Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe9  Probe Info 
Probe concentration Probe:20uM; negative probe:20uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 45 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 20.0
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 20.0
 LDTP02141  Alpha-galactosidase A (GLA) 20.0
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 20.0
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 20.0
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 20.0
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 20.0
 LDTP02198  Cathepsin D (CTSD) 20.0
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 20.0
 LDTP05171  Dermcidin (DCD) 20.0
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 20.0
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 20.0
 LDTP13751  Exonuclease 1 (EXO1) 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 20.0
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) 20.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 20.0
 LDTP04183  Lanosterol synthase (LSS) 20.0
 LDTP10888  Legumain (LGMN) 20.0
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 20.0
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 20.0
 LDTP00886  Nardilysin (NRDC) 20.0
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 20.0
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 20.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 20.0
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 20.0
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 20.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 20.0
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 20.0
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 20.0
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 20.0
 LDTP02006  Tissue alpha-L-fucosidase (FUCA1) 20.0
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 20.0
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 19.5
 LDTP02223  Cathepsin B (CTSB) 19.5
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 16.6
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 15.9
 LDTP02837  Beta-galactosidase (GLB1) 14.6
 LDTP03858  Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) 14.4
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 13.7
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 12.2
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 8.7
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 8.4
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 8.1
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 6.0
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 5.6
Transporter and channel
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02071  Amyloid-beta precursor protein (APP) 20.0
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 20.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 20.0
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 20.0
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 20.0
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 20.0
 LDTP02215  Prosaposin (PSAP) 20.0
 LDTP11615  Protein tweety homolog 3 (TTYH3) 20.0
 LDTP12042  Proton-activated chloride channel (PACC1) 20.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 20.0
 LDTP00310  Syntenin-1 (SDCBP) 20.0
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 20.0
 LDTP15481  Transmembrane protein 87A (TMEM87A) 20.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 20.0
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 15.4
 LDTP01969  Transferrin receptor protein 1 (TFRC) 13.0
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 7.4
 LDTP00592  Surfeit locus protein 4 (SURF4) 7.2
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 10.6
Other
Click to Show/Hide to Show 20 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05491  Amyloid beta precursor like protein 2 (APLP2) 20.0
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 20.0
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 20.0
 LDTP00887  Calumenin (CALU) 20.0
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 20.0
 LDTP09920  Golgi apparatus protein 1 (GLG1) 20.0
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 20.0
 LDTP08425  Hornerin (HRNR) 20.0
 LDTP05375  Nucleobindin-1 (NUCB1) 20.0
 LDTP16080  Protein FAM114A2 (FAM114A2) 20.0
 LDTP06097  Reticulocalbin-2 (RCN2) 20.0
 LDTP14458  Tetraspanin-6 (TSPAN6) 20.0
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 19.9
 LDTP13630  Neudesin (NENF) 19.6
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 17.2
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 16.7
 LDTP02756  Junction plakoglobin (JUP) 16.2
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 15.2
 LDTP06352  Reticulocalbin-1 (RCN1) 12.5
 LDTP02297  Vimentin (VIM) 5.2

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.