Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name aHNE  Probe Info 
Probe concentration 50 uM
Criteria Qualitation: Labeling site identification
Quantitative Method
Isotope tag
In Vivo Experiment Model Model Type Living cell
Derived Tissue Colon
Disease Model Colon carcinoma [ICD-11:2B90]
Model Name Human colon carcinoma cells (RKO)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 71 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP07447  2',5'-phosphodiesterase 12 (PDE12) C119
 LDTP05782  26S proteasome non-ATPase regulatory subunit 2 (PSMD2) C459
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119
 LDTP04876  Actin, cytoplasmic 1 (ACTB) C272
 LDTP08826  Activating signal cointegrator 1 complex subunit 3 (ASCC3) C1315
 LDTP03242  Adenosylhomocysteinase (AHCY) C421
 LDTP04636  Adenylate kinase 2, mitochondrial (AK2) C40
 LDTP05982  ADP-ribosylation factor-related protein 1 (ARFRP1) C125
 LDTP05480  Amidophosphoribosyltransferase (PPAT) C100
 LDTP13527  Aspartyl aminopeptidase (DNPEP) C337
 LDTP04083  ATP-dependent DNA helicase Q1 (RECQL) C606
 LDTP12459  Baculoviral IAP repeat-containing protein 6 (BIRC6) C463
 LDTP02222  Bifunctional glutamate/proline--tRNA ligase (EPRS1) C92
 LDTP02222  Bifunctional glutamate/proline--tRNA ligase (EPRS1) C744
 LDTP02911  Calpain-2 catalytic subunit (CAPN2) C82
 LDTP03145  Catechol O-methyltransferase (COMT) C223
 LDTP12159  Cytochrome P450 3A43 (CYP3A43) C152
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369
 LDTP12539  DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) C130
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC) C1904
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC) C2342
 LDTP13087  Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) C67
 LDTP04690  Double-stranded RNA-specific adenosine deaminase (ADAR) C622
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C29
 LDTP00273  Dynamin-1-like protein (DNM1L) C505
 LDTP00950  Dynamin-like 120 kDa protein, mitochondrial (OPA1) C801
 LDTP01265  E3 ubiquitin-protein ligase MYCBP2 (MYCBP2) C1169
 LDTP12138  E3 ubiquitin-protein ligase SMURF2 (SMURF2) C47
 LDTP02672  Elongation factor 2 (EEF2) C41
 LDTP02672  Elongation factor 2 (EEF2) C728
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C130
 LDTP05312  Exosome complex component 10 (EXOSC10) C612
 LDTP04243  Fatty acid synthase (FASN) C1448
 LDTP04186  Glutamate--cysteine ligase regulatory subunit (GCLM) C35
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152
 LDTP02225  Heat shock protein HSP 90-alpha (HSP90AA1) C420
 LDTP03540  Heme oxygenase 2 (HMOX2) C265
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) C333
 LDTP03764  Myosin-9 (MYH9) C91
 LDTP03764  Myosin-9 (MYH9) C1379
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) C195
 LDTP05503  Peroxiredoxin-1 (PRDX1) C173
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) C199
 LDTP04203  Phosphatidylserine synthase 1 (PTDSS1) C419
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126
 LDTP09961  Probable ubiquitin carboxyl-terminal hydrolase FAF-X (USP9X) C842
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58
 LDTP13492  Protein argonaute-2 (AGO2) C188
 LDTP15370  Pseudouridylate synthase RPUSD2 (RPUSD2) C246
 LDTP02002  RAF proto-oncogene serine/threonine-protein kinase (RAF1) C637
 LDTP05037  Ras-related C3 botulinum toxin substrate 1 (RAC1) C105
 LDTP04901  Ras-related protein Rab-14 (RAB14) C40
 LDTP03911  Replication factor C subunit 3 (RFC3) C193
 LDTP03259  Ribonucleoside-diphosphate reductase large subunit (RRM1) C492
 LDTP00693  Ribosomal RNA-processing protein 8 (RRP8) C451
 LDTP12473  Sialic acid synthase (NANS) C287
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) C26
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) C17
 LDTP02502  Thioredoxin (TXN) C73
 LDTP05698  TNF receptor-associated factor 2 (TRAF2) C287
 LDTP05074  Tubulin alpha-1B chain (TUBA1B) C347
 LDTP05074  Tubulin alpha-1B chain (TUBA1B) C295
 LDTP11074  Tubulin alpha-1C chain (TUBA1C) C347
 LDTP13344  Tyrosine-protein kinase BAZ1B (BAZ1B) C156
 LDTP14051  Ubiquitin carboxyl-terminal hydrolase 15 (USP15) C634
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) C961
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118
 LDTP00013  Ubiquitin-like modifier-activating enzyme 6 (UBA6) C347
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C323
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162
Transporter and channel
Click to Show/Hide to Show 22 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP04969  14-3-3 protein epsilon (YWHAE) C98
 LDTP03385  14-3-3 protein theta (YWHAQ) C134
 LDTP13490  Apoptotic chromatin condensation inducer in the nucleus (ACIN1) C1083
 LDTP01037  Catenin delta-1 (CTNND1) C618
 LDTP05252  Clathrin heavy chain 1 (CLTC) C870
 LDTP02009  Cystatin-B (CSTB) C3
 LDTP02057  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) C477
 LDTP11657  Eukaryotic translation initiation factor 5A-2 (EIF5A2) C73
 LDTP00810  Exportin-T (XPOT) C650
 LDTP11161  Extended synaptotagmin-1 (ESYT1) C635
 LDTP05292  Fatty acid-binding protein 5 (FABP5) C120
 LDTP03107  Filamin-A (FLNA) C2543
 LDTP09515  Importin-4 (IPO4) C350
 LDTP00266  Importin-5 (IPO5) C687
 LDTP01748  Mitochondrial import receptor subunit TOM40 homolog (TOMM40) C74
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522
 LDTP09204  Nucleoporin NUP35 (NUP35) C255
 LDTP12043  Phosphorylated adapter RNA export protein (PHAX) C51
 LDTP13262  Signal recognition particle subunit SRP68 (SRP68) C525
 LDTP05273  Spectrin beta chain, non-erythrocytic 1 (SPTBN1) C604
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C76
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C65
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP02786  Fos-related antigen 1 (FOSL1) C97
 LDTP05417  Transcription factor p65 (RELA) C109
 LDTP04281  Transcriptional repressor CTCF (CTCF) C155
 LDTP18206  Zinc finger protein 512 (ZNF512) C324
Other
Click to Show/Hide to Show 81 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP11597  182 kDa tankyrase-1-binding protein (TNKS1BP1) C1443
 LDTP00372  Acyl carrier protein, mitochondrial (NDUFAB1) C140
 LDTP02631  Alpha-actinin-1 (ACTN1) C370
 LDTP10947  Ataxin-2 (ATXN2) C892
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) C673
 LDTP13343  Bromodomain adjacent to zinc finger domain protein 2A (BAZ2A) C917
 LDTP18575  C2 domain-containing protein 2 (C2CD2) C244
 LDTP10864  Calponin-2 (CNN2) C175
 LDTP10864  Calponin-2 (CNN2) C215
 LDTP06383  Calponin-3 (CNN3) C173
 LDTP08902  CDGSH iron-sulfur domain-containing protein 2 (CISD2) C92
 LDTP06584  Cleavage and polyadenylation specificity factor subunit 6 (CPSF6) C159
 LDTP04570  Coatomer subunit beta (COPB1) C248
 LDTP03244  Cofilin-1 (CFL1) C139
 LDTP07200  Complex III assembly factor LYRM7 (LYRM7) C97
 LDTP12883  Constitutive coactivator of PPAR-gamma-like protein 1 (FAM120A) C919
 LDTP12883  Constitutive coactivator of PPAR-gamma-like protein 1 (FAM120A) C531
 LDTP12883  Constitutive coactivator of PPAR-gamma-like protein 1 (FAM120A) C1088
 LDTP12883  Constitutive coactivator of PPAR-gamma-like protein 1 (FAM120A) C1103
 LDTP13580  Coronin-1C (CORO1C) C456
 LDTP06021  Cytoskeleton-associated protein 5 (CKAP5) C1113
 LDTP04887  Destrin (DSTN) C135
 LDTP03367  Elongation factor 1-gamma (EEF1G) C266
 LDTP07400  Elongator complex protein 2 (ELP2) C204
 LDTP03247  Eukaryotic translation initiation factor 4B (EIF4B) C457
 LDTP04127  F-actin-capping protein subunit beta (CAPZB) C206
 LDTP12796  H/ACA ribonucleoprotein complex subunit 1 (GAR1) C80
 LDTP14545  Heat shock 70 kDa protein 4L (HSPA4L) C540
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) C267
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132
 LDTP02750  Heterogeneous nuclear ribonucleoprotein L (HNRNPL) C472
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C594
 LDTP06562  Histone-binding protein RBBP7 (RBBP7) C97
 LDTP05509  Large ribosomal subunit protein eL18 (RPL18) C134
 LDTP13241  LIM domain-containing protein 1 (LIMD1) C431
 LDTP04027  Matrin-3 (MATR3) C230
 LDTP06176  Mediator of DNA damage checkpoint protein 1 (MDC1) C1742
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325
 LDTP11079  Myb-binding protein 1A (MYBBP1A) C942
 LDTP06456  NGFI-A-binding protein 2 (NAB2) C481
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) C708
 LDTP14011  Nucleolar complex protein 2 homolog (NOC2L) C585
 LDTP11993  Nucleolar protein 6 (NOL6) C265
 LDTP15283  Nucleolar protein 9 (NOP9) C242
 LDTP14920  Otogelin-like protein (OTOGL) C1136
 LDTP01021  Perilipin-3 (PLIN3) C39
 LDTP02691  Plastin-2 (LCP1) C101
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C201
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194
 LDTP14342  POTE ankyrin domain family member F (POTEF) C965
 LDTP04078  Proliferation marker protein Ki-67 (MKI67) C643
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22
 LDTP10909  Protein SCAF11 (SCAF11) C542
 LDTP04594  Protein transport protein Sec24C (SEC24C) C1083
 LDTP13956  Putative RNA-binding protein Luc7-like 2 (LUC7L2) C348
 LDTP02656  Ribonuclease inhibitor (RNH1) C75
 LDTP14980  RRP12-like protein (RRP12) C31
 LDTP06385  Scaffold attachment factor B1 (SAFB) C362
 LDTP13991  Serine-threonine kinase receptor-associated protein (STRAP) C305
 LDTP12800  Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) C22
 LDTP00019  Shootin-1 (SHTN1) C565
 LDTP01294  Small subunit processome component 20 homolog (UTP20) C313
 LDTP01294  Small subunit processome component 20 homolog (UTP20) C2058
 LDTP01294  Small subunit processome component 20 homolog (UTP20) C312
 LDTP13970  Splicing factor 3B subunit 6 (SF3B6) C83
 LDTP03352  Splicing factor U2AF 65 kDa subunit (U2AF2) C429
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C608
 LDTP14502  Surfeit locus protein 6 (SURF6) C189
 LDTP14502  Surfeit locus protein 6 (SURF6) C19
 LDTP01362  Survival of motor neuron-related-splicing factor 30 (SMNDC1) C214
 LDTP05113  T-complex protein 1 subunit beta (CCT2) C395
 LDTP05767  TAR DNA-binding protein 43 (TARDBP) C50
 LDTP07205  Telomere-associated protein RIF1 (RIF1) C2169
 LDTP18494  Tropomodulin-3 (TMOD3) C150
 LDTP05068  Tropomyosin alpha-4 chain (TPM4) C247
 LDTP00312  U3 small nucleolar ribonucleoprotein protein MPP10 (MPHOSPH10) C27
 LDTP19499  UPF0598 protein C8orf82 (C8orf82) C98
 LDTP01299  WD repeat and HMG-box DNA-binding protein 1 (WDHD1) C1008
 LDTP06305  WD repeat-containing protein 43 (WDR43) C307
 LDTP08018  Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) C272

References

1 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764