Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe2  Probe Info 
Probe concentration Probe:20uM; negative probe:20uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 70 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 20.0
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 20.0
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 20.0
 LDTP07154  ATPase family AAA domain-containing protein 3B (ATAD3B) 20.0
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 20.0
 LDTP03145  Catechol O-methyltransferase (COMT) 20.0
 LDTP02198  Cathepsin D (CTSD) 20.0
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 20.0
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 20.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 20.0
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 20.0
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 20.0
 LDTP00950  Dynamin-like 120 kDa protein, mitochondrial (OPA1) 20.0
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 20.0
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 20.0
 LDTP13751  Exonuclease 1 (EXO1) 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 20.0
 LDTP04531  Hexokinase-2 (HK2) 20.0
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 20.0
 LDTP04581  Holocytochrome c-type synthase (HCCS) 20.0
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 20.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 20.0
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 20.0
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) 20.0
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 20.0
 LDTP03813  Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (CPOX) 20.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 20.0
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 20.0
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 20.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 20.0
 LDTP00988  Protein O-GlcNAcase (OGA) 20.0
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 20.0
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 20.0
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 20.0
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 20.0
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 20.0
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 18.2
 LDTP02188  Protein disulfide-isomerase (P4HB) 14.4
 LDTP12588  Isoleucine--tRNA ligase, mitochondrial (IARS2) 14.2
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 13.9
 LDTP02333  Glutathione S-transferase P (GSTP1) 13.8
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 13.5
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) 13.1
 LDTP00314  ATP-dependent RNA helicase DDX3X (DDX3X) 12.3
 LDTP02534  Endoplasmic reticulum chaperone BiP (HSPA5) 12.1
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) 11.8
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 9.2
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 8.4
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 7.9
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 7.1
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 6.9
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 6.9
 LDTP03610  Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) 6.7
 LDTP02733  Pyruvate kinase PKM (PKM) 6.5
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 6.5
 LDTP04884  Proteasome subunit alpha type-6 (PSMA6) 6.2
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 5.9
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 5.9
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 5.8
 LDTP06905  Acylglycerol kinase, mitochondrial (AGK) 5.7
 LDTP00616  Protein phosphatase 1G (PPM1G) 5.7
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 5.7
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 5.6
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 5.5
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) 5.3
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 5.2
 LDTP13816  RuvB-like 1 (RUVBL1) 5.2
 LDTP04398  Ras-related protein Rab-5C (RAB5C) 5.2
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 5.2
 LDTP13787  RuvB-like 2 (RUVBL2) 5.1
Transporter and channel
Click to Show/Hide to Show 48 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 20.0
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 20.0
 LDTP02815  Desmoplakin (DSP) 20.0
 LDTP13393  Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) 20.0
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 20.0
 LDTP12142  Exportin-5 (XPO5) 20.0
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 20.0
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 20.0
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 20.0
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 20.0
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 20.0
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 20.0
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 20.0
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 20.0
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 20.0
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 20.0
 LDTP01295  Nuclear pore complex protein Nup155 (NUP155) 20.0
 LDTP11213  Nucleoporin NDC1 (NDC1) 20.0
 LDTP02215  Prosaposin (PSAP) 20.0
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 20.0
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 20.0
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 20.0
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 20.0
 LDTP15948  Transmembrane protein 126A (TMEM126A) 20.0
 LDTP20002  Transmembrane protein 160 (TMEM160) 20.0
 LDTP09949  Transportin-1 (TNPO1) 20.0
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 20.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 20.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 20.0
 LDTP03405  Calnexin (CANX) 18.6
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 18.2
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 17.0
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 16.3
 LDTP04501  Importin subunit alpha-1 (KPNA2) 16.2
 LDTP04391  T-complex protein 1 subunit delta (CCT4) 15.5
 LDTP06660  MICOS complex subunit MIC60 (IMMT) 14.5
 LDTP00821  Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) 13.9
 LDTP00592  Surfeit locus protein 4 (SURF4) 13.3
 LDTP12090  Sideroflexin-1 (SFXN1) 13.1
 LDTP03717  Prohibitin 1 (PHB1) 12.5
 LDTP02609  ADP/ATP translocase 3 (SLC25A6) 12.3
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) 12.3
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) 12.3
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) 12.3
 LDTP02057  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) 12.2
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 7.6
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 6.0
 LDTP00266  Importin-5 (IPO5) 5.0
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) 12.1
 LDTP05065  Y-box-binding protein 1 (YBX1) 8.0
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 14.5
Other
Click to Show/Hide to Show 62 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00223  26S proteasome non-ATPase regulatory subunit 11 (PSMD11) 20.0
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 20.0
 LDTP01652  Centrosomal protein 43 (CEP43) 20.0
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 20.0
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 20.0
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 20.0
 LDTP17065  Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2) 20.0
 LDTP08425  Hornerin (HRNR) 20.0
 LDTP02756  Junction plakoglobin (JUP) 20.0
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 20.0
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 20.0
 LDTP13630  Neudesin (NENF) 20.0
 LDTP05375  Nucleobindin-1 (NUCB1) 20.0
 LDTP05160  Nucleobindin-2 (NUCB2) 20.0
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 20.0
 LDTP03520  Phosphatidylethanolamine-binding protein 1 (PEBP1) 20.0
 LDTP16080  Protein FAM114A2 (FAM114A2) 20.0
 LDTP10056  Protein FAM162A (FAM162A) 20.0
 LDTP00105  Protein unc-119 homolog B (UNC119B) 20.0
 LDTP06097  Reticulocalbin-2 (RCN2) 20.0
 LDTP11324  RNA-binding protein 4 (RBM4) 20.0
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 20.0
 LDTP02297  Vimentin (VIM) 20.0
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 18.4
 LDTP13813  Eukaryotic translation initiation factor 3 subunit L (EIF3L) 17.1
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 15.3
 LDTP12412  Reticulon-4 (RTN4) 15.2
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 15.1
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 15.1
 LDTP09938  Far upstream element-binding protein 2 (KHSRP) 15.0
 LDTP10078  Far upstream element-binding protein 1 (FUBP1) 14.9
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 14.8
 LDTP05525  KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) 14.7
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 13.7
 LDTP04500  Heterogeneous nuclear ribonucleoprotein M (HNRNPM) 13.6
 LDTP10684  RNA-binding protein 14 (RBM14) 13.4
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 13.4
 LDTP03775  RNA-binding protein FUS (FUS) 13.1
 LDTP10924  Prohibitin-2 (PHB2) 13.1
 LDTP01432  Mitochondrial import receptor subunit TOM70 (TOMM70) 12.8
 LDTP05400  Lamin-B2 (LMNB2) 12.8
 LDTP04027  Matrin-3 (MATR3) 12.5
 LDTP02734  Endoplasmin (HSP90B1) 12.5
 LDTP13167  Peflin (PEF1) 12.2
 LDTP02595  Polyadenylate-binding protein 1 (PABPC1) 12.1
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 11.4
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) 10.3
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) 10.2
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) 10.1
 LDTP06060  Ubiquitin-associated protein 2-like (UBAP2L) 9.9
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 9.7
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 9.6
 LDTP06032  Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) 9.6
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) 7.2
 LDTP10962  Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) 7.1
 LDTP05226  RNA-binding protein 3 (RBM3) 6.8
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) 6.7
 LDTP04495  Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) 5.9
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) 5.8
 LDTP03850  RNA-binding motif protein, X chromosome (RBMX) 5.1
 LDTP03322  Bromodomain-containing protein 2 (BRD2) 5.0
 LDTP06543  DNA damage-binding protein 1 (DDB1) 5.0

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.