Details of the Target

General Information of Target

Target ID LDTP06021
Target Name Cytoskeleton-associated protein 5 (CKAP5)
Gene Name CKAP5
Gene ID 9793
Synonyms
KIAA0097; Cytoskeleton-associated protein 5; Colonic and hepatic tumor overexpressed gene protein; Ch-TOG
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDDSEWLKLPVDQKCEHKLWKARLSGYEEALKIFQKIKDEKSPEWSKFLGLIKKFVTDS
NAVVQLKGLEAALVYVENAHVAGKTTGEVVSGVVSKVFNQPKAKAKELGIEICLMYIEIE
KGEAVQEELLKGLDNKNPKIIVACIETLRKALSEFGSKIILLKPIIKVLPKLFESREKAV
RDEAKLIAVEIYRWIRDALRPPLQNINSVQLKELEEEWVKLPTSAPRPTRFLRSQQELEA
KLEQQQSAGGDAEGGGDDGDEVPQIDAYELLEAVEILSKLPKDFYDKIEAKKWQERKEAL
ESVEVLIKNPKLEAGDYADLVKALKKVVGKDTNVMLVALAAKCLTGLAVGLRKKFGQYAG
HVVPTILEKFKEKKPQVVQALQEAIDAIFLTTTLQNISEDVLAVMDNKNPTIKQQTSLFI
ARSFRHCTASTLPKSLLKPFCAALLKHINDSAPEVRDAAFEALGTALKVVGEKAVNPFLA
DVDKLKLDKIKECSEKVELIHGKKAGLAADKKEFKPLPGRTAASGAAGDKDTKDISAPKP
GPLKKAPAAKAGGPPKKGKPAAPGGAGNTGTKNKKGLETKEIVEPELSIEVCEEKASAVL
PPTCIQLLDSSNWKERLACMEEFQKAVELMDRTEMPCQALVRMLAKKPGWKETNFQVMQM
KLHIVALIAQKGNFSKTSAQVVLDGLVDKIGDVKCGNNAKEAMTAIAEACMLPWTAEQVV
SMAFSQKNPKNQSETLNWLSNAIKEFGFSGLNVKAFISNVKTALAATNPAVRTAAITLLG
VMYLYVGPSLRMFFEDEKPALLSQIDAEFEKMQGQSPPAPTRGISKHSTSGTDEGEDGDE
PDDGSNDVVDLLPRTEISDKITSELVSKIGDKNWKIRKEGLDEVAGIINDAKFIQPNIGE
LPTALKGRLNDSNKILVQQTLNILQQLAVAMGPNIKQHVKNLGIPIITVLGDSKNNVRAA
ALATVNAWAEQTGMKEWLEGEDLSEELKKENPFLRQELLGWLAEKLPTLRSTPTDLILCV
PHLYSCLEDRNGDVRKKAQDALPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKVNM
PAKPAPPTKATSKPMGGSAPAKFQPASAPAEDCISSSTEPKPDPKKAKAPGLSSKAKSAQ
GKKMPSKTSLKEDEDKSGPIFIVVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQM
SSCVAKWLQDEMFHSDFQHHNKALAVMVDHLESEKEGVIGCLDLILKWLTLRFFDTNTSV
LMKALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVKVGEPKDVIRKDVRAILNRMCLVY
PASKMFPFIMEGTKSKNSKQRAECLEELGCLVESYGMNVCQPTPGKALKEIAVHIGDRDN
AVRNAALNTIVTVYNVHGDQVFKLIGNLSEKDMSMLEERIKRSAKRPSAAPIKQVEEKPQ
RAQNISSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQLDLDEIENDNGTVRC
EMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQA
LTQIDEVLRQEDKAEAMSGHIDQFLIATFMQLRLIYNTHMADEKLEKDEIIKLYSCIIGN
MISLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVIRSVNLLVVKVLEKSD
QTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFM
KVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKH
SMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKY
SDADIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRISTSTGISPQMEVTCVPTPTSTVS
SIGNTNGEEVGPSVYLERLKILRQRCGLDNTKQDDRPPLTSLLSKPAVPTVASSTDMLHS
KLSQLRESREQHQHSDLDSNQTHSSGTVTSSSSTANIDDLKKRLERIKSSRK
Target Bioclass
Other
Family
TOG/XMAP215 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments.
Uniprot ID
Q14008
Ensemble ID
ENST00000312055.9
HGNC ID
HGNC:28959

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.G558R DBIA    Probe Info 
COLO792 SNV: p.R1632G DBIA    Probe Info 
HCT15 SNV: p.E304Ter DBIA    Probe Info 
HEC1 SNV: p.K1826N DBIA    Probe Info 
HEC1B SNV: p.K1826N IA-alkyne    Probe Info 
HT115 SNV: p.D529Y DBIA    Probe Info 
ICC9 SNV: p.L901F DBIA    Probe Info 
IM95 SNV: p.F56I DBIA    Probe Info 
JURKAT SNV: p.R425H; p.P820S; p.P1905S Compound 10    Probe Info 
JURLMK1 SNV: p.S1428F DBIA    Probe Info 
LNCaP clone FGC SNV: p.T832A DBIA    Probe Info 
RKO SNV: p.N1871K DBIA    Probe Info 
SUPT1 SNV: p.N1620D DBIA    Probe Info 
TF1 SNV: p.A755V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.54  LDD0402  [1]
A-EBA
 Probe Info  		2.33  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y358(13.74); Y1879(11.98); Y1856(8.96); Y1394(7.71)  LDD0257  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K102(10.00); K1056(5.17); K1066(8.34); K1075(1.59)  LDD0277  [6]
BTD
 Probe Info  		C1113(1.37)  LDD1699  [7]
ONAyne
 Probe Info  		K1302(0.45); K1843(6.94); K1857(0.99)  LDD0275  [6]
Probe 1
 Probe Info  		Y1860(30.05)  LDD3495  [8]
P11
 Probe Info  		0.97  LDD0210  [9]
AHL-Pu-1
 Probe Info  		C1911(2.26); C1795(2.49)  LDD0168  [10]
DBIA
 Probe Info  		C1203(6.57); C1317(22.78); C1317(153.15); C1500(100.05)  LDD0209  [11]
HHS-475
 Probe Info  		Y1879(0.70); Y1860(0.84)  LDD0264  [12]
HHS-465
 Probe Info  		Y1394(0.96); Y1860(7.45)  LDD2237  [13]
ATP probe
 Probe Info  		N.A.  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C604(0.00); C637(0.00); C1500(0.00); C343(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C619(0.00); C441(0.00); C343(0.00); C637(0.00)  LDD0032  [16]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [17]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C604(0.00); C637(0.00); C1500(0.00); C1946(0.00)  LDD0037  [15]
TFBX
 Probe Info  		C343(0.00); C1317(0.00)  LDD0027  [18]
WYneN
 Probe Info  		C427(0.00); C1203(0.00); C637(0.00); C1795(0.00)  LDD0021  [19]
WYneO
 Probe Info  		C1203(0.00); C1113(0.00)  LDD0022  [19]
aHNE
 Probe Info  		N.A.  LDD0001  [19]
Compound 10
 Probe Info  		C1500(0.00); C1795(0.00); C1946(0.00); C619(0.00)  LDD2216  [20]
Compound 11
 Probe Info  		N.A.  LDD2213  [20]
ENE
 Probe Info  		C637(0.00); C1795(0.00)  LDD0006  [19]
IPM
 Probe Info  		C1203(0.00); C1795(0.00); C1113(0.00); C1500(0.00)  LDD0005  [19]
NPM
 Probe Info  		N.A.  LDD0016  [19]
PPMS
 Probe Info  		N.A.  LDD0008  [19]
SF
 Probe Info  		N.A.  LDD0028  [21]
VSF
 Probe Info  		C1360(0.00); C1113(0.00); C1500(0.00); C1946(0.00)  LDD0007  [19]
Phosphinate-6
 Probe Info  		C1751(0.00); C1113(0.00); C1768(0.00); C1946(0.00)  LDD0018  [22]
Ox-W18
 Probe Info  		N.A.  LDD2175  [23]
1c-yne
 Probe Info  		K559(0.00); K468(0.00); K892(0.00)  LDD0228  [24]
Acrolein
 Probe Info  		C619(0.00); H447(0.00); C1795(0.00); C637(0.00)  LDD0217  [25]
Methacrolein
 Probe Info  		C1795(0.00); C637(0.00); C1768(0.00)  LDD0218  [25]
W1
 Probe Info  		C1113(0.00); C637(0.00); C1203(0.00); C427(0.00)  LDD0236  [26]
NAIA_5
 Probe Info  		C604(0.00); C1500(0.00); C343(0.00); C1203(0.00)  LDD2223  [27]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [28]
Alk-rapa
 Probe Info  		6.89  LDD0213  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1113(0.97); C16(0.96)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C637(0.91); C1113(0.77); C16(1.03)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C637(0.77); C1113(0.59); C427(0.51)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C637(0.87); C427(0.95); C1203(1.06)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C637(1.01); C1113(0.94); C427(0.78); C144(1.25)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C427(1.24); C1768(1.38); C619(0.83); C1203(1.25)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1113(1.10)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C637(0.61); C1113(0.76); C1203(0.71); C16(0.59)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C637(0.72); C427(0.55); C1203(0.67); C16(0.66)  LDD2131  [7]
 LDCM0025  4SU-RNA HEK-293T C1911(2.26); C1795(2.49)  LDD0168  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1795(2.32); C1113(2.63)  LDD0169  [10]
 LDCM0214  AC1 HEK-293T C427(0.92); C1795(1.07); C1203(0.97); C1500(1.01)  LDD1507  [30]
 LDCM0215  AC10 HEK-293T C427(0.98); C1795(1.00); C1203(0.96); C1500(0.94)  LDD1508  [30]
 LDCM0226  AC11 HEK-293T C427(0.89); C1795(0.95); C1203(0.92); C1500(1.00)  LDD1509  [30]
 LDCM0237  AC12 HEK-293T C427(0.98); C1795(1.03); C1203(0.99); C1500(0.96)  LDD1510  [30]
 LDCM0259  AC14 HEK-293T C427(1.04); C1795(1.09); C1203(0.91); C1500(0.97)  LDD1512  [30]
 LDCM0270  AC15 HEK-293T C427(1.00); C1795(1.08); C1203(0.98); C1500(0.99)  LDD1513  [30]
 LDCM0276  AC17 HEK-293T C427(0.95); C1795(1.05); C1203(0.97); C1500(1.00)  LDD1515  [30]
 LDCM0277  AC18 HEK-293T C427(0.90); C1795(0.98); C1203(0.97); C1500(1.01)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C427(0.87); C1795(1.21); C1203(0.95); C1500(1.13)  LDD1517  [30]
 LDCM0279  AC2 HEK-293T C427(1.01); C1795(0.92); C1203(0.96); C1500(0.95)  LDD1518  [30]
 LDCM0280  AC20 HEK-293T C427(1.03); C1795(1.01); C1203(0.97); C1500(1.02)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C427(1.03); C1795(0.99); C1203(1.05); C1500(0.96)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C427(1.11); C1795(1.03); C1203(1.01); C1500(1.02)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C427(1.04); C1795(1.01); C1203(1.05); C1500(0.99)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C427(1.06); C1795(0.98); C1203(0.99); C1500(1.00)  LDD1523  [30]
 LDCM0285  AC25 HEK-293T C427(0.98); C1795(1.02); C1203(0.99); C1500(1.03)  LDD1524  [30]
 LDCM0286  AC26 HEK-293T C427(1.02); C1795(0.92); C1203(1.03); C1500(1.05)  LDD1525  [30]
 LDCM0287  AC27 HEK-293T C427(1.02); C1795(1.01); C1203(1.02); C1500(1.03)  LDD1526  [30]
 LDCM0288  AC28 HEK-293T C427(1.01); C1795(0.99); C1203(1.01); C1500(1.00)  LDD1527  [30]
 LDCM0289  AC29 HEK-293T C427(0.97); C1795(1.06); C1203(1.07); C1500(0.97)  LDD1528  [30]
 LDCM0290  AC3 HEK-293T C427(0.93); C1795(0.99); C1203(0.95); C1500(0.97)  LDD1529  [30]
 LDCM0291  AC30 HEK-293T C427(0.97); C1795(1.03); C1203(0.95); C1500(0.99)  LDD1530  [30]
 LDCM0292  AC31 HEK-293T C427(1.06); C1795(1.02); C1203(1.03); C1500(1.04)  LDD1531  [30]
 LDCM0293  AC32 HEK-293T C427(1.06); C1795(1.03); C1203(0.99); C1500(1.02)  LDD1532  [30]
 LDCM0294  AC33 HEK-293T C427(0.98); C1795(0.98); C1203(0.94); C1500(0.97)  LDD1533  [30]
 LDCM0295  AC34 HEK-293T C427(0.91); C1795(0.97); C1203(0.90); C1500(0.95)  LDD1534  [30]
 LDCM0296  AC35 HEK-293T C427(1.03); C1795(1.00); C1203(0.91); C1500(1.00)  LDD1535  [30]
 LDCM0297  AC36 HEK-293T C427(1.04); C1795(1.01); C1203(0.97); C1500(0.92)  LDD1536  [30]
 LDCM0298  AC37 HEK-293T C427(0.94); C1795(1.00); C1203(1.00); C1500(0.89)  LDD1537  [30]
 LDCM0299  AC38 HEK-293T C427(1.00); C1795(0.96); C1203(0.88); C1500(0.93)  LDD1538  [30]
 LDCM0300  AC39 HEK-293T C427(1.06); C1795(0.99); C1203(0.93); C1500(0.97)  LDD1539  [30]
 LDCM0301  AC4 HEK-293T C427(1.04); C1795(0.98); C1203(1.00); C1500(0.94)  LDD1540  [30]
 LDCM0302  AC40 HEK-293T C427(0.97); C1795(0.98); C1203(1.00); C1500(0.97)  LDD1541  [30]
 LDCM0303  AC41 HEK-293T C427(0.88); C1795(1.01); C1203(0.96); C1500(1.00)  LDD1542  [30]
 LDCM0304  AC42 HEK-293T C427(0.88); C1795(0.96); C1203(0.98); C1500(1.00)  LDD1543  [30]
 LDCM0305  AC43 HEK-293T C427(0.89); C1795(0.98); C1203(0.91); C1500(0.98)  LDD1544  [30]
 LDCM0306  AC44 HEK-293T C427(0.88); C1795(0.90); C1203(0.98); C1500(0.94)  LDD1545  [30]
 LDCM0307  AC45 HEK-293T C427(1.07); C1795(0.98); C1203(1.02); C1500(0.92)  LDD1546  [30]
 LDCM0308  AC46 HEK-293T C427(0.98); C1795(0.98); C1203(0.89); C1500(0.96)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C427(0.94); C1795(1.02); C1203(0.95); C1500(0.94)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C427(0.89); C1795(0.96); C1203(0.97); C1500(0.96)  LDD1549  [30]
 LDCM0311  AC49 HEK-293T C427(0.85); C1795(1.07); C1203(1.04); C1500(1.01)  LDD1550  [30]
 LDCM0312  AC5 HEK-293T C427(1.01); C1795(1.02); C1203(1.00); C1500(0.94)  LDD1551  [30]
 LDCM0313  AC50 HEK-293T C427(0.89); C1795(0.99); C1203(0.99); C1500(0.96)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C427(0.97); C1795(1.02); C1203(0.87); C1500(0.98)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C427(0.90); C1795(1.02); C1203(1.01); C1500(0.97)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C427(0.86); C1795(1.11); C1203(1.01); C1500(0.90)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C427(0.91); C1795(1.03); C1203(0.93); C1500(1.04)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C427(0.90); C1795(1.05); C1203(0.95); C1500(1.04)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C427(0.90); C1795(0.99); C1203(0.94); C1500(1.00)  LDD1558  [30]
 LDCM0320  AC57 HEK-293T C427(0.79); C1795(0.99); C1203(0.98); C1500(0.99)  LDD1559  [30]
 LDCM0321  AC58 HEK-293T C427(0.82); C1795(0.94); C1203(0.89); C1500(0.97)  LDD1560  [30]
 LDCM0322  AC59 HEK-293T C427(0.78); C1795(0.93); C1203(0.88); C1500(0.95)  LDD1561  [30]
 LDCM0323  AC6 HEK-293T C427(0.92); C1795(1.07); C1203(0.90); C1500(0.95)  LDD1562  [30]
 LDCM0324  AC60 HEK-293T C427(0.95); C1795(0.98); C1203(1.02); C1500(0.94)  LDD1563  [30]
 LDCM0325  AC61 HEK-293T C427(0.71); C1795(1.07); C1203(1.00); C1500(0.89)  LDD1564  [30]
 LDCM0326  AC62 HEK-293T C427(0.82); C1795(1.00); C1203(0.93); C1500(0.92)  LDD1565  [30]
 LDCM0327  AC63 HEK-293T C427(0.90); C1795(1.08); C1203(0.97); C1500(0.97)  LDD1566  [30]
 LDCM0328  AC64 HEK-293T C427(0.81); C1795(0.97); C1203(0.98); C1500(0.95)  LDD1567  [30]
 LDCM0334  AC7 HEK-293T C427(0.94); C1795(1.03); C1203(0.97); C1500(0.95)  LDD1568  [30]
 LDCM0345  AC8 HEK-293T C427(0.99); C1795(0.93); C1203(1.00); C1500(0.96)  LDD1569  [30]
 LDCM0545  Acetamide MDA-MB-231 C637(0.50); C427(0.55); C1203(0.62)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C427(1.08); C1203(0.98); C16(0.93)  LDD2113  [7]
 LDCM0248  AKOS034007472 HEK-293T C427(0.79); C1795(0.94); C1203(1.05); C1500(0.96)  LDD1511  [30]
 LDCM0356  AKOS034007680 HEK-293T C427(0.96); C1795(0.97); C1203(1.00); C1500(1.00)  LDD1570  [30]
 LDCM0275  AKOS034007705 HEK-293T C427(0.89); C1795(0.96); C1203(1.02); C1500(0.98)  LDD1514  [30]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0405  [1]
 LDCM0498  BS-3668 MDA-MB-231 C637(0.70); C1113(0.62); C427(0.50); C619(1.00)  LDD2091  [7]
 LDCM0089  C30 HEK-293T 0.97  LDD0210  [9]
 LDCM0088  C45 HEK-293T 1.12  LDD0211  [9]
 LDCM0108  Chloroacetamide HeLa H447(0.00); C619(0.00); C1795(0.00); C1113(0.00)  LDD0222  [25]
 LDCM0632  CL-Sc Hep-G2 C441(1.21); C1768(0.77); C427(0.68); C1500(0.66)  LDD2227  [27]
 LDCM0367  CL1 HEK-293T C427(0.97); C1795(0.92); C1203(1.00); C1500(0.94)  LDD1571  [30]
 LDCM0368  CL10 HEK-293T C427(1.31); C1795(1.02); C1203(1.76); C1500(0.87)  LDD1572  [30]
 LDCM0369  CL100 HEK-293T C427(0.98); C1795(0.94); C1203(1.08); C1500(0.96)  LDD1573  [30]
 LDCM0370  CL101 HEK-293T C427(0.88); C1795(0.91); C1203(0.94); C1500(1.01)  LDD1574  [30]
 LDCM0371  CL102 HEK-293T C427(1.02); C1795(0.99); C1203(1.22); C1500(0.98)  LDD1575  [30]
 LDCM0372  CL103 HEK-293T C427(0.96); C1795(0.69); C1203(1.03); C1500(0.99)  LDD1576  [30]
 LDCM0373  CL104 HEK-293T C427(0.89); C1795(0.89); C1203(1.15); C1500(0.98)  LDD1577  [30]
 LDCM0374  CL105 HEK-293T C427(0.94); C1795(0.98); C1203(0.99); C1500(1.05)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C427(1.05); C1795(1.04); C1203(1.08); C1500(1.00)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C427(0.96); C1795(0.65); C1203(1.03); C1500(1.02)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C427(0.98); C1795(0.85); C1203(1.07); C1500(1.05)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C427(1.04); C1795(0.93); C1203(1.05); C1500(1.02)  LDD1582  [30]
 LDCM0379  CL11 HEK-293T C427(1.17); C1795(0.86); C1203(1.05); C1500(0.91)  LDD1583  [30]
 LDCM0380  CL110 HEK-293T C427(1.04); C1795(0.99); C1203(1.42); C1500(0.98)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C427(0.95); C1795(0.75); C1203(1.15); C1500(0.99)  LDD1585  [30]
 LDCM0382  CL112 HEK-293T C427(0.95); C1795(0.90); C1203(0.99); C1500(1.10)  LDD1586  [30]
 LDCM0383  CL113 HEK-293T C427(0.93); C1795(0.89); C1203(0.94); C1500(0.96)  LDD1587  [30]
 LDCM0384  CL114 HEK-293T C427(0.97); C1795(0.94); C1203(1.36); C1500(0.97)  LDD1588  [30]
 LDCM0385  CL115 HEK-293T C427(1.03); C1795(0.72); C1203(0.94); C1500(0.99)  LDD1589  [30]
 LDCM0386  CL116 HEK-293T C427(0.95); C1795(0.90); C1203(1.11); C1500(0.96)  LDD1590  [30]
 LDCM0387  CL117 HEK-293T C427(0.86); C1795(0.93); C1203(0.89); C1500(1.00)  LDD1591  [30]
 LDCM0388  CL118 HEK-293T C427(0.90); C1795(1.09); C1203(0.97); C1500(1.08)  LDD1592  [30]
 LDCM0389  CL119 HEK-293T C427(0.94); C1795(0.72); C1203(0.95); C1500(0.98)  LDD1593  [30]
 LDCM0390  CL12 HEK-293T C427(1.00); C1795(1.07); C1203(1.02); C1500(0.95)  LDD1594  [30]
 LDCM0391  CL120 HEK-293T C427(0.96); C1795(0.95); C1203(1.06); C1500(0.98)  LDD1595  [30]
 LDCM0392  CL121 HEK-293T C427(0.87); C1795(0.95); C1203(0.95); C1500(1.04)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C427(0.82); C1795(1.06); C1203(1.05); C1500(1.06)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C427(0.97); C1795(0.70); C1203(1.24); C1500(0.98)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C427(0.73); C1795(0.87); C1203(1.19); C1500(1.02)  LDD1599  [30]
 LDCM0396  CL125 HEK-293T C427(0.56); C1795(0.96); C1203(0.93); C1500(1.03)  LDD1600  [30]
 LDCM0397  CL126 HEK-293T C427(0.78); C1795(0.89); C1203(0.99); C1500(0.96)  LDD1601  [30]
 LDCM0398  CL127 HEK-293T C427(0.63); C1795(0.85); C1203(0.94); C1500(0.95)  LDD1602  [30]
 LDCM0399  CL128 HEK-293T C427(0.72); C1795(0.93); C1203(0.98); C1500(0.93)  LDD1603  [30]
 LDCM0400  CL13 HEK-293T C427(0.75); C1795(0.91); C1203(0.90); C1500(1.03)  LDD1604  [30]
 LDCM0401  CL14 HEK-293T C427(0.96); C1795(0.90); C1203(0.97); C1500(1.01)  LDD1605  [30]
 LDCM0402  CL15 HEK-293T C427(1.02); C1795(0.82); C1203(1.52); C1500(0.96)  LDD1606  [30]
 LDCM0403  CL16 HEK-293T C427(0.94); C1795(0.92); C1203(1.18); C1500(0.95)  LDD1607  [30]
 LDCM0404  CL17 HEK-293T C427(0.93); C1795(1.13); C1203(1.58); C1500(0.98)  LDD1608  [30]
 LDCM0405  CL18 HEK-293T C427(0.87); C1795(1.03); C1203(0.89); C1500(0.97)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C427(0.85); C1795(1.09); C1203(0.92); C1500(1.07)  LDD1610  [30]
 LDCM0407  CL2 HEK-293T C427(0.91); C1795(0.92); C1203(0.95); C1500(1.01)  LDD1611  [30]
 LDCM0408  CL20 HEK-293T C427(0.97); C1795(1.15); C1203(1.03); C1500(0.93)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C427(1.02); C1795(0.62); C1203(1.57); C1500(0.82)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C427(1.05); C1795(0.92); C1203(0.98); C1500(0.95)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C427(1.13); C1795(0.87); C1203(0.97); C1500(0.95)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C427(0.98); C1795(1.22); C1203(1.01); C1500(0.99)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C427(0.90); C1795(0.84); C1203(1.16); C1500(0.88)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C427(1.02); C1795(1.03); C1203(0.96); C1500(0.99)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C427(1.01); C1795(0.73); C1203(1.02); C1500(1.00)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C427(0.97); C1795(0.90); C1203(1.12); C1500(1.06)  LDD1620  [30]
 LDCM0417  CL29 HEK-293T C427(0.96); C1795(1.11); C1203(0.93); C1500(1.01)  LDD1621  [30]
 LDCM0418  CL3 HEK-293T C427(0.97); C1795(0.89); C1203(1.05); C1500(0.95)  LDD1622  [30]
 LDCM0419  CL30 HEK-293T C427(0.97); C1795(1.05); C1203(0.97); C1500(0.98)  LDD1623  [30]
 LDCM0420  CL31 HEK-293T C427(1.02); C1795(1.19); C1203(1.07); C1500(1.13)  LDD1624  [30]
 LDCM0421  CL32 HEK-293T C427(0.88); C1795(1.16); C1203(1.00); C1500(1.01)  LDD1625  [30]
 LDCM0422  CL33 HEK-293T C427(1.20); C1795(0.65); C1203(1.75); C1500(0.88)  LDD1626  [30]
 LDCM0423  CL34 HEK-293T C427(1.08); C1795(0.90); C1203(1.06); C1500(0.98)  LDD1627  [30]
 LDCM0424  CL35 HEK-293T C427(1.07); C1795(0.77); C1203(1.05); C1500(0.91)  LDD1628  [30]
 LDCM0425  CL36 HEK-293T C427(1.09); C1795(1.29); C1203(1.15); C1500(0.99)  LDD1629  [30]
 LDCM0426  CL37 HEK-293T C427(0.87); C1795(0.87); C1203(1.00); C1500(0.96)  LDD1630  [30]
 LDCM0428  CL39 HEK-293T C427(1.00); C1795(0.72); C1203(1.02); C1500(0.96)  LDD1632  [30]
 LDCM0429  CL4 HEK-293T C427(0.83); C1795(0.93); C1203(1.18); C1500(0.92)  LDD1633  [30]
 LDCM0430  CL40 HEK-293T C427(1.04); C1795(0.96); C1203(1.01); C1500(0.96)  LDD1634  [30]
 LDCM0431  CL41 HEK-293T C427(0.95); C1795(0.99); C1203(1.13); C1500(1.04)  LDD1635  [30]
 LDCM0432  CL42 HEK-293T C427(0.81); C1795(0.99); C1203(1.00); C1500(0.98)  LDD1636  [30]
 LDCM0433  CL43 HEK-293T C427(0.99); C1795(1.04); C1203(0.98); C1500(1.06)  LDD1637  [30]
 LDCM0434  CL44 HEK-293T C427(1.04); C1795(1.22); C1203(1.08); C1500(0.99)  LDD1638  [30]
 LDCM0435  CL45 HEK-293T C427(0.93); C1795(0.65); C1203(1.23); C1500(0.92)  LDD1639  [30]
 LDCM0436  CL46 HEK-293T C427(1.08); C1795(0.87); C1203(1.02); C1500(0.96)  LDD1640  [30]
 LDCM0437  CL47 HEK-293T C427(1.15); C1795(0.77); C1203(1.08); C1500(0.96)  LDD1641  [30]
 LDCM0438  CL48 HEK-293T C427(0.96); C1795(1.30); C1203(1.12); C1500(1.00)  LDD1642  [30]
 LDCM0439  CL49 HEK-293T C427(0.75); C1795(0.86); C1203(0.94); C1500(0.88)  LDD1643  [30]
 LDCM0440  CL5 HEK-293T C427(0.72); C1795(0.97); C1203(0.96); C1500(0.91)  LDD1644  [30]
 LDCM0441  CL50 HEK-293T C427(1.02); C1795(0.90); C1203(1.08); C1500(1.03)  LDD1645  [30]
 LDCM0443  CL52 HEK-293T C427(1.00); C1795(0.94); C1203(1.19); C1500(0.95)  LDD1646  [30]
 LDCM0444  CL53 HEK-293T C427(1.06); C1795(1.02); C1203(1.42); C1500(0.97)  LDD1647  [30]
 LDCM0445  CL54 HEK-293T C427(0.94); C1795(1.23); C1203(1.45); C1500(0.95)  LDD1648  [30]
 LDCM0446  CL55 HEK-293T C427(0.93); C1795(1.22); C1203(0.87); C1500(0.99)  LDD1649  [30]
 LDCM0447  CL56 HEK-293T C427(1.00); C1795(1.22); C1203(1.04); C1500(0.88)  LDD1650  [30]
 LDCM0448  CL57 HEK-293T C427(0.80); C1795(0.71); C1203(1.24); C1500(0.86)  LDD1651  [30]
 LDCM0449  CL58 HEK-293T C427(0.92); C1795(0.94); C1203(0.94); C1500(0.94)  LDD1652  [30]
 LDCM0450  CL59 HEK-293T C427(1.03); C1795(0.80); C1203(1.00); C1500(0.91)  LDD1653  [30]
 LDCM0451  CL6 HEK-293T C427(0.76); C1795(1.02); C1203(1.37); C1500(0.98)  LDD1654  [30]
 LDCM0452  CL60 HEK-293T C427(1.02); C1795(1.33); C1203(1.03); C1500(0.98)  LDD1655  [30]
 LDCM0453  CL61 HEK-293T C427(0.83); C1795(0.91); C1203(0.91); C1500(0.90)  LDD1656  [30]
 LDCM0454  CL62 HEK-293T C427(1.00); C1795(0.94); C1203(1.01); C1500(0.94)  LDD1657  [30]
 LDCM0455  CL63 HEK-293T C427(0.94); C1795(0.76); C1203(0.98); C1500(0.99)  LDD1658  [30]
 LDCM0456  CL64 HEK-293T C427(1.02); C1795(0.94); C1203(1.50); C1500(0.96)  LDD1659  [30]
 LDCM0457  CL65 HEK-293T C427(0.95); C1795(1.09); C1203(0.94); C1500(0.97)  LDD1660  [30]
 LDCM0458  CL66 HEK-293T C427(0.88); C1795(1.01); C1203(1.00); C1500(0.95)  LDD1661  [30]
 LDCM0459  CL67 HEK-293T C427(1.00); C1795(1.01); C1203(0.89); C1500(0.95)  LDD1662  [30]
 LDCM0460  CL68 HEK-293T C427(0.92); C1795(1.07); C1203(1.04); C1500(0.88)  LDD1663  [30]
 LDCM0461  CL69 HEK-293T C427(0.79); C1795(0.66); C1203(1.13); C1500(0.84)  LDD1664  [30]
 LDCM0462  CL7 HEK-293T C427(0.80); C1795(0.92); C1203(0.95); C1500(0.97)  LDD1665  [30]
 LDCM0463  CL70 HEK-293T C427(1.07); C1795(0.95); C1203(0.96); C1500(0.95)  LDD1666  [30]
 LDCM0464  CL71 HEK-293T C427(0.96); C1795(0.86); C1203(1.04); C1500(0.93)  LDD1667  [30]
 LDCM0465  CL72 HEK-293T C427(0.98); C1795(1.19); C1203(1.09); C1500(0.97)  LDD1668  [30]
 LDCM0466  CL73 HEK-293T C427(0.86); C1795(0.83); C1203(0.97); C1500(0.92)  LDD1669  [30]
 LDCM0467  CL74 HEK-293T C427(0.90); C1795(0.97); C1203(0.95); C1500(1.06)  LDD1670  [30]
 LDCM0469  CL76 HEK-293T C427(0.90); C1795(0.93); C1203(1.07); C1500(0.96)  LDD1672  [30]
 LDCM0470  CL77 HEK-293T C427(0.90); C1795(1.02); C1203(1.27); C1500(1.02)  LDD1673  [30]
 LDCM0471  CL78 HEK-293T C427(0.88); C1795(1.01); C1203(0.94); C1500(1.02)  LDD1674  [30]
 LDCM0472  CL79 HEK-293T C427(0.86); C1795(1.06); C1203(0.91); C1500(0.98)  LDD1675  [30]
 LDCM0473  CL8 HEK-293T C427(1.48); C1795(1.32); C1203(2.36); C1500(0.87)  LDD1676  [30]
 LDCM0474  CL80 HEK-293T C427(0.88); C1795(1.14); C1203(1.08); C1500(0.94)  LDD1677  [30]
 LDCM0475  CL81 HEK-293T C427(0.83); C1795(0.65); C1203(1.10); C1500(0.92)  LDD1678  [30]
 LDCM0476  CL82 HEK-293T C427(0.99); C1795(0.94); C1203(0.94); C1500(0.96)  LDD1679  [30]
 LDCM0477  CL83 HEK-293T C427(0.98); C1795(0.90); C1203(1.14); C1500(0.95)  LDD1680  [30]
 LDCM0478  CL84 HEK-293T C427(0.94); C1795(1.09); C1203(1.29); C1500(0.94)  LDD1681  [30]
 LDCM0479  CL85 HEK-293T C427(0.66); C1795(0.88); C1203(0.88); C1500(0.92)  LDD1682  [30]
 LDCM0480  CL86 HEK-293T C427(0.67); C1795(0.91); C1203(0.98); C1500(0.93)  LDD1683  [30]
 LDCM0481  CL87 HEK-293T C427(0.67); C1795(1.02); C1203(0.98); C1500(0.92)  LDD1684  [30]
 LDCM0482  CL88 HEK-293T C427(0.66); C1795(0.90); C1203(0.97); C1500(0.90)  LDD1685  [30]
 LDCM0483  CL89 HEK-293T C427(0.63); C1795(0.90); C1203(0.97); C1500(0.95)  LDD1686  [30]
 LDCM0484  CL9 HEK-293T C427(0.88); C1795(0.67); C1203(1.17); C1500(0.84)  LDD1687  [30]
 LDCM0485  CL90 HEK-293T C427(0.75); C1795(1.04); C1203(2.72); C1500(0.92)  LDD1688  [30]
 LDCM0486  CL91 HEK-293T C427(0.68); C1795(0.94); C1203(0.88); C1500(0.99)  LDD1689  [30]
 LDCM0487  CL92 HEK-293T C427(0.79); C1795(0.96); C1203(1.12); C1500(0.89)  LDD1690  [30]
 LDCM0488  CL93 HEK-293T C427(0.84); C1795(0.72); C1203(1.23); C1500(0.89)  LDD1691  [30]
 LDCM0489  CL94 HEK-293T C427(0.95); C1795(0.99); C1203(0.91); C1500(0.93)  LDD1692  [30]
 LDCM0490  CL95 HEK-293T C427(1.09); C1795(1.11); C1203(2.45); C1500(0.89)  LDD1693  [30]
 LDCM0491  CL96 HEK-293T C427(0.68); C1795(0.90); C1203(1.26); C1500(0.92)  LDD1694  [30]
 LDCM0492  CL97 HEK-293T C427(0.93); C1795(0.94); C1203(1.12); C1500(0.98)  LDD1695  [30]
 LDCM0493  CL98 HEK-293T C427(1.01); C1795(1.00); C1203(1.03); C1500(0.99)  LDD1696  [30]
 LDCM0494  CL99 HEK-293T C427(0.85); C1795(0.92); C1203(1.00); C1500(0.96)  LDD1697  [30]
 LDCM0634  CY-0357 Hep-G2 C1317(1.16); C1500(1.03)  LDD2228  [27]
 LDCM0495  E2913 HEK-293T C427(0.94); C1795(0.81); C1203(0.92); C1500(0.92)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1203(16.96); C1768(15.85); C1795(12.95); C427(5.12)  LDD1702  [7]
 LDCM0625  F8 Ramos C1203(1.31); C637(2.59); C1113(2.28); C1946(0.93)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C1203(3.02); C637(0.87); C1113(0.91); C1946(0.66)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C1203(0.76); C637(0.09); C1113(3.28); C1946(9.97)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C1203(4.61); C637(0.90); C1113(0.68); C1946(0.63)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C1203(1.41); C637(0.98); C1113(1.18); C1946(0.58)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C1203(1.92); C637(2.75); C1113(1.04); C1946(0.88)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C1203(3.79); C637(0.96); C1113(0.61); C1946(0.62)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C1203(1.26); C637(1.02); C1113(1.14); C1946(0.61)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C1203(1.89); C637(0.38); C1113(1.47); C1946(0.74)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C1203(1.07); C637(0.60); C1113(1.59); C1946(0.58)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C1203(0.79); C637(0.44); C1113(0.73); C1946(0.45)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C1203(2.17); C637(0.93); C1113(1.72); C1946(0.79)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C1203(1.63); C637(1.62); C1113(1.65); C1946(0.62)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C1203(3.29); C637(0.76); C1113(1.64); C1946(0.72)  LDD2201  [31]
 LDCM0468  Fragment33 HEK-293T C427(0.92); C1795(0.71); C1203(0.93); C1500(1.01)  LDD1671  [30]
 LDCM0596  Fragment38 Ramos C1203(1.71); C637(0.81); C1113(1.11); C1946(0.73)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C1203(2.50); C637(1.64); C1113(1.01); C1946(0.73)  LDD2184  [31]
 LDCM0427  Fragment51 HEK-293T C427(1.18); C1795(0.96); C1203(0.96); C1500(0.95)  LDD1631  [30]
 LDCM0610  Fragment52 Ramos C1203(2.20); C637(0.88); C1113(1.93); C1946(0.77)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C1203(1.93); C637(0.73); C1113(1.86); C1946(0.69)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C1203(2.75); C637(1.14); C1113(0.89); C1946(0.97)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C1203(5.60); C637(1.28); C1113(1.04); C1946(0.47)  LDD2188  [31]
 LDCM0116  HHS-0101 DM93 Y1879(0.70); Y1860(0.84)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y1860(0.82); Y1879(0.90)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y1860(0.73); Y1879(0.79)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y1860(0.88); Y1879(1.05)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y1860(0.93); Y1879(1.14)  LDD0268  [12]
 LDCM0107  IAA HeLa H447(0.00); C619(0.00)  LDD0221  [25]
 LDCM0022  KB02 HEK-293T C427(0.97); C1946(0.84); C1795(0.86); C1203(0.74)  LDD1492  [30]
 LDCM0023  KB03 Jurkat C1203(6.57); C1317(22.78); C1317(153.15); C1500(100.05)  LDD0209  [11]
 LDCM0024  KB05 COLO792 C619(5.29); C1317(4.68)  LDD3310  [32]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1113(0.87)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C637(0.84); C1113(0.65); C427(0.70); C1203(0.90)  LDD2121  [7]
 LDCM0109  NEM HeLa H80(0.00); H447(0.00)  LDD0223  [25]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C637(0.70); C1113(0.71); C427(0.61); C1203(0.99)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C637(1.37); C1113(1.12); C16(1.12)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C637(0.98); C1113(1.08); C427(0.98); C16(0.80)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C427(0.86); C1768(1.56); C1203(1.04); C16(0.79)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1113(1.09); C427(1.16); C16(0.96)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1113(0.94); C427(0.83); C1203(4.73); C16(2.29)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C1203(0.84)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1113(0.83); C427(1.02); C16(0.80)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C637(0.75); C1113(0.95); C427(0.96); C1768(1.62)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1113(0.70)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1113(0.51); C1768(0.97); C619(0.84); C1203(1.06)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1113(0.68); C16(0.96)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1113(1.13); C427(1.53); C16(1.02)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C637(1.07); C1113(0.61); C16(0.63)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C637(0.72); C1113(1.03); C427(0.89); C1768(0.91)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C637(0.65); C1113(0.84); C427(0.64); C144(1.23)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C637(0.71); C1113(1.01)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C637(0.86); C1113(1.01); C427(0.78); C1768(1.21)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C637(0.79); C16(0.84)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C427(1.08); C1203(0.69); C16(0.70)  LDD2115  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C427(1.32); C16(2.52); C493(0.58)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1113(1.09); C427(1.47); C16(2.58)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C427(1.52); C1203(2.00)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1113(0.83); C16(0.92)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1113(1.09); C427(1.13); C1203(6.70); C493(0.72)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C637(0.72); C1113(0.98); C427(0.84); C1768(1.15)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1113(1.05); C427(1.34); C1203(4.17)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C637(0.79); C1113(0.68); C427(0.64); C1768(1.04)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C1113(0.99)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C637(0.84); C1113(0.95); C427(0.82); C619(0.96)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1113(0.91); C427(0.61); C16(0.74)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C427(0.87); C1795(1.56); C144(1.25); C1768(1.15)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1203(0.86)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1113(0.57); C1795(0.56); C1768(0.49); C619(0.47)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1113(1.00); C427(0.95); C1203(1.21); C16(0.60)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C637(0.78); C1113(1.13); C427(1.49); C144(1.40)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C637(0.93); C1113(1.01); C427(0.95); C1768(1.03)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1203(1.21); C16(1.10); C427(1.07)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C637(0.66); C1113(0.90); C427(0.67); C1768(0.65)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1113(0.88); C427(0.75); C16(0.79)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1113(0.93); C427(0.95); C16(1.13)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1113(2.60); C427(1.89); C1768(1.61); C1203(1.76)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C427(0.81); C1768(1.07); C619(1.21); C1203(1.00)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C1113(2.28); C16(6.23)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1113(0.52); C427(0.65); C1795(0.52); C144(0.73)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C1113(1.09); C427(1.20); C1203(5.23); C493(0.46)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C637(0.63); C1113(0.50); C427(0.61); C1768(0.61)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C1113(1.36)  LDD2151  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C1113(1.61); C16(1.13)  LDD2153  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C619(0.79)  LDD2206  [33]
 LDCM0628  OTUB2-COV-1 HEK-293T C619(1.57); C1317(0.15)  LDD2207  [33]
 LDCM0090  Rapamycin JHH-7 6.89  LDD0213  [29]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SLAIN motif-containing protein 2 (SLAIN2) SLAIN motif-containing family Q9P270
Transforming acidic coiled-coil-containing protein 1 (TACC1) TACC family O75410
Transforming acidic coiled-coil-containing protein 3 (TACC3) TACC family Q9Y6A5
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
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15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
24 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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Mass spectrometry data entry: PXD041264
28 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
29 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
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Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
33 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.