Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C145  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 76 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03540  Heme oxygenase 2 (HMOX2) 55.7
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 28.6
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 26.2
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 24.1
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 23.4
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 23.3
 LDTP03975  Exosome RNA helicase MTR4 (MTREX) 23.1
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 22.3
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 22.2
 LDTP06849  Prolyl endopeptidase-like (PREPL) 19.7
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 19.0
 LDTP12227  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) 18.4
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 17.9
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 17.8
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 17.4
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 16.9
 LDTP13751  Exonuclease 1 (EXO1) 16.7
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 15.8
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 15.5
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 15.3
 LDTP10329  Ceramide synthase 2 (CERS2) 15.2
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 15.2
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 15.2
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 15.1
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 13.9
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 13.8
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 13.8
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 13.6
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 13.5
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 13.5
 LDTP01803  Adenosine deaminase (ADA) 13.4
 LDTP02359  Heme oxygenase 1 (HMOX1) 13.4
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 13.1
 LDTP02713  Macrophage migration inhibitory factor (MIF) 12.6
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 12.3
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 12.3
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 12.3
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 12.0
 LDTP04183  Lanosterol synthase (LSS) 11.8
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 11.6
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) 11.4
 LDTP07504  Lysophospholipid acyltransferase 5 (LPCAT3) 11.4
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 11.2
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 11.2
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 11.1
 LDTP09110  NAD(P)H-hydrate epimerase (NAXE) 11.1
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 11.1
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 10.7
 LDTP01419  Retinal dehydrogenase 2 (ALDH1A2) 10.3
 LDTP12524  L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASDHPPT) 10.3
 LDTP10495  Ubiquitin carboxyl-terminal hydrolase 47 (USP47) 10.3
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 10.2
 LDTP00988  Protein O-GlcNAcase (OGA) 10.2
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 10.1
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 9.8
 LDTP13204  Gamma-adducin (ADD3) 9.7
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 9.6
 LDTP02141  Alpha-galactosidase A (GLA) 9.4
 LDTP07620  Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX) 9.4
 LDTP00325  Pirin (PIR) 9.3
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 9.3
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 9.0
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 8.8
 LDTP02505  Lysosomal protective protein (CTSA) 8.6
 LDTP09799  DCN1-like protein 4 (DCUN1D4) 8.6
 LDTP01769  Dihydrofolate reductase (DHFR) 8.6
 LDTP05408  Antigen peptide transporter 1 (TAP1) 8.5
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 8.5
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 8.5
 LDTP06283  Exosome complex component RRP42 (EXOSC7) 8.4
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 8.3
 LDTP04884  Proteasome subunit alpha type-6 (PSMA6) 8.3
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 8.3
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 8.2
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 8.1
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 8.1
Transporter and channel
Click to Show/Hide to Show 29 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 44.3
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 31.1
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 30.5
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 27.7
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 25.6
 LDTP04462  H(+)/Cl(-) exchange transporter 6 (CLCN6) 22.0
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 20.8
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 20.4
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 19.3
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 18.8
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 18.1
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 15.9
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 15.7
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 15.0
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 13.2
 LDTP07236  Protein GPR107 (GPR107) 11.9
 LDTP09261  Major facilitator superfamily domain-containing protein 8 (MFSD8) 11.1
 LDTP15481  Transmembrane protein 87A (TMEM87A) 10.8
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 10.4
 LDTP12451  Integral membrane protein 2C (ITM2C) 10.1
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 10.0
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 9.6
 LDTP00592  Surfeit locus protein 4 (SURF4) 9.6
 LDTP08881  Transmembrane protein 199 (TMEM199) 9.5
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 9.3
 LDTP11116  45 kDa calcium-binding protein (SDF4) 8.7
 LDTP11844  Protein spinster homolog 1 (SPNS1) 8.4
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 8.2
 LDTP16813  Tetraspanin-3 (TSPAN3) 8.2
Other
Click to Show/Hide to Show 50 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 41.9
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 26.7
 LDTP00105  Protein unc-119 homolog B (UNC119B) 18.1
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 17.6
 LDTP01652  Centrosomal protein 43 (CEP43) 15.5
 LDTP11076  Apolipoprotein L2 (APOL2) 15.2
 LDTP05226  RNA-binding protein 3 (RBM3) 14.0
 LDTP15714  Mdm2-binding protein (MTBP) 13.9
 LDTP05160  Nucleobindin-2 (NUCB2) 13.5
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 12.5
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 11.9
 LDTP06097  Reticulocalbin-2 (RCN2) 11.8
 LDTP15634  Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) 11.8
 LDTP16080  Protein FAM114A2 (FAM114A2) 11.6
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 11.3
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 11.0
 LDTP09920  Golgi apparatus protein 1 (GLG1) 10.8
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 10.8
 LDTP12377  Mediator of RNA polymerase II transcription subunit 4 (MED4) 10.7
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 10.2
 LDTP13630  Neudesin (NENF) 10.1
 LDTP05280  Serine/arginine-rich splicing factor 2 (SRSF2) 9.8
 LDTP02297  Vimentin (VIM) 9.6
 LDTP15623  Neuferricin (CYB5D2) 9.3
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 9.3
 LDTP11239  Protein misato homolog 1 (MSTO1) 9.3
 LDTP06060  Ubiquitin-associated protein 2-like (UBAP2L) 9.3
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 9.2
 LDTP00887  Calumenin (CALU) 9.0
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 9.0
 LDTP14058  Rap guanine nucleotide exchange factor 2 (RAPGEF2) 8.9
 LDTP14458  Tetraspanin-6 (TSPAN6) 8.9
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 8.8
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 8.8
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 8.8
 LDTP03850  RNA-binding motif protein, X chromosome (RBMX) 8.8
 LDTP08073  Tetratricopeptide repeat protein 21B (TTC21B) 8.8
 LDTP13402  Dynactin subunit 4 (DCTN4) 8.6
 LDTP15283  Nucleolar protein 9 (NOP9) 8.6
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 8.6
 LDTP14259  Testis-expressed protein 264 (TEX264) 8.6
 LDTP05277  Protein SET (SET) 8.5
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 8.4
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 8.3
 LDTP16078  Heme-binding protein 1 (HEBP1) 8.3
 LDTP03775  RNA-binding protein FUS (FUS) 8.3
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 8.2
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 8.2
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 8.2
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 8.2

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587