Details of the Target

General Information of Target

Target ID LDTP13991
Target Name Serine-threonine kinase receptor-associated protein (STRAP)
Gene Name STRAP
Gene ID 11171
Synonyms
MAWD; UNRIP; Serine-threonine kinase receptor-associated protein; MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLFGKTQEKPPKELVNEWSLKIRKEMRVVDRQIRDIQREEEKVKRSVKDAAKKGQKDVC
IVLAKEMIRSRKAVSKLYASKAHMNSVLMGMKNQLAVLRVAGSLQKSTEVMKAMQSLVKI
PEIQATMRELSKEMMKAGIIEEMLEDTFESMDDQEEMEEEAEMEIDRILFEITAGALGKA
PSKVTDALPEPEPPGAMAASEDEEEEEEALEAMQSRLATLRS
Target Type
Literature-reported
Target Bioclass
Other
Family
WD repeat STRAP family
Subcellular location
Cytoplasm
Function
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.
TTD ID
T93177
Uniprot ID
Q9Y3F4
DrugMap ID
TT165DP
Ensemble ID
ENST00000025399.10
HGNC ID
HGNC:30796

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ETK1 SNV: p.I52T DBIA    Probe Info 
MKN45 SNV: p.G24V DBIA    Probe Info 
SSP25 SNV: p.I52T DBIA    Probe Info 
SUPT1 Deletion: p.A149LfsTer26 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 46 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TH211
 Probe Info  		Y261(20.00); Y252(17.82); Y114(13.99); Y280(13.42)  LDD0257  [3]
TH214
 Probe Info  		Y114(10.03)  LDD0258  [3]
TH216
 Probe Info  		Y252(15.22); Y250(14.36); Y261(10.84); Y114(10.24)  LDD0259  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
ONAyne
 Probe Info  		K137(7.05)  LDD0274  [5]
Probe 1
 Probe Info  		Y127(19.80); Y250(20,277.87); Y252(456.76); Y261(75.02)  LDD3495  [6]
THZ1-DTB
 Probe Info  		C305(1.16)  LDD0460  [7]
BTD
 Probe Info  		C270(1.33); C10(0.60)  LDD2091  [8]
DA-P3
 Probe Info  		4.80  LDD0183  [9]
AHL-Pu-1
 Probe Info  		C340(3.55); C305(2.76)  LDD0169  [10]
EA-probe
 Probe Info  		C340(0.80)  LDD2210  [11]
HHS-475
 Probe Info  		Y114(1.18)  LDD0264  [12]
HHS-465
 Probe Info  		Y28(10.00)  LDD2237  [13]
DBIA
 Probe Info  		C305(1.26)  LDD0080  [14]
5E-2FA
 Probe Info  		H142(0.00); H269(0.00); H171(0.00); H209(0.00)  LDD2235  [15]
ATP probe
 Probe Info  		K262(0.00); K122(0.00); K131(0.00); K164(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C152(0.00); C305(0.00); C270(0.00); C340(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [18]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [19]
IPIAA_L
 Probe Info  		C305(0.00); C270(0.00)  LDD0031  [19]
Lodoacetamide azide
 Probe Info  		C152(0.00); C305(0.00); C270(0.00); C340(0.00)  LDD0037  [17]
IPM
 Probe Info  		C305(0.00); C340(0.00)  LDD0025  [20]
JW-RF-010
 Probe Info  		C340(0.00); C305(0.00)  LDD0026  [20]
NAIA_4
 Probe Info  		C305(0.00); C340(0.00); 0.00  LDD2226  [21]
TFBX
 Probe Info  		N.A.  LDD0027  [20]
WYneC
 Probe Info  		N.A.  LDD0014  [22]
WYneN
 Probe Info  		N.A.  LDD0021  [22]
WYneO
 Probe Info  		N.A.  LDD0022  [22]
aHNE
 Probe Info  		N.A.  LDD0001  [22]
Compound 10
 Probe Info  		N.A.  LDD2216  [23]
Compound 11
 Probe Info  		N.A.  LDD2213  [23]
ENE
 Probe Info  		N.A.  LDD0006  [22]
NHS
 Probe Info  		K164(0.00); K122(0.00)  LDD0010  [22]
NPM
 Probe Info  		N.A.  LDD0016  [22]
STPyne
 Probe Info  		K137(0.00); K104(0.00); K147(0.00)  LDD0009  [22]
VSF
 Probe Info  		C340(0.00); C305(0.00)  LDD0007  [22]
Phosphinate-6
 Probe Info  		C305(0.00); C340(0.00)  LDD0018  [24]
1c-yne
 Probe Info  		K104(0.00); K304(0.00); K298(0.00); K84(0.00)  LDD0228  [25]
Acrolein
 Probe Info  		C305(0.00); H171(0.00); C36(0.00); C340(0.00)  LDD0217  [26]
Crotonaldehyde
 Probe Info  		C270(0.00); C152(0.00); C36(0.00)  LDD0219  [26]
Methacrolein
 Probe Info  		C152(0.00); C270(0.00); C36(0.00)  LDD0218  [26]
W1
 Probe Info  		C270(0.00); C152(0.00)  LDD0236  [27]
AOyne
 Probe Info  		14.30  LDD0443  [28]
NAIA_5
 Probe Info  		C152(0.00); C305(0.00); C270(0.00); C340(0.00)  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		6.22  LDD0465  [29]
STS-1
 Probe Info  		N.A.  LDD0137  [30]
STS-2
 Probe Info  		N.A.  LDD0138  [30]
VE-P
 Probe Info  		N.A.  LDD0396  [31]
DA-2
 Probe Info  		N.A.  LDD0070  [32]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C305(0.89)  LDD2112  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C305(0.82)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C270(1.28); C152(1.61); C10(0.89); C305(0.79)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C270(1.51); C10(1.18)  LDD2152  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C305(0.75)  LDD2132  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C340(3.55); C305(2.76)  LDD0169  [10]
 LDCM0214  AC1 HCT 116 C152(1.08); C270(1.65); C305(1.04); C340(0.94)  LDD0531  [14]
 LDCM0215  AC10 HCT 116 C152(1.07); C270(0.94); C305(1.27); C340(1.22)  LDD0532  [14]
 LDCM0216  AC100 HCT 116 C152(0.99); C270(0.79); C305(0.95); C340(0.84)  LDD0533  [14]
 LDCM0217  AC101 HCT 116 C152(0.92); C270(0.62); C305(0.96); C340(0.90)  LDD0534  [14]
 LDCM0218  AC102 HCT 116 C152(0.87); C270(0.68); C305(0.94); C340(0.82)  LDD0535  [14]
 LDCM0219  AC103 HCT 116 C152(0.85); C270(0.65); C305(0.90); C340(1.41)  LDD0536  [14]
 LDCM0220  AC104 HCT 116 C152(0.77); C270(0.68); C305(0.88); C340(0.90)  LDD0537  [14]
 LDCM0221  AC105 HCT 116 C152(0.80); C270(0.59); C305(0.92); C340(1.14)  LDD0538  [14]
 LDCM0222  AC106 HCT 116 C152(0.87); C270(0.64); C305(0.89); C340(1.12)  LDD0539  [14]
 LDCM0223  AC107 HCT 116 C152(0.83); C270(0.70); C305(0.88); C340(1.17)  LDD0540  [14]
 LDCM0224  AC108 HCT 116 C152(0.84); C270(0.83); C305(0.94); C340(0.89)  LDD0541  [14]
 LDCM0225  AC109 HCT 116 C152(0.78); C270(1.35); C305(0.93); C340(0.70)  LDD0542  [14]
 LDCM0226  AC11 HCT 116 C152(1.03); C270(0.82); C305(1.23); C340(1.19)  LDD0543  [14]
 LDCM0227  AC110 HCT 116 C152(0.80); C270(0.79); C305(1.03); C340(0.70)  LDD0544  [14]
 LDCM0228  AC111 HCT 116 C152(0.81); C270(0.77); C305(0.97); C340(0.95)  LDD0545  [14]
 LDCM0229  AC112 HCT 116 C152(0.74); C270(0.73); C305(1.03); C340(1.07)  LDD0546  [14]
 LDCM0230  AC113 HCT 116 C152(1.33); C270(1.05); C305(0.99)  LDD0547  [14]
 LDCM0231  AC114 HCT 116 C152(1.18); C270(0.91); C305(1.03)  LDD0548  [14]
 LDCM0232  AC115 HCT 116 C152(1.19); C270(0.80); C305(1.02)  LDD0549  [14]
 LDCM0233  AC116 HCT 116 C152(1.15); C270(0.81); C305(1.12)  LDD0550  [14]
 LDCM0234  AC117 HCT 116 C152(1.14); C270(0.97); C305(1.04)  LDD0551  [14]
 LDCM0235  AC118 HCT 116 C152(1.23); C270(0.99); C305(0.88)  LDD0552  [14]
 LDCM0236  AC119 HCT 116 C152(1.18); C270(0.93); C305(1.12)  LDD0553  [14]
 LDCM0237  AC12 HCT 116 C152(1.02); C270(0.94); C305(1.15); C340(0.98)  LDD0554  [14]
 LDCM0238  AC120 HCT 116 C152(1.08); C270(0.89); C305(0.97)  LDD0555  [14]
 LDCM0239  AC121 HCT 116 C152(1.04); C270(1.08); C305(0.95)  LDD0556  [14]
 LDCM0240  AC122 HCT 116 C152(1.08); C270(0.98); C305(0.95)  LDD0557  [14]
 LDCM0241  AC123 HCT 116 C152(0.99); C270(1.21); C305(0.87)  LDD0558  [14]
 LDCM0242  AC124 HCT 116 C152(1.17); C270(1.02); C305(0.86)  LDD0559  [14]
 LDCM0243  AC125 HCT 116 C152(1.17); C270(0.92); C305(0.94)  LDD0560  [14]
 LDCM0244  AC126 HCT 116 C152(1.24); C270(0.94); C305(0.93)  LDD0561  [14]
 LDCM0245  AC127 HCT 116 C152(1.14); C270(1.00); C305(0.92)  LDD0562  [14]
 LDCM0246  AC128 HCT 116 C152(0.97); C270(0.87); C305(0.65); C340(1.30)  LDD0563  [14]
 LDCM0247  AC129 HCT 116 C152(1.18); C270(1.10); C305(0.79); C340(0.61)  LDD0564  [14]
 LDCM0249  AC130 HCT 116 C152(1.20); C270(1.14); C305(0.84); C340(0.88)  LDD0566  [14]
 LDCM0250  AC131 HCT 116 C152(1.13); C270(0.86); C305(0.74); C340(0.67)  LDD0567  [14]
 LDCM0251  AC132 HCT 116 C152(1.26); C270(1.03); C305(0.85); C340(0.75)  LDD0568  [14]
 LDCM0252  AC133 HCT 116 C152(1.09); C270(1.09); C305(0.90); C340(0.92)  LDD0569  [14]
 LDCM0253  AC134 HCT 116 C152(1.06); C270(0.89); C305(0.87); C340(1.06)  LDD0570  [14]
 LDCM0254  AC135 HCT 116 C152(1.06); C270(1.01); C305(0.78); C340(0.99)  LDD0571  [14]
 LDCM0255  AC136 HCT 116 C152(1.10); C270(0.98); C305(0.88); C340(0.93)  LDD0572  [14]
 LDCM0256  AC137 HCT 116 C152(1.10); C270(0.85); C305(0.76); C340(0.75)  LDD0573  [14]
 LDCM0257  AC138 HCT 116 C152(1.07); C270(0.64); C305(0.86); C340(0.90)  LDD0574  [14]
 LDCM0258  AC139 HCT 116 C152(1.23); C270(0.79); C305(0.97); C340(0.89)  LDD0575  [14]
 LDCM0259  AC14 HCT 116 C152(0.93); C270(0.96); C305(1.07); C340(0.95)  LDD0576  [14]
 LDCM0260  AC140 HCT 116 C152(1.07); C270(0.68); C305(0.94); C340(1.04)  LDD0577  [14]
 LDCM0261  AC141 HCT 116 C152(1.17); C270(0.68); C305(1.02); C340(0.98)  LDD0578  [14]
 LDCM0262  AC142 HCT 116 C152(1.25); C270(0.91); C305(0.89); C340(0.69)  LDD0579  [14]
 LDCM0263  AC143 HCT 116 C270(0.91); C152(0.91); C305(1.19); C340(1.35)  LDD0580  [14]
 LDCM0264  AC144 HCT 116 C305(0.74); C152(0.84); C270(0.85); C340(1.59)  LDD0581  [14]
 LDCM0265  AC145 HCT 116 C305(0.84); C152(0.87); C270(0.87); C340(1.33)  LDD0582  [14]
 LDCM0266  AC146 HCT 116 C305(0.84); C270(0.88); C152(0.90); C340(1.91)  LDD0583  [14]
 LDCM0267  AC147 HCT 116 C270(0.78); C152(0.79); C305(1.04); C340(1.76)  LDD0584  [14]
 LDCM0268  AC148 HCT 116 C152(0.66); C305(0.66); C270(0.72); C340(2.63)  LDD0585  [14]
 LDCM0269  AC149 HCT 116 C305(0.79); C270(0.80); C152(0.84); C340(2.08)  LDD0586  [14]
 LDCM0270  AC15 HCT 116 C152(0.91); C270(0.97); C305(1.10); C340(1.29)  LDD0587  [14]
 LDCM0271  AC150 HCT 116 C305(0.78); C270(0.85); C152(0.92); C340(1.19)  LDD0588  [14]
 LDCM0272  AC151 HCT 116 C270(0.78); C152(0.82); C305(0.91); C340(1.53)  LDD0589  [14]
 LDCM0273  AC152 HCT 116 C152(0.74); C270(0.78); C305(0.79); C340(2.08)  LDD0590  [14]
 LDCM0274  AC153 HCT 116 C270(0.63); C152(0.65); C305(0.69); C340(2.73)  LDD0591  [14]
 LDCM0621  AC154 HCT 116 C152(0.76); C270(0.79); C305(0.93); C340(1.35)  LDD2158  [14]
 LDCM0622  AC155 HCT 116 C152(0.82); C270(0.78); C305(0.71); C340(1.77)  LDD2159  [14]
 LDCM0623  AC156 HCT 116 C152(0.85); C270(0.97); C305(0.75); C340(1.24)  LDD2160  [14]
 LDCM0624  AC157 HCT 116 C152(0.78); C270(0.86); C305(0.80); C340(1.07)  LDD2161  [14]
 LDCM0276  AC17 HCT 116 C270(0.92); C305(1.16); C340(1.17)  LDD0593  [14]
 LDCM0277  AC18 HCT 116 C270(0.92); C305(1.48); C340(2.09)  LDD0594  [14]
 LDCM0278  AC19 HCT 116 C270(0.96); C305(1.10); C340(1.10)  LDD0595  [14]
 LDCM0279  AC2 HCT 116 C152(1.00); C340(1.01); C305(1.09); C270(1.15)  LDD0596  [14]
 LDCM0280  AC20 HCT 116 C270(0.91); C305(1.15); C340(1.32)  LDD0597  [14]
 LDCM0281  AC21 HCT 116 C270(0.96); C305(1.16); C340(1.33)  LDD0598  [14]
 LDCM0282  AC22 HCT 116 C340(0.81); C270(1.00); C305(1.09)  LDD0599  [14]
 LDCM0283  AC23 HCT 116 C270(0.91); C305(1.08); C340(1.13)  LDD0600  [14]
 LDCM0284  AC24 HCT 116 C340(0.95); C270(1.01); C305(1.03)  LDD0601  [14]
 LDCM0285  AC25 HCT 116 C305(1.02); C270(1.08); C152(1.18)  LDD0602  [14]
 LDCM0286  AC26 HCT 116 C270(0.84); C152(0.85); C305(1.15)  LDD0603  [14]
 LDCM0287  AC27 HCT 116 C152(0.66); C270(0.82); C305(1.07)  LDD0604  [14]
 LDCM0288  AC28 HCT 116 C152(0.73); C270(0.82); C305(1.09)  LDD0605  [14]
 LDCM0289  AC29 HCT 116 C152(0.44); C270(0.92); C305(1.19)  LDD0606  [14]
 LDCM0290  AC3 HCT 116 C340(0.98); C305(1.16); C152(1.28); C270(1.63)  LDD0607  [14]
 LDCM0291  AC30 HCT 116 C152(0.41); C270(0.75); C305(1.25)  LDD0608  [14]
 LDCM0292  AC31 HCT 116 C152(0.57); C270(0.93); C305(1.19)  LDD0609  [14]
 LDCM0293  AC32 HCT 116 C152(0.39); C270(0.75); C305(1.31)  LDD0610  [14]
 LDCM0294  AC33 HCT 116 C152(0.77); C270(0.81); C305(1.05)  LDD0611  [14]
 LDCM0295  AC34 HCT 116 C270(0.72); C152(0.83); C305(1.01)  LDD0612  [14]
 LDCM0296  AC35 HCT 116 C305(0.87); C270(1.15); C152(1.29)  LDD0613  [14]
 LDCM0297  AC36 HCT 116 C305(0.93); C152(1.09); C270(1.13)  LDD0614  [14]
 LDCM0298  AC37 HCT 116 C305(0.89); C270(1.13); C152(1.35)  LDD0615  [14]
 LDCM0299  AC38 HCT 116 C152(1.00); C270(1.03); C305(1.08)  LDD0616  [14]
 LDCM0300  AC39 HCT 116 C270(0.92); C305(0.93); C152(1.10)  LDD0617  [14]
 LDCM0301  AC4 HCT 116 C305(1.04); C340(1.11); C152(1.46); C270(1.61)  LDD0618  [14]
 LDCM0302  AC40 HCT 116 C270(0.94); C305(1.00); C152(1.14)  LDD0619  [14]
 LDCM0303  AC41 HCT 116 C270(0.96); C305(0.97); C152(1.02)  LDD0620  [14]
 LDCM0304  AC42 HCT 116 C270(0.91); C152(1.00); C305(1.02)  LDD0621  [14]
 LDCM0305  AC43 HCT 116 C270(0.86); C152(0.91); C305(1.10)  LDD0622  [14]
 LDCM0306  AC44 HCT 116 C270(1.00); C305(1.01); C152(1.20)  LDD0623  [14]
 LDCM0307  AC45 HCT 116 C270(0.98); C305(0.99); C152(1.17)  LDD0624  [14]
 LDCM0308  AC46 HCT 116 C270(0.90); C152(0.96); C305(1.02)  LDD0625  [14]
 LDCM0309  AC47 HCT 116 C270(0.88); C152(1.01); C305(1.03)  LDD0626  [14]
 LDCM0310  AC48 HCT 116 C305(1.01); C270(1.07); C152(1.21)  LDD0627  [14]
 LDCM0311  AC49 HCT 116 C152(0.84); C270(0.87); C305(1.11)  LDD0628  [14]
 LDCM0312  AC5 HCT 116 C340(1.09); C305(1.12); C152(1.38); C270(1.74)  LDD0629  [14]
 LDCM0313  AC50 HCT 116 C270(0.69); C152(0.83); C305(0.92)  LDD0630  [14]
 LDCM0314  AC51 HCT 116 C305(0.94); C270(1.06); C152(1.10)  LDD0631  [14]
 LDCM0315  AC52 HCT 116 C270(0.84); C152(0.92); C305(0.97)  LDD0632  [14]
 LDCM0316  AC53 HCT 116 C270(0.86); C152(1.01); C305(1.12)  LDD0633  [14]
 LDCM0317  AC54 HCT 116 C270(0.79); C152(0.90); C305(1.03)  LDD0634  [14]
 LDCM0318  AC55 HCT 116 C152(0.93); C270(0.94); C305(1.24)  LDD0635  [14]
 LDCM0319  AC56 HCT 116 C270(0.63); C152(0.72); C305(1.04)  LDD0636  [14]
 LDCM0320  AC57 HCT 116 C305(1.03); C270(1.04); C152(1.07); C340(1.44)  LDD0637  [14]
 LDCM0321  AC58 HCT 116 C270(0.87); C152(1.07); C305(1.19); C340(1.42)  LDD0638  [14]
 LDCM0322  AC59 HCT 116 C152(0.92); C270(0.92); C305(1.07); C340(1.59)  LDD0639  [14]
 LDCM0323  AC6 HCT 116 C270(0.87); C152(0.97); C340(1.16); C305(1.31)  LDD0640  [14]
 LDCM0324  AC60 HCT 116 C152(0.95); C270(1.02); C305(1.11); C340(1.47)  LDD0641  [14]
 LDCM0325  AC61 HCT 116 C305(1.11); C270(1.15); C340(1.22); C152(1.26)  LDD0642  [14]
 LDCM0326  AC62 HCT 116 C152(0.92); C270(0.95); C305(1.15); C340(1.55)  LDD0643  [14]
 LDCM0327  AC63 HCT 116 C305(0.97); C270(1.06); C152(1.08); C340(1.32)  LDD0644  [14]
 LDCM0328  AC64 HCT 116 C270(0.94); C152(1.00); C305(1.05); C340(1.76)  LDD0645  [14]
 LDCM0329  AC65 HCT 116 C270(1.04); C152(1.16); C340(1.26); C305(1.47)  LDD0646  [14]
 LDCM0330  AC66 HCT 116 C270(1.09); C340(1.17); C152(1.19); C305(1.20)  LDD0647  [14]
 LDCM0331  AC67 HCT 116 C270(0.73); C152(0.76); C305(1.05); C340(1.41)  LDD0648  [14]
 LDCM0332  AC68 HCT 116 C152(0.92); C305(1.03); C270(1.06)  LDD0649  [14]
 LDCM0333  AC69 HCT 116 C152(0.88); C270(1.02); C305(1.03)  LDD0650  [14]
 LDCM0334  AC7 HCT 116 C270(1.02); C340(1.03); C152(1.06); C305(1.14)  LDD0651  [14]
 LDCM0335  AC70 HCT 116 C152(0.63); C270(1.01); C305(1.06)  LDD0652  [14]
 LDCM0336  AC71 HCT 116 C305(0.91); C152(1.10); C270(1.18)  LDD0653  [14]
 LDCM0337  AC72 HCT 116 C152(0.78); C270(0.98); C305(1.01)  LDD0654  [14]
 LDCM0338  AC73 HCT 116 C152(0.68); C270(0.78); C305(1.21)  LDD0655  [14]
 LDCM0339  AC74 HCT 116 C270(0.88); C152(0.91); C305(1.09)  LDD0656  [14]
 LDCM0340  AC75 HCT 116 C152(0.59); C270(0.71); C305(1.34)  LDD0657  [14]
 LDCM0341  AC76 HCT 116 C270(0.99); C305(1.02); C152(1.09)  LDD0658  [14]
 LDCM0342  AC77 HCT 116 C152(0.79); C270(0.95); C305(1.14)  LDD0659  [14]
 LDCM0343  AC78 HCT 116 C305(1.01); C152(1.03); C270(1.23)  LDD0660  [14]
 LDCM0344  AC79 HCT 116 C152(0.75); C270(0.96); C305(1.05)  LDD0661  [14]
 LDCM0345  AC8 HCT 116 C270(0.86); C152(1.01); C305(1.21); C340(1.27)  LDD0662  [14]
 LDCM0346  AC80 HCT 116 C270(0.98); C305(1.01); C152(1.11)  LDD0663  [14]
 LDCM0347  AC81 HCT 116 C152(0.86); C305(0.95); C270(1.10)  LDD0664  [14]
 LDCM0348  AC82 HCT 116 C270(0.52); C152(0.60); C305(1.27)  LDD0665  [14]
 LDCM0349  AC83 HCT 116 C270(0.65); C152(0.79); C305(1.04); C340(1.41)  LDD0666  [14]
 LDCM0350  AC84 HCT 116 C270(0.68); C340(0.82); C152(0.83); C305(0.95)  LDD0667  [14]
 LDCM0351  AC85 HCT 116 C270(0.74); C340(0.76); C152(0.89); C305(1.02)  LDD0668  [14]
 LDCM0352  AC86 HCT 116 C270(0.64); C152(0.93); C340(0.95); C305(1.04)  LDD0669  [14]
 LDCM0353  AC87 HCT 116 C340(0.56); C270(0.84); C305(1.02); C152(1.02)  LDD0670  [14]
 LDCM0354  AC88 HCT 116 C270(0.70); C152(0.81); C305(1.00); C340(1.01)  LDD0671  [14]
 LDCM0355  AC89 HCT 116 C270(0.63); C340(0.77); C152(0.89); C305(1.04)  LDD0672  [14]
 LDCM0357  AC90 HCT 116 C340(0.69); C270(0.78); C305(1.08); C152(1.23)  LDD0674  [14]
 LDCM0358  AC91 HCT 116 C270(0.70); C152(0.74); C305(1.03); C340(1.35)  LDD0675  [14]
 LDCM0359  AC92 HCT 116 C270(0.65); C152(0.79); C305(1.07); C340(1.59)  LDD0676  [14]
 LDCM0360  AC93 HCT 116 C270(0.74); C340(0.74); C152(0.92); C305(1.06)  LDD0677  [14]
 LDCM0361  AC94 HCT 116 C152(0.83); C270(0.89); C305(0.96); C340(1.25)  LDD0678  [14]
 LDCM0362  AC95 HCT 116 C340(0.75); C270(1.02); C305(1.06); C152(1.30)  LDD0679  [14]
 LDCM0363  AC96 HCT 116 C270(0.78); C152(0.85); C340(0.92); C305(0.97)  LDD0680  [14]
 LDCM0364  AC97 HCT 116 C270(0.58); C152(0.75); C340(0.81); C305(1.20)  LDD0681  [14]
 LDCM0365  AC98 HCT 116 C270(0.31); C152(0.52); C305(1.11); C340(1.65)  LDD0682  [14]
 LDCM0366  AC99 HCT 116 C270(0.72); C340(0.78); C152(0.89); C305(1.05)  LDD0683  [14]
 LDCM0545  Acetamide MDA-MB-231 C10(0.23); C305(0.81)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C270(0.94); C10(0.76)  LDD2113  [8]
 LDCM0248  AKOS034007472 HCT 116 C152(1.09); C270(1.00); C305(1.09); C340(1.05)  LDD0565  [14]
 LDCM0356  AKOS034007680 HCT 116 C270(0.93); C152(1.00); C340(1.13); C305(1.13)  LDD0673  [14]
 LDCM0275  AKOS034007705 HCT 116 C270(0.85); C152(0.89); C305(1.57); C340(2.05)  LDD0592  [14]
 LDCM0156  Aniline NCI-H1299 13.21  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C270(1.33); C10(0.60)  LDD2091  [8]
 LDCM0630  CCW28-3 231MFP C340(1.27)  LDD2214  [33]
 LDCM0108  Chloroacetamide HeLa C36(0.00); C305(0.00); C152(0.00); H171(0.00)  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C305(0.97)  LDD2227  [21]
 LDCM0367  CL1 HCT 116 C10(0.94); C152(0.95); C270(0.95)  LDD0684  [14]
 LDCM0368  CL10 HCT 116 C10(0.88); C270(0.90); C152(1.37)  LDD0685  [14]
 LDCM0369  CL100 HCT 116 C152(0.96); C340(1.03); C305(1.13); C270(1.38)  LDD0686  [14]
 LDCM0370  CL101 HCT 116 C152(0.86); C270(0.95); C305(1.14); C340(1.44)  LDD0687  [14]
 LDCM0371  CL102 HCT 116 C340(0.95); C270(1.00); C152(1.02); C305(1.12)  LDD0688  [14]
 LDCM0372  CL103 HCT 116 C305(0.96); C340(0.96); C152(1.01); C270(1.09)  LDD0689  [14]
 LDCM0373  CL104 HCT 116 C152(0.82); C270(0.96); C305(1.02); C340(1.33)  LDD0690  [14]
 LDCM0374  CL105 HCT 116 C270(0.83); C305(1.20); C340(1.42)  LDD0691  [14]
 LDCM0375  CL106 HCT 116 C270(0.86); C340(1.19); C305(1.40)  LDD0692  [14]
 LDCM0376  CL107 HCT 116 C270(0.91); C340(1.22); C305(1.35)  LDD0693  [14]
 LDCM0377  CL108 HCT 116 C270(0.76); C305(1.42); C340(1.48)  LDD0694  [14]
 LDCM0378  CL109 HCT 116 C270(0.83); C305(1.17); C340(1.24)  LDD0695  [14]
 LDCM0379  CL11 HCT 116 C10(0.93); C270(0.94); C152(1.82)  LDD0696  [14]
 LDCM0380  CL110 HCT 116 C270(0.83); C340(1.17); C305(1.25)  LDD0697  [14]
 LDCM0381  CL111 HCT 116 C270(0.78); C340(0.85); C305(1.13)  LDD0698  [14]
 LDCM0382  CL112 HCT 116 C270(0.86); C152(0.93); C305(0.93)  LDD0699  [14]
 LDCM0383  CL113 HCT 116 C152(0.39); C270(0.83); C305(1.17)  LDD0700  [14]
 LDCM0384  CL114 HCT 116 C152(0.38); C270(0.82); C305(1.24)  LDD0701  [14]
 LDCM0385  CL115 HCT 116 C152(0.57); C270(0.75); C305(1.08)  LDD0702  [14]
 LDCM0386  CL116 HCT 116 C152(0.79); C270(0.81); C305(1.05)  LDD0703  [14]
 LDCM0387  CL117 HCT 116 C270(0.69); C152(0.82); C305(1.08)  LDD0704  [14]
 LDCM0388  CL118 HCT 116 C270(0.90); C305(0.99); C152(1.00)  LDD0705  [14]
 LDCM0389  CL119 HCT 116 C270(0.93); C305(1.08); C152(1.09)  LDD0706  [14]
 LDCM0390  CL12 HCT 116 C10(0.76); C270(0.88); C152(1.21)  LDD0707  [14]
 LDCM0391  CL120 HCT 116 C270(0.92); C152(1.00); C305(1.06)  LDD0708  [14]
 LDCM0392  CL121 HCT 116 C270(0.82); C152(0.84); C305(1.14)  LDD0709  [14]
 LDCM0393  CL122 HCT 116 C270(0.84); C152(0.89); C305(1.14)  LDD0710  [14]
 LDCM0394  CL123 HCT 116 C270(0.79); C152(0.98); C305(0.99)  LDD0711  [14]
 LDCM0395  CL124 HCT 116 C270(0.73); C152(0.83); C305(1.03)  LDD0712  [14]
 LDCM0396  CL125 HCT 116 C340(0.94); C270(1.03); C152(1.15); C305(1.23)  LDD0713  [14]
 LDCM0397  CL126 HCT 116 C340(0.81); C270(0.90); C152(0.92); C305(1.35)  LDD0714  [14]
 LDCM0398  CL127 HCT 116 C270(1.01); C152(1.02); C340(1.05); C305(1.27)  LDD0715  [14]
 LDCM0399  CL128 HCT 116 C270(0.89); C152(1.04); C305(1.09); C340(1.31)  LDD0716  [14]
 LDCM0400  CL13 HCT 116 C10(0.89); C270(0.94); C152(1.65)  LDD0717  [14]
 LDCM0401  CL14 HCT 116 C10(0.86); C270(1.05); C152(1.17)  LDD0718  [14]
 LDCM0402  CL15 HCT 116 C270(0.86); C10(1.05); C152(1.45)  LDD0719  [14]
 LDCM0403  CL16 HCT 116 C270(0.76); C152(0.91); C305(1.11)  LDD0720  [14]
 LDCM0404  CL17 HCT 116 C305(0.69); C270(1.05); C152(1.05)  LDD0721  [14]
 LDCM0405  CL18 HCT 116 C305(0.82); C270(1.11); C152(1.12)  LDD0722  [14]
 LDCM0406  CL19 HCT 116 C152(0.92); C270(0.94); C305(0.96)  LDD0723  [14]
 LDCM0407  CL2 HCT 116 C10(0.74); C152(0.89); C270(1.05)  LDD0724  [14]
 LDCM0408  CL20 HCT 116 C270(0.86); C152(0.92); C305(0.98)  LDD0725  [14]
 LDCM0409  CL21 HCT 116 C305(0.82); C270(0.90); C152(0.92)  LDD0726  [14]
 LDCM0410  CL22 HCT 116 C270(0.79); C152(0.81); C305(0.99)  LDD0727  [14]
 LDCM0411  CL23 HCT 116 C152(0.87); C270(0.87); C305(0.95)  LDD0728  [14]
 LDCM0412  CL24 HCT 116 C152(0.90); C270(0.84); C305(1.02)  LDD0729  [14]
 LDCM0413  CL25 HCT 116 C152(0.79); C270(0.79); C305(0.99)  LDD0730  [14]
 LDCM0414  CL26 HCT 116 C152(0.74); C270(0.82); C305(0.97)  LDD0731  [14]
 LDCM0415  CL27 HCT 116 C152(0.95); C270(0.92); C305(1.04)  LDD0732  [14]
 LDCM0416  CL28 HCT 116 C152(0.80); C270(0.78); C305(0.82)  LDD0733  [14]
 LDCM0417  CL29 HCT 116 C152(1.02); C270(0.90); C305(0.97)  LDD0734  [14]
 LDCM0418  CL3 HCT 116 C10(0.88); C152(0.98); C270(1.09)  LDD0735  [14]
 LDCM0419  CL30 HCT 116 C152(1.00); C270(0.96); C305(0.25)  LDD0736  [14]
 LDCM0420  CL31 HCT 116 C10(0.97); C152(1.03); C270(0.88); C305(1.00)  LDD0737  [14]
 LDCM0421  CL32 HCT 116 C10(0.74); C152(1.39); C270(1.00); C305(1.14)  LDD0738  [14]
 LDCM0422  CL33 HCT 116 C10(0.99); C152(1.05); C270(0.85); C305(1.19)  LDD0739  [14]
 LDCM0423  CL34 HCT 116 C10(0.90); C152(0.85); C270(1.09); C305(1.23)  LDD0740  [14]
 LDCM0424  CL35 HCT 116 C10(1.08); C152(1.00); C270(0.67); C305(1.11)  LDD0741  [14]
 LDCM0425  CL36 HCT 116 C10(0.91); C152(0.93); C270(0.66); C305(1.08)  LDD0742  [14]
 LDCM0426  CL37 HCT 116 C10(1.05); C152(1.06); C270(0.80); C305(1.24)  LDD0743  [14]
 LDCM0428  CL39 HCT 116 C10(1.05); C152(1.03); C270(0.79); C305(1.27)  LDD0745  [14]
 LDCM0429  CL4 HCT 116 C10(0.99); C152(1.25); C270(0.96)  LDD0746  [14]
 LDCM0430  CL40 HCT 116 C10(0.79); C152(1.24); C270(0.77); C305(1.16)  LDD0747  [14]
 LDCM0431  CL41 HCT 116 C10(0.78); C152(1.00); C270(0.79); C305(1.09)  LDD0748  [14]
 LDCM0432  CL42 HCT 116 C10(0.92); C152(0.82); C270(0.66); C305(1.68)  LDD0749  [14]
 LDCM0433  CL43 HCT 116 C10(0.82); C152(0.92); C270(0.73); C305(1.19)  LDD0750  [14]
 LDCM0434  CL44 HCT 116 C10(0.81); C152(1.18); C270(0.83); C305(1.18)  LDD0751  [14]
 LDCM0435  CL45 HCT 116 C10(0.73); C152(1.15); C270(0.78); C305(1.29)  LDD0752  [14]
 LDCM0436  CL46 HCT 116 C10(0.92); C270(0.95); C305(1.21)  LDD0753  [14]
 LDCM0437  CL47 HCT 116 C10(0.94); C270(0.91); C305(1.15)  LDD0754  [14]
 LDCM0438  CL48 HCT 116 C10(0.79); C270(0.96); C305(1.18)  LDD0755  [14]
 LDCM0439  CL49 HCT 116 C10(0.81); C270(0.95); C305(1.11)  LDD0756  [14]
 LDCM0440  CL5 HCT 116 C10(0.84); C152(1.67); C270(1.07)  LDD0757  [14]
 LDCM0441  CL50 HCT 116 C10(0.65); C270(0.92); C305(1.15)  LDD0758  [14]
 LDCM0442  CL51 HCT 116 C10(0.65); C270(1.01); C305(1.06)  LDD0759  [14]
 LDCM0443  CL52 HCT 116 C10(0.89); C270(0.85); C305(1.20)  LDD0760  [14]
 LDCM0444  CL53 HCT 116 C10(1.39); C270(0.87); C305(1.12)  LDD0761  [14]
 LDCM0445  CL54 HCT 116 C10(0.84); C270(1.02); C305(1.19)  LDD0762  [14]
 LDCM0446  CL55 HCT 116 C10(0.74); C270(1.04); C305(1.13)  LDD0763  [14]
 LDCM0447  CL56 HCT 116 C10(1.06); C270(0.95); C305(1.20)  LDD0764  [14]
 LDCM0448  CL57 HCT 116 C10(1.09); C270(0.98); C305(1.22)  LDD0765  [14]
 LDCM0449  CL58 HCT 116 C10(0.83); C270(0.96); C305(1.15)  LDD0766  [14]
 LDCM0450  CL59 HCT 116 C10(0.82); C270(1.01); C305(1.26)  LDD0767  [14]
 LDCM0451  CL6 HCT 116 C10(0.65); C152(1.20); C270(1.21)  LDD0768  [14]
 LDCM0452  CL60 HCT 116 C10(0.72); C270(0.95); C305(1.24)  LDD0769  [14]
 LDCM0453  CL61 HCT 116 C10(1.43); C152(1.02); C270(0.94); C305(0.98)  LDD0770  [14]
 LDCM0454  CL62 HCT 116 C10(1.15); C152(1.05); C270(0.93); C305(0.98)  LDD0771  [14]
 LDCM0455  CL63 HCT 116 C10(1.09); C152(1.06); C270(0.96); C305(1.01)  LDD0772  [14]
 LDCM0456  CL64 HCT 116 C10(1.09); C152(0.85); C270(0.84); C305(1.01)  LDD0773  [14]
 LDCM0457  CL65 HCT 116 C10(1.11); C152(1.01); C270(1.07); C305(0.95)  LDD0774  [14]
 LDCM0458  CL66 HCT 116 C10(1.06); C152(0.91); C270(0.86); C305(0.98)  LDD0775  [14]
 LDCM0459  CL67 HCT 116 C10(1.07); C152(0.90); C270(0.98); C305(0.92)  LDD0776  [14]
 LDCM0460  CL68 HCT 116 C10(1.40); C152(1.07); C270(0.95); C305(1.04)  LDD0777  [14]
 LDCM0461  CL69 HCT 116 C10(0.99); C152(1.23); C270(1.16); C305(1.00)  LDD0778  [14]
 LDCM0462  CL7 HCT 116 C10(0.78); C152(1.63); C270(1.01)  LDD0779  [14]
 LDCM0463  CL70 HCT 116 C10(0.98); C152(1.08); C270(1.03); C305(1.02)  LDD0780  [14]
 LDCM0464  CL71 HCT 116 C10(1.07); C152(0.95); C270(0.79); C305(0.94)  LDD0781  [14]
 LDCM0465  CL72 HCT 116 C10(0.84); C152(1.03); C270(0.89); C305(0.97)  LDD0782  [14]
 LDCM0466  CL73 HCT 116 C10(1.04); C152(0.85); C270(0.82); C305(0.93)  LDD0783  [14]
 LDCM0467  CL74 HCT 116 C10(0.96); C152(0.89); C270(0.83); C305(0.94)  LDD0784  [14]
 LDCM0469  CL76 HCT 116 C10(0.94); C152(0.93); C270(1.03); C305(0.95)  LDD0786  [14]
 LDCM0470  CL77 HCT 116 C10(1.00); C152(0.69); C270(0.66); C305(0.88)  LDD0787  [14]
 LDCM0471  CL78 HCT 116 C10(0.88); C152(0.81); C270(0.91); C305(0.87)  LDD0788  [14]
 LDCM0472  CL79 HCT 116 C10(0.89); C152(0.86); C270(0.89); C305(0.91)  LDD0789  [14]
 LDCM0473  CL8 HCT 116 C10(0.92); C152(0.92); C270(0.81)  LDD0790  [14]
 LDCM0474  CL80 HCT 116 C10(0.94); C152(0.91); C270(1.24); C305(0.88)  LDD0791  [14]
 LDCM0475  CL81 HCT 116 C10(0.70); C152(0.93); C270(0.90); C305(0.89)  LDD0792  [14]
 LDCM0476  CL82 HCT 116 C10(1.36); C152(1.01); C270(0.85); C305(0.97)  LDD0793  [14]
 LDCM0477  CL83 HCT 116 C10(1.03); C152(0.87); C270(0.87); C305(1.05)  LDD0794  [14]
 LDCM0478  CL84 HCT 116 C10(0.99); C152(0.92); C270(0.76); C305(1.13)  LDD0795  [14]
 LDCM0479  CL85 HCT 116 C10(1.10); C152(0.87); C270(0.98); C305(1.16)  LDD0796  [14]
 LDCM0480  CL86 HCT 116 C10(1.02); C152(0.94); C270(0.97); C305(1.14)  LDD0797  [14]
 LDCM0481  CL87 HCT 116 C10(1.08); C152(1.01); C270(0.93); C305(1.12)  LDD0798  [14]
 LDCM0482  CL88 HCT 116 C10(1.06); C152(0.97); C270(0.91); C305(0.96)  LDD0799  [14]
 LDCM0483  CL89 HCT 116 C10(0.99); C152(0.89); C270(0.78); C305(0.93)  LDD0800  [14]
 LDCM0484  CL9 HCT 116 C10(0.92); C152(0.92); C270(0.95)  LDD0801  [14]
 LDCM0485  CL90 HCT 116 C10(1.27); C152(0.82); C270(0.87); C305(0.82)  LDD0802  [14]
 LDCM0486  CL91 HCT 116 C152(1.14); C270(0.94); C305(1.13); C340(1.23)  LDD0803  [14]
 LDCM0487  CL92 HCT 116 C152(1.26); C270(1.26); C305(1.01); C340(1.05)  LDD0804  [14]
 LDCM0488  CL93 HCT 116 C152(1.40); C270(1.56); C305(1.01); C340(1.08)  LDD0805  [14]
 LDCM0489  CL94 HCT 116 C152(1.02); C270(1.45); C305(0.93); C340(1.45)  LDD0806  [14]
 LDCM0490  CL95 HCT 116 C152(1.38); C270(1.21); C305(0.91); C340(1.33)  LDD0807  [14]
 LDCM0491  CL96 HCT 116 C152(1.11); C270(1.13); C305(1.05); C340(1.29)  LDD0808  [14]
 LDCM0492  CL97 HCT 116 C152(1.06); C270(1.01); C305(1.13); C340(1.08)  LDD0809  [14]
 LDCM0493  CL98 HCT 116 C152(0.92); C270(1.38); C305(1.11); C340(1.07)  LDD0810  [14]
 LDCM0494  CL99 HCT 116 C152(0.93); C270(1.90); C305(1.09); C340(1.07)  LDD0811  [14]
 LDCM0634  CY-0357 Hep-G2 C305(1.13)  LDD2228  [21]
 LDCM0495  E2913 HEK-293T C10(1.39); C270(0.93); C152(0.94); C305(1.02)  LDD1698  [34]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C305(0.94); C270(0.92); C10(0.85)  LDD1702  [8]
 LDCM0031  Epigallocatechin gallate HEK-293T 4.80  LDD0183  [9]
 LDCM0175  Ethacrynic acid HeLa C340(0.80)  LDD2210  [11]
 LDCM0625  F8 Ramos C305(1.31); C152(0.78); C340(0.49)  LDD2187  [35]
 LDCM0572  Fragment10 Ramos C305(0.84); C152(0.89); C340(0.72)  LDD2189  [35]
 LDCM0573  Fragment11 Ramos C305(0.02); C152(0.33); C340(3.63)  LDD2190  [35]
 LDCM0574  Fragment12 Ramos C305(1.39); C152(1.03); C340(0.60)  LDD2191  [35]
 LDCM0575  Fragment13 Ramos C305(1.27); C152(1.06); C340(0.67)  LDD2192  [35]
 LDCM0576  Fragment14 Ramos C305(0.64); C152(0.90); C340(0.91)  LDD2193  [35]
 LDCM0579  Fragment20 Ramos C305(1.10); C152(0.90); C340(0.39)  LDD2194  [35]
 LDCM0580  Fragment21 Ramos C305(1.04); C152(1.23); C340(0.52)  LDD2195  [35]
 LDCM0582  Fragment23 Ramos C305(1.17); C152(1.45); C340(1.10)  LDD2196  [35]
 LDCM0578  Fragment27 Ramos C305(1.03); C152(1.25); C340(0.72)  LDD2197  [35]
 LDCM0586  Fragment28 Ramos C305(0.64); C152(0.74); C340(0.32)  LDD2198  [35]
 LDCM0588  Fragment30 Ramos C305(1.56); C152(1.55); C340(0.95)  LDD2199  [35]
 LDCM0589  Fragment31 Ramos C305(1.24); C152(1.05); C340(0.91)  LDD2200  [35]
 LDCM0590  Fragment32 Ramos C305(1.13); C152(0.77); C340(0.92)  LDD2201  [35]
 LDCM0468  Fragment33 HCT 116 C10(0.88); C152(0.86); C270(0.91); C305(0.99)  LDD0785  [14]
 LDCM0596  Fragment38 Ramos C305(1.28); C152(1.35); C340(0.56)  LDD2203  [35]
 LDCM0566  Fragment4 Ramos C305(0.83); C152(0.63); C340(0.80)  LDD2184  [35]
 LDCM0427  Fragment51 HCT 116 C10(0.91); C152(0.88); C270(0.62); C305(1.39)  LDD0744  [14]
 LDCM0610  Fragment52 Ramos C305(2.48); C152(0.69); C340(0.53)  LDD2204  [35]
 LDCM0614  Fragment56 Ramos C305(2.03); C152(1.43); C340(1.00)  LDD2205  [35]
 LDCM0569  Fragment7 Ramos C305(0.74); C152(0.61); C340(0.79)  LDD2186  [35]
 LDCM0571  Fragment9 Ramos C305(0.93); C152(0.90); C340(0.74)  LDD2188  [35]
 LDCM0116  HHS-0101 DM93 Y114(1.18)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y114(0.62)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y114(1.44)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y114(1.63)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y114(0.91)  LDD0268  [12]
 LDCM0107  IAA HeLa H171(0.00); H264(0.00); C36(0.00); H232(0.00)  LDD0221  [26]
 LDCM0022  KB02 HCT 116 C305(1.26)  LDD0080  [14]
 LDCM0023  KB03 HCT 116 C305(1.23)  LDD0081  [14]
 LDCM0024  KB05 HCT 116 C305(1.21)  LDD0082  [14]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C10(0.65)  LDD2121  [8]
 LDCM0109  NEM HeLa H209(0.00); H99(0.00); H171(0.00); H264(0.00)  LDD0223  [26]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C270(1.50); C10(0.98)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C270(0.81)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C270(0.40)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C270(0.97)  LDD2097  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C270(1.04); C152(1.84); C10(0.80)  LDD2099  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C305(0.91)  LDD2104  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C305(0.93)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C270(1.03); C10(0.81)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C270(0.69); C10(0.77)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C270(1.39); C10(0.95)  LDD2111  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C270(0.62); C10(0.60)  LDD2115  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C270(1.03)  LDD2116  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C270(0.92)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C270(1.67)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C270(0.46)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C270(0.40)  LDD2122  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C270(1.08); C10(0.90)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C270(0.52)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C270(1.06); C152(1.20); C10(0.71)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C270(0.51)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C270(1.56); C152(1.66); C10(0.98)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C270(0.42)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C270(1.48); C152(1.28); C10(0.86)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C270(1.05)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C10(0.47)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C270(1.82); C152(1.76); C10(1.08)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C270(1.79)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C270(1.33); C152(1.00); C10(0.97)  LDD2137  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C270(1.13); C10(0.58)  LDD2140  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C270(0.51)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C270(1.57); C152(1.80)  LDD2144  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C270(1.15); C152(1.52); C10(0.75)  LDD2146  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C270(0.60)  LDD2147  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C270(0.52)  LDD2148  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C270(0.63)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C270(0.80); C10(0.46); C305(0.65)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C270(0.58)  LDD2151  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C10(0.84)  LDD2153  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C305(0.78); C340(0.73)  LDD2206  [36]
 LDCM0628  OTUB2-COV-1 HEK-293T C340(0.88); C305(0.52)  LDD2207  [36]
 LDCM0131  RA190 MM1.R C340(1.07)  LDD0304  [37]
 LDCM0021  THZ1 HeLa S3 C305(1.16)  LDD0460  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoside diphosphate kinase A (NME1) NDK family P15531
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gem-associated protein 7 (GEMIN7) Gemin-7 family Q9H840
Gem-associated protein 6 (GEMIN6) . Q8WXD5

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
26 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
27 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
28 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
29 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
30 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
31 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
32 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
33 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
34 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
35 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
36 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
37 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.