Details of the Target

General Information of Target

Target ID LDTP00266
Target Name Importin-5 (IPO5)
Gene Name IPO5
Gene ID 3843
Synonyms
KPNB3; RANBP5; Importin-5; Imp5; Importin subunit beta-3; Karyopherin beta-3; Ran-binding protein 5; RanBP5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRNTTAAEEARQ
MAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKVCDIAAELARNL
IDEDGNNQWPEGLKFLFDSVSSQNVGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLVQC
MQDQEHPSIRTLSARATAAFILANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLKSL
VEIADTVPKYLRPHLEATLQLSLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKHTNI
VAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMACGLGGKLVLPMIK
EHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAAC
NAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQAHAAAALINFTEDCPKSLLIP
YLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKH
IVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDFNDMEDDDPQ
ISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFV
NLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVR
VAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVM
GDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILT
KVSDILHSIFSSYKEKVLPWFEQLLPLIVNLICPHRPWPDRQWGLCIFDDVIEHCSPASF
KYAEYFLRPMLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADS
KTKENVNATENCISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLI
ESNHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECIA
QLSPEQQAAIQELLNSA
Target Bioclass
Transporter and channel
Family
Importin beta family, Importin beta-3 subfamily
Subcellular location
Cytoplasm
Function
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
Uniprot ID
O00410
Ensemble ID
ENST00000261574.10
HGNC ID
HGNC:6402
ChEMBL ID
CHEMBL4295647

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.K496R DBIA    Probe Info 
CAL33 SNV: p.L489M DBIA    Probe Info 
COLO320 SNV: p.S652G DBIA    Probe Info 
LNCaP clone FGC SNV: p.E319D DBIA    Probe Info 
MEWO SNV: p.Q808Ter DBIA    Probe Info 
NCIH1155 SNV: p.A338T DBIA    Probe Info 
RKO Deletion: p.I868SfsTer24 DBIA    Probe Info 
RVH421 SNV: p.G378R DBIA    Probe Info 
SKMEL3 SNV: p.M61T DBIA    Probe Info 
SUDHL4 Insertion: p.E549GfsTer11 DBIA    Probe Info 
UACC257 SNV: p.G555E DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 52 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.04  LDD0402  [1]
A-EBA
 Probe Info  		4.51  LDD0215  [2]
CHEMBL5175495
 Probe Info  		7.58  LDD0196  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
TH211
 Probe Info  		Y940(10.99); Y714(7.30)  LDD0257  [5]
TH214
 Probe Info  		Y853(15.15)  LDD0258  [5]
YN-4
 Probe Info  		100.00  LDD0445  [6]
ONAyne
 Probe Info  		K108(0.50); K800(0.20); K961(0.59)  LDD0274  [7]
STPyne
 Probe Info  		K108(7.61); K436(10.00); K548(1.61); K613(4.74)  LDD0277  [7]
Probe 1
 Probe Info  		Y699(26.87)  LDD3495  [8]
JZ128-DTB
 Probe Info  		C972(0.00); C682(0.00); C473(0.00); C1078(0.00)  LDD0462  [9]
THZ1-DTB
 Probe Info  		C733(1.08); C420(1.10); C944(1.02); C1078(0.98)  LDD0460  [9]
Sulforaphane-probe2
 Probe Info  		2.04  LDD0042  [10]
DA-P3
 Probe Info  		8.89  LDD0183  [11]
AHL-Pu-1
 Probe Info  		C784(4.71); C473(3.52); C229(20.00); C915(3.48)  LDD0169  [12]
EA-probe
 Probe Info  		C733(0.75)  LDD2210  [13]
DBIA
 Probe Info  		C682(4.36); C687(4.36); C560(4.44)  LDD0204  [14]
HHS-475
 Probe Info  		Y905(0.82)  LDD0264  [15]
HHS-465
 Probe Info  		Y622(4.97); Y714(2.86); Y905(10.00); Y935(2.82)  LDD2237  [16]
5E-2FA
 Probe Info  		H206(0.00); H186(0.00); H461(0.00)  LDD2235  [17]
ATP probe
 Probe Info  		K1052(0.00); K1059(0.00); K108(0.00); K806(0.00)  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		C972(0.00); C750(0.00); C1057(0.00); C229(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		C266(0.00); C944(0.00); C348(0.00); C473(0.00)  LDD0032  [20]
IPIAA_H
 Probe Info  		C110(0.00); C733(0.00); C944(0.00); C229(0.00)  LDD0030  [21]
IPIAA_L
 Probe Info  		C420(0.00); C944(0.00); C733(0.00); C750(0.00)  LDD0031  [21]
Lodoacetamide azide
 Probe Info  		C972(0.00); C986(0.00); C750(0.00); C229(0.00)  LDD0037  [19]
BTD
 Probe Info  		N.A.  LDD0004  [22]
JW-RF-010
 Probe Info  		C733(0.00); C180(0.00); C473(0.00); C110(0.00)  LDD0026  [23]
NAIA_4
 Probe Info  		C180(0.00); C229(0.00); C420(0.00); C473(0.00)  LDD2226  [24]
TFBX
 Probe Info  		C110(0.00); C972(0.00); C420(0.00); C266(0.00)  LDD0027  [23]
WYneN
 Probe Info  		C972(0.00); C733(0.00); C110(0.00)  LDD0021  [22]
WYneO
 Probe Info  		C733(0.00); C110(0.00); C972(0.00); C266(0.00)  LDD0022  [22]
aHNE
 Probe Info  		N.A.  LDD0001  [22]
1d-yne
 Probe Info  		N.A.  LDD0356  [25]
Compound 10
 Probe Info  		C1057(0.00); C110(0.00); C420(0.00); C473(0.00)  LDD2216  [26]
Compound 11
 Probe Info  		N.A.  LDD2213  [26]
ENE
 Probe Info  		C348(0.00); C1057(0.00); C972(0.00); C110(0.00)  LDD0006  [22]
IPM
 Probe Info  		C733(0.00); C110(0.00); C972(0.00); C473(0.00)  LDD0005  [22]
PF-06672131
 Probe Info  		N.A.  LDD0017  [27]
PPMS
 Probe Info  		N.A.  LDD0008  [22]
VSF
 Probe Info  		C110(0.00); C972(0.00)  LDD0007  [22]
Ox-W18
 Probe Info  		N.A.  LDD2175  [28]
1c-yne
 Probe Info  		K693(0.00); K712(0.00); K441(0.00); K617(0.00)  LDD0228  [25]
Acrolein
 Probe Info  		C972(0.00); C473(0.00); C180(0.00); C733(0.00)  LDD0217  [29]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [29]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [29]
Methacrolein
 Probe Info  		C473(0.00); C972(0.00); C420(0.00); C110(0.00)  LDD0218  [29]
W1
 Probe Info  		C915(0.00); C733(0.00); C110(0.00); C972(0.00)  LDD0236  [30]
AOyne
 Probe Info  		9.70  LDD0443  [31]
NAIA_5
 Probe Info  		C972(0.00); C986(0.00); C560(0.00); C389(0.00)  LDD2223  [24]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		14.43  LDD0475  [32]
FFF probe14
 Probe Info  		12.64  LDD0477  [32]
FFF probe2
 Probe Info  		5.54  LDD0463  [32]
FFF probe3
 Probe Info  		6.22  LDD0465  [32]
JN0003
 Probe Info  		12.07  LDD0469  [32]
STS-1
 Probe Info  		4.60  LDD0136  [33]
STS-2
 Probe Info  		8.20  LDD0138  [33]
VE-P
 Probe Info  		N.A.  LDD0396  [34]
DA-2
 Probe Info  		N.A.  LDD0071  [35]
OEA-DA
 Probe Info  		4.98  LDD0046  [36]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C972(0.53); C733(0.58); C348(0.46); C180(0.44)  LDD2142  [37]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C972(0.71); C733(0.85); C348(0.71); C180(0.80)  LDD2112  [37]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C972(1.10); C733(0.71); C348(0.66); C180(0.64)  LDD2095  [37]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C972(0.91); C733(0.90); C348(0.90); C180(1.01)  LDD2130  [37]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C972(1.00); C733(1.32); C348(0.84); C180(1.11)  LDD2117  [37]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C972(1.29); C733(1.47); C348(1.01); C180(1.20)  LDD2152  [37]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C733(1.07); C348(1.07); C180(1.17); C110(1.12)  LDD2103  [37]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C348(0.55); C180(0.50); C110(0.90); C420(0.40)  LDD2132  [37]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C972(0.64); C733(0.68); C348(0.75); C180(0.83)  LDD2131  [37]
 LDCM0025  4SU-RNA DM93 C229(2.03); C915(2.33); C886(2.84)  LDD0170  [12]
 LDCM0026  4SU-RNA+native RNA HEK-293T C784(4.71); C473(3.52); C229(20.00); C915(3.48)  LDD0169  [12]
 LDCM0214  AC1 HEK-293T C1057(1.02); C180(1.01); C266(0.87); C348(0.98)  LDD1507  [38]
 LDCM0215  AC10 HEK-293T C1057(1.00); C180(0.99); C266(0.94); C348(0.98)  LDD1508  [38]
 LDCM0226  AC11 HEK-293T C1057(0.99); C180(1.06); C266(0.94); C348(0.92)  LDD1509  [38]
 LDCM0237  AC12 HEK-293T C1057(1.06); C180(0.98); C266(0.90); C348(0.92)  LDD1510  [38]
 LDCM0259  AC14 HEK-293T C1057(0.98); C180(1.02); C266(0.93); C348(0.93)  LDD1512  [38]
 LDCM0270  AC15 HEK-293T C1057(0.94); C180(1.04); C266(0.91); C348(0.90)  LDD1513  [38]
 LDCM0276  AC17 HEK-293T C1057(1.06); C180(1.04); C266(0.91); C348(1.04)  LDD1515  [38]
 LDCM0277  AC18 HEK-293T C1057(1.00); C180(0.95); C266(0.97); C348(1.06)  LDD1516  [38]
 LDCM0278  AC19 HEK-293T C1057(1.19); C180(0.88); C266(0.88); C348(1.26)  LDD1517  [38]
 LDCM0279  AC2 HEK-293T C1057(0.96); C180(0.95); C266(0.96); C348(0.95)  LDD1518  [38]
 LDCM0280  AC20 HEK-293T C1057(1.04); C180(1.02); C266(0.99); C348(0.99)  LDD1519  [38]
 LDCM0281  AC21 HEK-293T C1057(1.00); C180(0.95); C266(0.93); C348(0.99)  LDD1520  [38]
 LDCM0282  AC22 HEK-293T C1057(1.00); C180(1.02); C266(0.93); C348(1.00)  LDD1521  [38]
 LDCM0283  AC23 HEK-293T C1057(0.94); C180(1.02); C266(0.97); C348(0.95)  LDD1522  [38]
 LDCM0284  AC24 HEK-293T C1057(0.95); C266(1.00); C348(1.00); C972(1.01)  LDD1523  [38]
 LDCM0285  AC25 HEK-293T C1057(1.02); C180(1.02); C266(0.93); C348(1.02)  LDD1524  [38]
 LDCM0286  AC26 HEK-293T C1057(1.03); C180(0.98); C266(0.98); C348(0.99)  LDD1525  [38]
 LDCM0287  AC27 HEK-293T C1057(1.04); C180(0.97); C266(1.04); C348(1.04)  LDD1526  [38]
 LDCM0288  AC28 HEK-293T C1057(1.00); C180(1.04); C266(0.95); C348(0.97)  LDD1527  [38]
 LDCM0289  AC29 HEK-293T C1057(0.99); C180(1.02); C266(0.95); C348(1.00)  LDD1528  [38]
 LDCM0290  AC3 HEK-293T C1057(1.01); C180(0.96); C266(0.94); C348(0.95)  LDD1529  [38]
 LDCM0291  AC30 HEK-293T C1057(1.01); C180(1.01); C266(1.02); C348(0.99)  LDD1530  [38]
 LDCM0292  AC31 HEK-293T C1057(0.97); C180(0.98); C266(0.99); C348(0.96)  LDD1531  [38]
 LDCM0293  AC32 HEK-293T C1057(0.94); C266(1.00); C348(1.03); C972(0.98)  LDD1532  [38]
 LDCM0294  AC33 HEK-293T C1057(0.94); C180(1.02); C266(0.82); C348(1.00)  LDD1533  [38]
 LDCM0295  AC34 HEK-293T C1057(0.97); C180(1.00); C266(0.97); C348(0.93)  LDD1534  [38]
 LDCM0296  AC35 HEK-293T C1057(0.97); C180(1.03); C266(0.98); C348(0.90)  LDD1535  [38]
 LDCM0297  AC36 HEK-293T C1057(1.02); C180(1.01); C266(0.89); C348(0.89)  LDD1536  [38]
 LDCM0298  AC37 HEK-293T C1057(0.88); C180(1.07); C266(0.97); C348(0.87)  LDD1537  [38]
 LDCM0299  AC38 HEK-293T C1057(0.90); C180(1.09); C266(0.96); C348(0.91)  LDD1538  [38]
 LDCM0300  AC39 HEK-293T C1057(0.84); C180(0.99); C266(0.90); C348(0.87)  LDD1539  [38]
 LDCM0301  AC4 HEK-293T C1057(1.07); C180(0.96); C266(0.94); C348(0.88)  LDD1540  [38]
 LDCM0302  AC40 HEK-293T C1057(0.87); C266(0.97); C348(0.96); C972(0.90)  LDD1541  [38]
 LDCM0303  AC41 HEK-293T C1057(0.91); C180(1.01); C266(0.98); C348(0.99)  LDD1542  [38]
 LDCM0304  AC42 HEK-293T C1057(1.02); C180(1.03); C266(1.00); C348(1.01)  LDD1543  [38]
 LDCM0305  AC43 HEK-293T C1057(0.98); C180(1.03); C266(0.96); C348(0.92)  LDD1544  [38]
 LDCM0306  AC44 HEK-293T C1057(1.03); C180(0.98); C266(0.94); C348(0.93)  LDD1545  [38]
 LDCM0307  AC45 HEK-293T C1057(0.92); C180(0.98); C266(0.96); C348(0.95)  LDD1546  [38]
 LDCM0308  AC46 HEK-293T C1057(0.99); C180(1.08); C266(1.00); C348(0.96)  LDD1547  [38]
 LDCM0309  AC47 HEK-293T C1057(0.87); C180(1.01); C266(0.92); C348(0.88)  LDD1548  [38]
 LDCM0310  AC48 HEK-293T C1057(0.90); C266(1.03); C348(0.94); C972(0.88)  LDD1549  [38]
 LDCM0311  AC49 HEK-293T C1057(0.98); C180(0.86); C266(0.90); C348(0.99)  LDD1550  [38]
 LDCM0312  AC5 HEK-293T C1057(0.91); C180(1.02); C266(0.95); C348(0.94)  LDD1551  [38]
 LDCM0313  AC50 HEK-293T C1057(0.93); C180(0.99); C266(1.01); C348(0.95)  LDD1552  [38]
 LDCM0314  AC51 HEK-293T C1057(0.97); C180(1.04); C266(0.94); C348(0.95)  LDD1553  [38]
 LDCM0315  AC52 HEK-293T C1057(1.07); C180(0.97); C266(0.95); C348(0.91)  LDD1554  [38]
 LDCM0316  AC53 HEK-293T C1057(0.95); C180(0.94); C266(0.96); C348(0.93)  LDD1555  [38]
 LDCM0317  AC54 HEK-293T C1057(0.96); C180(0.93); C266(0.98); C348(0.93)  LDD1556  [38]
 LDCM0318  AC55 HEK-293T C1057(0.94); C180(0.93); C266(0.95); C348(0.89)  LDD1557  [38]
 LDCM0319  AC56 HEK-293T C1057(0.90); C266(0.99); C348(0.98); C972(0.85)  LDD1558  [38]
 LDCM0320  AC57 HEK-293T C1057(1.02); C180(0.92); C266(0.99); C348(1.04)  LDD1559  [38]
 LDCM0321  AC58 HEK-293T C1057(0.94); C180(0.91); C266(0.94); C348(0.95)  LDD1560  [38]
 LDCM0322  AC59 HEK-293T C1057(0.94); C180(0.98); C266(0.95); C348(0.94)  LDD1561  [38]
 LDCM0323  AC6 HEK-293T C1057(0.99); C180(0.96); C266(0.98); C348(0.94)  LDD1562  [38]
 LDCM0324  AC60 HEK-293T C1057(1.06); C180(0.97); C266(0.90); C348(0.99)  LDD1563  [38]
 LDCM0325  AC61 HEK-293T C1057(0.96); C180(0.90); C266(0.94); C348(0.95)  LDD1564  [38]
 LDCM0326  AC62 HEK-293T C1057(0.99); C180(1.02); C266(0.98); C348(1.00)  LDD1565  [38]
 LDCM0327  AC63 HEK-293T C1057(0.93); C180(0.94); C266(0.98); C348(0.94)  LDD1566  [38]
 LDCM0328  AC64 HEK-293T C1057(0.92); C266(0.99); C348(0.99); C972(0.94)  LDD1567  [38]
 LDCM0334  AC7 HEK-293T C1057(0.95); C180(1.02); C266(0.94); C348(0.87)  LDD1568  [38]
 LDCM0345  AC8 HEK-293T C1057(0.92); C266(0.98); C348(0.96); C972(0.88)  LDD1569  [38]
 LDCM0545  Acetamide MDA-MB-231 C972(0.48); C733(1.04); C348(0.60); C180(0.72)  LDD2138  [37]
 LDCM0520  AKOS000195272 MDA-MB-231 C972(0.77); C733(0.80); C348(0.90); C180(0.86)  LDD2113  [37]
 LDCM0248  AKOS034007472 HEK-293T C1057(0.99); C180(0.95); C266(0.97); C348(0.94)  LDD1511  [38]
 LDCM0356  AKOS034007680 HEK-293T C1057(0.97); C180(0.94); C266(0.95); C348(0.99)  LDD1570  [38]
 LDCM0275  AKOS034007705 HEK-293T C1057(0.97); C266(1.02); C348(0.99); C972(0.96)  LDD1514  [38]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0405  [1]
 LDCM0102  BDHI 8 Jurkat C682(4.36); C687(4.36); C560(4.44)  LDD0204  [14]
 LDCM0498  BS-3668 MDA-MB-231 C972(0.67); C733(0.85); C348(0.54); C180(0.99)  LDD2091  [37]
 LDCM0630  CCW28-3 231MFP C915(1.14)  LDD2214  [39]
 LDCM0108  Chloroacetamide HeLa C473(0.00); C180(0.00); C972(0.00); C420(0.00)  LDD0222  [29]
 LDCM0632  CL-Sc Hep-G2 C110(20.00); C733(1.08); C420(0.85); C682(0.79)  LDD2227  [24]
 LDCM0367  CL1 HEK-293T C1057(0.99); C180(1.04); C266(0.93); C348(1.00)  LDD1571  [38]
 LDCM0368  CL10 HEK-293T C1057(2.00); C180(1.17); C266(1.21); C348(1.74)  LDD1572  [38]
 LDCM0369  CL100 HEK-293T C1057(1.06); C180(0.84); C266(0.82); C348(1.06)  LDD1573  [38]
 LDCM0370  CL101 HEK-293T C1057(0.98); C180(1.03); C266(0.93); C348(0.98)  LDD1574  [38]
 LDCM0371  CL102 HEK-293T C180(0.91); C266(0.88); C348(1.16); C972(0.98)  LDD1575  [38]
 LDCM0372  CL103 HEK-293T C1057(0.99); C180(1.01); C266(0.89); C348(0.99)  LDD1576  [38]
 LDCM0373  CL104 HEK-293T C1057(1.02); C180(0.92); C266(0.84); C348(0.98)  LDD1577  [38]
 LDCM0374  CL105 HEK-293T C1057(1.03); C180(0.94); C266(0.99); C348(1.05)  LDD1578  [38]
 LDCM0375  CL106 HEK-293T C180(0.91); C266(0.79); C348(1.05); C972(0.98)  LDD1579  [38]
 LDCM0376  CL107 HEK-293T C1057(0.95); C180(0.96); C266(0.88); C348(1.01)  LDD1580  [38]
 LDCM0377  CL108 HEK-293T C1057(0.95); C180(0.99); C266(0.76); C348(0.99)  LDD1581  [38]
 LDCM0378  CL109 HEK-293T C1057(1.11); C180(1.03); C266(0.96); C348(1.13)  LDD1582  [38]
 LDCM0379  CL11 HEK-293T C1057(0.81); C180(1.28); C266(1.05); C348(0.94)  LDD1583  [38]
 LDCM0380  CL110 HEK-293T C180(0.96); C266(0.86); C348(1.38); C972(1.03)  LDD1584  [38]
 LDCM0381  CL111 HEK-293T C1057(1.08); C180(0.86); C266(0.96); C348(1.11)  LDD1585  [38]
 LDCM0382  CL112 HEK-293T C1057(0.98); C180(0.92); C266(0.82); C348(1.03)  LDD1586  [38]
 LDCM0383  CL113 HEK-293T C1057(0.90); C180(1.05); C266(0.90); C348(0.90)  LDD1587  [38]
 LDCM0384  CL114 HEK-293T C180(0.98); C266(0.89); C348(1.27); C972(1.01)  LDD1588  [38]
 LDCM0385  CL115 HEK-293T C1057(0.91); C180(1.03); C266(0.91); C348(0.92)  LDD1589  [38]
 LDCM0386  CL116 HEK-293T C1057(0.93); C180(0.89); C266(0.76); C348(0.94)  LDD1590  [38]
 LDCM0387  CL117 HEK-293T C1057(0.91); C180(1.03); C266(0.92); C348(0.92)  LDD1591  [38]
 LDCM0388  CL118 HEK-293T C180(0.92); C266(0.95); C348(0.96); C972(0.93)  LDD1592  [38]
 LDCM0389  CL119 HEK-293T C1057(0.93); C180(0.95); C266(0.82); C348(0.93)  LDD1593  [38]
 LDCM0390  CL12 HEK-293T C1057(0.81); C266(1.07); C348(0.95); C972(0.91)  LDD1594  [38]
 LDCM0391  CL120 HEK-293T C1057(0.94); C180(0.91); C266(0.77); C348(0.92)  LDD1595  [38]
 LDCM0392  CL121 HEK-293T C1057(0.95); C180(0.99); C266(0.93); C348(0.90)  LDD1596  [38]
 LDCM0393  CL122 HEK-293T C180(0.89); C266(0.89); C348(1.00); C972(0.98)  LDD1597  [38]
 LDCM0394  CL123 HEK-293T C1057(1.90); C180(0.98); C266(0.98); C348(1.45)  LDD1598  [38]
 LDCM0395  CL124 HEK-293T C1057(1.26); C180(0.89); C266(0.77); C348(1.06)  LDD1599  [38]
 LDCM0396  CL125 HEK-293T C1057(0.94); C180(0.92); C266(1.01); C348(1.00)  LDD1600  [38]
 LDCM0397  CL126 HEK-293T C180(0.85); C266(0.93); C348(1.03); C972(0.99)  LDD1601  [38]
 LDCM0398  CL127 HEK-293T C1057(0.96); C180(0.91); C266(0.92); C348(0.99)  LDD1602  [38]
 LDCM0399  CL128 HEK-293T C1057(0.97); C180(0.79); C266(0.87); C348(0.97)  LDD1603  [38]
 LDCM0400  CL13 HEK-293T C1057(0.97); C180(1.01); C266(0.87); C348(0.89)  LDD1604  [38]
 LDCM0401  CL14 HEK-293T C180(0.99); C266(0.79); C348(0.84); C972(0.98)  LDD1605  [38]
 LDCM0402  CL15 HEK-293T C1057(2.06); C180(0.98); C266(0.81); C348(1.48)  LDD1606  [38]
 LDCM0403  CL16 HEK-293T C1057(0.90); C180(0.97); C266(0.72); C348(0.92)  LDD1607  [38]
 LDCM0404  CL17 HEK-293T C1057(2.20); C180(0.99); C266(0.86); C348(1.50)  LDD1608  [38]
 LDCM0405  CL18 HEK-293T C1057(1.02); C180(0.95); C266(0.97); C348(0.88)  LDD1609  [38]
 LDCM0406  CL19 HEK-293T C1057(1.03); C180(1.03); C266(0.95); C348(0.91)  LDD1610  [38]
 LDCM0407  CL2 HEK-293T C180(0.96); C266(0.77); C348(0.86); C972(1.03)  LDD1611  [38]
 LDCM0408  CL20 HEK-293T C1057(0.91); C180(1.05); C266(0.92); C348(0.77)  LDD1612  [38]
 LDCM0409  CL21 HEK-293T C1057(1.24); C180(1.02); C266(1.01); C348(1.34)  LDD1613  [38]
 LDCM0410  CL22 HEK-293T C1057(0.91); C180(1.11); C266(1.02); C348(0.92)  LDD1614  [38]
 LDCM0411  CL23 HEK-293T C1057(0.71); C180(1.46); C266(1.01); C348(0.81)  LDD1615  [38]
 LDCM0412  CL24 HEK-293T C1057(0.69); C266(1.17); C348(0.90); C972(0.91)  LDD1616  [38]
 LDCM0413  CL25 HEK-293T C1057(1.37); C180(1.05); C266(1.11); C348(1.30)  LDD1617  [38]
 LDCM0414  CL26 HEK-293T C180(0.97); C266(0.89); C348(0.92); C972(0.95)  LDD1618  [38]
 LDCM0415  CL27 HEK-293T C1057(0.98); C180(0.98); C266(0.93); C348(0.95)  LDD1619  [38]
 LDCM0416  CL28 HEK-293T C1057(0.99); C180(0.95); C266(0.84); C348(1.02)  LDD1620  [38]
 LDCM0417  CL29 HEK-293T C1057(0.97); C180(0.96); C266(0.92); C348(0.93)  LDD1621  [38]
 LDCM0418  CL3 HEK-293T C1057(1.17); C180(1.04); C266(0.85); C348(1.00)  LDD1622  [38]
 LDCM0419  CL30 HEK-293T C1057(0.99); C180(1.08); C266(0.90); C348(0.94)  LDD1623  [38]
 LDCM0420  CL31 HEK-293T C1057(1.07); C180(0.93); C266(0.95); C348(1.02)  LDD1624  [38]
 LDCM0421  CL32 HEK-293T C1057(0.96); C180(1.00); C266(0.89); C348(0.85)  LDD1625  [38]
 LDCM0422  CL33 HEK-293T C1057(2.00); C180(1.01); C266(1.15); C348(2.36)  LDD1626  [38]
 LDCM0423  CL34 HEK-293T C1057(0.97); C180(1.13); C266(1.08); C348(1.08)  LDD1627  [38]
 LDCM0424  CL35 HEK-293T C1057(0.70); C180(1.33); C266(1.05); C348(0.89)  LDD1628  [38]
 LDCM0425  CL36 HEK-293T C1057(0.66); C266(1.21); C348(1.00); C972(0.89)  LDD1629  [38]
 LDCM0426  CL37 HEK-293T C1057(1.06); C180(0.99); C266(0.94); C348(1.00)  LDD1630  [38]
 LDCM0428  CL39 HEK-293T C1057(1.00); C180(1.10); C266(0.87); C348(0.98)  LDD1632  [38]
 LDCM0429  CL4 HEK-293T C1057(1.11); C180(1.01); C266(0.74); C348(1.05)  LDD1633  [38]
 LDCM0430  CL40 HEK-293T C1057(1.00); C180(0.95); C266(0.93); C348(0.91)  LDD1634  [38]
 LDCM0431  CL41 HEK-293T C1057(1.43); C180(1.02); C266(0.91); C348(1.11)  LDD1635  [38]
 LDCM0432  CL42 HEK-293T C1057(1.04); C180(0.96); C266(0.90); C348(1.01)  LDD1636  [38]
 LDCM0433  CL43 HEK-293T C1057(1.03); C180(1.12); C266(0.99); C348(0.95)  LDD1637  [38]
 LDCM0434  CL44 HEK-293T C1057(0.96); C180(1.03); C266(0.96); C348(0.93)  LDD1638  [38]
 LDCM0435  CL45 HEK-293T C1057(0.99); C180(0.96); C266(1.06); C348(1.10)  LDD1639  [38]
 LDCM0436  CL46 HEK-293T C1057(0.93); C180(1.18); C266(1.11); C348(1.04)  LDD1640  [38]
 LDCM0437  CL47 HEK-293T C1057(0.74); C180(1.30); C266(1.07); C348(0.94)  LDD1641  [38]
 LDCM0438  CL48 HEK-293T C1057(0.68); C266(1.15); C348(1.03); C972(0.95)  LDD1642  [38]
 LDCM0439  CL49 HEK-293T C1057(0.97); C180(1.01); C266(0.94); C348(0.87)  LDD1643  [38]
 LDCM0440  CL5 HEK-293T C1057(1.00); C180(0.99); C266(0.88); C348(0.93)  LDD1644  [38]
 LDCM0441  CL50 HEK-293T C180(0.96); C266(0.83); C348(0.98); C972(0.90)  LDD1645  [38]
 LDCM0443  CL52 HEK-293T C1057(0.95); C180(1.00); C266(0.73); C348(0.91)  LDD1646  [38]
 LDCM0444  CL53 HEK-293T C1057(1.96); C180(1.05); C266(0.87); C348(1.38)  LDD1647  [38]
 LDCM0445  CL54 HEK-293T C1057(2.19); C180(0.97); C266(0.98); C348(1.75)  LDD1648  [38]
 LDCM0446  CL55 HEK-293T C1057(1.01); C180(1.09); C266(0.98); C348(0.87)  LDD1649  [38]
 LDCM0447  CL56 HEK-293T C1057(0.88); C180(1.04); C266(0.95); C348(0.78)  LDD1650  [38]
 LDCM0448  CL57 HEK-293T C1057(0.97); C180(0.94); C266(0.91); C348(1.15)  LDD1651  [38]
 LDCM0449  CL58 HEK-293T C1057(0.90); C180(1.09); C266(1.01); C348(0.95)  LDD1652  [38]
 LDCM0450  CL59 HEK-293T C1057(0.71); C180(1.29); C266(1.11); C348(0.85)  LDD1653  [38]
 LDCM0451  CL6 HEK-293T C1057(1.53); C180(1.01); C266(1.02); C348(1.22)  LDD1654  [38]
 LDCM0452  CL60 HEK-293T C1057(0.63); C266(1.16); C348(0.97); C972(0.86)  LDD1655  [38]
 LDCM0453  CL61 HEK-293T C1057(0.92); C180(1.03); C266(0.99); C348(0.88)  LDD1656  [38]
 LDCM0454  CL62 HEK-293T C180(0.94); C266(0.88); C348(0.88); C972(0.93)  LDD1657  [38]
 LDCM0455  CL63 HEK-293T C1057(0.94); C180(0.90); C266(0.95); C348(0.88)  LDD1658  [38]
 LDCM0456  CL64 HEK-293T C1057(1.37); C180(0.90); C266(0.76); C348(1.19)  LDD1659  [38]
 LDCM0457  CL65 HEK-293T C1057(1.00); C180(1.01); C266(0.89); C348(0.92)  LDD1660  [38]
 LDCM0458  CL66 HEK-293T C1057(1.02); C180(0.97); C266(0.95); C348(0.96)  LDD1661  [38]
 LDCM0459  CL67 HEK-293T C1057(1.01); C180(1.13); C266(0.96); C348(0.91)  LDD1662  [38]
 LDCM0460  CL68 HEK-293T C1057(0.88); C180(1.07); C266(0.97); C348(0.90)  LDD1663  [38]
 LDCM0461  CL69 HEK-293T C1057(0.95); C180(0.93); C266(1.00); C348(1.02)  LDD1664  [38]
 LDCM0462  CL7 HEK-293T C1057(1.06); C180(1.02); C266(0.89); C348(0.95)  LDD1665  [38]
 LDCM0463  CL70 HEK-293T C1057(1.00); C180(1.11); C266(1.02); C348(0.97)  LDD1666  [38]
 LDCM0464  CL71 HEK-293T C1057(0.76); C180(1.31); C266(1.05); C348(0.85)  LDD1667  [38]
 LDCM0465  CL72 HEK-293T C1057(0.72); C266(1.14); C348(0.94); C972(0.94)  LDD1668  [38]
 LDCM0466  CL73 HEK-293T C1057(1.08); C180(0.92); C266(0.91); C348(0.99)  LDD1669  [38]
 LDCM0467  CL74 HEK-293T C180(0.86); C266(0.85); C348(0.89); C972(0.98)  LDD1670  [38]
 LDCM0469  CL76 HEK-293T C1057(0.95); C180(0.90); C266(0.82); C348(0.96)  LDD1672  [38]
 LDCM0470  CL77 HEK-293T C1057(1.34); C180(0.98); C266(0.88); C348(1.19)  LDD1673  [38]
 LDCM0471  CL78 HEK-293T C1057(0.94); C180(0.97); C266(0.94); C348(0.94)  LDD1674  [38]
 LDCM0472  CL79 HEK-293T C1057(1.01); C180(1.01); C266(0.96); C348(0.93)  LDD1675  [38]
 LDCM0473  CL8 HEK-293T C1057(10.76); C180(1.46); C266(1.39); C348(7.50)  LDD1676  [38]
 LDCM0474  CL80 HEK-293T C1057(0.88); C180(1.02); C266(0.96); C348(0.87)  LDD1677  [38]
 LDCM0475  CL81 HEK-293T C1057(0.87); C180(0.98); C266(1.01); C348(0.95)  LDD1678  [38]
 LDCM0476  CL82 HEK-293T C1057(0.94); C180(1.12); C266(1.05); C348(0.95)  LDD1679  [38]
 LDCM0477  CL83 HEK-293T C1057(0.95); C180(1.28); C266(1.02); C348(0.97)  LDD1680  [38]
 LDCM0478  CL84 HEK-293T C1057(1.00); C266(1.12); C348(1.12); C972(0.96)  LDD1681  [38]
 LDCM0479  CL85 HEK-293T C1057(0.91); C180(0.92); C266(0.92); C348(0.86)  LDD1682  [38]
 LDCM0480  CL86 HEK-293T C180(0.77); C266(0.87); C348(0.92); C972(0.94)  LDD1683  [38]
 LDCM0481  CL87 HEK-293T C1057(0.96); C180(0.88); C266(0.89); C348(0.93)  LDD1684  [38]
 LDCM0482  CL88 HEK-293T C1057(0.94); C180(0.82); C266(0.78); C348(0.89)  LDD1685  [38]
 LDCM0483  CL89 HEK-293T C1057(1.03); C180(0.85); C266(0.92); C348(0.95)  LDD1686  [38]
 LDCM0484  CL9 HEK-293T C1057(0.86); C180(1.06); C266(1.00); C348(0.93)  LDD1687  [38]
 LDCM0485  CL90 HEK-293T C1057(3.53); C180(0.92); C266(1.14); C348(2.65)  LDD1688  [38]
 LDCM0486  CL91 HEK-293T C1057(0.96); C180(0.92); C266(1.01); C348(0.87)  LDD1689  [38]
 LDCM0487  CL92 HEK-293T C1057(1.26); C180(0.95); C266(0.92); C348(1.03)  LDD1690  [38]
 LDCM0488  CL93 HEK-293T C1057(1.14); C180(0.91); C266(1.00); C348(1.19)  LDD1691  [38]
 LDCM0489  CL94 HEK-293T C1057(0.99); C180(1.05); C266(1.02); C348(0.93)  LDD1692  [38]
 LDCM0490  CL95 HEK-293T C1057(2.92); C180(1.02); C266(1.24); C348(3.02)  LDD1693  [38]
 LDCM0491  CL96 HEK-293T C1057(1.21); C266(1.06); C348(1.14); C972(0.97)  LDD1694  [38]
 LDCM0492  CL97 HEK-293T C1057(1.22); C180(1.04); C266(0.95); C348(1.13)  LDD1695  [38]
 LDCM0493  CL98 HEK-293T C180(1.00); C266(0.84); C348(1.04); C972(0.95)  LDD1696  [38]
 LDCM0494  CL99 HEK-293T C1057(0.95); C180(0.95); C266(0.88); C348(0.94)  LDD1697  [38]
 LDCM0634  CY-0357 Hep-G2 C1057(2.22)  LDD2228  [24]
 LDCM0495  E2913 HEK-293T C1057(0.84); C180(0.99); C266(0.88); C348(0.84)  LDD1698  [38]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C733(6.17); C972(4.06); C420(3.78); C110(3.55)  LDD1702  [37]
 LDCM0031  Epigallocatechin gallate HEK-293T 8.89  LDD0183  [11]
 LDCM0175  Ethacrynic acid HeLa C733(0.75)  LDD2210  [13]
 LDCM0625  F8 Ramos C1057(1.73); C348(0.63); C110(1.10); C266(1.05)  LDD2187  [40]
 LDCM0572  Fragment10 Ramos C1057(0.82); C348(1.40); C110(0.67); C266(0.58)  LDD2189  [40]
 LDCM0573  Fragment11 Ramos C1057(0.10); C348(0.04); C110(0.01); C266(3.00)  LDD2190  [40]
 LDCM0574  Fragment12 Ramos C1057(0.88); C348(1.54); C110(0.93); C266(0.58)  LDD2191  [40]
 LDCM0575  Fragment13 Ramos C1057(0.95); C348(1.10); C110(0.95); C266(0.90)  LDD2192  [40]
 LDCM0576  Fragment14 Ramos C1057(1.65); C348(1.07); C110(1.77); C266(1.74)  LDD2193  [40]
 LDCM0579  Fragment20 Ramos C1057(1.10); C348(1.17); C110(0.87); C266(0.53)  LDD2194  [40]
 LDCM0580  Fragment21 Ramos C1057(0.60); C348(0.63); C110(0.85); C266(0.62)  LDD2195  [40]
 LDCM0582  Fragment23 Ramos C1057(1.35); C348(0.82); C110(1.31); C266(1.29)  LDD2196  [40]
 LDCM0578  Fragment27 Ramos C1057(1.23); C348(0.81); C110(1.01); C266(0.81)  LDD2197  [40]
 LDCM0586  Fragment28 Ramos C1057(0.52); C348(0.78); C110(0.95); C266(0.53)  LDD2198  [40]
 LDCM0588  Fragment30 Ramos C1057(0.71); C348(1.12); C110(0.79); C266(0.78)  LDD2199  [40]
 LDCM0589  Fragment31 Ramos C1057(1.26); C348(1.05); C110(1.02); C266(0.94)  LDD2200  [40]
 LDCM0590  Fragment32 Ramos C1057(1.02); C348(1.26); C110(0.72); C266(0.53)  LDD2201  [40]
 LDCM0468  Fragment33 HEK-293T C1057(0.98); C180(0.93); C266(0.90); C348(0.93)  LDD1671  [38]
 LDCM0596  Fragment38 Ramos C1057(0.89); C348(1.34); C110(1.05); C266(1.39)  LDD2203  [40]
 LDCM0566  Fragment4 Ramos C1057(1.26); C348(1.11); C110(1.63); C266(0.68)  LDD2184  [40]
 LDCM0427  Fragment51 HEK-293T C180(0.97); C266(0.87); C348(0.94); C972(1.02)  LDD1631  [38]
 LDCM0610  Fragment52 Ramos C1057(0.85); C348(1.30); C110(0.98); C266(0.96)  LDD2204  [40]
 LDCM0614  Fragment56 Ramos C1057(1.17); C348(1.30); C110(0.86); C266(1.18)  LDD2205  [40]
 LDCM0569  Fragment7 Ramos C1057(1.07); C348(1.39); C110(1.33); C266(0.78)  LDD2186  [40]
 LDCM0571  Fragment9 Ramos C1057(0.83); C348(1.22); C110(1.01); C266(0.66)  LDD2188  [40]
 LDCM0116  HHS-0101 DM93 Y905(0.82)  LDD0264  [15]
 LDCM0117  HHS-0201 DM93 Y905(0.91)  LDD0265  [15]
 LDCM0118  HHS-0301 DM93 Y169(0.05); Y905(1.05)  LDD0266  [15]
 LDCM0119  HHS-0401 DM93 Y905(0.91)  LDD0267  [15]
 LDCM0120  HHS-0701 DM93 Y905(0.91)  LDD0268  [15]
 LDCM0015  HNE MDA-MB-231 C972(0.81)  LDD0346  [40]
 LDCM0107  IAA HeLa H771(0.00); H540(0.00); C972(0.00); C180(0.00)  LDD0221  [29]
 LDCM0179  JZ128 PC-3 C972(0.00); C682(0.00); C473(0.00); C1078(0.00)  LDD0462  [9]
 LDCM0022  KB02 HEK-293T C1057(0.73); C348(0.85); C180(1.02); C266(0.96)  LDD1492  [38]
 LDCM0023  KB03 Jurkat C473(8.60); C110(4.75)  LDD0209  [14]
 LDCM0024  KB05 COLO792 C284(2.88); C491(2.21)  LDD3310  [41]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C972(1.07); C348(1.39); C180(0.84); C110(1.01)  LDD2102  [37]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C972(0.68); C733(0.94); C348(0.61); C180(1.15)  LDD2121  [37]
 LDCM0109  NEM HeLa H461(0.00); H847(0.00); H540(0.00); H362(0.00)  LDD0223  [29]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C972(0.81); C733(0.99); C348(0.64); C180(1.12)  LDD2089  [37]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C972(0.83); C348(0.96); C180(1.07); C110(1.03)  LDD2090  [37]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C972(1.00); C733(1.16); C348(1.13); C180(1.11)  LDD2092  [37]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C972(1.01); C733(1.28); C348(1.09); C180(1.27)  LDD2093  [37]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C972(2.13); C733(1.58); C348(1.57); C180(1.77)  LDD2094  [37]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C972(0.17); C348(0.83); C180(0.06); C110(0.26)  LDD2096  [37]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C972(1.05); C733(0.98); C348(0.84); C180(0.95)  LDD2097  [37]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C972(1.10); C733(0.97); C348(0.72); C180(0.88)  LDD2098  [37]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C972(0.90); C733(1.12); C348(0.93); C180(1.37)  LDD2099  [37]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C972(0.56); C733(0.69); C348(0.65); C180(0.52)  LDD2100  [37]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C972(0.94); C733(0.90); C348(1.22); C180(0.95)  LDD2101  [37]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C972(0.62); C733(0.58); C348(0.62); C180(0.46)  LDD2104  [37]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C972(2.71); C733(1.34); C348(1.32); C180(1.48)  LDD2105  [37]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C972(0.66); C733(0.65); C180(0.42); C110(0.65)  LDD2106  [37]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C972(0.79); C733(0.86); C348(0.68); C180(0.98)  LDD2107  [37]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C972(0.67); C733(0.69); C348(0.46); C180(0.54)  LDD2108  [37]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C972(0.70); C733(0.62); C348(0.56); C180(0.65)  LDD2109  [37]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C972(0.76); C733(1.10); C180(0.58); C110(1.04)  LDD2110  [37]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C972(1.04); C733(1.27); C348(0.85); C180(1.25)  LDD2111  [37]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C733(0.65); C348(1.04); C180(0.58); C266(0.57)  LDD2114  [37]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C972(0.46); C733(0.47); C348(0.51); C180(0.44)  LDD2115  [37]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C972(0.73); C180(0.10); C110(0.60); C682(0.55)  LDD2116  [37]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C972(0.49); C733(0.12); C348(0.32); C110(0.43)  LDD2118  [37]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C972(2.03); C733(1.93); C348(1.96); C180(1.63)  LDD2119  [37]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C972(0.96); C348(0.82); C180(0.57); C110(0.90)  LDD2120  [37]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C733(0.11); C348(0.10); C180(0.12); C110(0.43)  LDD2122  [37]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C348(0.75); C180(1.08); C266(1.16); C110(0.86)  LDD2123  [37]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C110(0.44); C682(0.35); C687(0.85)  LDD2124  [37]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C972(0.83); C733(0.93); C348(0.73); C180(1.03)  LDD2125  [37]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C972(0.38); C348(0.08); C180(0.08); C110(0.31)  LDD2126  [37]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C972(0.99); C733(1.20); C348(0.81); C180(1.23)  LDD2127  [37]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C972(0.78); C348(0.93); C180(0.58); C110(1.47)  LDD2128  [37]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C972(1.21); C733(1.38); C348(0.87); C180(1.22)  LDD2129  [37]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C972(0.50); C733(0.54); C348(0.58); C180(0.52)  LDD2133  [37]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C733(0.52); C180(0.47); C110(0.59); C1057(0.53)  LDD2134  [37]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C972(0.98); C733(0.89); C348(0.85); C180(1.28)  LDD2135  [37]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C972(1.09); C733(1.42); C348(0.94); C180(1.49)  LDD2136  [37]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C972(1.23); C733(0.97); C348(0.72); C180(1.05)  LDD2137  [37]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C180(3.88); C733(3.41); C972(2.48); C1057(2.28)  LDD1700  [37]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C972(0.76); C733(1.02); C348(0.65); C180(1.08)  LDD2140  [37]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C972(0.66); C733(0.61); C348(0.42); C180(0.53)  LDD2141  [37]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C972(0.84); C348(0.91); C180(0.59); C110(0.98)  LDD2143  [37]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C972(2.22); C733(2.02); C348(2.15); C180(1.86)  LDD2144  [37]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C110(13.46)  LDD2145  [37]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C972(0.86); C733(1.00); C348(0.79); C180(1.07)  LDD2146  [37]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C972(2.60); C348(2.26); C110(2.77)  LDD2147  [37]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C972(0.97); C733(0.42); C348(0.40); C180(0.59)  LDD2148  [37]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C972(0.71); C180(0.07); C110(0.35); C687(0.90)  LDD2149  [37]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C972(0.62); C733(0.74); C348(0.48); C180(0.84)  LDD2150  [37]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C972(0.47); C733(0.24); C180(0.11); C110(0.44)  LDD2151  [37]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C972(1.29); C733(2.08); C180(2.25); C110(2.60)  LDD2153  [37]
 LDCM0627  NUDT7-COV-1 HEK-293T C972(1.42); C110(1.31); C944(1.27)  LDD2206  [42]
 LDCM0628  OTUB2-COV-1 HEK-293T C348(1.13); C266(0.87); C972(0.86); C110(0.78)  LDD2207  [42]
 LDCM0131  RA190 MM1.R C687(1.70); C110(1.66); C972(1.65)  LDD0304  [43]
 LDCM0003  Sulforaphane MCF-7 2.04  LDD0042  [10]
 LDCM0021  THZ1 HeLa S3 C733(1.08); C420(1.10); C944(1.02); C1078(0.98)  LDD0460  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein (GABARAP) ATG8 family O95166
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) ATG8 family Q9BXW4
Large ribosomal subunit protein uL30 (RPL7) Universal ribosomal protein uL30 family P18124
Adrenocortical dysplasia protein homolog (ACD) . Q96AP0

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
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Mass spectrometry data entry: PXD028270
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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10 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
11 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
14 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
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16 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
17 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
18 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
20 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
21 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD029255
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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Mass spectrometry data entry: PXD022279
27 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
28 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
29 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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31 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
32 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
33 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
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Mass spectrometry data entry: PXD007570
37 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
38 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
39 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
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Mass spectrometry data entry: PXD027578
41 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
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