCM0316  AC53 HCT 116 C167(0.74); C267(1.11); C392(1.16); C391(1.26)  LDD0633  [14]
 LDCM0317  AC54 HCT 116 C167(0.62); C392(1.01); C391(1.02); C267(1.04)  LDD0634  [14]
 LDCM0318  AC55 HCT 116 C167(0.64); C392(0.99); C391(1.05); C267(1.24)  LDD0635  [14]
 LDCM0319  AC56 HCT 116 C167(0.70); C392(1.07); C391(1.14); C267(1.28)  LDD0636  [14]
 LDCM0320  AC57 HCT 116 C392(0.98); C391(1.07); C267(1.20)  LDD0637  [14]
 LDCM0321  AC58 HCT 116 C392(1.08); C391(1.08); C267(1.38)  LDD0638  [14]
 LDCM0322  AC59 HCT 116 C391(0.91); C392(0.94); C267(1.20)  LDD0639  [14]
 LDCM0323  AC6 HCT 116 C391(1.14); C392(1.16); C267(1.18)  LDD0640  [14]
 LDCM0324  AC60 HCT 116 C391(0.93); C392(1.03); C267(1.25)  LDD0641  [14]
 LDCM0325  AC61 HCT 116 C392(1.01); C391(1.02); C267(1.17)  LDD0642  [14]
 LDCM0326  AC62 HCT 116 C392(1.07); C391(1.14); C267(1.16)  LDD0643  [14]
 LDCM0327  AC63 HCT 116 C392(1.05); C391(1.05); C267(1.24)  LDD0644  [14]
 LDCM0328  AC64 HCT 116 C392(1.07); C391(1.15); C267(1.23)  LDD0645  [14]
 LDCM0329  AC65 HCT 116 C391(1.06); C392(1.07); C267(1.15)  LDD0646  [14]
 LDCM0330  AC66 HCT 116 C391(1.08); C267(1.10); C392(1.11)  LDD0647  [14]
 LDCM0331  AC67 HCT 116 C392(1.11); C267(1.11); C391(1.13)  LDD0648  [14]
 LDCM0332  AC68 HCT 116 C391(0.70); C392(0.72); C167(0.96); C267(1.24)  LDD0649  [14]
 LDCM0333  AC69 HCT 116 C391(0.58); C392(0.58); C167(0.72); C267(1.13)  LDD0650  [14]
 LDCM0334  AC7 HCT 116 C267(1.12); C392(1.30); C391(1.46)  LDD0651  [14]
 LDCM0335  AC70 HCT 116 C391(0.63); C167(0.64); C392(0.65); C267(1.13)  LDD0652  [14]
 LDCM0336  AC71 HCT 116 C392(0.93); C391(0.94); C267(1.21); C167(1.66)  LDD0653  [14]
 LDCM0337  AC72 HCT 116 C391(0.57); C392(0.60); C167(0.61); C267(1.28)  LDD0654  [14]
 LDCM0338  AC73 HCT 116 C391(0.65); C392(0.66); C167(0.75); C267(1.39)  LDD0655  [14]
 LDCM0339  AC74 HCT 116 C392(0.59); C391(0.61); C167(0.94); C267(1.42)  LDD0656  [14]
 LDCM0340  AC75 HCT 116 C392(0.63); C391(0.64); C167(0.90); C267(1.71)  LDD0657  [14]
 LDCM0341  AC76 HCT 116 C392(0.62); C391(0.64); C167(0.72); C267(1.31)  LDD0658  [14]
 LDCM0342  AC77 HCT 116 C392(0.56); C391(0.56); C167(0.64); C267(1.18)  LDD0659  [14]
 LDCM0343  AC78 HCT 116 C392(0.74); C391(0.76); C267(1.17); C167(1.18)  LDD0660  [14]
 LDCM0344  AC79 HCT 116 C391(0.71); C392(0.71); C167(0.92); C267(1.15)  LDD0661  [14]
 LDCM0345  AC8 HCT 116 C391(1.12); C392(1.12); C267(1.26)  LDD0662  [14]
 LDCM0346  AC80 HCT 116 C392(0.61); C391(0.64); C167(0.82); C267(1.20)  LDD0663  [14]
 LDCM0347  AC81 HCT 116 C167(0.71); C391(0.84); C392(0.84); C267(1.41)  LDD0664  [14]
 LDCM0348  AC82 HCT 116 C392(0.61); C391(0.62); C167(0.96); C267(1.76)  LDD0665  [14]
 LDCM0349  AC83 HCT 116 C453(0.99); C391(1.07); C392(1.22); C267(1.73)  LDD0666  [14]
 LDCM0350  AC84 HCT 116 C391(1.07); C453(1.09); C392(1.31); C267(1.63)  LDD0667  [14]
 LDCM0351  AC85 HCT 116 C391(1.18); C453(1.21); C392(1.31); C267(1.56)  LDD0668  [14]
 LDCM0352  AC86 HCT 116 C391(1.14); C392(1.17); C453(1.21); C267(1.33)  LDD0669  [14]
 LDCM0353  AC87 HCT 116 C453(1.01); C391(1.10); C267(1.13); C392(1.16)  LDD0670  [14]
 LDCM0354  AC88 HCT 116 C453(1.05); C391(1.18); C392(1.21); C267(1.23)  LDD0671  [14]
 LDCM0355  AC89 HCT 116 C453(0.90); C391(1.20); C392(1.29); C267(1.37)  LDD0672  [14]
 LDCM0357  AC90 HCT 116 C267(0.96); C453(1.15); C392(1.17); C391(1.19)  LDD0674  [14]
 LDCM0358  AC91 HCT 116 C391(1.06); C392(1.09); C453(1.20); C267(1.55)  LDD0675  [14]
 LDCM0359  AC92 HCT 116 C453(1.06); C392(1.15); C391(1.15); C267(1.53)  LDD0676  [14]
 LDCM0360  AC93 HCT 116 C453(1.00); C391(1.30); C392(1.30); C267(1.38)  LDD0677  [14]
 LDCM0361  AC94 HCT 116 C392(1.21); C453(1.22); C391(1.29); C267(1.36)  LDD0678  [14]
 LDCM0362  AC95 HCT 116 C391(1.08); C392(1.16); C453(1.27); C267(1.31)  LDD0679  [14]
 LDCM0363  AC96 HCT 116 C392(1.06); C453(1.07); C391(1.11); C267(1.52)  LDD0680  [14]
 LDCM0364  AC97 HCT 116 C453(1.12); C392(1.26); C391(1.27); C267(1.75)  LDD0681  [14]
 LDCM0365  AC98 HCT 116 C391(0.98); C392(0.98); C267(1.52)  LDD0682  [14]
 LDCM0366  AC99 HCT 116 C267(0.94); C391(0.94); C392(0.94)  LDD0683  [14]
 LDCM0248  AKOS034007472 HCT 116 C391(1.16); C392(1.09); C267(1.04)  LDD0565  [14]
 LDCM0356  AKOS034007680 HCT 116 C267(1.15); C392(1.39); C391(1.52)  LDD0673  [14]
 LDCM0275  AKOS034007705 HCT 116 C392(1.12); C391(1.14); C267(1.51)  LDD0592  [14]
 LDCM0156  Aniline NCI-H1299 C216(0.00); C453(0.00); C267(0.00)  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C392(0.97); C267(0.94)  LDD0078  [14]
 LDCM0498  BS-3668 MDA-MB-231 C267(0.63)  LDD2091  [10]
 LDCM0630  CCW28-3 231MFP C216(2.89)  LDD2214  [34]
 LDCM0108  Chloroacetamide HeLa C267(0.00); C131(0.00); C431(0.00); H57(0.00)  LDD0222  [25]
 LDCM0632  CL-Sc Hep-G2 C431(0.78); C267(0.72); C391(0.18)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C267(0.99); C392(1.03); C167(1.17); C391(1.60)  LDD0684  [14]
 LDCM0368  CL10 HCT 116 C167(0.87); C392(1.15); C391(1.33); C267(1.60)  LDD0685  [14]
 LDCM0369  CL100 HCT 116 C167(0.89); C453(0.91); C391(0.96); C392(1.08)  LDD0686  [14]
 LDCM0370  CL101 HCT 116 C267(1.29); C392(1.42); C391(1.60)  LDD0687  [14]
 LDCM0371  CL102 HCT 116 C267(1.24); C392(2.59); C391(3.07)  LDD0688  [14]
 LDCM0372  CL103 HCT 116 C392(1.04); C391(1.24); C267(1.24)  LDD0689  [14]
 LDCM0373  CL104 HCT 116 C267(1.08); C392(1.29); C391(1.49)  LDD0690  [14]
 LDCM0374  CL105 HCT 116 C392(1.06); C267(1.22); C391(1.27)  LDD0691  [14]
 LDCM0375  CL106 HCT 116 C392(1.00); C391(1.17); C267(1.44)  LDD0692  [14]
 LDCM0376  CL107 HCT 116 C392(1.01); C391(1.05); C267(1.27)  LDD0693  [14]
 LDCM0377  CL108 HCT 116 C392(0.93); C391(1.01); C267(1.32)  LDD0694  [14]
 LDCM0378  CL109 HCT 116 C392(1.08); C391(1.29); C267(1.38)  LDD0695  [14]
 LDCM0379  CL11 HCT 116 C167(0.41); C267(1.44); C392(1.44); C391(3.13)  LDD0696  [14]
 LDCM0380  CL110 HCT 116 C392(1.31); C391(1.51); C267(1.57)  LDD0697  [14]
 LDCM0381  CL111 HCT 116 C392(1.21); C267(1.25); C391(1.26)  LDD0698  [14]
 LDCM0382  CL112 HCT 116 C453(0.76); C392(0.98); C391(1.11); C267(1.21)  LDD0699  [14]
 LDCM0383  CL113 HCT 116 C453(0.73); C391(0.84); C392(0.85); C267(1.31)  LDD0700  [14]
 LDCM0384  CL114 HCT 116 C453(0.93); C392(1.02); C391(1.19); C267(1.51)  LDD0701  [14]
 LDCM0385  CL115 HCT 116 C453(0.76); C391(0.91); C392(0.91); C267(1.41)  LDD0702  [14]
 LDCM0386  CL116 HCT 116 C392(0.85); C391(0.86); C453(0.93); C267(1.28)  LDD0703  [14]
 LDCM0387  CL117 HCT 116 C167(0.76); C391(1.18); C267(1.31); C392(1.41)  LDD0704  [14]
 LDCM0388  CL118 HCT 116 C167(0.82); C391(1.11); C267(1.11); C392(1.18)  LDD0705  [14]
 LDCM0389  CL119 HCT 116 C167(0.69); C267(1.11); C391(1.17); C392(1.20)  LDD0706  [14]
 LDCM0390  CL12 HCT 116 C167(0.43); C392(1.03); C267(1.24); C391(1.24)  LDD0707  [14]
 LDCM0391  CL120 HCT 116 C391(1.03); C267(1.03); C392(1.03); C167(1.26)  LDD0708  [14]
 LDCM0392  CL121 HCT 116 C167(0.75); C267(1.03); C391(1.11); C392(1.12)  LDD0709  [14]
 LDCM0393  CL122 HCT 116 C267(1.04); C167(1.09); C391(1.35); C392(1.44)  LDD0710  [14]
 LDCM0394  CL123 HCT 116 C167(1.53); C267(1.60); C392(2.26); C391(2.48)  LDD0711  [14]
 LDCM0395  CL124 HCT 116 C167(0.59); C267(1.32); C392(1.43); C391(1.55)  LDD0712  [14]
 LDCM0396  CL125 HCT 116 C392(1.17); C267(1.20); C391(1.22)  LDD0713  [14]
 LDCM0397  CL126 HCT 116 C267(1.08); C391(1.68); C392(1.77)  LDD0714  [14]
 LDCM0398  CL127 HCT 116 C391(1.10); C267(1.12); C392(1.15)  LDD0715  [14]
 LDCM0399  CL128 HCT 116 C392(0.96); C391(1.02); C267(1.26)  LDD0716  [14]
 LDCM0400  CL13 HCT 116 C167(0.67); C391(0.96); C392(0.99); C267(1.17)  LDD0717  [14]
 LDCM0401  CL14 HCT 116 C167(1.14); C392(1.17); C267(1.22); C391(1.34)  LDD0718  [14]
 LDCM0402  CL15 HCT 116 C167(0.80); C267(1.53); C392(1.76); C391(3.28)  LDD0719  [14]
 LDCM0403  CL16 HCT 116 C391(0.93); C392(0.93); C267(1.10)  LDD0720  [14]
 LDCM0404  CL17 HCT 116 C267(1.40); C392(1.45); C391(1.56)  LDD0721  [14]
 LDCM0405  CL18 HCT 116 C391(0.87); C392(0.89); C267(1.08)  LDD0722  [14]
 LDCM0406  CL19 HCT 116 C392(0.88); C391(0.90); C267(1.15)  LDD0723  [14]
 LDCM0407  CL2 HCT 116 C267(0.88); C167(1.04); C392(1.11); C391(1.11)  LDD0724  [14]
 LDCM0408  CL20 HCT 116 C391(0.92); C392(0.94); C267(1.20)  LDD0725  [14]
 LDCM0409  CL21 HCT 116 C392(1.46); C391(1.60); C267(1.82)  LDD0726  [14]
 LDCM0410  CL22 HCT 116 C391(0.87); C392(1.08); C267(1.41)  LDD0727  [14]
 LDCM0411  CL23 HCT 116 C391(0.86); C392(0.90); C267(1.16)  LDD0728  [14]
 LDCM0412  CL24 HCT 116 C391(0.89); C392(0.93); C267(1.24)  LDD0729  [14]
 LDCM0413  CL25 HCT 116 C391(1.53); C392(1.26); C267(1.47)  LDD0730  [14]
 LDCM0414  CL26 HCT 116 C391(0.86); C392(0.94); C267(1.23)  LDD0731  [14]
 LDCM0415  CL27 HCT 116 C391(0.91); C392(0.92); C267(1.19)  LDD0732  [14]
 LDCM0416  CL28 HCT 116 C391(1.01); C392(1.09); C267(1.21)  LDD0733  [14]
 LDCM0417  CL29 HCT 116 C391(0.89); C392(0.97); C267(1.16)  LDD0734  [14]
 LDCM0418  CL3 HCT 116 C391(1.11); C392(0.97); C167(1.18); C267(0.99)  LDD0735  [14]
 LDCM0419  CL30 HCT 116 C391(0.98); C392(1.04); C267(1.15)  LDD0736  [14]
 LDCM0420  CL31 HCT 116 C391(1.09); C392(1.00); C453(0.95); C167(1.18)  LDD0737  [14]
 LDCM0421  CL32 HCT 116 C391(1.04); C392(1.01); C453(1.19); C167(1.16)  LDD0738  [14]
 LDCM0422  CL33 HCT 116 C391(2.70); C392(2.64); C453(7.52); C167(1.41)  LDD0739  [14]
 LDCM0423  CL34 HCT 116 C391(0.78); C392(0.78); C453(1.42); C167(0.56)  LDD0740  [14]
 LDCM0424  CL35 HCT 116 C391(0.56); C392(0.57); C453(1.06); C167(0.58)  LDD0741  [14]
 LDCM0425  CL36 HCT 116 C391(0.75); C392(0.67); C453(1.09); C167(0.61)  LDD0742  [14]
 LDCM0426  CL37 HCT 116 C391(0.57); C392(0.57); C453(0.86); C167(0.50)  LDD0743  [14]
 LDCM0428  CL39 HCT 116 C391(0.84); C392(0.80); C453(1.97); C167(0.67)  LDD0745  [14]
 LDCM0429  CL4 HCT 116 C391(1.43); C392(1.42); C167(1.35); C267(1.15)  LDD0746  [14]
 LDCM0430  CL40 HCT 116 C391(1.35); C392(1.00); C453(1.13); C167(0.53)  LDD0747  [14]
 LDCM0431  CL41 HCT 116 C391(0.73); C392(0.70); C453(1.00); C167(0.69)  LDD0748  [14]
 LDCM0432  CL42 HCT 116 C391(0.73); C392(0.70); C453(1.36); C167(0.57)  LDD0749  [14]
 LDCM0433  CL43 HCT 116 C391(0.67); C392(0.62); C453(1.24); C167(0.60)  LDD0750  [14]
 LDCM0434  CL44 HCT 116 C391(0.79); C392(0.74); C453(1.70); C167(0.82)  LDD0751  [14]
 LDCM0435  CL45 HCT 116 C391(0.92); C392(0.77); C453(1.43); C167(0.62)  LDD0752  [14]
 LDCM0436  CL46 HCT 116 C391(1.48); C392(1.47); C267(0.83)  LDD0753  [14]
 LDCM0437  CL47 HCT 116 C391(1.33); C392(1.32); C267(0.93)  LDD0754  [14]
 LDCM0438  CL48 HCT 116 C391(1.13); C392(1.12); C267(0.72)  LDD0755  [14]
 LDCM0439  CL49 HCT 116 C391(1.06); C392(1.05); C267(0.87)  LDD0756  [14]
 LDCM0440  CL5 HCT 116 C391(0.81); C392(0.94); C167(0.82); C267(1.08)  LDD0757  [14]
 LDCM0441  CL50 HCT 116 C391(1.29); C392(1.26); C267(0.89)  LDD0758  [14]
 LDCM0442  CL51 HCT 116 C391(1.20); C392(1.15); C267(0.85)  LDD0759  [14]
 LDCM0443  CL52 HCT 116 C391(1.18); C392(1.17); C267(0.89)  LDD0760  [14]
 LDCM0444  CL53 HCT 116 C391(1.46); C392(1.46); C267(0.92)  LDD0761  [14]
 LDCM0445  CL54 HCT 116 C391(2.11); C392(2.06); C267(0.72)  LDD0762  [14]
 LDCM0446  CL55 HCT 116 C391(1.22); C392(1.21); C267(0.79)  LDD0763  [14]
 LDCM0447  CL56 HCT 116 C391(1.17); C392(1.15); C267(1.10)  LDD0764  [14]
 LDCM0448  CL57 HCT 116 C391(1.89); C392(1.76); C267(0.84)  LDD0765  [14]
 LDCM0449  CL58 HCT 116 C391(1.13); C392(1.13); C267(0.80)  LDD0766  [14]
 LDCM0450  CL59 HCT 116 C391(1.03); C392(1.03); C267(1.02)  LDD0767  [14]
 LDCM0451  CL6 HCT 116 C391(1.62); C392(1.12); C167(0.94); C267(1.40)  LDD0768  [14]
 LDCM0452  CL60 HCT 116 C391(1.21); C392(1.18); C267(1.32)  LDD0769  [14]
 LDCM0453  CL61 HCT 116 C391(0.94); C392(0.94); C167(1.05); C267(1.24)  LDD0770  [14]
 LDCM0454  CL62 HCT 116 C391(1.02); C392(1.02); C167(1.12); C267(1.17)  LDD0771  [14]
 LDCM0455  CL63 HCT 116 C391(1.48); C392(1.48); C167(0.92); C267(1.19)  LDD0772  [14]
 LDCM0456  CL64 HCT 116 C391(1.06); C392(1.06); C167(0.54); C267(1.41)  LDD0773  [14]
 LDCM0457  CL65 HCT 116 C391(0.86); C392(0.86); C167(0.95); C267(1.20)  LDD0774  [14]
 LDCM0458  CL66 HCT 116 C391(1.31); C392(1.31); C167(0.38); C267(1.54)  LDD0775  [14]
 LDCM0459  CL67 HCT 116 C391(0.84); C392(0.84); C167(0.42); C267(1.27)  LDD0776  [14]
 LDCM0460  CL68 HCT 116 C391(1.22); C392(1.22); C167(0.91); C267(1.18)  LDD0777  [14]
 LDCM0461  CL69 HCT 116 C391(1.86); C392(1.86); C167(1.20); C267(1.05)  LDD0778  [14]
 LDCM0462  CL7 HCT 116 C391(0.95); C392(0.85); C167(0.52); C267(1.03)  LDD0779  [14]
 LDCM0463  CL70 HCT 116 C391(1.00); C392(1.00); C167(0.78); C267(1.22)  LDD0780  [14]
 LDCM0464  CL71 HCT 116 C391(1.05); C392(1.05); C167(0.68); C267(1.39)  LDD0781  [14]
 LDCM0465  CL72 HCT 116 C391(1.02); C392(1.02); C167(0.97); C267(1.09)  LDD0782  [14]
 LDCM0466  CL73 HCT 116 C391(1.43); C392(1.43); C167(1.04); C267(1.38)  LDD0783  [14]
 LDCM0467  CL74 HCT 116 C391(1.10); C392(1.10); C167(0.76); C267(1.32)  LDD0784  [14]
 LDCM0469  CL76 HCT 116 C391(1.13); C392(1.13); C167(0.92); C267(1.21)  LDD0786  [14]
 LDCM0470  CL77 HCT 116 C391(1.13); C392(1.13); C167(1.32); C267(1.33)  LDD0787  [14]
 LDCM0471  CL78 HCT 116 C391(1.17); C392(1.17); C167(0.67); C267(1.19)  LDD0788  [14]
 LDCM0472  CL79 HCT 116 C391(0.98); C392(0.98); C167(0.38); C267(1.33)  LDD0789  [14]
 LDCM0473  CL8 HCT 116 C391(16.54); C392(5.12); C167(0.44); C267(2.01)  LDD0790  [14]
 LDCM0474  CL80 HCT 116 C391(0.94); C392(0.94); C167(0.78); C267(1.20)  LDD0791  [14]
 LDCM0475  CL81 HCT 116 C391(1.06); C392(1.06); C167(0.68); C267(1.25)  LDD0792  [14]
 LDCM0476  CL82 HCT 116 C391(1.07); C392(1.07); C167(0.35); C267(1.44)  LDD0793  [14]
 LDCM0477  CL83 HCT 116 C391(1.51); C392(1.51); C167(0.41); C267(1.45)  LDD0794  [14]
 LDCM0478  CL84 HCT 116 C391(1.29); C392(1.29); C167(0.39); C267(1.63)  LDD0795  [14]
 LDCM0479  CL85 HCT 116 C391(1.05); C392(1.05); C167(0.67); C267(1.14)  LDD0796  [14]
 LDCM0480  CL86 HCT 116 C391(1.02); C392(1.02); C167(0.75); C267(1.04)  LDD0797  [14]
 LDCM0481  CL87 HCT 116 C391(1.07); C392(1.07); C167(0.58); C267(1.12)  LDD0798  [14]
 LDCM0482  CL88 HCT 116 C391(0.94); C392(0.94); C167(0.38); C267(1.28)  LDD0799  [14]
 LDCM0483  CL89 HCT 116 C391(1.06); C392(1.06); C167(0.40); C267(1.61)  LDD0800  [14]
 LDCM0484  CL9 HCT 116 C391(1.03); C392(1.25); C167(0.59); C267(1.17)  LDD0801  [14]
 LDCM0485  CL90 HCT 116 C391(1.90); C392(1.90); C167(0.64); C267(1.28)  LDD0802  [14]
 LDCM0486  CL91 HCT 116 C391(1.21); C392(1.25); C453(0.85); C167(1.02)  LDD0803  [14]
 LDCM0487  CL92 HCT 116 C391(1.32); C392(1.50); C453(1.20); C167(0.82)  LDD0804  [14]
 LDCM0488  CL93 HCT 116 C391(1.21); C392(1.09); C453(1.57); C167(0.94)  LDD0805  [14]
 LDCM0489  CL94 HCT 116 C391(1.52); C392(1.46); C453(1.00); C167(0.72)  LDD0806  [14]
 LDCM0490  CL95 HCT 116 C391(1.28); C392(1.23); C453(1.11); C167(0.92)  LDD0807  [14]
 LDCM0491  CL96 HCT 116 C391(1.08); C392(1.16); C453(0.95); C167(0.66)  LDD0808  [14]
 LDCM0492  CL97 HCT 116 C391(1.59); C392(1.40); C453(1.06); C167(0.89)  LDD0809  [14]
 LDCM0493  CL98 HCT 116 C391(1.19); C392(1.22); C453(1.04); C167(0.91)  LDD0810  [14]
 LDCM0494  CL99 HCT 116 C391(0.98); C392(1.14); C453(1.09); C167(0.81)  LDD0811  [14]
 LDCM0634  CY-0357 Hep-G2 C267(0.69)  LDD2228  [18]
 LDCM0495  E2913 HEK-293T C267(1.06); C431(1.11); C453(1.22); C216(1.02)  LDD1698  [35]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [12]
 LDCM0625  F8 Ramos C167(0.61); C267(1.97); C431(0.72)  LDD2187  [36]
 LDCM0572  Fragment10 MDA-MB-231 C216(2.25)  LDD1465  [37]
 LDCM0573  Fragment11 MDA-MB-231 C216(1.86)  LDD1467  [37]
 LDCM0574  Fragment12 MDA-MB-231 C216(20.00)  LDD1468  [37]
 LDCM0575  Fragment13 Ramos C216(1.75)  LDD1470  [37]
 LDCM0576  Fragment14 MDA-MB-231 C216(1.03)  LDD1471  [37]
 LDCM0579  Fragment20 Ramos C167(0.60); C267(1.00); C431(0.87)  LDD2194  [36]
 LDCM0580  Fragment21 MDA-MB-231 C216(2.16)  LDD1473  [37]
 LDCM0582  Fragment23 Ramos C167(1.07); C267(0.92); C431(0.84)  LDD2196  [36]
 LDCM0578  Fragment27 MDA-MB-231 C216(1.00)  LDD1474  [37]
 LDCM0586  Fragment28 Ramos C167(1.15); C267(0.90); C431(1.37)  LDD2198  [36]
 LDCM0588  Fragment30 Ramos C167(0.90); C267(1.37); C431(0.52)  LDD2199  [36]
 LDCM0589  Fragment31 Ramos C167(1.43); C267(1.00); C431(0.79)  LDD2200  [36]
 LDCM0590  Fragment32 Ramos C167(0.68); C267(1.28); C431(0.41)  LDD2201  [36]
 LDCM0468  Fragment33 HCT 116 C391(1.27); C392(1.27); C167(0.97); C267(1.36)  LDD0785  [14]
 LDCM0596  Fragment38 Ramos C167(1.37); C267(1.11); C431(0.46)  LDD2203  [36]
 LDCM0566  Fragment4 MDA-MB-231 C216(5.85)  LDD1461  [37]
 LDCM0599  Fragment41 MDA-MB-231 C216(1.01)  LDD1481  [37]
 LDCM0603  Fragment45 MDA-MB-231 C216(6.97)  LDD1482  [37]
 LDCM0427  Fragment51 HCT 116 C391(1.17); C392(1.02); C453(0.98); C167(0.55)  LDD0744  [14]
 LDCM0610  Fragment52 Ramos C167(0.94); C267(1.14); C431(0.95)  LDD2204  [36]
 LDCM0614  Fragment56 MDA-MB-231 C216(0.66)  LDD1484  [37]
 LDCM0569  Fragment7 Ramos C167(0.64); C267(1.47); C431(0.51)  LDD2186  [36]
 LDCM0570  Fragment8 MDA-MB-231 C216(3.91)  LDD1462  [37]
 LDCM0571  Fragment9 Ramos C216(3.33)  LDD1464  [37]
 LDCM0107  IAA HeLa H266(0.00); C131(0.00)  LDD0221  [25]
 LDCM0123  JWB131 DM93 Y413(2.35)  LDD0285  [13]
 LDCM0124  JWB142 DM93 Y413(1.22)  LDD0286  [13]
 LDCM0125  JWB146 DM93 Y413(2.47)  LDD0287  [13]
 LDCM0126  JWB150 DM93 Y413(2.60)  LDD0288  [13]
 LDCM0127  JWB152 DM93 Y413(5.09)  LDD0289  [13]
 LDCM0128  JWB198 DM93 Y413(1.89)  LDD0290  [13]
 LDCM0129  JWB202 DM93 Y413(1.87)  LDD0291  [13]
 LDCM0130  JWB211 DM93 Y413(1.93)  LDD0292  [13]
 LDCM0022  KB02 HCT 116 C391(8.09); C453(2.24); C267(3.58); C392(4.05)  LDD0080  [14]
 LDCM0023  KB03 HCT 116 C391(5.72); C453(15.02); C267(1.39); C392(1.06)  LDD0081  [14]
 LDCM0024  KB05 HCT 116 C391(3.71); C453(3.04); C267(2.57); C392(0.71)  LDD0082  [14]
 LDCM0109  NEM HeLa N.A.  LDD0223  [25]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C267(0.77)  LDD2089  [10]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C392(1.05)  LDD2092  [10]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C392(1.64)  LDD2094  [10]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C391(0.48)  LDD2096  [10]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C392(1.31)  LDD2098  [10]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C431(0.54)  LDD2100  [10]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C392(1.48)  LDD2105  [10]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C267(0.55)  LDD2106  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C392(1.06); C431(1.41)  LDD2107  [10]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C267(1.03)  LDD2108  [10]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C392(0.91); C431(0.67)  LDD2111  [10]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C391(0.74)  LDD2116  [10]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C391(1.17)  LDD2118  [10]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C391(0.61)  LDD2122  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C431(0.80)  LDD2123  [10]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C391(0.51)  LDD2124  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C431(0.94)  LDD2125  [10]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C391(0.51)  LDD2126  [10]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C267(0.58); C431(0.94)  LDD2127  [10]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C392(0.89)  LDD2129  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C392(1.41); C431(0.82)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C431(0.96)  LDD2137  [10]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C431(1.03)  LDD2140  [10]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C267(0.78)  LDD2141  [10]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C267(0.76)  LDD2144  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C431(1.06)  LDD2146  [10]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C431(0.52)  LDD2149  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C267(0.96); C216(0.09); C216(0.07); C453(0.07)  LDD2206  [38]
 LDCM0628  OTUB2-COV-1 HEK-293T C453(1.25); C216(0.88); C267(0.82); C392(0.78)  LDD2207  [38]
 LDCM0099  Phenelzine MDA-MB-231 4.81  LDD0384  [9]
 LDCM0131  RA190 MM1.R C267(1.48)  LDD0304  [39]
 LDCM0021  THZ1 HCT 116 C392(1.07); C267(0.89)  LDD2173  [14]
 LDCM0112  W16 Hep-G2 C267(0.88)  LDD0239  [4]
 LDCM0113  W17 Hep-G2 C267(5.34)  LDD0240  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCC1) . Q96RQ3

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Biotin Small molecular drug DB00121

References

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3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
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Mass spectrometry data entry: PXD028270
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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Mass spectrometry data entry: PXD039908 , PXD029761
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD033004
23 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
24 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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Mass spectrometry data entry: PXD038010
29 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD044402
36 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
37 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
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39 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.