Details of the Target

General Information of Target

Target ID LDTP02815
Target Name Desmoplakin (DSP)
Gene Name DSP
Gene ID 1832
Synonyms
Desmoplakin; DP; 250/210 kDa paraneoplastic pemphigus antigen
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG
TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI
LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW
DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA
DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD
KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW
ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE
LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD
ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL
YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF
GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE
NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA
EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT
EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS
QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK
WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD
YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM
LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE
ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD
QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYN
EEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSI
LQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI
QDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQL
TMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEV
SQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCL
EDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQ
NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE
QASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL
RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE
ADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQE
SKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQI
QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDS
TRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQL
YECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLI
SPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPF
SGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYR
SLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVT
ELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKI
GLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYN
DPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEE
LSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNT
LRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLV
DRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDD
VFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERG
IVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEG
VKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRA
AQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMS
SAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH
Target Bioclass
Transporter and channel
Family
Plakin or cytolinker family
Subcellular location
Cell junction, desmosome
Function
Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance.
Uniprot ID
P15924
Ensemble ID
ENST00000379802.8
HGNC ID
HGNC:3052

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A311T DBIA    Probe Info 
A204 SNV: p.E683D DBIA    Probe Info 
CCK81 SNV: p.W550Ter DBIA    Probe Info 
CHL1 SNV: p.G1154D .
COLO792 SNV: p.P24Q DBIA    Probe Info 
DU145 SNV: p.A951T DBIA    Probe Info 
EGI1 SNV: p.R1762W DBIA    Probe Info 
HCC44 SNV: p.Q175H DBIA    Probe Info 
HCT15 SNV: p.I120T; p.W901Ter; p.I1610T DBIA    Probe Info 
HEC1 SNV: p.Q1179R DBIA    Probe Info 
HEC1B SNV: p.L411M; p.Q1179R IA-alkyne    Probe Info 
HT SNV: p.L510P .
HT115 SNV: p.E2193K DBIA    Probe Info 
ICC137 SNV: p.D406N DBIA    Probe Info 
ICC4 SNV: p.A200V DBIA    Probe Info 
KYSE510 SNV: p.Y391N DBIA    Probe Info 
LN18 SNV: p.F917C .
MDST8 SNV: p.E1294Ter DBIA    Probe Info 
MEC1 SNV: p.G697Ter .
MFE319 SNV: p.L392P DBIA    Probe Info 
NCIH446 SNV: p.E1716Ter DBIA    Probe Info 
OVTOKO SNV: p.Q841E DBIA    Probe Info 
P31FUJ SNV: p.T184A; p.C2259G DBIA    Probe Info 
REH SNV: p.K432R .
RKO Insertion: p.K1892RfsTer38
SNV: .		 DBIA    Probe Info 
RL952 Deletion: p.K1054del DBIA    Probe Info 
SAOS2 SNV: p.Q58Ter .
SF295 SNV: p.V1530I DBIA    Probe Info 
SKMEL5 SNV: p.V1808M DBIA    Probe Info 
SW1783 SNV: p.R1738Ter .
U118MG SNV: p.K906Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		7.69  LDD0452  [1]
P2
 Probe Info  		10.00  LDD0453  [1]
P3
 Probe Info  		7.72  LDD0454  [1]
11RK72
 Probe Info  		3.13  LDD0327  [2]
11RK73
 Probe Info  		3.44  LDD0328  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
YN-4
 Probe Info  		100.00  LDD0445  [3]
Nap-2
 Probe Info  		N.A.  LDD0435  [4]
ONAyne
 Probe Info  		K1916(0.39)  LDD0274  [5]
STPyne
 Probe Info  		K1028(5.88); K1056(5.00); K1073(2.19); K1075(9.07)  LDD0277  [5]
BTD
 Probe Info  		C2656(1.51)  LDD1700  [6]
AHL-Pu-1
 Probe Info  		C899(6.51); C798(2.44); C467(7.57); C2776(3.41)  LDD0168  [7]
DBIA
 Probe Info  		C1499(6.38)  LDD0206  [8]
W1
 Probe Info  		C174(1.02)  LDD0239  [9]
5E-2FA
 Probe Info  		H2742(0.00); H2195(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
m-APA
 Probe Info  		H2742(0.00); H2195(0.00)  LDD2231  [10]
N1
 Probe Info  		E1211(0.00); E1213(0.00)  LDD0245  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		C1069(0.00); C110(0.00)  LDD0032  [14]
WYneN
 Probe Info  		C3(0.00); C2776(0.00); C1805(0.00); C482(0.00)  LDD0021  [15]
WYneO
 Probe Info  		C1805(0.00); C135(0.00)  LDD0022  [15]
ENE
 Probe Info  		C3(0.00); C1052(0.00); C1280(0.00); C1589(0.00)  LDD0006  [15]
IPM
 Probe Info  		C174(0.00); C740(0.00); C1805(0.00); C1069(0.00)  LDD0005  [15]
NPM
 Probe Info  		N.A.  LDD0016  [15]
PF-06672131
 Probe Info  		C174(0.00); C2776(0.00)  LDD0017  [16]
PPMS
 Probe Info  		N.A.  LDD0008  [15]
SF
 Probe Info  		K1692(0.00); Y2316(0.00)  LDD0028  [17]
TFBX
 Probe Info  		C1280(0.00); C954(0.00); C1052(0.00); C1100(0.00)  LDD0148  [18]
VSF
 Probe Info  		C57(0.00); C1589(0.00); C1957(0.00); C1805(0.00)  LDD0007  [15]
Phosphinate-6
 Probe Info  		C1805(0.00); C1589(0.00); C1148(0.00); C1052(0.00)  LDD0018  [19]
1c-yne
 Probe Info  		K2523(0.00); K245(0.00)  LDD0228  [20]
Acrolein
 Probe Info  		N.A.  LDD0217  [21]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [21]
Methacrolein
 Probe Info  		C1805(0.00); C682(0.00); C174(0.00)  LDD0218  [21]
AOyne
 Probe Info  		8.10  LDD0443  [22]
NAIA_5
 Probe Info  		C467(0.00); C1052(0.00); C2442(0.00); C110(0.00)  LDD2223  [23]
HHS-465
 Probe Info  		K2317(0.00); Y2720(0.00); Y95(0.00)  LDD2240  [24]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0471  [25]
FFF probe12
 Probe Info  		20.00  LDD0474  [25]
FFF probe13
 Probe Info  		20.00  LDD0475  [25]
FFF probe2
 Probe Info  		20.00  LDD0479  [25]
FFF probe6
 Probe Info  		20.00  LDD0482  [25]
FFF probe9
 Probe Info  		20.00  LDD0470  [25]
JN0003
 Probe Info  		20.00  LDD0484  [25]
STS-1
 Probe Info  		N.A.  LDD0136  [26]
STS-2
 Probe Info  		N.A.  LDD0138  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C899(6.51); C798(2.44); C467(7.57); C2776(3.41)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C899(2.60); C798(2.38); C768(2.25); C740(2.11)  LDD0169  [7]
 LDCM0104  BDHI 13 Jurkat C1499(6.38)  LDD0206  [8]
 LDCM0108  Chloroacetamide HeLa C682(0.00); C1805(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C1280(20.00); C1499(20.00); C135(20.00); C1069(7.26)  LDD2227  [23]
 LDCM0634  CY-0357 Hep-G2 C1052(0.98); C3(0.88); C57(0.84); C1957(0.78)  LDD2228  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C367(2.24); C2776(0.98)  LDD1702  [6]
 LDCM0022  KB02 22RV1 C1280(2.59); C1499(1.40); C1052(1.35); C174(3.55)  LDD2243  [27]
 LDCM0023  KB03 Jurkat C174(47.43)  LDD0209  [8]
 LDCM0024  KB05 G361 C1280(1.37)  LDD3311  [27]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1499(0.81)  LDD2093  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1499(0.61)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1499(1.03)  LDD2099  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C2656(0.56)  LDD2109  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1499(0.92); C2776(0.99); C1100(1.22)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1499(0.70); C2776(0.92); C1280(1.02)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C2776(1.02)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C2656(1.30); C1499(0.77)  LDD2129  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1499(0.72)  LDD2135  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1280(1.51)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C2656(1.51)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1499(0.94); C2776(0.75)  LDD2140  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C2776(0.83)  LDD2143  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C2656(1.07)  LDD2146  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1499(1.12)  LDD2150  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C57(0.70); C57(0.07)  LDD2206  [28]
 LDCM0628  OTUB2-COV-1 HEK-293T C57(0.79)  LDD2207  [28]
 LDCM0112  W16 Hep-G2 C174(1.02)  LDD0239  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein kinase Fes/Fps (FES) Tyr protein kinase family P07332
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule-associated protein RP/EB family member 1 (MAPRE1) MAPRE family Q15691
Desmoglein-1 (DSG1) . Q02413

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638
Zinc . DB01593
Zinc Acetate . DB14487

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 Proteome-Wide Identification of On- and Off-Targets of Bcl-2 Inhibitors in Native Biological Systems by Using Affinity-Based Probes (AfBPs). Chembiochem. 2018 Nov 2;19(21):2312-2320. doi: 10.1002/cbic.201800380. Epub 2018 Oct 18.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
24 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
27 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
28 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.