Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0089
Competitor Name
C30
Synonyms
naphthalen-2-ylhydrazine; 2243-57-4; 2-naphthylhydrazine; NAPHTHALEN-2-YL-HYDRAZINE; (naphthalen-2-yl)hydrazine; (2-Naphthalenyl)hydrazine; ss-Naphthylhydrazin; beta-naphthylhydrazine; ?2-Naphthylhydrazine; 1-(2-Naphthyl)hydrazine; Naphthalene, 2-hydrazino-; 1-(2-Naphthyl)hydrazine #; SCHEMBL526498; DTXSID101034443; MFCD00486012; STK005798; AKOS000200818; MCULE-5531423055; SB35581; FAROPENEMSODIUMSALTHEMIPENTAHYDRATE; CS-0216113; EN300-33896; F21338; A816203
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 158.2
Lipid-water partition coefficient (xlogp) 2.7
Rotatable Bond Count (rotbonds) 1
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 2
Chemical Identifiers
Formula
C10H10N2
IUPAC Name
naphthalen-2-ylhydrazine
Canonical SMILES
C1=CC=C2C=C(C=CC2=C1)NN
InChI
InChI=1S/C10H10N2/c11-12-10-6-5-8-3-1-2-4-9(8)7-10/h1-7,12H,11H2
InChIKey
VNICRWVQYFRWDK-UHFFFAOYSA-N

The Competitor Interaction Atlas

Probe(s) Related This Competitor

ABPP Probe
Click To Hide/Show 1 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
P11
 Probe Info  		1 uM Human normal cell lysate (HEK-293T) [1]

Target(s) List of this Competitor

5 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
ATP-dependent 6-phosphofructokinase, muscle type (PFKM) LDTP02261 1.08  LDD0210 
Cytochrome b5 type B (CYB5B) LDTP00697 2.63  LDD0210 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 1.31  LDD0210 
Pyrroline-5-carboxylate reductase 2 (PYCR2) LDTP10159 1.28  LDD0210 
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) LDTP12954 1.06  LDD0210 
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3 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Signal recognition particle 14 kDa protein (SRP14) LDTP03837 1.25  LDD0210 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 1.14  LDD0210 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 1.35  LDD0210 
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4 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
BRCA1-associated ATM activator 1 (BRAT1) LDTP07598 1.11  LDD0210 
Cytoskeleton-associated protein 5 (CKAP5) LDTP06021 0.97  LDD0210 
Receptor expression-enhancing protein 5 (REEP5) LDTP05257 1.12  LDD0210 
Spartin (SPART) LDTP08735 1.46  LDD0210 
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Full Information of The Labelling Profiles of This Competitor

Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 1 uM
Quantitative Method SILAC
Competitor Name C30
Competitor Concentration 1 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (HEK-293T)
Interaction Atlas ID  LDD0210  Download The Altas

References

1 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.