Details of the Target

General Information of Target

Target ID LDTP05588
Target Name RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2)
Gene Name NSUN2
Gene ID 54888
Synonyms
SAKI; TRM4; RNA cytosine C(5)-methyltransferase NSUN2; EC 2.1.1.-; Myc-induced SUN domain-containing protein; Misu; NOL1/NOP2/Sun domain family member 2; Substrate of AIM1/Aurora kinase B; mRNA cytosine C(5)-methyltransferase; EC 2.1.1.-; tRNA cytosine C(5)-methyltransferase; EC 2.1.1.-, EC 2.1.1.203; tRNA methyltransferase 4 homolog; hTrm4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRRSRGRRLQQQQRPEDAEDGAEGGGKRGEAGWEGGYPEIVKENKLFEHYYQELKIVPE
GEWGQFMDALREPLPATLRITGYKSHAKEILHCLKNKYFKELEDLEVDGQKVEVPQPLSW
YPEELAWHTNLSRKILRKSPHLEKFHQFLVSETESGNISRQEAVSMIPPLLLNVRPHHKI
LDMCAAPGSKTTQLIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVN
HDASSIPRLQIDVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQL
RIATRGAEQLAEGGRMVYSTCSLNPIEDEAVIASLLEKSEGALELADVSNELPGLKWMPG
ITQWKVMTKDGQWFTDWDAVPHSRHTQIRPTMFPPKDPEKLQAMHLERCLRILPHHQNTG
GFFVAVLVKKSSMPWNKRQPKLQGKSAETRESTQLSPADLTEGKPTDPSKLESPSFTGTG
DTEIAHATEDLENNGSKKDGVCGPPPSKKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALD
PSFPRMNLLTRTTEGKKRQLYMVSKELRNVLLNNSEKMKVINTGIKVWCRNNSGEEFDCA
FRLAQEGIYTLYPFINSRIITVSMEDVKILLTQENPFFRKLSSETYSQAKDLAKGSIVLK
YEPDSANPDALQCPIVLCGWRGKASIRTFVPKNERLHYLRMMGLEVLGEKKKEGVILTNE
SAASTGQPDNDVTEGQRAGEPNSPDAEEANSPDVTAGCDPAGVHPPR
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family, TRM4 subfamily
Subcellular location
Nucleus, nucleolus
Function
RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay. Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs). Also mediates C(5)-methylation of mitochondrial tRNAs. Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts. Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling. Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs. Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity.
Uniprot ID
Q08J23
Ensemble ID
ENST00000264670.11
HGNC ID
HGNC:25994
ChEMBL ID
CHEMBL4739683

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.R264Ter DBIA    Probe Info 
COLO792 SNV: p.P674L DBIA    Probe Info 
HCT116 SNV: p.F145S DBIA    Probe Info 
HS936T SNV: p.P394S DBIA    Probe Info 
KMS27 SNV: p.V204L DBIA    Probe Info 
MCC13 SNV: p.S432L DBIA    Probe Info 
MFE319 Deletion: p.S339VfsTer17 DBIA    Probe Info 
TE10 Deletion: p.P528HfsTer19 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 50 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.63  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y51(20.00); Y98(20.00); Y38(14.57); Y52(12.24)  LDD0257  [4]
TH216
 Probe Info  		Y646(20.00); Y83(10.62); Y98(8.37); Y52(7.22)  LDD0259  [4]
STPyne
 Probe Info  		K279(10.00); K369(3.94); K445(8.71); K511(7.69)  LDD0277  [5]
BTD
 Probe Info  		C502(6.76)  LDD1699  [6]
ONAyne
 Probe Info  		K650(6.25)  LDD0275  [5]
OPA-S-S-alkyne
 Probe Info  		K257(1.71); K28(2.49)  LDD3494  [7]
Probe 1
 Probe Info  		Y38(17.34); Y646(37.21)  LDD3495  [8]
THZ1-DTB
 Probe Info  		C673(1.01)  LDD0460  [9]
AHL-Pu-1
 Probe Info  		C93(3.68); C758(4.18); C673(2.84); C599(2.14)  LDD0168  [10]
EA-probe
 Probe Info  		C321(0.60)  LDD2210  [11]
HHS-482
 Probe Info  		Y646(1.30)  LDD0288  [12]
HHS-475
 Probe Info  		Y38(0.76); Y646(0.77); Y612(0.82)  LDD0264  [13]
HHS-465
 Probe Info  		Y38(10.00)  LDD2237  [14]
DBIA
 Probe Info  		C321(1.39); C502(1.03); C599(1.01); C758(0.99)  LDD0078  [15]
5E-2FA
 Probe Info  		N.A.  LDD2235  [16]
ATP probe
 Probe Info  		K95(0.00); K654(0.00); K640(0.00); K279(0.00)  LDD0199  [17]
1d-yne
 Probe Info  		N.A.  LDD0358  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		C758(0.00); C221(0.00); C502(0.00); C93(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		C673(0.00); C235(0.00); C599(0.00); C184(0.00)  LDD0032  [20]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [21]
IPIAA_L
 Probe Info  		C599(0.00); C502(0.00); C235(0.00)  LDD0031  [21]
Lodoacetamide azide
 Probe Info  		C758(0.00); C221(0.00); C502(0.00); C93(0.00)  LDD0037  [19]
ATP probe
 Probe Info  		K279(0.00); K710(0.00); K257(0.00); K88(0.00)  LDD0035  [22]
JW-RF-010
 Probe Info  		C758(0.00); C599(0.00); C321(0.00); C184(0.00)  LDD0026  [23]
NAIA_4
 Probe Info  		C321(0.00); C502(0.00); C599(0.00); C758(0.00)  LDD2226  [24]
TFBX
 Probe Info  		C235(0.00); C599(0.00); C93(0.00); C184(0.00)  LDD0027  [23]
WYneN
 Probe Info  		C502(0.00); C758(0.00)  LDD0021  [25]
WYneO
 Probe Info  		N.A.  LDD0022  [25]
Compound 10
 Probe Info  		C502(0.00); C599(0.00); C93(0.00)  LDD2216  [26]
Compound 11
 Probe Info  		C502(0.00); C599(0.00)  LDD2213  [26]
ENE
 Probe Info  		C271(0.00); C502(0.00)  LDD0006  [25]
IPM
 Probe Info  		C93(0.00); C502(0.00); C221(0.00)  LDD0005  [25]
PF-06672131
 Probe Info  		N.A.  LDD0017  [27]
SF
 Probe Info  		N.A.  LDD0028  [28]
VSF
 Probe Info  		C271(0.00); C502(0.00)  LDD0007  [25]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [29]
Ox-W18
 Probe Info  		N.A.  LDD2175  [30]
1c-yne
 Probe Info  		K497(0.00); K286(0.00); K356(0.00)  LDD0228  [18]
Acrolein
 Probe Info  		C235(0.00); H146(0.00); C599(0.00); H50(0.00)  LDD0217  [31]
Cinnamaldehyde
 Probe Info  		C599(0.00); C235(0.00)  LDD0220  [31]
Crotonaldehyde
 Probe Info  		C235(0.00); C599(0.00); C184(0.00); C267(0.00)  LDD0219  [31]
Methacrolein
 Probe Info  		C235(0.00); C758(0.00); C599(0.00); C502(0.00)  LDD0218  [31]
W1
 Probe Info  		C184(0.00); C599(0.00); C235(0.00); C267(0.00)  LDD0236  [32]
AOyne
 Probe Info  		14.40  LDD0443  [33]
NAIA_5
 Probe Info  		C221(0.00); C502(0.00); C93(0.00); C184(0.00)  LDD2223  [24]
PAL-AfBPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		13.36  LDD1725  [34]
C040
 Probe Info  		16.56  LDD1740  [34]
C070
 Probe Info  		9.25  LDD1766  [34]
C091
 Probe Info  		43.11  LDD1782  [34]
C138
 Probe Info  		5.10  LDD1820  [34]
C145
 Probe Info  		13.09  LDD1827  [34]
C165
 Probe Info  		12.82  LDD1845  [34]
C170
 Probe Info  		9.25  LDD1850  [34]
C177
 Probe Info  		8.88  LDD1856  [34]
C187
 Probe Info  		17.15  LDD1865  [34]
C216
 Probe Info  		8.11  LDD1890  [34]
C218
 Probe Info  		11.16  LDD1892  [34]
C232
 Probe Info  		35.75  LDD1905  [34]
C235
 Probe Info  		21.56  LDD1908  [34]
C239
 Probe Info  		6.45  LDD1912  [34]
C249
 Probe Info  		13.55  LDD1922  [34]
C296
 Probe Info  		11.24  LDD1966  [34]
C322
 Probe Info  		5.66  LDD1988  [34]
C346
 Probe Info  		24.42  LDD2007  [34]
C348
 Probe Info  		10.27  LDD2009  [34]
C353
 Probe Info  		5.90  LDD2014  [34]
C363
 Probe Info  		23.92  LDD2024  [34]
C383
 Probe Info  		26.17  LDD2042  [34]
C419
 Probe Info  		11.63  LDD2074  [34]
C420
 Probe Info  		10.34  LDD2075  [34]
C424
 Probe Info  		7.36  LDD2079  [34]
FFF probe11
 Probe Info  		6.28  LDD0472  [35]
FFF probe13
 Probe Info  		5.34  LDD0475  [35]
FFF probe2
 Probe Info  		14.37  LDD0463  [35]
FFF probe3
 Probe Info  		12.47  LDD0464  [35]
FFF probe6
 Probe Info  		6.01  LDD0468  [35]
FFF probe9
 Probe Info  		20.00  LDD0485  [35]
JN0003
 Probe Info  		20.00  LDD0469  [35]
STS-1
 Probe Info  		N.A.  LDD0136  [36]
STS-2
 Probe Info  		N.A.  LDD0138  [36]
VE-P
 Probe Info  		N.A.  LDD0396  [37]
DA-2
 Probe Info  		N.A.  LDD0070  [38]
OEA-DA
 Probe Info  		4.26  LDD0046  [39]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C502(0.73); C93(0.59)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C184(0.83); C502(0.90)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C235(0.89); C184(0.88)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C235(1.02); C502(0.88); C93(0.78)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C235(1.16); C184(1.27); C502(0.95); C93(1.15)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C235(1.26); C184(1.39); C502(0.94)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C235(1.03); C502(0.94); C93(0.82)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C235(0.87); C502(0.59); C93(0.50)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C502(0.70); C93(0.66)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C93(3.68); C758(4.18); C673(2.84); C599(2.14)  LDD0168  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C93(2.11); C758(5.89)  LDD0169  [10]
 LDCM0214  AC1 HCT 116 C184(1.31); C221(1.00); C235(1.05); C267(0.88)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C184(1.02); C221(1.06); C235(0.86); C267(1.06)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C184(0.89); C221(1.04); C235(0.78); C267(1.21)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C184(0.81); C221(0.97); C235(0.93); C267(1.19)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C184(0.86); C221(0.93); C235(0.88); C267(1.20)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C184(0.68); C221(1.11); C235(0.82); C267(0.75)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C184(0.86); C221(1.01); C235(0.93); C267(0.87)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C184(0.79); C221(1.10); C235(0.84); C267(0.93)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C184(0.77); C221(0.99); C235(0.81); C267(0.95)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C184(0.73); C221(1.09); C235(0.78); C267(0.85)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C184(0.87); C221(0.94); C235(0.80); C267(1.37)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C184(0.93); C221(0.92); C235(1.01); C267(1.21)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C184(1.11); C221(1.20); C235(0.77); C267(1.02)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C184(0.88); C221(0.95); C235(0.88); C267(1.14)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C184(0.87); C221(0.91); C235(0.85); C267(0.94)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C184(0.74); C221(0.97); C235(0.92); C267(1.48)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C184(1.13); C221(0.97); C235(0.91); C267(0.94)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C184(1.00); C221(1.13); C235(1.05); C267(0.97)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C184(0.90); C221(1.19); C235(1.03); C267(0.91)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C184(0.87); C221(1.10); C235(0.95); C267(0.93)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C184(0.94); C221(1.04); C235(1.15); C267(1.08)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C184(1.14); C221(1.10); C235(1.19); C267(1.07)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C184(0.88); C221(1.13); C235(1.06); C267(1.07)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C184(1.47); C221(1.01); C235(0.85); C267(1.20)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C184(1.02); C221(1.16); C235(1.12); C267(0.94)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C184(1.26); C221(0.96); C235(1.34); C267(1.29)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C184(0.99); C221(1.04); C235(1.16); C267(1.02)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C184(1.54); C221(0.94); C235(1.56); C267(1.12)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C184(1.21); C221(0.98); C235(1.22); C267(1.25)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C184(1.06); C221(1.06); C235(1.15); C267(1.15)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C184(1.14); C221(1.12); C235(1.16); C267(1.18)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C184(1.10); C221(1.07); C235(1.33); C267(1.21)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C184(1.65); C221(1.44); C235(1.35); C267(1.06)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C184(1.47); C221(1.00); C235(1.13); C267(1.26)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C184(1.25); C221(1.06); C235(0.90); C267(0.99)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C184(1.22); C221(0.91); C235(1.16); C267(1.17)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C184(1.06); C221(1.08); C235(0.92); C267(1.25)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C184(1.10); C221(1.16); C235(1.02); C267(1.02)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C184(1.02); C221(1.46); C235(1.19); C267(1.01)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C184(1.37); C221(1.14); C235(1.12); C267(1.06)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C184(0.98); C221(1.10); C235(1.00); C267(1.07)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C184(1.28); C221(1.11); C235(1.24); C267(1.21)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C184(0.97); C221(1.14); C235(1.09); C267(1.00)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C184(0.87); C221(1.38); C235(0.95); C267(1.06)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C184(1.07); C221(1.07); C235(1.00); C267(1.04)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C184(0.87); C221(1.12); C235(1.01); C267(1.01)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C184(0.98); C221(1.07); C235(1.08); C267(1.05)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C184(1.18); C221(1.05); C235(1.02); C267(1.22)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C673(0.94); C678(0.97); C221(0.97); C267(0.98)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C673(0.84); C678(0.85); C267(0.87); C271(0.88)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C673(0.95); C502(0.99); C678(1.01); C599(1.01)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C673(0.83); C271(0.90); C678(0.91); C267(0.92)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C673(0.90); C267(0.92); C678(0.97); C271(0.99)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C673(0.69); C678(0.75); C267(0.76); C271(0.78)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C673(0.71); C267(0.71); C271(0.74); C678(0.77)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C235(0.95); C184(0.97); C271(1.00); C502(1.04)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C599(0.86); C673(0.88); C678(0.92); C267(1.03)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C673(0.93); C678(0.98); C221(1.02); C235(1.09)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C673(0.73); C678(0.81); C267(0.87); C271(0.90)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C673(0.61); C678(0.68); C271(0.74); C267(0.75)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C221(1.19); C235(1.17); C267(1.02); C271(1.08)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C221(1.12); C235(1.11); C267(0.96); C271(0.96)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C221(1.02); C235(1.01); C267(1.09); C271(1.10)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C221(0.93); C235(1.23); C267(1.09); C271(1.09)  LDD2161  [15]
 LDCM0276  AC17 HCT 116 C221(0.98); C267(1.01); C271(1.01); C93(1.02)  LDD0593  [15]
 LDCM0277  AC18 HCT 116 C267(0.67); C271(0.67); C678(0.84); C184(0.85)  LDD0594  [15]
 LDCM0278  AC19 HCT 116 C267(0.86); C271(0.86); C221(0.93); C184(0.96)  LDD0595  [15]
 LDCM0279  AC2 HCT 116 C235(0.87); C267(0.88); C271(0.88); C221(0.88)  LDD0596  [15]
 LDCM0280  AC20 HCT 116 C502(0.99); C678(1.03); C221(1.05); C93(1.10)  LDD0597  [15]
 LDCM0281  AC21 HCT 116 C267(0.88); C271(0.88); C221(0.92); C184(1.03)  LDD0598  [15]
 LDCM0282  AC22 HCT 116 C267(0.94); C271(0.94); C93(0.95); C235(0.95)  LDD0599  [15]
 LDCM0283  AC23 HCT 116 C93(0.93); C221(0.96); C267(1.01); C271(1.01)  LDD0600  [15]
 LDCM0284  AC24 HCT 116 C93(0.89); C221(0.92); C502(1.06); C599(1.08)  LDD0601  [15]
 LDCM0285  AC25 HCT 116 C221(0.71); C184(0.77); C267(0.85); C673(0.89)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C221(0.69); C184(0.77); C267(0.87); C235(0.88)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C221(0.79); C271(0.84); C267(0.87); C184(0.94)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C221(0.51); C184(0.77); C267(0.89); C673(0.94)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C184(0.70); C267(0.79); C599(0.80); C221(0.86)  LDD0606  [15]
 LDCM0290  AC3 HCT 116 C673(0.89); C502(0.91); C221(0.91); C267(0.92)  LDD0607  [15]
 LDCM0291  AC30 HCT 116 C267(0.69); C184(0.70); C221(0.79); C599(0.80)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C221(0.86); C235(0.90); C678(0.96); C673(0.97)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C184(0.75); C221(0.78); C235(0.86); C267(0.86)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C184(0.52); C267(0.79); C221(0.81); C599(0.84)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C184(0.52); C267(0.76); C599(0.78); C235(0.83)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C502(0.74); C221(0.83); C93(0.87); C599(0.97)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C93(0.91); C599(0.92); C221(0.96); C502(0.97)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C599(0.81); C93(0.90); C221(0.91); C502(0.99)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C221(0.83); C93(0.97); C271(0.98); C235(0.99)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C221(0.92); C673(0.94); C599(0.99); C93(1.00)  LDD0617  [15]
 LDCM0301  AC4 HCT 116 C502(0.75); C221(0.93); C673(0.98); C267(1.02)  LDD0618  [15]
 LDCM0302  AC40 HCT 116 C599(0.70); C267(0.82); C184(0.83); C271(0.84)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C599(0.82); C221(0.82); C93(0.89); C235(0.93)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C235(0.85); C599(0.90); C267(0.92); C221(0.95)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C599(0.75); C221(0.89); C235(0.92); C93(0.93)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C599(0.92); C221(0.98); C267(1.00); C271(1.00)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C599(0.89); C267(0.91); C221(0.91); C271(0.95)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C184(0.72); C267(0.80); C271(0.80); C235(0.83)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C673(0.91); C184(0.92); C235(0.95); C678(0.99)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C235(0.80); C678(0.88); C673(0.89); C184(0.92)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C184(0.71); C235(0.77); C267(0.83); C271(0.83)  LDD0628  [15]
 LDCM0312  AC5 HCT 116 C502(0.78); C221(0.88); C673(0.94); C678(1.16)  LDD0629  [15]
 LDCM0313  AC50 HCT 116 C184(0.75); C235(0.88); C267(0.91); C271(0.91)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C93(0.89); C184(0.89); C267(0.95); C271(0.95)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C184(0.85); C235(0.87); C267(0.97); C271(0.97)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C235(0.85); C673(0.88); C221(0.90); C184(0.91)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C678(0.97); C673(0.97); C184(0.97); C221(0.99)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C235(0.72); C678(0.86); C673(0.87); C184(0.97)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C235(0.62); C678(0.77); C673(0.77); C184(0.79)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C267(0.68); C271(0.68); C221(0.82); C235(0.97)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C267(0.69); C271(0.69); C221(0.82); C184(1.06)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C267(0.67); C271(0.67); C221(0.82); C184(0.84)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C271(0.84); C267(0.86); C235(0.88); C184(0.91)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C267(0.67); C271(0.67); C221(0.82); C235(0.83)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C267(0.63); C271(0.63); C221(0.89); C184(0.92)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C267(0.69); C271(0.69); C184(0.75); C221(0.79)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C221(0.74); C184(0.75); C267(0.82); C271(0.82)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C221(0.76); C184(0.78); C267(0.80); C271(0.80)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C267(0.71); C271(0.71); C221(0.80); C235(0.83)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C267(0.73); C271(0.73); C221(0.77); C235(0.95)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C267(0.54); C271(0.54); C184(0.64); C221(0.78)  LDD0648  [15]
 LDCM0332  AC68 HCT 116 C678(0.80); C184(0.85); C221(0.87); C599(0.91)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C673(0.88); C678(0.88); C184(0.92); C267(0.92)  LDD0650  [15]
 LDCM0334  AC7 HCT 116 C235(0.64); C221(0.99); C267(1.04); C502(1.04)  LDD0651  [15]
 LDCM0335  AC70 HCT 116 C678(0.64); C184(0.74); C267(0.76); C271(0.76)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C221(0.92); C502(0.93); C673(0.93); C678(0.97)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C678(0.81); C184(0.81); C267(0.96); C271(0.96)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C184(0.69); C267(0.70); C271(0.70); C678(0.71)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C678(0.76); C673(0.84); C267(0.85); C271(0.85)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C267(0.63); C271(0.63); C184(0.66); C235(0.88)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C221(0.86); C673(0.87); C184(0.89); C267(1.01)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C678(0.74); C267(0.86); C271(0.86); C221(0.90)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C678(0.79); C673(0.90); C221(0.92); C93(0.94)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C678(0.87); C184(0.94); C673(0.95); C221(0.96)  LDD0661  [15]
 LDCM0345  AC8 HCT 116 C235(0.72); C267(0.96); C271(1.00); C221(1.05)  LDD0662  [15]
 LDCM0346  AC80 HCT 116 C678(0.75); C221(0.91); C673(0.92); C235(0.93)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C673(0.81); C599(0.82); C678(0.94); C221(0.94)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C267(0.72); C271(0.72); C184(0.79); C235(0.84)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C184(0.60); C678(0.65); C267(0.70); C271(0.74)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C184(0.57); C678(0.67); C673(0.74); C267(0.75)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C184(0.70); C678(0.70); C673(0.74); C235(0.75)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C184(0.72); C673(0.74); C678(0.75); C235(0.78)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C678(0.69); C673(0.72); C184(0.80); C235(0.90)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C184(0.70); C678(0.77); C673(0.82); C235(0.95)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C184(0.63); C678(0.65); C673(0.69); C267(0.81)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C678(0.67); C673(0.68); C221(0.92); C184(0.95)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C678(0.58); C184(0.63); C673(0.65); C271(0.74)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C678(0.54); C184(0.65); C673(0.67); C267(0.77)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C678(0.60); C673(0.60); C267(0.83); C271(0.84)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C673(0.58); C678(0.83); C221(0.86); C599(1.02)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C678(0.62); C673(0.67); C184(0.68); C221(0.84)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C673(0.61); C678(0.69); C184(0.74); C221(0.86)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C678(0.50); C184(0.56); C673(0.63); C267(0.70)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C184(0.45); C267(0.53); C271(0.53); C599(0.81)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C599(0.79); C184(0.82); C502(0.85); C235(0.90)  LDD0683  [15]
 LDCM0545  Acetamide MDA-MB-231 C235(0.72); C184(0.99); C502(0.41)  LDD2138  [6]
 LDCM0248  AKOS034007472 HCT 116 C184(1.22); C221(1.02); C235(0.82); C267(1.10)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C235(0.68); C267(0.96); C271(1.03); C221(1.03)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C267(0.73); C184(0.79); C271(0.83); C235(0.95)  LDD0592  [15]
 LDCM0156  Aniline NCI-H1299 12.69  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C321(1.39); C502(1.03); C599(1.01); C758(0.99)  LDD0078  [15]
 LDCM0498  BS-3668 MDA-MB-231 C235(1.16); C184(0.63); C502(0.58); C93(0.55)  LDD2091  [6]
 LDCM0630  CCW28-3 231MFP C321(2.79)  LDD2214  [40]
 LDCM0108  Chloroacetamide HeLa C235(0.00); H146(0.00); C758(0.00); C184(0.00)  LDD0222  [31]
 LDCM0632  CL-Sc Hep-G2 C221(20.00); C673(6.64); C93(2.29); C235(1.27)  LDD2227  [24]
 LDCM0367  CL1 HCT 116 C184(0.84); C221(0.88); C235(0.90); C93(0.97)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C184(0.80); C235(0.89); C599(0.91); C678(0.98)  LDD0685  [15]
 LDCM0369  CL100 HCT 116 C673(0.86); C502(0.86); C267(0.92); C271(0.92)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C184(0.91); C267(0.94); C271(0.96); C678(1.10)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C235(0.88); C93(0.97); C184(1.00); C221(1.01)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C235(0.81); C184(0.90); C221(0.91); C678(0.97)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C235(0.92); C271(0.97); C93(0.98); C267(0.99)  LDD0690  [15]
 LDCM0374  CL105 HCT 116 C267(0.87); C271(0.87); C184(0.99); C221(1.00)  LDD0691  [15]
 LDCM0375  CL106 HCT 116 C267(0.65); C271(0.65); C678(0.92); C184(0.92)  LDD0692  [15]
 LDCM0376  CL107 HCT 116 C267(0.74); C271(0.74); C184(0.84); C235(1.05)  LDD0693  [15]
 LDCM0377  CL108 HCT 116 C267(0.84); C271(0.84); C221(0.91); C678(0.96)  LDD0694  [15]
 LDCM0378  CL109 HCT 116 C267(0.72); C271(0.72); C184(0.90); C221(0.94)  LDD0695  [15]
 LDCM0379  CL11 HCT 116 C184(0.79); C235(0.91); C678(0.92); C267(0.93)  LDD0696  [15]
 LDCM0380  CL110 HCT 116 C221(0.85); C267(0.90); C271(0.90); C678(1.01)  LDD0697  [15]
 LDCM0381  CL111 HCT 116 C267(0.69); C271(0.69); C184(0.81); C235(0.90)  LDD0698  [15]
 LDCM0382  CL112 HCT 116 C221(0.76); C184(0.86); C235(0.88); C673(0.92)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C184(0.79); C267(0.82); C599(0.83); C221(0.89)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C184(0.51); C267(0.71); C235(0.73); C271(0.75)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C184(0.69); C267(0.77); C599(0.79); C271(0.87)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C184(0.60); C267(0.77); C599(0.83); C271(0.83)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C184(0.75); C599(0.75); C235(0.76); C678(0.81)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C235(0.89); C221(0.90); C599(0.91); C267(0.93)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C184(0.89); C235(0.91); C599(0.92); C267(0.93)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C184(0.81); C267(0.82); C271(0.82); C235(0.95)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C235(0.87); C599(0.88); C221(0.89); C93(0.95)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C184(0.78); C267(0.86); C271(0.86); C599(0.92)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C184(0.76); C267(0.79); C271(0.79); C235(0.81)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C184(0.75); C235(0.86); C221(0.91); C678(0.98)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C184(0.78); C235(0.78); C267(0.84); C271(0.84)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C235(0.84); C221(0.90); C502(1.02); C673(1.02)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C184(0.84); C221(0.95); C235(0.96); C502(1.02)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C267(0.78); C271(0.78); C184(0.97); C502(1.00)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C267(0.60); C271(0.60); C184(0.90); C221(0.92)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C184(0.82); C267(0.90); C271(0.90); C599(0.93)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C221(0.88); C184(0.89); C235(1.01); C93(1.04)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C184(0.88); C599(0.92); C678(0.98); C221(0.99)  LDD0719  [15]
 LDCM0403  CL16 HCT 116 C673(0.74); C184(0.76); C678(0.79); C235(0.79)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C235(0.70); C184(0.74); C678(0.85); C673(0.96)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C184(0.65); C235(0.67); C267(0.69); C271(0.79)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C184(0.82); C235(0.86); C267(0.92); C271(0.98)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C235(0.86); C599(0.89); C221(0.89); C184(0.98)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C267(0.76); C184(0.77); C235(0.78); C678(0.83)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C184(0.66); C235(0.69); C267(0.69); C271(0.73)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C184(0.60); C235(0.67); C267(0.71); C271(0.77)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C267(0.76); C235(0.77); C184(0.78); C271(0.82)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C184(0.70); C267(0.71); C235(0.73); C271(0.80)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C184(0.68); C221(1.19); C235(0.65); C267(0.78)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C184(0.80); C221(1.17); C235(0.82); C267(0.84)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C184(0.90); C221(1.13); C235(0.81); C267(1.01)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C184(0.71); C221(1.25); C235(0.65); C267(0.90)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C184(0.66); C221(1.34); C235(0.69); C267(0.77)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C184(1.10); C221(0.95); C235(1.16); C267(1.05)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C184(0.86); C221(1.15); C235(0.74); C267(0.99)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C184(0.87); C221(0.93); C235(0.90); C267(1.22)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C184(0.73); C221(1.09); C235(0.78); C267(0.72)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C184(0.71); C221(1.22); C235(0.81); C267(0.89)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C184(0.71); C221(1.14); C235(0.96); C267(0.59)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C184(0.73); C221(1.26); C235(0.91); C267(0.62)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C184(0.73); C221(1.25); C235(0.96); C267(0.78)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C184(0.78); C221(1.18); C235(0.99); C267(0.58)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C184(0.80); C221(1.09); C235(0.88); C267(1.71)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C184(0.91); C221(0.89); C235(0.89); C267(1.11)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C184(0.81); C221(1.14); C235(1.02); C267(0.88)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C184(0.81); C221(1.14); C235(1.02); C267(0.86)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C184(0.78); C221(1.28); C235(0.80); C267(0.68)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C184(0.73); C221(1.21); C235(0.92); C267(0.70)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C184(0.75); C221(1.15); C235(1.01); C267(0.88)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C184(0.75); C221(1.26); C235(0.91); C267(0.77)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C184(1.07); C221(0.81); C235(0.95); C267(1.36)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C184(0.94); C221(0.84); C235(1.07); C267(1.54)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C184(1.15); C221(0.91); C235(1.08); C267(1.38)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C184(1.01); C221(0.92); C235(1.18); C267(1.08)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C184(1.01); C221(0.91); C235(1.07); C267(1.13)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C184(0.94); C221(0.87); C235(1.12); C267(1.07)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C184(0.94); C221(0.88); C235(1.06); C267(1.16)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C184(1.06); C221(0.82); C235(1.01); C267(0.94)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C184(0.82); C221(0.92); C235(1.13); C267(0.97)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C184(0.91); C221(0.76); C235(0.96); C267(1.43)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C184(1.11); C221(0.93); C235(1.09); C267(1.20)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C184(0.81); C221(0.88); C235(1.09); C267(1.53)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C184(0.84); C221(0.89); C235(1.14); C267(1.17)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C184(1.09); C221(0.83); C235(1.12); C267(1.11)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C184(0.98); C221(0.89); C235(1.16); C267(1.12)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C184(0.77); C221(0.95); C235(0.88); C267(0.80)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C184(0.86); C221(0.87); C235(1.06); C267(1.39)  LDD0769  [15]
 LDCM0453  CL61 HCT 116 C184(0.88); C221(0.77); C235(0.65); C267(1.06)  LDD0770  [15]
 LDCM0454  CL62 HCT 116 C184(0.85); C221(0.81); C235(0.69); C267(0.87)  LDD0771  [15]
 LDCM0455  CL63 HCT 116 C184(0.79); C221(0.80); C235(0.74); C267(0.78)  LDD0772  [15]
 LDCM0456  CL64 HCT 116 C184(0.62); C221(0.68); C235(0.65); C267(0.79)  LDD0773  [15]
 LDCM0457  CL65 HCT 116 C184(0.80); C221(0.74); C235(0.67); C267(0.96)  LDD0774  [15]
 LDCM0458  CL66 HCT 116 C184(0.58); C221(0.77); C235(0.67); C267(0.85)  LDD0775  [15]
 LDCM0459  CL67 HCT 116 C184(0.66); C221(0.71); C235(0.90); C267(0.86)  LDD0776  [15]
 LDCM0460  CL68 HCT 116 C184(0.62); C221(0.76); C235(0.69); C267(1.00)  LDD0777  [15]
 LDCM0461  CL69 HCT 116 C184(0.54); C221(0.59); C235(0.67); C267(0.86)  LDD0778  [15]
 LDCM0462  CL7 HCT 116 C184(0.96); C221(1.02); C235(0.91); C267(0.96)  LDD0779  [15]
 LDCM0463  CL70 HCT 116 C184(0.65); C221(0.76); C235(0.61); C267(0.88)  LDD0780  [15]
 LDCM0464  CL71 HCT 116 C184(0.68); C221(0.71); C235(0.64); C267(0.81)  LDD0781  [15]
 LDCM0465  CL72 HCT 116 C184(0.91); C221(0.66); C235(0.61); C267(0.97)  LDD0782  [15]
 LDCM0466  CL73 HCT 116 C184(0.65); C221(0.62); C235(0.64); C267(0.83)  LDD0783  [15]
 LDCM0467  CL74 HCT 116 C184(0.69); C221(0.68); C235(0.71); C267(0.76)  LDD0784  [15]
 LDCM0469  CL76 HCT 116 C184(0.89); C221(1.03); C235(1.12); C267(0.79)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C184(0.88); C221(0.92); C235(0.99); C267(0.83)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C184(1.08); C221(0.94); C235(0.92); C267(0.82)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C184(0.95); C221(1.16); C235(1.03); C267(0.69)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C184(0.72); C221(1.07); C235(0.76); C267(0.80)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C184(1.12); C221(1.12); C235(0.97); C267(0.71)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C184(0.98); C221(0.98); C235(1.08); C267(0.85)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C184(1.10); C221(1.12); C235(1.07); C267(0.81)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C184(1.00); C221(1.04); C235(1.08); C267(0.74)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C184(0.99); C221(1.07); C235(0.91); C267(0.60)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C184(0.91); C221(1.09); C235(0.87); C267(0.80)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C184(0.97); C221(0.95); C235(1.06); C267(0.97)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C184(1.03); C221(1.11); C235(1.19); C267(0.97)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C184(1.11); C221(1.24); C235(1.21); C267(0.84)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C184(1.24); C221(1.25); C235(1.27); C267(0.64)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C184(0.84); C221(0.87); C235(0.72); C267(1.16)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C184(0.60); C221(0.99); C235(0.84); C267(1.19)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C184(0.99); C221(0.96); C235(1.08); C267(0.84)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C184(1.00); C221(0.93); C235(1.02); C267(0.91)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C184(1.41); C221(0.96); C235(1.33); C267(0.98)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C184(1.09); C221(0.86); C235(1.00); C267(0.94)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C184(0.92); C221(0.90); C235(1.08); C267(0.78)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C184(1.00); C221(0.96); C235(1.16); C267(0.74)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C184(0.86); C221(0.96); C235(1.07); C267(0.71)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C184(1.04); C221(1.05); C235(0.98); C267(0.93)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C184(1.12); C221(1.03); C235(1.05); C267(0.97)  LDD0811  [15]
 LDCM0185  Compound 17 HEK-293T 5.85  LDD0512  [35]
 LDCM0191  Compound 21 HEK-293T 6.46  LDD0508  [35]
 LDCM0190  Compound 34 HEK-293T 5.75  LDD0510  [35]
 LDCM0192  Compound 35 HEK-293T 4.67  LDD0509  [35]
 LDCM0193  Compound 36 HEK-293T 6.63  LDD0511  [35]
 LDCM0634  CY-0357 Hep-G2 C502(0.78); C221(0.69); C758(0.57); C502(0.51)  LDD2228  [24]
 LDCM0495  E2913 HEK-293T C502(0.99); C221(0.90); C93(0.99); C184(0.79)  LDD1698  [41]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C93(2.20); C235(1.84); C184(1.74); C271(1.73)  LDD1702  [6]
 LDCM0175  Ethacrynic acid HeLa C321(0.60)  LDD2210  [11]
 LDCM0625  F8 Ramos C93(1.10); C502(1.87); C599(1.28); C221(1.18)  LDD2187  [42]
 LDCM0572  Fragment10 Ramos C93(0.73); C502(0.96); C599(0.22); C221(0.58)  LDD2189  [42]
 LDCM0573  Fragment11 Ramos C93(0.07); C502(0.75); C599(11.23); C221(1.65)  LDD2190  [42]
 LDCM0574  Fragment12 Ramos C93(1.36); C502(0.75); C599(0.25); C221(0.51)  LDD2191  [42]
 LDCM0575  Fragment13 Ramos C93(1.00); C502(1.77); C599(0.51); C321(0.49)  LDD2192  [42]
 LDCM0576  Fragment14 Ramos C93(0.77); C502(0.86); C599(0.64); C221(0.82)  LDD2193  [42]
 LDCM0579  Fragment20 Ramos C93(0.80); C502(0.74); C599(0.21); C221(0.70)  LDD2194  [42]
 LDCM0580  Fragment21 Ramos C93(1.07); C502(0.94); C599(0.68); C221(1.20)  LDD2195  [42]
 LDCM0582  Fragment23 Ramos C93(1.23); C502(1.27); C599(0.36); C221(0.94)  LDD2196  [42]
 LDCM0578  Fragment27 Ramos C93(0.98); C502(1.23); C599(0.75); C221(1.32)  LDD2197  [42]
 LDCM0586  Fragment28 Ramos C93(0.64); C502(0.65); C599(0.99); C321(0.33)  LDD2198  [42]
 LDCM0588  Fragment30 Ramos C93(1.16); C502(1.82); C599(0.54); C221(1.35)  LDD2199  [42]
 LDCM0589  Fragment31 Ramos C93(0.90); C502(0.96); C599(0.54); C221(1.22)  LDD2200  [42]
 LDCM0590  Fragment32 Ramos C93(2.49); C502(1.17); C599(0.33); C221(0.68)  LDD2201  [42]
 LDCM0468  Fragment33 HCT 116 C184(0.63); C221(0.70); C235(0.60); C267(1.04)  LDD0785  [15]
 LDCM0596  Fragment38 Ramos C93(1.09); C502(1.00); C599(0.41); C221(1.18)  LDD2203  [42]
 LDCM0566  Fragment4 Ramos C93(0.81); C502(0.76); C599(0.83); C221(1.25)  LDD2184  [42]
 LDCM0427  Fragment51 HCT 116 C184(0.67); C221(1.38); C235(0.82); C267(0.65)  LDD0744  [15]
 LDCM0610  Fragment52 Ramos C93(1.32); C502(1.63); C599(0.50); C221(1.72)  LDD2204  [42]
 LDCM0614  Fragment56 Ramos C93(1.40); C502(1.32); C599(0.56); C221(1.54)  LDD2205  [42]
 LDCM0569  Fragment7 Ramos C93(0.68); C502(0.80); C599(0.73); C221(0.61)  LDD2186  [42]
 LDCM0571  Fragment9 Ramos C93(1.27); C502(0.64); C599(0.20); C221(0.53)  LDD2188  [42]
 LDCM0116  HHS-0101 DM93 Y38(0.76); Y646(0.77); Y612(0.82)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y646(0.72); Y612(0.85); Y38(1.38)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y612(1.14); Y38(1.44); Y646(1.78)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y646(0.62); Y38(0.71); Y612(1.72)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y646(0.96); Y38(1.08); Y612(1.19)  LDD0268  [13]
 LDCM0107  IAA HeLa C235(0.00); H146(0.00); C184(0.00); C267(0.00)  LDD0221  [31]
 LDCM0126  JWB150 DM93 Y646(1.30)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y646(0.47)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y646(0.26)  LDD0290  [12]
 LDCM0022  KB02 HCT 116 C502(1.34); C93(1.58); C267(1.35); C599(1.78)  LDD0080  [15]
 LDCM0023  KB03 HCT 116 C502(1.12); C93(1.35); C267(2.23); C599(1.03)  LDD0081  [15]
 LDCM0024  KB05 HCT 116 C502(1.49); C93(1.22); C267(1.01); C599(0.95)  LDD0082  [15]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C235(0.90); C502(0.82); C93(0.83)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C235(0.86); C502(0.42); C93(0.76)  LDD2121  [6]
 LDCM0109  NEM HeLa H146(0.00); H296(0.00); H50(0.00); C235(0.00)  LDD0223  [31]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C235(0.90); C184(0.91); C502(0.44); C93(0.95)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C235(0.97); C184(1.05); C502(0.97)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C235(0.87); C502(0.73); C93(0.86)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C235(1.27); C502(0.75)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C235(0.90); C502(0.91); C93(1.20)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C235(0.25); C93(0.38)  LDD2096  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C235(0.84); C502(0.81); C93(0.94)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C235(1.16); C184(1.24); C502(0.82); C93(1.72)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C235(0.46); C184(1.35); C502(0.73)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C184(0.74); C502(0.73)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C184(0.65); C502(0.67); C93(0.72)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C235(1.26); C502(1.22); C93(1.17)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C184(0.76); C502(0.59); C93(0.77)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C235(1.08); C184(1.24); C221(1.03)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C184(0.75); C502(0.73); C93(0.47)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C235(0.85); C184(0.85); C502(0.69)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C235(0.72); C502(1.11)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C235(1.12); C184(1.13); C502(0.77); C93(1.49)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C184(0.99); C502(0.64)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C235(1.03); C502(0.49); C93(0.88)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C502(1.04)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C502(1.48)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C235(1.71); C184(1.40); C502(2.50); C93(1.98)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C502(0.86); C93(0.51)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C235(0.38); C184(1.52); C502(1.18); C93(0.29)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C235(1.04); C502(0.69); C221(1.44)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C235(1.81)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C235(1.08); C184(0.81); C502(0.77); C221(1.23)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C235(0.37); C502(1.14)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C235(1.26); C184(1.00); C502(0.89); C93(0.92)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C235(0.74); C502(0.99); C93(0.64)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C235(1.34); C502(0.67)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C93(0.97)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C235(1.11); C502(0.49)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C235(1.62); C502(0.86); C93(1.40)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C235(1.14); C184(1.52); C502(0.76); C93(1.11)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C235(0.98); C184(1.01); C502(0.77); C93(1.07)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C93(3.23); C235(1.41); C502(0.68)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C235(1.01); C184(0.75); C502(0.59); C93(1.32)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C502(0.67); C93(0.52)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C235(0.66); C502(1.11); C93(0.70)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C235(1.65); C184(2.42); C502(2.38); C93(2.17)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C235(1.29); C502(0.70); C93(1.28)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C502(3.92); C93(1.24)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C235(0.82); C502(0.69)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C502(0.89); C93(0.33)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C502(0.57); C93(0.39)  LDD2150  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C235(1.53); C502(1.32); C93(2.11)  LDD2153  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C93(1.09); C93(0.53)  LDD2206  [43]
 LDCM0628  OTUB2-COV-1 HEK-293T C93(0.80)  LDD2207  [43]
 LDCM0131  RA190 MM1.R C673(1.37); C678(1.37); C321(0.81)  LDD0304  [44]
 LDCM0021  THZ1 HeLa S3 C673(1.01)  LDD0460  [9]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
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13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
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16 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
17 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
20 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
21 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
22 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
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23 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
26 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
27 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
28 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
29 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
30 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
31 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
32 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
33 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
34 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
35 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
36 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
37 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
38 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
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Mass spectrometry data entry: PXD007570
40 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
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42 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
43 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
44 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.