Details of the Target

General Information of Target

Target ID LDTP13343
Target Name Bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
Gene Name BAZ2A
Gene ID 11176
Synonyms
KIAA0314; TIP5; Bromodomain adjacent to zinc finger domain protein 2A; Transcription termination factor I-interacting protein 5; TTF-I-interacting protein 5; Tip5; hWALp3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
ALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQ
KSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIA
KASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEE
NTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKV
IKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKK
WTDTFKVS
Target Type
Literature-reported
Target Bioclass
Other
Family
WAL family
Subcellular location
Nucleus, nucleolus
Function
Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex. The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex. Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing.
TTD ID
T95682
Uniprot ID
Q9UIF9
DrugMap ID
TT2MV0R
Ensemble ID
ENST00000551812.5
HGNC ID
HGNC:962
ChEMBL ID
CHEMBL3108642

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K799(10.00)  LDD0277  [1]
m-APA
 Probe Info  		12.27  LDD0403  [2]
BTD
 Probe Info  		C917(0.68)  LDD2109  [3]
AHL-Pu-1
 Probe Info  		C917(4.46)  LDD0168  [4]
DBIA
 Probe Info  		C583(1.08); C1694(0.99); C1697(0.99); C1701(0.96)  LDD0078  [5]
IA-alkyne
 Probe Info  		C1037(0.00); C943(0.00); C854(0.00); C726(0.00)  LDD0162  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
aHNE
 Probe Info  		N.A.  LDD0001  [9]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		N.A.  LDD0005  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Methacrolein
 Probe Info  		C726(0.00); C1679(0.00)  LDD0218  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C917(4.46)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C917(5.08); C1037(2.27)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C726(0.89); C1369(0.99); C1436(0.82); C1540(1.38)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C726(0.97); C1436(0.79); C1540(0.96); C1679(0.95)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C1540(0.61); C1679(0.97); C1682(0.97); C1694(0.67)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C1540(0.55); C1679(0.94); C1682(0.94); C1694(0.66)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C1540(0.50); C1679(0.79); C1682(0.79); C1694(0.75)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C1540(0.69); C1679(0.89); C1682(0.89); C1694(0.68)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C1540(0.90); C1679(0.93); C1682(0.93); C1694(0.70)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C1540(0.61); C1679(0.77); C1682(0.77); C1694(0.65)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C1540(0.49); C1679(0.99); C1682(0.99); C1694(0.69)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C1540(0.57); C1679(0.90); C1682(0.90); C1694(0.82)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C1540(0.61); C1679(1.00); C1682(1.00); C1694(0.71)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C1540(0.73); C1679(0.86); C1682(0.86); C1694(0.66)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C726(0.78); C1436(0.92); C1540(1.23); C1679(0.87)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C1540(0.71); C1679(1.05); C1682(1.05); C1694(0.77)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C1540(0.84); C1679(1.05); C1682(1.05); C1694(0.74)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C1540(0.53); C1679(0.92); C1682(0.92); C1694(0.70)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C726(1.14); C1037(1.18); C1436(0.91); C1540(1.45)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C726(1.09); C1037(0.94); C1436(0.90); C1540(1.04)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C726(1.07); C1037(1.00); C1436(1.00); C1540(1.05)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C726(1.17); C1037(1.18); C1436(1.04); C1540(1.22)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C726(1.13); C1037(1.07); C1436(1.02); C1540(1.84)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C726(0.96); C1037(1.03); C1436(0.84); C1540(1.19)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C726(1.32); C1037(1.06); C1436(0.95); C1540(0.81)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C726(1.05); C1436(0.85); C1540(0.98); C1679(0.99)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C726(1.20); C1037(0.89); C1436(0.94); C1540(0.88)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C726(0.91); C1037(0.73); C1436(0.94); C1540(0.93)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C726(1.21); C1037(0.91); C1436(0.99); C1540(0.93)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C726(1.03); C1037(0.65); C1436(1.07); C1540(1.00)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C726(1.06); C1037(0.70); C1436(1.46); C1540(0.89)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C726(1.02); C1037(0.72); C1436(0.97); C1540(1.04)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C726(0.81); C1037(0.68); C1436(1.03); C1540(1.04)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C726(0.93); C1037(0.83); C1436(1.10); C1540(1.81)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C726(0.36); C1679(1.02); C1682(1.02); C1694(1.21)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C726(0.41); C1679(1.01); C1682(1.01); C1694(0.80)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C726(0.41); C1679(1.03); C1682(1.03); C1694(0.84)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C726(0.42); C1679(1.06); C1682(1.06); C1694(0.86)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C726(0.51); C1679(1.12); C1682(1.12); C1694(0.71)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C726(0.47); C1679(1.04); C1682(1.04); C1694(0.84)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C726(0.55); C1679(0.90); C1682(0.90); C1694(0.73)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C726(0.47); C1679(0.92); C1682(0.92); C1694(0.88)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C726(0.53); C1679(1.03); C1682(1.03); C1694(0.80)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C726(0.48); C1679(0.97); C1682(0.97); C1694(0.79)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C726(0.60); C1679(0.89); C1682(0.89); C1694(0.69)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C726(0.58); C1679(0.94); C1682(0.94); C1694(0.83)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C726(0.84); C1436(0.84); C1540(1.30); C1679(0.83)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C726(0.63); C1679(1.13); C1682(1.13); C1694(0.73)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C726(0.62); C1679(1.04); C1682(1.04); C1694(0.78)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C726(0.46); C1679(1.01); C1682(1.01); C1694(0.79)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C726(1.46); C1369(1.10); C1436(0.94); C1540(0.52)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C1658(0.66); C1660(0.66); C1540(0.77); C1679(0.83)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C1658(0.59); C1660(0.59); C1436(0.79); C1540(0.79)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C1658(0.73); C1660(0.73); C1679(0.85); C1682(0.85)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C1658(0.61); C1660(0.61); C1679(0.99); C1682(0.99)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C1658(0.98); C1660(0.98); C726(1.17); C1679(1.19)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C1658(0.74); C1660(0.74); C1436(1.01); C1701(1.09)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C1436(0.74); C1679(0.87); C1682(0.87); C1540(0.95)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C1658(0.57); C1660(0.57); C1679(0.76); C1682(0.76)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C1658(0.52); C1660(0.52); C1694(0.91); C1679(0.96)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C1658(0.77); C1660(0.77); C1540(0.80); C1694(0.95)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C1658(1.08); C1660(1.08); C1694(1.15); C1697(1.15)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C726(1.25); C1369(1.70); C1436(1.19); C1540(0.85)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C726(1.27); C1369(1.58); C1436(1.02); C1540(1.50)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C726(1.18); C1369(1.44); C1436(0.79); C1540(0.59)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C726(1.26); C1369(1.67); C1436(0.84); C1540(1.44)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C1679(0.62); C1682(0.62); C1694(0.79); C1697(0.79)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C1436(0.68); C1540(0.74); C1694(0.81); C1697(0.81)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C1540(0.47); C1436(0.83); C1694(0.85); C1697(0.85)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C1694(0.84); C1697(0.84); C1369(0.92); C1436(0.93)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C1694(0.93); C1697(0.93); C1540(1.01); C917(1.10)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C1540(0.49); C1658(0.71); C1660(0.71); C1694(0.96)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C1679(0.74); C1682(0.74); C1694(0.92); C1697(0.92)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C1679(0.77); C1682(0.77); C1694(0.83); C1697(0.83)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C1694(0.80); C1697(0.80); C917(0.88); C1540(0.98)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C1540(0.75); C1694(0.79); C1697(0.79); C1701(0.83)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C1701(0.61); C1705(0.61); C1694(0.69); C1697(0.69)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C1540(0.42); C1694(0.76); C1697(0.76); C1701(0.84)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C1540(0.43); C1694(0.73); C1697(0.73); C1701(0.76)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C1540(0.49); C1694(0.64); C1697(0.64); C955(0.84)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C1369(0.73); C1436(0.74); C1694(0.80); C1697(0.80)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C1540(0.47); C1694(0.64); C1697(0.64); C955(0.84)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C1540(0.49); C1694(0.80); C1697(0.80); C1701(0.83)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C1540(0.43); C1694(0.66); C1697(0.66); C1701(0.85)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C1540(0.39); C1694(0.77); C1697(0.77); C955(0.94)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C1540(0.56); C1694(0.72); C1697(0.72); C1037(0.82)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C1694(0.85); C1697(0.85); C943(0.93); C955(0.93)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C1679(0.83); C1682(0.83); C1436(0.87); C1694(0.90)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C1679(0.74); C1682(0.74); C583(0.90); C1694(0.95)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C1436(0.81); C1694(0.99); C1697(0.99); C583(1.00)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C1436(0.73); C1679(0.96); C1682(0.96); C943(0.97)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C726(0.69); C1694(0.88); C1697(0.88); C943(0.89)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C1436(0.85); C1679(1.01); C1682(1.01); C583(1.06)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C1436(0.87); C1694(0.91); C1697(0.91); C583(0.97)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C1679(0.91); C1682(0.91); C1694(0.91); C1697(0.91)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C1694(0.95); C1697(0.95); C1436(0.99); C943(1.08)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C1679(0.97); C1682(0.97); C1694(1.01); C1697(1.01)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C1679(0.90); C1682(0.90); C1694(1.02); C1697(1.02)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C1540(0.83); C917(0.95); C943(0.97); C1694(0.99)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C917(0.80); C1436(0.87); C943(0.94); C1694(0.98)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C943(0.86); C1540(0.87); C917(0.90); C955(0.92)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C1540(0.78); C917(0.86); C943(0.99); C955(1.00)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C726(0.56); C1436(0.74); C1369(0.79); C1694(0.89)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C917(0.87); C1540(0.91); C1694(1.05); C1697(1.05)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C917(0.77); C1540(0.81); C943(0.82); C1436(0.88)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C917(0.82); C1540(0.83); C1694(0.92); C1697(0.92)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C917(0.61); C1540(0.95); C943(0.97); C955(1.02)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C917(0.88); C1540(0.93); C943(0.97); C955(1.03)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C917(0.67); C1540(1.08); C1694(1.14); C1697(1.14)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C917(0.82); C1540(0.92); C943(1.21); C955(1.30)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C1658(0.30); C1660(0.30); C1540(0.86); C1701(0.89)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C1658(0.38); C1660(0.38); C1540(0.89); C1694(0.90)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C1658(0.46); C1660(0.46); C1540(0.93); C1694(0.94)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C1540(0.90); C1679(0.90); C1682(0.90); C1694(0.91)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C1658(0.58); C1660(0.58); C1540(0.87); C1694(1.03)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C1658(0.52); C1660(0.52); C1694(0.91); C1697(0.91)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C1658(0.68); C1660(0.68); C1540(0.87); C1694(0.92)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C1540(0.85); C1701(0.92); C1705(0.92); C1658(0.98)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C1658(0.37); C1660(0.37); C1701(0.89); C1705(0.89)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C1658(0.54); C1660(0.54); C1701(0.74); C1705(0.74)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C1658(0.55); C1660(0.55); C1701(0.72); C1705(0.72)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C1658(0.48); C1660(0.48); C1701(0.67); C1705(0.67)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C1037(0.41); C1540(0.84); C917(0.97); C583(1.03)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C1037(0.41); C1679(0.94); C1682(0.94); C917(1.00)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C1436(0.77); C1694(0.95); C1697(0.95); C726(0.97)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C1540(0.94); C917(0.95); C1679(0.96); C1682(0.96)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C1037(0.63); C917(0.97); C1679(0.99); C1682(0.99)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C917(0.92); C1694(1.00); C1697(1.00); C1701(1.01)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C917(0.92); C1694(1.07); C1697(1.07); C1701(1.14)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C1037(0.74); C1679(1.04); C1682(1.04); C917(1.07)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C1037(0.84); C917(0.89); C1679(1.06); C1682(1.06)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C1037(0.78); C1679(0.92); C1682(0.92); C917(0.95)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C1037(0.42); C1679(0.84); C1682(0.84); C917(0.94)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C1037(0.68); C583(0.90); C917(0.93); C1679(0.94)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C1037(0.92); C1679(0.94); C1682(0.94); C917(0.96)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C1436(0.85); C1679(0.93); C1682(0.93); C1694(0.96)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C1037(0.85); C917(0.96); C1679(1.06); C1682(1.06)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C1037(0.80); C583(0.98); C1679(0.98); C1682(0.98)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C1037(0.76); C917(1.04); C1679(1.20); C1682(1.20)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C1658(0.62); C1660(0.62); C955(0.66); C943(0.78)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C955(0.77); C1540(0.82); C1658(0.83); C1660(0.83)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C1658(0.45); C1660(0.45); C955(0.59); C943(0.68)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C1658(0.46); C1660(0.46); C1694(0.77); C1697(0.77)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C1658(0.52); C1660(0.52); C1679(0.83); C1682(0.83)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C1658(0.57); C1660(0.57); C955(0.70); C1694(0.74)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C955(0.64); C943(0.68); C1658(0.73); C1660(0.73)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C1658(0.60); C1660(0.60); C955(0.70); C943(0.74)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C943(0.80); C955(0.83); C583(0.87); C1658(0.98)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C955(0.59); C943(0.67); C1658(0.74); C1660(0.74)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C1658(0.60); C1660(0.60); C955(0.62); C943(0.68)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C1658(0.65); C1660(0.65); C1694(0.78); C1697(0.78)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C955(0.63); C943(0.67); C1694(0.87); C1697(0.87)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C1658(0.46); C1660(0.46); C1679(0.81); C1682(0.81)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C955(0.55); C943(0.58); C1658(0.69); C1660(0.69)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C1701(0.53); C1705(0.53); C1694(0.73); C1697(0.73)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C1701(0.55); C1705(0.55); C1540(0.61); C1694(0.62)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C726(1.13); C1436(0.82); C1540(1.13); C1679(0.89)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C1436(0.74); C726(0.83); C1679(0.97); C1682(0.97)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C1679(1.04); C1682(1.04); C1694(1.08); C1697(1.08)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 12.27  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C583(1.08); C1694(0.99); C1697(0.99); C1701(0.96)  LDD0078  [5]
 LDCM0632  CL-Sc Hep-G2 C726(20.00); C795(1.89)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C1679(0.56); C1682(0.56); C1037(0.88); C726(0.94)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C1679(0.62); C1682(0.62); C1037(0.91); C1540(1.02)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C943(0.85); C955(0.85); C1694(0.87); C1697(0.87)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C1679(0.78); C1682(0.78); C1436(0.82); C1540(0.89)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C1679(0.60); C1682(0.60); C1436(0.87); C1694(0.88)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C726(0.78); C1436(0.81); C917(0.96); C1679(0.97)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C726(0.84); C1679(0.88); C1682(0.88); C1436(0.94)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C1540(0.53); C1679(0.58); C1682(0.58); C1694(0.79)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C1436(0.91); C1694(0.93); C1697(0.93); C1679(0.99)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C1679(0.52); C1682(0.52); C1694(0.79); C1697(0.79)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C1540(0.69); C1694(0.76); C1697(0.76); C1658(0.96)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C1540(0.73); C1694(0.84); C1697(0.84); C1679(0.86)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C1037(0.56); C726(0.84); C917(0.95); C1679(1.07)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C1540(0.48); C1679(0.73); C1682(0.73); C1694(0.81)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C1540(0.53); C1679(0.77); C1682(0.77); C1694(0.77)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C1540(0.51); C955(0.71); C1694(0.73); C1697(0.73)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C1540(0.54); C1694(0.62); C1697(0.62); C955(0.86)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C1540(0.38); C1694(0.56); C1697(0.56); C1436(0.75)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C1540(0.41); C1694(0.65); C1697(0.65); C1701(0.69)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C1540(0.50); C1694(0.69); C1697(0.69); C1701(0.71)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C1694(1.30); C1697(1.30); C583(1.33); C1679(1.33)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C1694(0.96); C1697(0.96); C1436(0.98); C726(0.99)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C1679(1.01); C1682(1.01); C1694(1.08); C1697(1.08)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C1037(0.44); C726(0.94); C917(0.94); C1679(1.03)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C1694(0.93); C1697(0.93); C1679(0.96); C1682(0.96)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C1436(0.72); C1540(0.93); C917(0.99); C583(1.10)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C1540(0.79); C917(1.00); C1694(1.01); C1697(1.01)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C1540(0.75); C917(0.93); C943(1.00); C955(1.02)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C917(0.88); C943(0.96); C1694(0.98); C1697(0.98)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C1658(0.39); C1660(0.39); C955(0.83); C1701(0.84)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C1658(0.49); C1660(0.49); C1694(0.86); C1697(0.86)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C1658(0.42); C1660(0.42); C1701(0.76); C1705(0.76)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C1658(0.42); C1660(0.42); C1540(0.67); C1694(1.04)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C1037(0.57); C726(0.83); C917(1.00); C1540(1.03)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C1037(0.66); C917(0.90); C726(0.91); C1679(0.91)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C1037(0.59); C726(0.78); C917(0.82); C1679(1.12)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C1540(0.65); C1694(0.96); C1697(0.96); C955(0.98)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C1540(0.75); C917(0.78); C1694(0.93); C1697(0.93)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C917(0.85); C1369(0.85); C1694(1.02); C1697(1.02)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C1369(0.92); C917(0.99); C1540(1.01); C583(1.01)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C1679(0.65); C1682(0.65); C1037(0.80); C1694(0.90)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C1540(0.79); C917(0.88); C1694(0.97); C1697(0.97)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C917(0.82); C1369(0.96); C1540(0.96); C1694(1.01)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C583(0.98); C1037(1.04); C1369(1.06); C917(1.07)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C1540(0.72); C1694(0.90); C1697(0.90); C1369(0.99)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C1369(0.90); C1540(0.90); C583(1.00); C917(1.01)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C726(0.83); C1037(1.20); C1369(0.86); C1540(1.04)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C726(1.72); C1037(1.23); C1369(0.82); C1540(0.76)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C726(1.23); C1037(1.43); C1369(1.02); C1540(0.92)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C726(1.28); C1037(1.36); C1369(0.90); C1540(0.73)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C726(1.12); C1037(1.69); C1369(1.20); C1540(0.88)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C726(0.97); C1037(0.52); C1540(1.32); C1679(0.81)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C726(1.41); C1037(1.59); C1369(1.06); C1540(0.64)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C726(1.00); C1037(0.93); C1369(0.98); C1540(0.69)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C726(0.99); C1369(1.16); C1540(0.79); C1679(1.42)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C726(1.33); C1369(0.86); C1540(0.97); C1679(0.83)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C726(1.26); C1369(0.94); C1540(1.02); C1679(1.24)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C726(1.35); C1369(0.94); C1540(0.79); C1679(1.33)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C726(1.56); C1369(1.04); C1540(0.60); C1679(0.81)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C726(1.50); C1369(1.06); C1540(0.75); C1679(1.11)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C726(1.21); C1369(1.08); C1540(0.74); C1679(1.08)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C726(0.77); C1037(0.81); C1540(1.06); C1679(1.00)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C726(1.26); C1369(1.50); C1540(0.72); C1679(1.01)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C726(1.25); C1369(1.08); C1540(0.71); C1679(0.93)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C726(1.39); C1369(1.30); C1540(0.91); C1679(1.18)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C726(1.41); C1369(1.04); C1540(0.99); C1679(1.12)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C726(1.25); C1369(0.95); C1540(0.84); C1679(1.01)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C726(0.98); C1369(1.10); C1540(0.77); C1679(1.29)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C1037(1.14); C1369(0.84); C1679(1.00); C1682(1.00)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C1037(0.98); C1369(0.69); C1679(1.03); C1682(1.03)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C1037(0.79); C1369(0.68); C1679(0.72); C1682(0.72)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C1037(1.02); C1369(0.83); C1679(1.05); C1682(1.05)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C726(0.79); C1037(1.01); C1540(0.99); C1679(0.78)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C1037(0.87); C1369(0.72); C1679(0.97); C1682(0.97)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C1037(1.03); C1369(0.73); C1679(0.98); C1682(0.98)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C1037(1.31); C1369(0.84); C1679(0.59); C1682(0.59)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C1037(1.03); C1369(0.86); C1679(0.78); C1682(0.78)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C1037(0.87); C1369(0.87); C1679(0.93); C1682(0.93)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C1037(0.92); C1369(0.89); C1679(0.96); C1682(0.96)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C1037(0.87); C1369(0.79); C1679(0.82); C1682(0.82)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C1037(0.74); C1369(0.72); C1679(1.08); C1682(1.08)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C1037(0.98); C1369(0.89); C1679(1.57); C1682(1.57)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C1037(1.06); C1369(0.91); C1679(0.81); C1682(0.81)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C726(0.90); C1037(1.31); C1540(1.38); C1679(1.11)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C1037(0.92); C1369(0.81); C1679(0.45); C1682(0.45)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C1037(1.58); C1369(1.02); C1436(0.90); C1540(0.88)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C1037(1.45); C1369(1.05); C1436(0.81); C1540(1.15)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C1037(1.35); C1369(0.83); C1436(0.89); C1540(1.82)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C1037(1.43); C1369(0.91); C1436(1.05); C1540(1.27)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C1037(1.39); C1369(1.04); C1436(0.95); C1540(1.19)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C1037(1.36); C1369(0.81); C1436(0.92); C1540(1.53)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C1037(1.20); C1369(0.98); C1436(1.05); C1540(1.37)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C1037(1.12); C1369(1.05); C1436(0.87); C1540(0.88)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C1037(1.38); C1369(0.93); C1436(1.46); C1540(1.29)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C726(0.87); C1037(1.96); C1540(1.10); C1679(0.82)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C1037(1.29); C1369(0.80); C1436(0.98); C1540(1.51)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C1037(1.29); C1369(0.82); C1436(0.83); C1540(1.09)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C1037(1.21); C1369(0.85); C1436(0.81); C1540(1.56)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C1037(1.12); C1369(1.13); C1436(0.88); C1540(1.18)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C1037(1.33); C1369(1.00); C1436(0.86); C1540(0.99)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C1436(1.13); C1540(0.66); C1679(0.98); C1682(0.98)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C1436(1.08); C1540(0.38); C1679(0.93); C1682(0.93)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C1436(0.94); C1540(0.75); C1679(0.78); C1682(0.78)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C1436(1.14); C1540(0.82); C1679(1.22); C1682(1.22)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C726(1.03); C1037(0.62); C1540(1.50); C1679(0.86)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C1436(1.66); C1540(0.49); C1679(0.97); C1682(0.97)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C1436(1.08); C1540(0.78); C1679(0.94); C1682(0.94)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C1436(1.41); C1540(0.65); C1679(1.15); C1682(1.15)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C1436(1.19); C1540(0.62); C1679(1.09); C1682(1.09)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C1436(1.69); C1540(0.63); C1679(0.97); C1682(0.97)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C1436(1.02); C1540(0.78); C1679(0.91); C1682(0.91)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C1436(0.86); C1540(0.62); C1679(0.97); C1682(0.97)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C1436(0.97); C1540(0.81); C1679(0.90); C1682(0.90)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C1436(1.23); C1540(0.71); C1679(1.04); C1682(1.04)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C1436(1.66); C1540(0.80); C1679(1.01); C1682(1.01)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C726(0.98); C1037(0.60); C1540(1.29); C1679(0.74)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C1436(1.11); C1540(0.54); C1679(1.04); C1682(1.04)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C726(1.06); C1369(1.33); C1436(0.70); C1540(0.89)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C726(1.38); C1369(1.23); C1436(1.10); C1540(0.96)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C726(0.89); C1369(1.58); C1436(0.93); C1540(0.66)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C726(0.81); C1369(1.36); C1436(0.83); C1540(1.54)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C726(1.03); C1369(1.11); C1436(0.75); C1540(1.20)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C726(0.94); C1369(1.00); C1436(0.73); C1540(0.87)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C726(1.11); C1369(1.04); C1436(0.61); C1540(0.76)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C726(1.24); C1369(0.80); C1436(0.71); C1540(1.25)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C726(0.97); C1369(0.97); C1436(0.65); C1540(1.16)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C726(0.86); C1037(0.95); C888(1.12); C917(1.20)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C726(1.26); C795(1.02)  LDD1702  [3]
 LDCM0625  F8 Ramos C726(1.55)  LDD2187  [13]
 LDCM0573  Fragment11 Ramos C726(20.00)  LDD2190  [13]
 LDCM0468  Fragment33 HCT 116 C1037(1.53); C1369(1.06); C1436(0.92); C1540(1.22)  LDD0785  [5]
 LDCM0566  Fragment4 Ramos C726(0.92)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C726(1.67); C1369(2.12); C1540(1.27); C1679(1.23)  LDD0744  [5]
 LDCM0569  Fragment7 Ramos C726(1.14)  LDD2186  [13]
 LDCM0022  KB02 HCT 116 C1658(3.23); C1660(3.23); C943(2.38); C955(2.38)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C1658(4.35); C1660(4.35); C943(1.75); C955(1.75)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C1658(5.18); C1660(5.18); C943(2.73); C955(2.73)  LDD0082  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C917(0.68)  LDD2109  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C795(0.83)  LDD2120  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C795(0.50)  LDD2122  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C726(1.00)  LDD2141  [3]
 LDCM0021  THZ1 HCT 116 C583(1.11); C1679(1.51); C1682(1.51); C917(0.88)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Baz2-icr Small molecular drug D0I4FP
Gsk2801 Small molecular drug D0T3WL

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578