Details of the Target

General Information of Target

Target ID LDTP07447
Target Name 2',5'-phosphodiesterase 12 (PDE12)
Gene Name PDE12
Gene ID 201626
Synonyms
2',5'-phosphodiesterase 12; 2'-PDE; 2-PDE; EC 3.1.4.-; Mitochondrial deadenylase; EC 3.1.13.4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWRLPGARAALRVIRTAVEKLSRAEAGSQTAAGAMERAVVRCVPSEPKLSLSFALADGSH
KNMQRDQSEPLGRVLSRIATNALKGHAKAAAAKKSRKSRPNASGGAACSGPGPEPAVFCE
PVVKLYYREEAVAEDVLNVDAWQDGAVLQIGDVKYKVERNPPAFTELQLPRYIMAGFPVC
PKLSLEFGDPASSLFRWYKEAKPGAAEPEVGVPSSLSPSSPSSSWTETDVEERVYTPSNA
DIGLRLKLHCTPGDGQRFGHSRELESVCVVEAGPGTCTFDHRHLYTKKVTEDALIRTVSY
NILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADVICLQEVDRAVFSDS
LVPALEAFGLEGVFRIKQHEGLATFYRKSKFSLLSQHDISFYEALESDPLHKELLEKLVL
YPSAQEKVLQRSSVLQVSVLQSTKDSSKRICVANTHLYWHPKGGYIRLIQMAVALAHIRH
VSCDLYPGIPVIFCGDFNSTPSTGMYHFVINGSIPEDHEDWASNGEEERCNMSLTHFFKL
KSACGEPAYTNYVGGFHGCLDYIFIDLNALEVEQVIPLPSHEEVTTHQALPSVSHPSDHI
ALVCDLKWK
Target Bioclass
Enzyme
Family
CCR4/nocturin family
Subcellular location
Mitochondrion matrix
Function
Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells.
Uniprot ID
Q6L8Q7
Ensemble ID
ENST00000311180.9
HGNC ID
HGNC:25386
ChEMBL ID
CHEMBL4523342

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL120 SNV: p.N531S DBIA    Probe Info 
LN229 SNV: p.D292N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y172(10.94)  LDD0260  [3]
BTD
 Probe Info  		C250(3.00)  LDD1700  [4]
AHL-Pu-1
 Probe Info  		C119(2.15); C108(2.30)  LDD0169  [5]
EA-probe
 Probe Info  		N.A.  LDD0440  [6]
HHS-465
 Probe Info  		Y307(4.14)  LDD2237  [7]
DBIA
 Probe Info  		C108(1.10); C119(1.10); C268(0.89); C277(0.89)  LDD0078  [8]
AMP probe
 Probe Info  		N.A.  LDD0200  [9]
ATP probe
 Probe Info  		K377(0.00); K247(0.00); K84(0.00); K88(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C530(0.00); C348(0.00); C250(0.00); C180(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C530(0.00); C42(0.00); C451(0.00); C250(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C530(0.00); C42(0.00); C451(0.00); C180(0.00)  LDD0037  [10]
ATP probe
 Probe Info  		N.A.  LDD0035  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
DA-P3
 Probe Info  		N.A.  LDD0178  [13]
aHNE
 Probe Info  		N.A.  LDD0001  [14]
Compound 10
 Probe Info  		C108(0.00); C119(0.00); C180(0.00)  LDD2216  [15]
Compound 11
 Probe Info  		C108(0.00); C119(0.00); C180(0.00)  LDD2213  [15]
IPM
 Probe Info  		N.A.  LDD0005  [14]
NHS
 Probe Info  		N.A.  LDD0010  [14]
SF
 Probe Info  		N.A.  LDD0028  [16]
STPyne
 Probe Info  		N.A.  LDD0009  [14]
VSF
 Probe Info  		C108(0.00); C119(0.00)  LDD0007  [14]
Phosphinate-6
 Probe Info  		C119(0.00); C108(0.00); C42(0.00)  LDD0018  [17]
Acrolein
 Probe Info  		H249(0.00); C250(0.00); C180(0.00); C119(0.00)  LDD0217  [18]
Methacrolein
 Probe Info  		C108(0.00); C119(0.00); C250(0.00)  LDD0218  [18]
W1
 Probe Info  		C108(0.00); C119(0.00); C180(0.00); C250(0.00)  LDD0236  [19]
AOyne
 Probe Info  		9.70  LDD0443  [20]
NAIA_5
 Probe Info  		C530(0.00); C42(0.00); C250(0.00); C180(0.00)  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe14
 Probe Info  		20.00  LDD0477  [22]
STS-1
 Probe Info  		N.A.  LDD0136  [23]
STS-2
 Probe Info  		N.A.  LDD0139  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C108(0.60)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C250(0.45)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C250(0.96)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C250(1.35)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C250(0.97)  LDD2103  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C250(0.97)  LDD2131  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C119(2.15); C108(2.30)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C108(0.77); C119(0.76); C180(1.22); C268(0.93)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C108(0.82); C119(0.80); C180(1.18); C268(1.26)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C108(0.95); C119(0.94); C180(0.63); C268(0.94)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C108(0.90); C119(0.90); C180(0.60); C268(0.58)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C108(1.01); C119(1.03); C180(0.62); C268(0.73)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C108(1.24); C119(1.24); C180(0.45); C268(0.51)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C108(1.13); C119(1.11); C180(0.54); C268(0.58)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C108(1.12); C119(1.13); C180(0.48); C268(0.55)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C108(1.13); C119(1.11); C180(0.45); C268(0.51)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C108(1.18); C119(0.96); C180(0.46); C268(0.53)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C108(0.86); C119(0.87); C180(0.62); C268(0.68)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C108(0.91); C119(0.86); C180(0.68); C268(0.87)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C108(0.86); C119(0.85); C180(0.62); C268(1.33)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C108(1.07); C119(1.01); C180(0.57); C268(0.61)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C108(1.14); C119(1.08); C180(0.57); C268(0.68)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C108(1.15); C119(1.05); C180(0.49); C268(0.44)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C108(0.93); C119(0.93); C180(1.15); C268(0.60)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C108(1.05); C119(1.03); C180(0.86); C268(0.82)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C108(1.11); C119(1.10); C180(0.70); C268(0.87)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C108(1.13); C119(1.07); C180(0.72); C268(0.62)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C108(1.08); C119(0.94); C180(0.93); C268(0.96)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C108(0.95); C119(0.89); C180(1.03); C268(1.05)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C108(1.00); C119(0.94); C180(0.86); C268(0.68)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C108(0.82); C119(0.83); C180(1.06); C268(1.66)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C108(1.11); C119(1.14); C180(0.91); C268(0.76)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C108(0.99); C119(0.82); C180(1.05); C268(1.75)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C108(0.92); C119(0.91); C180(0.80); C268(0.95)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C108(1.23); C119(0.84); C180(1.34); C268(1.51)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C108(0.97); C119(0.92); C180(1.02); C268(1.29)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C108(1.03); C119(1.08); C180(0.92); C268(1.25)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C108(1.06); C119(1.07); C180(0.79); C268(0.99)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C108(1.14); C119(1.09); C180(0.77); C268(1.20)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C108(0.85); C119(0.85); C180(0.51); C268(1.94)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C108(0.94); C119(0.94); C180(1.05); C268(1.27)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C108(0.87); C119(0.87); C180(0.64); C268(1.52)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C108(1.37); C119(1.37); C180(1.18); C268(1.48)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C108(0.64); C119(0.64); C180(1.23); C268(1.11)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C108(0.68); C119(0.68); C180(0.77); C268(1.17)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C108(0.78); C119(0.78); C180(0.68); C268(0.83)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C108(0.68); C119(0.68); C180(0.71); C268(0.95)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C108(0.70); C119(0.70); C180(0.84); C268(0.82)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C108(0.64); C119(0.64); C180(1.11); C268(1.02)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C108(0.82); C119(0.82); C180(0.81); C268(0.80)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C108(0.72); C119(0.72); C180(0.96); C268(0.75)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C108(0.85); C119(0.87); C180(0.82); C268(1.49)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C108(0.77); C119(0.77); C180(0.75); C268(0.70)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C108(0.78); C119(0.78); C180(0.92); C268(0.77)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C108(0.58); C119(0.58); C180(1.17); C268(0.93)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C277(0.77); C180(0.82); C250(0.87); C119(0.99)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C250(0.45); C180(0.59); C277(0.81); C42(1.00)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C250(0.74); C180(0.75); C119(0.96); C42(1.03)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C250(0.50); C180(0.63); C277(0.76); C119(1.03)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C250(0.50); C180(0.60); C277(0.73); C42(0.87)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C250(0.26); C180(0.48); C277(0.73); C119(1.20)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C250(0.41); C180(0.51); C277(0.71); C268(1.05)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C108(0.90); C119(0.91); C180(1.22); C277(1.26)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C250(0.71); C180(0.82); C119(0.89); C277(0.91)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C277(0.66); C250(0.93); C180(0.96); C119(1.01)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C250(0.46); C180(0.60); C277(0.74); C42(0.99)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C250(0.23); C180(0.51); C277(0.84); C42(1.38)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C108(1.19); C119(1.14); C180(0.69); C250(0.54)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C108(1.36); C119(1.23); C180(0.76); C250(0.63)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C108(1.07); C119(0.98); C180(0.93); C250(0.69)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C108(1.58); C119(1.50); C180(0.96); C250(0.70)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C321(0.71); C180(0.99); C277(1.15); C268(1.23)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C180(0.83); C321(1.00); C277(1.18); C268(1.21)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C321(0.73); C180(1.11); C277(1.25); C119(1.35)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C119(0.66); C108(0.68); C268(0.80); C321(0.82)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C277(1.03); C180(1.08); C321(1.17); C268(1.19)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C180(1.05); C321(1.09); C277(1.28); C268(1.42)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C321(0.71); C268(0.95); C277(1.02); C180(1.14)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C321(0.92); C180(1.10); C268(1.20); C277(1.28)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C180(1.10); C277(1.28); C268(1.30); C119(1.38)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C321(0.75); C42(0.88); C180(0.94); C108(1.08)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C321(0.63); C268(0.78); C180(0.82); C42(0.93)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C321(0.67); C268(0.75); C277(0.76); C180(0.78)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C321(0.51); C277(0.84); C180(0.84); C268(1.00)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C321(0.55); C268(0.61); C277(0.62); C180(0.75)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C119(0.59); C108(0.60); C321(0.78); C42(0.92)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C321(0.49); C268(0.66); C180(0.67); C277(0.74)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C321(0.62); C180(0.78); C42(0.82); C268(0.84)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C268(0.50); C180(0.57); C321(0.62); C277(0.67)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C180(0.66); C268(0.69); C277(0.79); C321(0.83)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C180(0.63); C268(0.68); C277(0.73); C42(0.82)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C108(0.88); C119(0.88); C250(1.30); C268(1.33)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C108(0.83); C119(0.83); C268(0.96); C277(1.04)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C119(0.88); C108(0.89); C277(1.06); C268(1.09)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C108(0.96); C119(0.97); C268(0.97); C180(1.12)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C108(0.79); C119(0.81); C180(1.01); C277(1.07)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C119(0.63); C108(0.63); C42(0.98); C321(1.14)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C180(0.85); C277(0.94); C119(1.02); C108(1.03)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C268(0.80); C119(0.93); C108(0.94); C277(0.96)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C180(0.92); C268(0.92); C277(0.94); C108(0.97)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C180(0.81); C108(0.89); C119(0.91); C268(0.93)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C119(0.93); C108(0.94); C268(0.95); C180(0.99)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C277(0.82); C180(0.89); C268(0.90); C250(1.07)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C277(0.82); C268(0.82); C180(0.89); C108(1.03)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C268(0.69); C277(0.78); C180(0.86); C108(0.96)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C321(0.32); C180(0.56); C277(0.59); C268(0.60)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C180(0.44); C277(0.51); C268(0.53); C321(0.53)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C108(0.52); C119(0.52); C42(0.79); C180(1.15)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C180(0.49); C277(0.57); C268(0.60); C321(0.73)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C268(0.75); C277(0.91); C108(1.02); C119(1.02)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C268(0.68); C277(0.74); C180(0.92); C321(0.92)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C180(0.57); C277(0.68); C268(0.78); C321(0.96)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C180(0.63); C321(0.68); C277(0.81); C268(1.11)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C180(0.42); C321(0.59); C277(0.72); C268(0.93)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C180(0.33); C277(0.47); C268(0.54); C321(0.65)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C180(0.57); C277(0.69); C268(0.76); C119(0.89)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C180(0.54); C277(0.74); C268(0.78); C250(0.85)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C180(0.46); C277(0.61); C268(0.61); C119(0.91)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C277(0.91); C108(0.95); C180(0.96); C119(0.98)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C180(0.45); C277(0.56); C268(0.59); C119(0.81)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C180(0.48); C277(0.56); C268(0.62); C250(0.66)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C180(0.41); C277(0.71); C268(0.77); C250(0.79)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C180(0.45); C277(0.62); C268(0.66); C250(0.82)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C180(0.43); C277(0.65); C268(0.69); C250(0.73)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C180(0.50); C277(0.59); C268(0.60); C119(0.64)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C180(0.51); C268(0.62); C277(0.65); C119(0.69)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C180(0.31); C277(0.43); C250(0.49); C268(0.57)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C277(0.69); C268(0.72); C180(0.79); C250(0.93)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C268(0.64); C277(0.65); C180(0.81); C250(0.86)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C119(0.75); C108(0.76); C321(0.95); C180(1.00)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C268(0.57); C277(0.59); C180(0.70); C250(0.79)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C119(0.83); C108(0.89); C277(0.94); C268(0.96)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C277(0.73); C268(0.75); C180(0.81); C321(0.89)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C268(0.50); C277(0.52); C250(0.59); C180(0.65)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C268(0.64); C250(0.65); C277(0.74); C180(0.75)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C277(0.54); C268(0.55); C180(0.64); C250(0.65)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C250(0.82); C277(0.82); C268(0.84); C180(0.85)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C277(0.66); C268(0.67); C180(0.74); C250(0.89)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C277(0.70); C268(0.73); C180(0.85); C250(1.08)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C277(0.76); C268(0.77); C180(0.92); C119(0.99)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C180(0.85); C119(0.85); C108(0.86); C277(0.93)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C277(0.77); C268(0.79); C180(0.85); C250(0.88)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C268(0.99); C277(0.99); C119(1.01); C180(1.02)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C268(0.59); C277(0.60); C180(0.73); C250(0.79)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C268(0.49); C277(0.53); C321(0.80); C180(1.07)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C268(0.47); C277(0.51); C321(0.79); C250(1.14)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C268(0.52); C277(0.55); C321(0.60); C119(0.87)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C321(0.58); C180(0.84); C268(0.85); C119(0.87)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C321(0.63); C268(0.66); C277(0.70); C180(0.84)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C321(0.74); C180(0.79); C268(0.89); C277(0.94)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C321(0.55); C268(0.66); C277(0.70); C180(0.87)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C321(0.45); C180(0.76); C119(0.77); C108(0.90)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C268(0.53); C277(0.56); C321(0.57); C180(1.18)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C321(0.51); C277(0.58); C268(0.58); C250(1.17)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C268(0.67); C321(0.69); C277(0.70); C250(0.99)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C277(0.71); C268(0.79); C321(1.04); C119(1.20)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C268(0.59); C321(0.60); C277(0.64); C180(0.80)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C277(0.78); C268(0.91); C250(1.19); C321(1.23)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C321(0.38); C268(0.51); C277(0.56); C180(0.71)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C268(0.27); C277(0.28); C180(0.30); C321(0.43)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C321(0.58); C180(0.69); C42(0.75); C268(0.76)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C108(0.72); C119(0.69); C180(1.03); C268(1.24)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C180(0.71); C119(0.78); C108(0.82); C321(1.01)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C277(1.01); C180(1.04); C268(1.04); C321(1.07)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 11.95  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C108(1.10); C119(1.10); C268(0.89); C277(0.89)  LDD0078  [8]
 LDCM0498  BS-3668 MDA-MB-231 C250(0.80)  LDD2091  [4]
 LDCM0630  CCW28-3 231MFP C108(1.39)  LDD2214  [24]
 LDCM0108  Chloroacetamide HeLa C250(0.00); C180(0.00); H249(0.00); C277(0.00)  LDD0222  [18]
 LDCM0367  CL1 HCT 116 C321(0.74); C42(0.90); C268(0.99); C108(1.10)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C321(0.16); C180(0.59); C277(0.74); C42(0.89)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C268(0.64); C321(0.75); C119(0.77); C108(0.78)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C180(0.98); C108(1.03); C119(1.04); C277(1.18)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C119(1.08); C180(1.14); C108(1.25); C277(1.25)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C180(1.09); C119(1.17); C108(1.19); C277(1.31)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C180(0.99); C119(1.07); C277(1.13); C108(1.14)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C180(0.90); C321(0.93); C277(1.17); C268(1.24)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C180(0.77); C108(1.27); C119(1.28); C321(1.32)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C321(0.89); C180(0.98); C108(1.11); C119(1.15)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C321(0.81); C180(0.83); C108(1.23); C119(1.24)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C321(0.70); C180(0.85); C277(1.01); C268(1.07)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C321(0.28); C180(0.68); C277(0.88); C42(0.90)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C180(0.83); C321(0.87); C277(1.24); C268(1.36)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C321(0.69); C277(0.85); C180(0.87); C268(0.96)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C277(0.83); C321(0.84); C268(0.90); C42(0.95)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C268(0.61); C277(0.64); C180(0.68); C321(0.80)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C268(0.47); C277(0.53); C180(0.75); C42(0.87)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C268(0.55); C277(0.63); C180(0.77); C42(0.92)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C268(0.66); C277(0.73); C180(0.78); C321(0.88)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C180(0.65); C277(0.70); C250(1.04); C108(1.05)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C108(0.84); C119(0.85); C277(0.88); C268(0.92)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C277(0.75); C268(0.82); C180(0.85); C250(0.95)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C321(0.17); C180(0.69); C42(0.82); C277(0.86)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C268(0.83); C108(0.86); C119(0.86); C277(0.97)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C180(0.48); C277(0.76); C268(1.33); C321(1.61)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C180(0.56); C268(0.58); C277(0.58); C321(0.91)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C180(0.58); C321(0.74); C277(0.81); C268(1.26)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C180(0.49); C277(0.57); C268(0.64); C321(0.73)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C268(0.80); C180(0.85); C119(0.85); C108(0.86)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C268(0.60); C180(0.68); C277(0.79); C119(0.83)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C180(0.63); C268(0.78); C277(0.89); C119(0.92)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C180(0.59); C277(0.67); C268(0.75); C250(0.93)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C180(0.73); C277(0.81); C268(0.95); C42(0.98)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C321(0.67); C42(0.82); C180(0.91); C268(0.98)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C180(0.80); C277(0.89); C42(0.92); C108(1.17)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C321(0.54); C268(0.64); C180(0.71); C277(0.71)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C180(0.67); C277(0.79); C321(0.83); C268(0.92)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C180(0.51); C277(0.69); C321(0.88); C268(0.97)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C180(0.62); C277(0.76); C268(0.86); C321(1.17)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C321(0.90); C268(0.94); C42(0.98); C108(1.05)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C180(0.55); C277(0.56); C268(0.61); C321(1.16)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C180(0.52); C277(0.57); C268(0.83); C321(1.57)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C180(0.49); C277(0.60); C268(0.83); C119(1.54)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C180(0.64); C268(0.69); C277(0.71); C321(0.87)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C321(0.35); C180(0.52); C277(0.61); C268(0.73)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C108(1.68); C119(1.71); C180(0.52); C268(0.79)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C108(1.54); C119(1.54); C180(0.60); C268(0.66)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C108(1.17); C119(1.18); C180(0.71); C268(0.89)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C108(1.61); C119(1.61); C180(0.49); C268(0.59)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C108(1.37); C119(1.38); C180(0.52); C268(0.74)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C108(1.02); C119(1.02); C180(1.02); C268(1.47)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C108(1.36); C119(1.36); C180(0.72); C268(1.03)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C108(1.26); C119(1.26); C180(0.84); C268(1.05)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C108(1.15); C119(1.14); C180(0.55); C268(0.76)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C108(1.71); C119(1.71); C180(0.51); C268(0.75)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C108(1.35); C119(1.35); C180(0.50); C268(0.78)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C108(1.78); C119(1.76); C180(0.51); C268(0.84)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C108(1.61); C119(1.59); C180(0.59); C268(0.93)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C108(1.66); C119(1.61); C180(0.55); C268(0.92)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C108(1.53); C119(1.50); C180(0.56); C268(0.95)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C108(1.21); C119(1.21); C180(0.94); C268(1.14)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C108(1.64); C119(1.61); C180(0.52); C268(1.02)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C108(1.56); C119(1.52); C180(0.61); C268(0.94)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C108(1.63); C119(1.54); C180(0.50); C268(0.97)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C108(1.69); C119(1.65); C180(0.55); C268(0.85)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C108(1.52); C119(1.50); C180(0.57); C268(0.94)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C108(1.47); C119(1.47); C180(0.50); C268(0.88)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C108(1.18); C119(1.18); C268(2.13); C277(2.14)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C108(1.01); C119(1.01); C268(1.19); C277(1.19)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C108(1.36); C119(1.36); C268(2.01); C277(2.00)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C108(1.61); C119(1.61); C268(1.26); C277(1.21)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C108(1.08); C119(1.08); C180(0.96); C268(1.32)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C108(1.12); C119(1.12); C268(1.36); C277(1.37)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C108(1.19); C119(1.19); C268(1.36); C277(1.36)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C108(1.18); C119(1.18); C268(1.60); C277(1.60)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C108(1.69); C119(1.69); C268(1.57); C277(1.56)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C108(1.33); C119(1.33); C268(1.42); C277(1.41)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C108(1.36); C119(1.36); C268(1.91); C277(1.89)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C108(1.15); C119(1.15); C268(1.11); C277(1.12)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C108(1.11); C119(1.11); C268(1.45); C277(1.44)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C108(1.24); C119(1.24); C268(1.60); C277(1.61)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C108(1.21); C119(1.21); C268(1.39); C277(1.39)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C108(1.20); C119(1.20); C180(0.71); C268(1.10)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C108(1.40); C119(1.40); C268(1.34); C277(1.32)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C108(0.93); C119(0.85); C268(0.95); C277(1.01)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C108(0.99); C119(0.95); C268(0.66); C277(0.90)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C108(0.96); C119(0.89); C268(0.83); C277(0.95)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C108(1.08); C119(1.01); C268(0.71); C277(0.73)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C108(0.82); C119(0.75); C268(0.88); C277(0.95)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C108(1.02); C119(0.97); C268(0.62); C277(0.87)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C108(1.10); C119(0.99); C268(0.90); C277(0.90)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C108(0.93); C119(0.85); C268(0.60); C277(0.63)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C108(1.08); C119(1.04); C268(0.67); C277(0.74)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C108(1.03); C119(1.03); C180(0.78); C268(1.22)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C108(0.93); C119(0.93); C268(0.54); C277(0.61)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C108(1.07); C119(1.01); C268(0.67); C277(0.73)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C108(0.90); C119(0.85); C268(0.70); C277(0.82)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C108(1.54); C119(1.46); C268(0.70); C277(0.74)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C108(1.17); C119(1.10); C268(0.71); C277(0.76)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C108(1.06); C119(1.04); C180(1.53); C268(1.36)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C108(3.97); C119(3.92); C180(1.46); C268(1.16)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C108(1.04); C119(1.02); C180(1.01); C268(0.94)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C108(1.25); C119(1.23); C180(1.58); C268(1.22)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C108(1.76); C119(1.76); C180(0.71); C268(1.10)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C108(1.12); C119(1.09); C180(1.46); C268(1.05)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C108(1.06); C119(1.03); C180(1.90); C268(1.58)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C108(1.18); C119(1.18); C180(2.64); C268(2.52)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C108(1.12); C119(1.12); C180(1.98); C268(1.98)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C108(1.18); C119(1.19); C180(1.46); C268(1.42)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C108(1.00); C119(1.01); C180(1.06); C268(1.23)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C108(0.79); C119(0.79); C180(1.42); C268(1.23)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C108(1.05); C119(1.06); C180(2.30); C268(2.06)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C108(1.24); C119(1.24); C180(2.35); C268(2.61)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C108(1.00); C119(1.02); C180(1.40); C268(1.25)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C108(1.22); C119(1.22); C180(0.83); C268(0.99)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C108(0.93); C119(0.91); C180(2.07); C268(1.82)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C108(0.89); C119(0.90); C180(0.86); C268(1.35)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C108(0.91); C119(0.90); C180(0.88); C268(1.21)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C108(0.87); C119(0.88); C180(1.23); C268(1.18)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C108(1.04); C119(1.04); C180(1.27); C268(0.81)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C108(0.96); C119(0.92); C180(1.01); C268(1.30)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C108(0.81); C119(0.82); C180(0.96); C268(1.05)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C108(0.83); C119(0.84); C180(0.84); C268(0.98)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C108(0.71); C119(0.71); C180(0.91); C268(0.82)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C108(0.73); C119(0.72); C180(1.09); C268(0.80)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C530(1.18); C180(0.91); C42(1.01); C108(1.01)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C250(0.67)  LDD1702  [4]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [6]
 LDCM0625  F8 Ramos C180(0.80); 1.29  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C42(0.51); C180(0.52); C321(1.59)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C42(20.00); C180(1.04); 0.92  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C42(0.62); C180(0.71); C321(0.79); 0.78  LDD2191  [26]
 LDCM0575  Fragment13 Ramos C42(1.27); C180(0.88); C321(1.19); 1.59  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C42(0.51); C180(1.33); 0.89  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C42(0.46); C180(0.62); C321(1.13)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos C42(1.02); C180(0.79); C321(0.35); 1.07  LDD2195  [26]
 LDCM0582  Fragment23 Ramos C42(0.63); C180(0.83); C321(1.15)  LDD2196  [26]
 LDCM0578  Fragment27 Ramos C42(2.04); C180(0.90); C321(1.30); 1.05  LDD2197  [26]
 LDCM0586  Fragment28 Ramos C42(0.14); C180(0.62); C321(0.86); 0.89  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C42(1.87); C180(1.02); 0.97  LDD2199  [26]
 LDCM0589  Fragment31 Ramos C42(0.96); C180(1.23); C321(1.93); 1.27  LDD2200  [26]
 LDCM0590  Fragment32 Ramos C42(0.69); C180(0.53)  LDD2201  [26]
 LDCM0468  Fragment33 HCT 116 C108(0.92); C119(0.85); C268(0.77); C277(0.81)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C42(6.79); C180(0.67); C321(0.39); 0.37  LDD2203  [26]
 LDCM0566  Fragment4 Ramos C180(0.75); 1.13  LDD2184  [26]
 LDCM0427  Fragment51 HCT 116 C108(1.87); C119(1.89); C180(0.56); C268(1.08)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C180(0.92); C321(0.11); 2.05  LDD2204  [26]
 LDCM0614  Fragment56 Ramos C42(1.85); C180(1.06); C321(0.16); 1.25  LDD2205  [26]
 LDCM0569  Fragment7 Ramos C180(0.56); 1.11  LDD2186  [26]
 LDCM0571  Fragment9 Ramos C42(0.46); C180(0.57); C321(0.60); 1.68  LDD2188  [26]
 LDCM0107  IAA HeLa C348(0.00); C180(0.00); H249(0.00); C250(0.00)  LDD0221  [18]
 LDCM0022  KB02 HCT 116 C108(2.64); C119(2.64); C180(1.35); C268(0.99)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C108(1.42); C119(1.42); C180(2.16); C268(1.19)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C108(2.51); C119(2.51); C180(1.22); C268(1.06)  LDD0082  [8]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C108(0.68)  LDD2102  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [18]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C108(0.91)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C108(1.08)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C250(0.99)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C108(1.05)  LDD2094  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C250(0.60); C108(1.25)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C250(1.16)  LDD2099  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C250(0.50)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C108(1.53)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C250(1.04)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C250(0.40)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C250(0.50)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C250(1.08)  LDD2111  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C250(2.17)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C250(0.81)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C42(1.51)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C250(0.81)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C250(1.20)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C250(1.18)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C250(0.54)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C250(0.50)  LDD2134  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C250(1.51)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C250(0.97)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C250(3.00)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C250(0.81)  LDD2140  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C250(2.64)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C250(0.93)  LDD2146  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C250(0.62)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C250(1.49)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C108(2.15)  LDD2153  [4]
 LDCM0628  OTUB2-COV-1 HEK-293T C108(1.00)  LDD2207  [27]
 LDCM0131  RA190 MM1.R C108(1.59)  LDD0304  [28]
 LDCM0021  THZ1 HCT 116 C108(1.09); C119(1.09)  LDD2173  [8]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
28 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.