General Information of Target

Target ID LDTP05171
Target Name Dermcidin (DCD)
Gene Name DCD
Gene ID 117159
Synonyms
AIDD; DSEP; Dermcidin; EC 3.4.-.-; Preproteolysin) [Cleaved into: Survival-promoting peptide; DCD-1]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRFMTLLFLTALAGALVCAYDPEAASAPGSGNPCHEASAAQKENAGEDPGLARQAPKPRK
QRSSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSVL
Target Bioclass
Enzyme
Subcellular location
Secreted
Function
[DCD-1]: Found in sweat, has an antimicrobial activity during early bacterial colonization. The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen membranes. Once inserted in bacteria membranes forms anion channels probably altering the transmembrane potential essential for bacterial survival. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues.; [Survival-promoting peptide]: Promotes survival of neurons and displays phosphatase activity. It may bind IgG.
Uniprot ID
P81605
Ensemble ID
ENST00000293371.11
HGNC ID
HGNC:14669
ChEMBL ID
CHEMBL4523267

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info 
1.87  LDD0448  [1]
P2
 Probe Info 
2.02  LDD0449  [1]
P3
 Probe Info 
1.54  LDD0454  [1]
YN-1
 Probe Info 
100.00  LDD0444  [2]
YN-4
 Probe Info 
100.00  LDD0445  [2]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info 
20.00  LDD0471  [3]
FFF probe15
 Probe Info 
20.00  LDD0478  [3]
FFF probe6
 Probe Info 
20.00  LDD0468  [3]
FFF probe9
 Probe Info 
20.00  LDD0470  [3]
JN0003
 Probe Info 
20.00  LDD0484  [3]
PARPYnD
 Probe Info 
1.43  LDD0376  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0147  AZ0108 MDA-MB-468 1.43  LDD0376  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid protein-binding protein 2 (APPBP2) . Q92624

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
4 Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. doi: 10.1021/acschembio.9b00963. Epub 2020 Feb 10.