Details of the Target

General Information of Target

Target ID LDTP01265
Target Name E3 ubiquitin-protein ligase MYCBP2 (MYCBP2)
Gene Name MYCBP2
Gene ID 23077
Synonyms
KIAA0916; PAM; E3 ubiquitin-protein ligase MYCBP2; EC 2.3.2.33; Myc-binding protein 2; Protein associated with Myc
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMMCAATASPAAASSGLGGDGFYPAATFSSSPAPGALFMPVPDGSVAAAGLGLGLPAADS
RGHYQLLLSGRALADRYRRIYTAALNDRDQGGGSAGHPASRNKKILNKKKLKRKQKSKSK
VKTRSKSENLENTVIIPDIKLHSNPSAFNIYCNVRHCVLEWQKKEISLAAASKNSVQSGE
SDSDEEEESKEPPIKLPKIIEVGLCEVFELIKETRFSHPSLCLRSLQALLNVLQGQQPEG
LQSEPPEVLESLFQLLLEITVRSTGMNDSTGQSLTALSCACLFSLVASWGETGRTLQAIS
AILTNNGSHACQTIQVPTILNSLQRSVQAVLVGKIQIQDWFSNGIKKAALMHKWPLKEIS
VDEDDQCLLQNDGFFLYLLCKDGLYKIGSGYSGTVRGHIYNSTSRIRNRKEKKSWLGYAQ
GYLLYRDVNNHSMTAIRISPETLEQDGTVMLPDCHTEGQNILFTDGEYINQIAASRDDGF
VVRIFATSTEPVLQQELQLKLARKCLHACGISLFDLEKDLHIISTGFDEESAILGAGREF
ALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPITKSPKIVHFSVGHDGSHALLVAED
GSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVISKDGELY
MFGKDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAM
NQGGKGFGVENMATAMDEDLEEELDEKDEKSMMCPPGMHKWKLEQCMVCTVCGDCTGYGA
SCVSSGRPDRVPGGICGCGSGESGCAVCGCCKACARELDGQEARQRGILDAVKEMIPLDL
LLAVPVPGVNIEEHLQLRQEEKRQRVIRRHRLEEGRGPLVFAGPIFMNHREQALARLRSH
PAQLKHKRDKHKDGSGERGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGD
VYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTFGSFSK
GQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGASGDQTFLRIDEALINSHVLATSEI
FASKHIIGLVPASISEPPPFKCLLINKVDGSCKTFNDSEQEDLQGFGVCLDPVYDVIWRF
RPNTRELWCYNAVVADARLPSAADMQSRCSILSPELALPTGSRALTTRSHAALHILGCLD
TLAAMQDLKMGVASTEEETQAVMKVYSKEDYSVVNRFESHGGGWGYSAHSVEAIRFSADT
DILLGGLGLFGGRGEYTAKIKLFELGPDGGDHETDGDLLAETDVLAYDCAAREKYAMMFD
EPVLLQAGWWYVAWARVSGPSSDCGSHGQASITTDDGVVFQFKSSKKSNNGTDVNAGQIP
QLLYRLPTSDGSASKGKQQTSEPVHILKRSFARTVSVECFESLLSILHWSWTTLVLGVEE
LRGLKGFQFTATLLDLERLRFVGTCCLRLLRVYTCEIYPVSATGKAVVEETSKLAECIGK
TRTLLRKILSEGVDHCMVKLDNDPQGYLSQPLSLLEAVLQECHNTFTACFHSFYPTPALQ
WACLCDLLNCLDQDIQEANFKTSSSRLLAAVMSALCHTSVKLTSIFPIAYDGEVLLRSIV
KQVSTENDSTLVHRFPLLVAHMEKLSQSEENISGMTSFREVLEKMLVIVVLPVRNSLRRE
NELFSSHLVSNTCGLLASIVSELTASALGSEVDGLNSLHSVKASANRFTKTSQGRSWNTG
NGSPDAICFSVDKPGIVVVGFSVYGGGGIHEYELEVLVDDSEHAGDSTHSHRWTSLELVK
GTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNYGSRTANGDGGMTTVQCPDGVTFTF
STCSLSSNGTNQTRGQIPQILYYRSEFDGDLQSQLLSKANEEDKNCSRALSVVSTVVRAS
KDLLHRALAVDADDIPELLSSSSLFSMLLPLIIAYIGPVAAAIPKVAVEVFGLVQQLLPS
VAILNQKYAPPAFNPNQSTDSTTGNQPEQGLSACTTSSHYAVIESEHPYKPACVMHYKVT
FPECVRWMTIEFDPQCGTAQSEDVLRLLIPVRTVQNSGYGPKLTSVHENLNSWIELKKFS
GSSGWPTMVLVLPGNEALFSLETASDYVKDDKASFYGFKCFAIGYEFSPGPDEGVIQLEK
ELANLGGVCAAALMKKDLALPIGNELEEDLEILEEAALQVCKTHSGILGKGLALSHSPTI
LEALEGNLPLQIQSNEQSFLDDFIACVPGSSGGRLARWLQPDSYADPQKTSLILNKDDIR
CGWPTTITVQTKDQYGDVVHVPNMKVEVKAVPVSQKKMSLQQDQAKKPQRIPGSPAVTAA
SSNTDMTYGGLASPKLDVSYEPMIVKEARYIAITMMKVYENYSFEELRFASPTPKRPSEN
MLIRVNNDGTYCANWTPGAIGLYTLHVTIDGIEIDAGLEVKVKDPPKGMIPPGTQLVKPK
SEPQPNKVRKFVAKDSAGLRIRSHPSLQSEQIGIVKVNGTITFIDEIHNDDGVWLRLNDE
TIKKYVPNMNGYTEAWCLSFNQHLGKSLLVPVDESKTNTDDFFKDINSCCPQEATMQEQD
MPFLRGGPGMYKVVKTGPSGHNIRSCPNLRGIPIGMLVLGNKVKAVGEVTNSEGTWVQLD
QNSMVEFCESDEGEAWSLARDRGGNQYLRHEDEQALLDQNSQTPPPSPFSVQAFNKGASC
SAQGFDYGLGNSKGDRGNISTSSKPASTSGKSELSSKHSRSLKPDGRMSRTTADQKKPRG
TESLSASESLILKSDAAKLRSDSHSRSLSPNHNTLQTLKSDGRMPSSSRAESPGPGSRLS
SPKPKTLPANRSSPSGASSPRSSSPHDKNLPQKSTAPVKTKLDPPRERSKSDSYTLDPDT
LRKKKMPLTEPLRGRSTSPKPKSVPKDSTDSPGSENRAPSPHVVQENLHSEVVEVCTSST
LKTNSLTDSTCDDSSEFKSVDEGSNKVHFSIGKAPLKDEQEMRASPKISRKCANRHTRPK
KEKSSFLFKGDGSKPLEPAKQAMSPSVAECARAVFASFLWHEGIVHDAMACSSFLKFHPE
LSKEHAPIRSSLNSQQPTEEKETKLKNRHSLEISSALNMFNIAPHGPDISKMGSINKNKV
LSMLKEPPLHEKCEDGKTETTFEMSMHNTMKSKSPLPLTLQHLVAFWEDISLATIKAASQ
NMIFPSPGSCAVLKKKECEKENKKSKKEKKKKEKAEVRPRGNLFGEMAQLAVGGPEKDTI
CELCGESHPYPVTYHMRQAHPGCGRYAGGQGYNSIGHFCGGWAGNCGDGGIGGSTWYLVC
DRCREKYLREKQAAAREKVKQSRRKPMQVKTPRALPTMEAHQVIKANALFLLSLSSAAEP
SILCYHPAKPFQSQLPSVKEGISEDLPVKMPCLYLQTLARHHHENFVGYQDDNLFQDEMR
YLRSTSVPAPYISVTPDASPNVFEEPESNMKSMPPSLETSPITDTDLAKRTVFQRSYSVV
ASEYDKQHSILPARVKAIPRRRVNSGDTEVGSSLLRHPSPELSRLISAHSSLSKGERNFQ
WPVLAFVIQHHDLEGLEIAMKQALRKSACRVFAMEAFNWLLCNVIQTTSLHDILWHFVAS
LTPAPVEPEEEEDEENKTSKENSEQEKDTRVCEHPLSDIVIAGEAAHPLPHTFHRLLQTI
SDLMMSLPSGSSLQQMALRCWSLKFKQSDHQFLHQSNVFHHINNILSKSDDGDSEESFSI
SIQSGFEAMSQELCIVMCLKDLTSIVDIKTSSRPAMIGSLTDGSTETFWESGDEDKNKTK
NITINCVKGINARYVSVHVDNSRDLGNKVTSMTFLTGKAVEDLCRIKQVDLDSRHIGWVT
SELPGGDNHIIKIELKGPENTLRVRQVKVLGWKDGESTKIAGQISASVAQQRNCEAETLR
VFRLITSQVFGKLISGDAEPTPEQEEKALLSSPEGEEKVYNATSDADLKEHMVGIIFSRS
KLTNLQKQVCAHIVQAIRMEATRVREEWEHAISSKENANSQPNDEDASSDAYCFELLSMV
LALSGSNVGRQYLAQQLTLLQDLFSLLHTASPRVQRQVTSLLRRVLPEVTPSRLASIIGV
KSLPPADISDIIHSTEKGDWNKLGILDMFLGCIAKALTVQLKAKGTTITGTAGTTVGKGV
TTVTLPMIFNSSYLRRGESHWWMKGSTPTQISEIIIKLIKDMAAGHLSEAWSRVTKNAIA
ETIIALTKMEEEFRSPVRCIATTRLWLALASLCVLDQDHVDRLSSGRWMGKDGQQKQMPM
CDNHDDGETAAIILCNVCGNLCTDCDRFLHLHRRTKTHQRQVFKEEEEAIKVDLHEGCGR
TKLFWLMALADSKTMKAMVEFREHTGKPTTSSSEACRFCGSRSGTELSAVGSVCSDADCQ
EYAKIACSKTHPCGHPCGGVKNEEHCLPCLHGCDKSATSLKQDADDMCMICFTEALSAAP
AIQLDCSHIFHLQCCRRVLENRWLGPRITFGFISCPICKNKINHIVLKDLLDPIKELYED
VRRKALMRLEYEGLHKSEAITTPGVRFYNDPAGYAMNRYAYYVCYKCRKAYFGGEARCDA
EAGRGDDYDPRELICGACSDVSRAQMCPKHGTDFLEYKCRYCCSVAVFFCFGTTHFCNAC
HDDFQRMTSIPKEELPHCPAGPKGKQLEGTECPLHVVHPPTGEEFALGCGVCRNAHTF
Target Bioclass
Enzyme
Family
RING-Cys relay (RCR) family
Subcellular location
Nucleus
Function
Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues. Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates. Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3. Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (Probable). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration. Required for the formation of major central nervous system axon tracts. Required for proper axon growth by regulating axon navigation and axon branching: acts by regulating the subcellular location and stability of MAP3K12/DLK. Required for proper localization of retinogeniculate projections but not for eye-specific segregation. Regulates axon guidance in the olfactory system. Involved in Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons: acts by promoting destabilization of NMNAT2, probably via ubiquitination of NMNAT2. Catalyzes ubiquitination of threonine and/or serine residues on NMNAT2, consequences of threonine and/or serine ubiquitination are however unknown. Regulates the internalization of TRPV1 in peripheral sensory neurons. Mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Independently of the E3 ubiquitin-protein ligase activity, also acts as a guanosine exchange factor (GEF) for RAN in neurons of dorsal root ganglia. May function as a facilitator or regulator of transcriptional activation by MYC. Acts in concert with HUWE1 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1.
Uniprot ID
O75592
Ensemble ID
ENST00000544440.7
HGNC ID
HGNC:23386

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.D3689V DBIA    Probe Info 
A431 SNV: p.K2958N DBIA    Probe Info 
AN3CA SNV: p.E2931D; p.V4028I DBIA    Probe Info 
CAL148 SNV: p.G4098A DBIA    Probe Info 
CAL33 SNV: p.N1544S DBIA    Probe Info 
CAMA1 SNV: p.E3715K DBIA    Probe Info 
COLO792 SNV: p.V3953A DBIA    Probe Info 
DOTC24510 Substitution: p.W3988L DBIA    Probe Info 
HCC1187 SNV: p.S3013Y DBIA    Probe Info 
HCT116 SNV: p.W415S; p.V1374I; p.F1761L DBIA    Probe Info 
HCT15 SNV: p.R1659S; p.E3208K; p.A4328V DBIA    Probe Info 
HEC1 SNV: p.S2134P DBIA    Probe Info 
HUH28 SNV: p.G700E DBIA    Probe Info 
IGROV1 SNV: p.A1899G DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.G91R; p.D1628G DBIA    Probe Info 
JHH6 SNV: p.E4306K DBIA    Probe Info 
JHH7 Substitution: p.P238A .
JURKAT SNV: p.K2474R; p.M4536T .
KMRC20 SNV: p.K3209R DBIA    Probe Info 
KYM1 SNV: p.V1821I DBIA    Probe Info 
LNCaP clone FGC SNV: p.P992S; p.E2652K DBIA    Probe Info 
LS180 Deletion: p.L1637FfsTer19;p.Ter4679RfsTer24
SNV: p.D2131G;p.H3835R		 DBIA    Probe Info 
MEWO SNV: p.R2998M DBIA    Probe Info 
MFE319 Deletion: p.L1063YfsTer24
SNV: p.A2124V		 DBIA    Probe Info 
MOLT4 SNV: p.S3071I IA-alkyne    Probe Info 
NCIH1155 SNV: p.A4369V DBIA    Probe Info 
NCIH1993 SNV: p.E2225Ter .
OCUG1 SNV: p.W4248R DBIA    Probe Info 
OVCAR5 SNV: p.V683I DBIA    Probe Info 
OVK18 Deletion: p.G2704DfsTer45
SNV: p.R1926I		 DBIA    Probe Info 
OVKATE SNV: p.K2556T DBIA    Probe Info 
REH SNV: p.E2008K DBIA    Probe Info 
RKO SNV: p.S1698N DBIA    Probe Info 
SKMEL24 SNV: p.G16E DBIA    Probe Info 
SNU1 SNV: p.R3323S DBIA    Probe Info 
SUPT1 SNV: p.R1839H DBIA    Probe Info 
SW403 SNV: p.P219T DBIA    Probe Info 
SW948 SNV: p.E1321G DBIA    Probe Info 
T24 SNV: p.K3014N DBIA    Probe Info 
TGBC52TKB SNV: p.I3109R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.57  LDD0402  [1]
STPyne
 Probe Info  		K2987(6.67)  LDD0277  [2]
BTD
 Probe Info  		C1906(0.68)  LDD2093  [3]
AHL-Pu-1
 Probe Info  		C2913(5.92); C2532(2.76)  LDD0170  [4]
DBIA
 Probe Info  		C3152(5.18); C2531(2.51); C2532(2.51); C2662(2.63)  LDD0080  [5]
IA-alkyne
 Probe Info  		C1906(0.00); C3263(0.00); C1169(0.00)  LDD0162  [6]
NAIA_4
 Probe Info  		C1169(0.00); C3190(0.00); C4558(0.00)  LDD2226  [7]
aHNE
 Probe Info  		N.A.  LDD0001  [8]
IPM
 Probe Info  		C1169(0.00); C3190(0.00)  LDD0005  [8]
NPM
 Probe Info  		N.A.  LDD0016  [8]
TFBX
 Probe Info  		C1169(0.00); C2700(0.00); C1906(0.00); C938(0.00)  LDD0148  [9]
Acrolein
 Probe Info  		C2951(0.00); C2044(0.00); C938(0.00); C4356(0.00)  LDD0217  [10]
Methacrolein
 Probe Info  		C2951(0.00); C1906(0.00); C222(0.00)  LDD0218  [10]
AOyne
 Probe Info  		10.90  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C2913(5.92); C2532(2.76)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C416(2.43); C3160(3.56); C2913(5.21); C2662(2.01)  LDD0171  [4]
 LDCM0561  Abegg_cp(-)-10 HeLa C1906(2.55)  LDD0312  [9]
 LDCM0214  AC1 HCT 116 C1131(1.00); C114(1.26); C1427(0.60); C1428(0.60)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C1111(0.45); C1131(0.99); C1814(0.73); C1825(0.73)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C1131(1.42); C114(1.05); C1437(0.99); C1814(0.76)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C1131(1.34); C114(1.18); C1437(0.86); C1814(0.60)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C1131(1.21); C114(1.00); C1437(0.77); C1814(0.34)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C1131(1.26); C114(1.05); C1437(0.97); C1814(0.54)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C1131(1.20); C114(1.15); C1437(1.11); C1814(0.37)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C1131(1.31); C114(0.98); C1437(0.82); C1814(0.39)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C1131(1.94); C114(1.03); C1437(0.97); C1814(0.43)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C1131(1.13); C114(0.99); C1437(1.00); C1814(0.45)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C1131(1.35); C114(1.11); C1437(0.87); C1814(0.24)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C1131(1.50); C114(1.22); C1437(0.92); C1814(0.41)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C1111(0.48); C1131(1.07); C1814(0.57); C1825(0.57)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C1131(1.52); C114(1.03); C1437(1.21); C1814(0.47)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C1131(1.72); C114(1.08); C1437(1.15); C1814(1.00)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C1131(1.52); C114(1.10); C1437(0.94); C1814(0.59)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C1131(1.11); C1437(0.90); C2243(1.08); C2662(0.95)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C1131(1.01); C1437(0.89); C2243(1.00); C2662(1.21)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C1131(0.92); C1437(0.90); C2243(0.91); C2662(1.35)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C1131(1.02); C1437(0.95); C2243(0.95); C2662(1.32)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C1131(1.24); C1437(0.90); C2243(0.84); C2662(1.10)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C1131(1.00); C1437(1.11); C2243(1.08); C2662(1.07)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C1131(1.09); C1437(0.98); C2243(1.00); C2662(1.15)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C1111(0.56); C1131(0.85); C1814(0.96); C1825(0.96)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C1131(1.23); C1437(1.15); C2243(1.04); C2662(1.33)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C1131(1.03); C1437(0.92); C2243(0.98); C2662(1.01)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C1131(1.05); C1437(0.93); C2243(1.09); C2662(1.23)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C1131(1.03); C1437(0.97); C2243(1.02); C2662(1.11)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C1131(0.91); C1437(0.87); C2243(0.94); C2662(1.11)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C1131(1.04); C1437(1.04); C2243(1.14); C2662(1.20)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C1131(0.97); C1437(0.88); C2243(1.34); C2662(1.28)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C1131(0.95); C1437(1.01); C2243(0.94); C2662(1.41)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C1111(1.04); C1437(1.23); C2243(1.02); C2662(0.82)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C1111(0.93); C1437(1.05); C2243(0.98); C2662(0.97)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C1111(1.05); C1437(0.94); C2243(0.95); C2662(1.07)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C1111(1.25); C1437(1.19); C2243(1.14); C2662(0.97)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C1111(1.00); C1437(1.02); C2243(1.01); C2662(1.11)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C1111(1.04); C1437(1.02); C2243(0.91); C2662(1.02)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C1111(1.03); C1437(0.97); C2243(1.06); C2662(1.25)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C1111(1.17); C1437(0.89); C2243(1.05); C2662(1.09)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C1111(1.04); C1437(1.15); C2243(0.97); C2662(1.10)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C1111(1.13); C1437(0.96); C2243(1.04); C2662(0.96)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C1111(1.02); C1437(0.96); C2243(0.95); C2662(1.33)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C1111(1.17); C1437(1.07); C2243(0.94); C2662(1.29)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C1111(0.42); C1131(0.85); C1814(0.71); C1825(0.71)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C1111(0.95); C1437(1.09); C2243(0.99); C2662(1.42)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C1111(1.07); C1437(0.89); C2243(0.99); C2662(1.34)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C1111(1.24); C1437(0.96); C2243(1.01); C2662(1.03)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C1437(0.75); C2243(0.84); C2531(0.91); C2532(0.91)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C4631(0.74); C2532(0.83); C4355(0.87); C4359(0.87)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C4537(0.67); C4540(0.67); C4631(0.83); C2243(0.86)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C1437(0.75); C4631(0.78); C2531(0.79); C2243(0.91)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C467(0.81); C471(0.81); C1437(0.82); C2532(0.86)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C2531(0.78); C1437(0.84); C4355(0.84); C4359(0.84)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C1437(0.74); C4631(0.80); C2243(0.90); C2531(0.92)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C1814(0.56); C1825(0.56); C3856(0.76); C3152(0.81)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C4631(0.84); C2531(0.92); C1437(0.97); C4537(0.98)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C1437(0.81); C4631(0.87); C2243(0.88); C4355(0.95)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C2243(0.85); C4355(0.87); C4359(0.87); C1437(0.89)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C4355(0.75); C4359(0.75); C467(0.84); C471(0.84)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C1131(1.35); C1437(0.82); C2243(0.95); C2531(0.95)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C1131(1.26); C1437(0.82); C2243(0.91); C2531(1.05)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C1131(1.07); C1437(0.83); C2243(0.96); C2531(0.83)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C1131(1.00); C1437(0.88); C2243(0.93); C2531(1.11)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C1814(0.75); C1825(0.75); C467(0.80); C471(0.80)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C1814(0.44); C1825(0.44); C2243(0.78); C3225(0.85)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C1111(0.71); C1814(0.73); C1825(0.73); C2006(0.81)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C1427(0.73); C1428(0.73); C3856(0.75); C3354(0.83)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C4614(0.71); C2006(0.74); C467(0.85); C471(0.85)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C467(0.78); C471(0.78); C4614(0.78); C1814(0.78)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C2243(0.95); C3786(0.95); C2531(0.98); C2532(0.98)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C1814(0.77); C1825(0.77); C1131(0.80); C4631(0.83)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C1111(0.83); C467(0.85); C471(0.85); C4631(0.88)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C1111(0.58); C467(0.69); C471(0.69); C4355(0.84)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C1111(0.51); C4355(0.78); C4359(0.78); C1814(0.82)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C1111(0.48); C467(0.72); C471(0.72); C114(0.83)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C467(0.62); C471(0.62); C1814(0.71); C1825(0.71)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C1111(0.68); C4355(0.80); C4359(0.80); C467(0.84)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C3856(0.63); C1427(0.65); C1428(0.65); C3354(0.81)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C1111(0.67); C467(0.75); C471(0.75); C4355(0.84)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C467(0.82); C471(0.82); C2243(0.85); C1814(0.89)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C1814(0.55); C1825(0.55); C1111(0.66); C467(0.76)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C1111(0.75); C467(0.77); C471(0.77); C1814(0.80)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C1111(0.70); C1814(0.73); C1825(0.73); C4355(0.75)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C2531(0.65); C2532(0.65); C4631(0.65); C4634(0.65)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C1427(0.65); C1428(0.65); C1814(0.78); C1825(0.78)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C4631(0.64); C4634(0.64); C2662(0.76); C1427(0.77)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C4631(0.87); C4634(0.87); C2662(0.88); C1437(0.90)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C4631(0.71); C4634(0.71); C1427(0.76); C1428(0.76)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C1427(0.67); C1428(0.67); C3856(0.67); C4537(0.78)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C4631(0.76); C4634(0.76); C1427(0.85); C1428(0.85)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C1427(0.72); C1428(0.72); C1814(0.79); C1825(0.79)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C1427(0.80); C1428(0.80); C3225(0.88); C4355(0.91)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C4631(0.72); C4634(0.72); C1427(0.77); C1428(0.77)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C1427(0.76); C1428(0.76); C4631(0.76); C4634(0.76)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C4631(0.62); C4634(0.62); C1427(0.80); C1428(0.80)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C2006(0.78); C1437(0.89); C4355(0.91); C4359(0.91)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C2006(0.79); C4280(0.85); C2531(0.87); C2532(0.87)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C2006(0.72); C4280(0.76); C2243(0.87); C1437(0.91)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C4355(0.82); C4359(0.82); C2006(0.92); C2243(0.93)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C3856(0.71); C1427(0.74); C1428(0.74); C3354(0.78)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C4355(0.77); C4359(0.77); C2006(0.82); C2243(0.89)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C2006(0.71); C2243(0.84); C1437(0.86); C4280(0.87)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C2006(0.66); C4280(0.66); C1131(0.78); C4355(0.89)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C4280(0.63); C4355(0.86); C4359(0.86); C2006(0.90)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C4280(0.58); C2006(0.73); C1131(0.81); C4355(0.89)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C2006(0.76); C4280(0.91); C4355(0.92); C4359(0.92)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C4280(0.64); C4355(0.67); C4359(0.67); C1131(0.89)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C4506(0.88); C2243(0.89); C3354(0.89); C1814(0.97)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C2243(0.77); C4355(0.92); C4359(0.92); C4368(0.94)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C1814(0.66); C1825(0.66); C2243(0.78); C3354(0.78)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C1111(0.59); C1814(0.61); C1825(0.61); C4537(0.81)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C2243(0.78); C3354(0.79); C1814(0.85); C1825(0.85)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C3354(0.81); C2243(0.91); C4280(0.91); C2531(0.94)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C4355(0.79); C4359(0.79); C3354(0.81); C2243(0.88)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C1814(0.72); C1825(0.72); C2243(0.78); C3354(0.86)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C3354(0.79); C2243(0.81); C4355(0.88); C4359(0.88)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C2243(0.80); C3354(0.83); C3225(0.93); C4355(1.01)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C2243(0.84); C3354(0.92); C4368(0.99); C4355(1.00)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C4355(0.58); C4359(0.58); C1814(0.70); C1825(0.70)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C1131(0.78); C1437(0.81); C4280(0.81); C1427(0.86)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C1131(0.73); C4520(0.74); C2243(0.86); C1427(0.87)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C1111(0.60); C4506(0.78); C3225(0.85); C4537(0.86)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C1437(0.69); C2006(0.71); C1427(0.81); C1428(0.81)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C1131(0.75); C114(0.83); C4368(0.87); C4371(0.87)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C4355(0.84); C4359(0.84); C114(0.88); C4368(0.88)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C4368(0.76); C4371(0.76); C4375(0.76); C4355(0.76)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C4355(0.77); C4359(0.77); C4368(0.83); C4371(0.83)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C4355(0.58); C4359(0.58); C4368(0.66); C4371(0.66)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C4318(0.79); C1427(0.83); C1428(0.83); C4355(0.83)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C1131(0.78); C1437(0.82); C4280(0.83); C1427(0.86)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C4368(0.82); C4371(0.82); C4375(0.82); C1131(0.83)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C2531(0.75); C2532(0.75); C114(0.79); C4355(0.80)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C1111(0.61); C1814(0.77); C1825(0.77); C3354(0.82)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C4355(0.79); C4359(0.79); C4368(0.82); C4371(0.82)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C4368(0.67); C4371(0.67); C4375(0.67); C4614(0.77)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C4355(0.50); C4359(0.50); C4368(0.60); C4371(0.60)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C4355(0.77); C4359(0.77); C2243(0.82); C4537(0.88)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C2243(0.75); C4355(0.83); C4359(0.83); C4631(0.88)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C2243(0.71); C4355(0.84); C4359(0.84); C4537(0.85)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C2243(0.76); C4355(0.83); C4359(0.83); C1111(0.94)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C4355(0.68); C4359(0.68); C3856(0.77); C2243(0.86)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C2243(0.78); C4355(0.78); C4359(0.78); C4506(0.89)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C4355(0.72); C4359(0.72); C2243(0.76); C4506(0.87)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C3152(0.81); C2243(0.85); C4355(0.87); C4359(0.87)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C4355(0.74); C4359(0.74); C2243(0.78); C4506(0.79)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C4355(0.80); C4359(0.80); C2243(0.84); C1437(0.89)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C2243(0.74); C3856(0.86); C4355(0.86); C4359(0.86)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C3856(0.73); C2243(0.76); C4355(0.80); C4359(0.80)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C4355(0.82); C4359(0.82); C4280(0.84); C2243(0.85)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C4355(0.72); C4359(0.72); C2243(0.77); C3856(0.78)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C2243(0.73); C4355(0.77); C4359(0.77); C3856(0.80)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C1814(0.36); C1825(0.36); C4355(0.48); C4359(0.48)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C1814(0.54); C1825(0.54); C2243(0.64); C3225(0.65)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C1111(0.80); C1131(0.91); C1814(0.73); C1825(0.73)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C1111(0.53); C4506(0.74); C4631(0.84); C4634(0.84)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C1814(0.46); C1825(0.46); C1111(0.47); C3225(0.84)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C4537(1.42); C4540(1.42); C4336(1.25); C4341(1.25)  LDD2171  [5]
 LDCM0108  Chloroacetamide HeLa C4356(0.00); C2044(0.00); C938(0.00); C2951(0.00)  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C3392(1.02); C3198(0.39)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C4537(0.77); C4540(0.77); C2006(0.84); C2531(0.85)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C3786(0.89); C1437(0.90); C2006(0.91); C4520(0.95)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C3856(0.54); C1427(0.61); C1428(0.61); C4280(0.86)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C1814(0.65); C1825(0.65); C4537(0.76); C4540(0.76)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C1111(0.48); C4506(0.64); C4537(0.68); C4540(0.68)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C1111(0.53); C4506(0.68); C4537(0.77); C4540(0.77)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C1111(0.48); C3856(0.75); C4506(0.81); C3225(0.82)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C1814(0.62); C1825(0.62); C467(0.67); C471(0.67)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C1814(0.61); C1825(0.61); C467(0.74); C471(0.74)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C1814(0.43); C1825(0.43); C467(0.70); C471(0.70)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C1814(0.54); C1825(0.54); C467(0.68); C471(0.68)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C1814(0.44); C1825(0.44); C4614(0.70); C467(0.79)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C2006(0.64); C4520(0.86); C3152(0.86); C3786(0.91)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C1814(0.59); C1825(0.59); C4614(0.59); C4634(0.78)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C1814(0.68); C1825(0.68); C2243(0.76); C1111(0.80)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C1111(0.76); C4355(0.79); C4359(0.79); C467(0.81)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C1111(0.57); C4355(0.74); C4359(0.74); C467(0.78)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C4355(0.70); C4359(0.70); C1111(0.72); C467(0.72)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C1814(0.64); C1825(0.64); C4355(0.71); C4359(0.71)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C1111(0.64); C467(0.75); C471(0.75); C4355(0.81)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C4631(0.55); C4634(0.55); C2006(0.65); C1131(0.79)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C4631(0.80); C4634(0.80); C2531(0.90); C2532(0.90)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C1427(0.83); C1428(0.83); C3152(0.90); C2243(0.91)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C2006(0.68); C4520(0.82); C3786(0.90); C3354(0.94)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C4631(0.74); C4634(0.74); C1427(0.84); C1428(0.84)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C4280(0.67); C3354(0.67); C2006(0.75); C1437(0.88)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C4280(0.60); C2006(0.77); C3225(0.86); C1437(0.89)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C4280(0.40); C4355(0.66); C4359(0.66); C2006(0.68)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C4280(0.44); C2006(0.75); C4355(0.80); C4359(0.80)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C2531(0.72); C2532(0.72); C3354(0.83); C2243(0.89)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C3354(0.81); C2243(0.81); C2531(0.85); C2532(0.85)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C3354(0.77); C2531(0.78); C2532(0.78); C2243(0.80)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C3354(0.76); C1814(0.76); C1825(0.76); C2243(0.89)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C2006(0.77); C1437(0.89); C3786(0.99); C4280(1.05)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C2006(0.78); C3786(0.89); C4520(0.93); C4371(0.96)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C2006(0.82); C1437(0.94); C3786(0.95); C4280(1.00)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C3354(0.79); C4280(0.83); C1427(0.95); C1428(0.95)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C4280(0.82); C3354(0.86); C3225(0.86); C4355(0.89)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C4280(0.69); C3786(0.81); C3354(0.93); C2531(0.94)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C4280(0.79); C3786(0.84); C3354(0.88); C1427(0.91)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C2006(0.78); C2531(0.87); C2532(0.87); C1131(0.92)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C4280(0.88); C3354(1.01); C4614(1.01); C4634(1.01)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C1427(0.80); C1428(0.80); C3786(0.81); C4280(0.85)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C4520(0.80); C4614(0.86); C4634(0.86); C3786(0.90)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C4280(0.84); C1111(0.85); C1427(0.86); C1428(0.86)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C3354(0.88); C4280(0.88); C1427(0.95); C1428(0.95)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C1111(0.92); C1131(1.06); C1427(0.87); C1428(0.87)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C1111(0.94); C1131(1.12); C1427(0.87); C1428(0.87)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C1111(0.99); C1131(1.11); C1427(0.97); C1428(0.97)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C1111(1.11); C1131(1.40); C1427(0.99); C1428(0.99)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C1111(0.95); C1131(1.17); C1427(1.09); C1428(1.09)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C1131(1.04); C1437(0.86); C2006(0.65); C2243(1.05)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C1111(1.03); C1131(1.13); C1427(0.96); C1428(0.96)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C1111(1.06); C1131(0.90); C1437(0.99); C2006(1.05)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C1131(1.16); C1437(0.91); C2006(0.94); C2243(0.81)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C1131(1.20); C1437(0.66); C2006(0.81); C2243(0.83)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C1131(1.25); C1437(0.92); C2006(1.21); C2243(0.93)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C1131(1.32); C1437(0.94); C2006(0.99); C2243(0.82)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C1131(1.37); C1437(0.92); C2006(0.90); C2243(0.74)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C1131(1.27); C1437(0.97); C2006(1.09); C2243(0.78)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C1131(1.09); C1437(0.88); C2006(1.02); C2243(0.81)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C1131(1.15); C1437(0.96); C2006(0.78); C2243(1.13)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C1131(1.27); C1437(0.86); C2006(0.95); C2243(0.74)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C1131(1.18); C1437(0.92); C2006(1.02); C2243(0.78)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C1131(1.14); C1437(1.05); C2006(1.30); C2243(0.78)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C1131(1.25); C1437(1.11); C2006(1.12); C2243(1.19)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C1131(1.20); C1437(0.88); C2006(0.89); C2243(0.81)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C1131(1.30); C1437(0.85); C2006(1.20); C2243(0.79)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C1111(1.04); C1131(0.98); C1437(1.00); C2006(0.96)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C1111(1.09); C1131(1.01); C1437(0.93); C2006(0.95)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C1111(1.09); C1131(1.13); C1437(0.95); C2006(1.08)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C1111(1.15); C1131(1.31); C1437(1.20); C2006(1.02)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C1131(1.40); C1437(0.96); C2006(0.98); C2243(1.19)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C1111(0.86); C1131(1.19); C1437(1.15); C2006(1.07)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C1111(0.98); C1131(1.01); C1437(1.23); C2006(1.03)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C1111(1.01); C1131(1.63); C1437(1.06); C2006(1.08)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C1111(0.87); C1131(1.03); C1437(0.86); C2006(0.91)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C1111(0.96); C1131(0.87); C1437(1.07); C2006(0.96)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C1111(0.91); C1131(1.11); C1437(1.03); C2006(1.12)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C1111(0.82); C1131(0.79); C1437(1.03); C2006(1.09)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C1111(1.07); C1131(0.93); C1437(1.10); C2006(1.02)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C1111(1.47); C1131(1.09); C1437(1.08); C2006(1.00)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C1111(0.88); C1131(1.08); C1437(1.16); C2006(0.99)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C1131(1.69); C1437(0.99); C2006(0.91); C2243(1.15)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C1111(1.23); C1131(1.09); C1437(1.13); C2006(1.04)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C1111(0.79); C114(1.11); C1427(0.78); C1428(0.78)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C1111(0.77); C114(1.04); C1427(0.88); C1428(0.88)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C1111(0.77); C114(1.08); C1427(0.74); C1428(0.74)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C1111(0.78); C114(1.07); C1427(1.05); C1428(1.05)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C1111(0.75); C114(1.10); C1427(0.67); C1428(0.67)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C1111(0.88); C114(1.09); C1427(0.95); C1428(0.95)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C1111(0.90); C114(1.12); C1427(0.96); C1428(0.96)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C1111(1.02); C114(0.89); C1427(0.79); C1428(0.79)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C1111(0.97); C114(0.98); C1427(0.70); C1428(0.70)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C1131(1.50); C1437(1.04); C2006(0.92); C2243(1.28)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C1111(0.85); C114(1.00); C1427(0.97); C1428(0.97)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C1111(0.93); C114(1.03); C1427(0.98); C1428(0.98)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C1111(0.88); C114(1.14); C1427(0.88); C1428(0.88)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C1111(0.88); C114(1.02); C1427(1.05); C1428(1.05)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C1111(0.90); C114(1.14); C1427(0.96); C1428(0.96)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C1111(0.65); C1131(1.04); C1437(1.43); C2006(1.00)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C1111(0.68); C1131(0.78); C1437(1.49); C2006(0.73)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C1111(0.46); C1131(1.30); C1437(1.32); C2006(1.02)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C1111(0.99); C1131(0.94); C1437(1.26); C2006(1.22)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C1131(2.40); C1437(0.88); C2006(0.78); C2243(1.01)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C1111(0.71); C1131(1.01); C1437(1.27); C2006(1.16)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C1111(0.46); C1131(1.01); C1437(1.49); C2006(1.15)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C1111(0.77); C1131(0.91); C1437(1.39); C2006(0.78)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C1111(1.02); C1131(0.99); C1437(1.26); C2006(0.80)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C1111(0.73); C1131(1.80); C1437(1.22); C2006(0.75)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C1111(0.64); C1131(1.06); C1437(1.26); C2006(0.74)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C1111(1.18); C1131(1.12); C1437(1.20); C2006(0.91)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C1111(0.91); C1131(1.06); C1437(1.11); C2006(0.77)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C1111(0.85); C1131(0.93); C1437(1.09); C2006(0.71)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C1111(1.13); C1131(1.14); C1437(1.72); C2006(0.67)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C1131(1.40); C1437(0.82); C2006(0.92); C2243(1.14)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C1111(0.58); C1131(1.15); C1437(1.24); C2006(0.50)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C1131(1.10); C114(1.19); C1427(0.70); C1428(0.70)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C1131(0.92); C114(0.91); C1427(0.53); C1428(0.53)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C1131(1.21); C114(0.98); C1427(0.78); C1428(0.78)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C1131(1.06); C114(1.04); C1427(0.51); C1428(0.51)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C1131(1.19); C114(0.99); C1427(0.80); C1428(0.80)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C1131(1.15); C114(0.96); C1427(0.55); C1428(0.55)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C1131(1.14); C114(1.14); C1427(0.48); C1428(0.48)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C1131(1.04); C114(1.12); C1427(0.42); C1428(0.42)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C1131(0.94); C114(1.07); C1427(0.78); C1428(0.78)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C3263(1.12); C4356(0.94); C754(0.95); C4638(0.92)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C222(2.90); C1516(1.80); C3190(1.57); C3263(0.82)  LDD1702  [3]
 LDCM0625  F8 Ramos C1906(0.51); 0.73; C4356(1.10); C1169(0.99)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C1906(0.41); C3392(1.06); 0.65; C4356(0.30)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C1906(20.00); 4.62; C4356(6.41); C1169(0.28)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C1906(0.38); C3392(1.01); 0.62; C4356(0.33)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C1906(0.72); C4356(0.43); C1169(1.06); C3190(1.31)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C1906(0.32); 0.47; C4356(0.79); C1169(0.86)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C1906(0.34); C3392(1.25); 0.50; C4356(0.35)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C1906(0.69); C3392(1.17); 1.62; C4356(0.48)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C1906(0.75); C3392(0.65); C4356(1.04); C1169(1.09)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C1906(0.69); C4356(1.49); C1169(0.77); C3190(0.82)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C1906(0.58); C3392(0.81); C4356(0.31); C1169(0.75)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C1906(1.01); 0.50; C4356(0.53); C1169(1.19)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C1906(0.64); 1.21; C4356(0.72); C1169(0.83)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C1906(0.60); C3392(1.23); 0.62; C4356(0.34)  LDD2201  [13]
 LDCM0468  Fragment33 HCT 116 C1111(0.78); C114(1.09); C1427(0.62); C1428(0.62)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C1906(0.64); C3392(0.57); 0.39; C4356(1.14)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C1906(0.45); 0.52; C4356(0.66); C1169(4.57)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C1131(1.74); C1437(1.07); C2006(1.24); C2243(0.68)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C1906(1.29); C4356(0.82); C1169(1.44); C3190(0.79)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C1906(1.06); C3392(0.82); 1.04; C4356(0.69)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C1906(0.20); 0.40; C4356(0.51); C1169(1.06)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C1906(0.43); C3392(1.07); C4356(0.24); C4638(0.58)  LDD2188  [13]
 LDCM0022  KB02 HCT 116 C3152(5.18); C2531(2.51); C2532(2.51); C2662(2.63)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C3152(1.40); C2531(2.03); C2532(2.03); C2662(1.52)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C3152(2.58); C2531(2.46); C2532(2.46); C2662(2.07)  LDD0082  [5]
 LDCM0109  NEM HeLa H398(0.00); H3065(0.00)  LDD0223  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1906(0.68)  LDD2093  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1906(0.73)  LDD2109  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1906(0.86)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1906(0.77); C222(1.09)  LDD2125  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1906(1.15)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1906(1.01)  LDD2140  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C222(1.04)  LDD2146  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C3970(15.00)  LDD2206  [14]
 LDCM0021  THZ1 HCT 116 C4537(1.42); C4540(1.42); C4336(1.25); C4341(1.25)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.