General Information of Experiment

Probe Name P3  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
LFQ
In Vivo Experiment Model Model Type Living cell
Derived Tissue Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cells (HeLa)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 22 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04886  Cell division control protein 42 homolog (CDC42) 10.0
 LDTP02534  Endoplasmic reticulum chaperone BiP (HSPA5) 10.0
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) 10.0
 LDTP04876  Actin, cytoplasmic 1 (ACTB) 8.4
 LDTP08190  E3 ubiquitin-protein ligase RNF180 (RNF180) 7.4
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) 6.2
 LDTP07932  Probable ATP-dependent RNA helicase DDX46 (DDX46) 3.7
 LDTP02616  Creatine kinase B-type (CKB) 3.2
 LDTP05460  Elongation factor 1-alpha 2 (EEF1A2) 3.2
 LDTP04878  Eukaryotic initiation factor 4A-I (EIF4A1) 2.6
 LDTP01124  Probable phospholipid-transporting ATPase IIA (ATP9A) 2.3
 LDTP03242  Adenosylhomocysteinase (AHCY) 2.1
 LDTP01766  L-lactate dehydrogenase A chain (LDHA) 2.0
 LDTP02541  Heat shock cognate 71 kDa protein (HSPA8) 2.0
 LDTP03487  Transketolase (TKT) 1.9
 LDTP02008  Fructose-bisphosphate aldolase A (ALDOA) 1.8
 LDTP02733  Pyruvate kinase PKM (PKM) 1.7
 LDTP05911  Serine/threonine-protein kinase PRP4 homolog (PRPF4B) 1.6
 LDTP04851  Triosephosphate isomerase (TPI1) 1.6
 LDTP05171  Dermcidin (DCD) 1.5
 LDTP02774  Phosphoglycerate mutase 2 (PGAM2) 1.5
 LDTP03166  Ubiquitin-like modifier-activating enzyme 1 (UBA1) 1.5
Transporter and channel
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02307  Annexin A5 (ANXA5) 10.0
 LDTP00362  Astrotactin-1 (ASTN1) 10.0
 LDTP03107  Filamin-A (FLNA) 10.0
 LDTP06242  Importin subunit beta-1 (KPNB1) 10.0
 LDTP05832  Urea transporter 1 (SLC14A1) 10.0
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) 7.9
 LDTP02815  Desmoplakin (DSP) 7.7
 LDTP02010  Annexin A1 (ANXA1) 3.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 2.6
 LDTP03385  14-3-3 protein theta (YWHAQ) 2.3
 LDTP05043  14-3-3 protein zeta/delta (YWHAZ) 1.6
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16710  Zinc finger protein 99 (ZNF99) 10.0
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP17677  Olfactory receptor 8H2 (OR8H2) 2.2
Other
Click to Show/Hide to Show 26 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) 10.0
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) 10.0
 LDTP02125  Keratin, type II cytoskeletal 8 (KRT8) 10.0
 LDTP02109  Large ribosomal subunit protein uL10 (RPLP0) 10.0
 LDTP03346  Moesin (MSN) 10.0
 LDTP01932  Prelamin-A/C (LMNA) 10.0
 LDTP10650  Serpin B11 (SERPINB11) 10.0
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 10.0
 LDTP08139  Centriolin (CNTRL) 9.5
 LDTP04355  Rab GDP dissociation inhibitor beta (GDI2) 8.9
 LDTP03620  Protein S100-A11 (S100A11) 8.4
 LDTP02297  Vimentin (VIM) 6.3
 LDTP01534  Luc7-like protein 3 (LUC7L3) 5.7
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) 5.2
 LDTP06598  Fascin (FSCN1) 4.0
 LDTP03244  Cofilin-1 (CFL1) 2.6
 LDTP02341  Galectin-1 (LGALS1) 2.4
 LDTP05014  Small ribosomal subunit protein eS26 (RPS26) 2.3
 LDTP19229  Cilia- and flagella- associated protein 210 (CFAP210) 2.3
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) 1.9
 LDTP04106  Large ribosomal subunit protein uL18 (RPL5) 1.8
 LDTP05023  Large ribosomal subunit protein eL31 (RPL31) 1.8
 LDTP09562  Splicing factor U2AF 26 kDa subunit (U2AF1L4) 1.8
 LDTP14045  Disheveled-associated activator of morphogenesis 1 (DAAM1) 1.7
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) 1.7
 LDTP04974  Small ribosomal subunit protein uS15 (RPS13) 1.5

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.