Details of the Target

General Information of Target

Target ID LDTP08735
Target Name Spartin (SPART)
Gene Name SPART
Gene ID 23111
Synonyms
KIAA0610; SPG20; TAHCCP1; Spartin; Spastic paraplegia 20 protein; Trans-activated by hepatitis C virus core protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEQEPQNGEPAEIKIIREAYKKAFLFVNKGLNTDELGQKEEAKNYYKQGIGHLLRGISIS
SKESEHTGPGWESARQMQQKMKETLQNVRTRLEILEKGLATSLQNDLQEVPKLYPEFPPK
DMCEKLPEPQSFSSAPQHAEVNGNTSTPSAGAVAAPASLSLPSQSCPAEAPPAYTPQAAE
GHYTVSYGTDSGEFSSVGEEFYRNHSQPPPLETLGLDADELILIPNGVQIFFVNPAGEVS
APSYPGYLRIVRFLDNSLDTVLNRPPGFLQVCDWLYPLVPDRSPVLKCTAGAYMFPDTML
QAAGCFVGVVLSSELPEDDRELFEDLLRQMSDLRLQANWNRAEEENEFQIPGRTRPSSDQ
LKEASGTDVKQLDQGNKDVRHKGKRGKRAKDTSSEEVNLSHIVPCEPVPEEKPKELPEWS
EKVAHNILSGASWVSWGLVKGAEITGKAIQKGASKLRERIQPEEKPVEVSPAVTKGLYIA
KQATGGAAKVSQFLVDGVCTVANCVGKELAPHVKKHGSKLVPESLKKDKDGKSPLDGAMV
VAASSVQGFSTVWQGLECAAKCIVNNVSAETVQTVRYKYGYNAGEATHHAVDSAVNVGVT
AYNINNIGIKAMVKKTATQTGHTLLEDYQIVDNSQRENQEGAANVNVRGEKDEQTKEVKE
AKKKDK
Target Bioclass
Other
Subcellular location
Cytoplasm
Function May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis.
Uniprot ID
Q8N0X7
Ensemble ID
ENST00000355182.8
HGNC ID
HGNC:18514

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P2
 Probe Info  		4.33  LDD0348  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
TH216
 Probe Info  		Y478(20.00); Y579(14.48)  LDD0259  [4]
P11
 Probe Info  		1.46  LDD0210  [5]
THZ1-DTB
 Probe Info  		C499(1.08)  LDD0460  [6]
Sulforaphane-probe2
 Probe Info  		1.89  LDD0160  [7]
DA-P3
 Probe Info  		7.50  LDD0179  [2]
AHL-Pu-1
 Probe Info  		C562(4.05); C558(15.67); C504(2.03); C499(2.79)  LDD0169  [8]
EA-probe
 Probe Info  		N.A.  LDD0440  [9]
HHS-475
 Probe Info  		Y478(0.99); Y579(1.21); Y602(1.96)  LDD0264  [10]
HHS-465
 Probe Info  		Y602(5.47)  LDD2237  [11]
DBIA
 Probe Info  		C499(7.27); C504(7.27)  LDD0080  [12]
5E-2FA
 Probe Info  		H66(0.00); H622(0.00)  LDD2235  [13]
ATP probe
 Probe Info  		K481(0.00); K29(0.00); K390(0.00); K62(0.00)  LDD0199  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [18]
NAIA_4
 Probe Info  		C272(0.00); C405(0.00); C504(0.00); C558(0.00)  LDD2226  [19]
NAIA_5
 Probe Info  		N.A.  LDD2224  [19]
TFBX
 Probe Info  		N.A.  LDD0027  [18]
IPM
 Probe Info  		C405(0.00); C504(0.00)  LDD0005  [20]
NPM
 Probe Info  		N.A.  LDD0016  [20]
STPyne
 Probe Info  		N.A.  LDD0009  [20]
VSF
 Probe Info  		C405(0.00); C504(0.00); C562(0.00); C499(0.00)  LDD0007  [20]
Phosphinate-6
 Probe Info  		C558(0.00); C504(0.00); C405(0.00)  LDD0018  [21]
1c-yne
 Probe Info  		K29(0.00); K440(0.00)  LDD0228  [22]
AOyne
 Probe Info  		15.00  LDD0443  [23]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C092
 Probe Info  		18.90  LDD1783  [24]
C178
 Probe Info  		16.34  LDD1857  [24]
C187
 Probe Info  		17.39  LDD1865  [24]
C191
 Probe Info  		16.00  LDD1868  [24]
C193
 Probe Info  		4.96  LDD1869  [24]
C420
 Probe Info  		10.63  LDD2075  [24]
FFF probe13
 Probe Info  		20.00  LDD0475  [25]
FFF probe2
 Probe Info  		20.00  LDD0463  [25]
VE-P
 Probe Info  		N.A.  LDD0396  [26]
OEA-DA
 Probe Info  		10.16  LDD0046  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C272(3.50)  LDD0172  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C562(4.05); C558(15.67); C504(2.03); C499(2.79)  LDD0169  [8]
 LDCM0561  Abegg_cp(-)-10 HeLa C562(2.06)  LDD0312  [18]
 LDCM0214  AC1 HEK-293T C499(1.01)  LDD0812  [12]
 LDCM0215  AC10 HEK-293T C499(1.07)  LDD0813  [12]
 LDCM0216  AC100 HEK-293T C499(1.48); C562(1.21)  LDD0814  [12]
 LDCM0217  AC101 HEK-293T C499(1.32); C562(1.36)  LDD0815  [12]
 LDCM0218  AC102 HEK-293T C499(1.41); C562(1.38)  LDD0816  [12]
 LDCM0219  AC103 HEK-293T C499(1.39); C562(1.35)  LDD0817  [12]
 LDCM0220  AC104 HEK-293T C499(1.53); C562(1.36)  LDD0818  [12]
 LDCM0221  AC105 HEK-293T C499(1.18); C562(1.46)  LDD0819  [12]
 LDCM0222  AC106 HEK-293T C499(0.89); C562(1.10)  LDD0820  [12]
 LDCM0223  AC107 HEK-293T C499(1.35); C562(1.19)  LDD0821  [12]
 LDCM0224  AC108 HEK-293T C499(1.10); C562(1.12)  LDD0822  [12]
 LDCM0225  AC109 HEK-293T C499(1.15); C562(1.25)  LDD0823  [12]
 LDCM0226  AC11 HEK-293T C499(1.03)  LDD0824  [12]
 LDCM0227  AC110 HEK-293T C499(1.72); C562(1.73)  LDD0825  [12]
 LDCM0228  AC111 HEK-293T C499(2.01); C562(2.39)  LDD0826  [12]
 LDCM0229  AC112 HEK-293T C499(1.78); C562(1.60)  LDD0827  [12]
 LDCM0230  AC113 PaTu 8988t C562(1.10); C504(0.82); C499(0.82)  LDD1109  [12]
 LDCM0231  AC114 PaTu 8988t C562(1.13); C504(0.80); C499(0.80)  LDD1110  [12]
 LDCM0232  AC115 PaTu 8988t C562(1.26); C504(1.11); C499(1.11)  LDD1111  [12]
 LDCM0233  AC116 PaTu 8988t C562(1.14); C504(0.84); C499(0.84)  LDD1112  [12]
 LDCM0234  AC117 PaTu 8988t C562(1.13); C504(0.90); C499(0.90)  LDD1113  [12]
 LDCM0235  AC118 PaTu 8988t C562(0.88); C504(0.94); C499(0.94)  LDD1114  [12]
 LDCM0236  AC119 PaTu 8988t C562(0.89); C504(0.86); C499(0.86)  LDD1115  [12]
 LDCM0237  AC12 HEK-293T C499(0.97)  LDD0835  [12]
 LDCM0238  AC120 PaTu 8988t C562(1.17); C504(0.67); C499(0.67)  LDD1117  [12]
 LDCM0239  AC121 PaTu 8988t C562(0.93); C504(0.80); C499(0.80)  LDD1118  [12]
 LDCM0240  AC122 PaTu 8988t C562(0.77); C504(0.72); C499(0.72)  LDD1119  [12]
 LDCM0241  AC123 PaTu 8988t C562(0.70); C504(0.81); C499(0.81)  LDD1120  [12]
 LDCM0242  AC124 PaTu 8988t C562(1.19); C504(0.82); C499(0.82)  LDD1121  [12]
 LDCM0243  AC125 PaTu 8988t C562(1.12); C504(1.04); C499(1.04)  LDD1122  [12]
 LDCM0244  AC126 PaTu 8988t C562(0.68); C504(0.85); C499(0.85)  LDD1123  [12]
 LDCM0245  AC127 PaTu 8988t C562(0.71); C504(0.84); C499(0.84)  LDD1124  [12]
 LDCM0246  AC128 HEK-293T C562(0.79)  LDD0844  [12]
 LDCM0247  AC129 HEK-293T C562(0.77)  LDD0845  [12]
 LDCM0249  AC130 HEK-293T C562(0.76)  LDD0847  [12]
 LDCM0250  AC131 HEK-293T C562(0.78)  LDD0848  [12]
 LDCM0251  AC132 HEK-293T C562(0.81)  LDD0849  [12]
 LDCM0252  AC133 HEK-293T C562(0.99)  LDD0850  [12]
 LDCM0253  AC134 HEK-293T C562(1.01)  LDD0851  [12]
 LDCM0254  AC135 HEK-293T C562(0.91)  LDD0852  [12]
 LDCM0255  AC136 HEK-293T C562(0.93)  LDD0853  [12]
 LDCM0256  AC137 HEK-293T C562(0.97)  LDD0854  [12]
 LDCM0257  AC138 HEK-293T C562(0.98)  LDD0855  [12]
 LDCM0258  AC139 HEK-293T C562(1.06)  LDD0856  [12]
 LDCM0259  AC14 HEK-293T C499(1.16)  LDD0857  [12]
 LDCM0260  AC140 HEK-293T C562(1.05)  LDD0858  [12]
 LDCM0261  AC141 HEK-293T C562(1.16)  LDD0859  [12]
 LDCM0262  AC142 HEK-293T C562(0.93)  LDD0860  [12]
 LDCM0263  AC143 HEK-293T C499(1.03); C562(1.23)  LDD0861  [12]
 LDCM0264  AC144 HEK-293T C499(1.48); C562(1.08)  LDD0862  [12]
 LDCM0265  AC145 HEK-293T C499(1.24); C562(1.01)  LDD0863  [12]
 LDCM0266  AC146 HEK-293T C499(1.31); C562(1.02)  LDD0864  [12]
 LDCM0267  AC147 HEK-293T C499(1.25); C562(0.82)  LDD0865  [12]
 LDCM0268  AC148 HEK-293T C499(0.98); C562(0.93)  LDD0866  [12]
 LDCM0269  AC149 HEK-293T C499(1.26); C562(1.35)  LDD0867  [12]
 LDCM0270  AC15 HEK-293T C499(1.37)  LDD0868  [12]
 LDCM0271  AC150 HEK-293T C499(1.12); C562(0.77)  LDD0869  [12]
 LDCM0272  AC151 HEK-293T C499(1.90); C562(0.89)  LDD0870  [12]
 LDCM0273  AC152 HEK-293T C499(1.76); C562(1.18)  LDD0871  [12]
 LDCM0274  AC153 HEK-293T C499(1.38); C562(1.21)  LDD0872  [12]
 LDCM0621  AC154 HEK-293T C499(1.16); C562(1.42)  LDD2162  [12]
 LDCM0622  AC155 HEK-293T C499(1.26); C562(1.12)  LDD2163  [12]
 LDCM0623  AC156 HEK-293T C499(1.05); C562(1.18)  LDD2164  [12]
 LDCM0624  AC157 HEK-293T C499(1.84); C562(1.01)  LDD2165  [12]
 LDCM0276  AC17 HEK-293T C562(1.04); C405(0.95); C558(0.89); C504(1.02)  LDD1515  [28]
 LDCM0277  AC18 HEK-293T C562(0.87); C405(1.01); C272(1.03); C504(0.94)  LDD1516  [28]
 LDCM0278  AC19 HEK-293T C562(0.90); C405(1.02); C558(1.22); C272(0.94)  LDD1517  [28]
 LDCM0279  AC2 HEK-293T C499(1.23)  LDD0877  [12]
 LDCM0280  AC20 HEK-293T C562(0.96); C405(1.02); C558(1.04); C504(1.01)  LDD1519  [28]
 LDCM0281  AC21 HEK-293T C562(1.00); C405(1.05); C558(0.88); C272(0.96)  LDD1520  [28]
 LDCM0282  AC22 HEK-293T C562(1.04); C405(0.94); C558(1.11); C504(0.97)  LDD1521  [28]
 LDCM0283  AC23 HEK-293T C562(0.94); C405(1.01); C558(0.89); C504(0.97)  LDD1522  [28]
 LDCM0284  AC24 HEK-293T C562(1.11); C405(0.93); C558(0.97); C272(1.07)  LDD1523  [28]
 LDCM0285  AC25 HEK-293T C499(1.03); C562(0.85)  LDD0883  [12]
 LDCM0286  AC26 HEK-293T C499(1.14); C562(0.99)  LDD0884  [12]
 LDCM0287  AC27 HEK-293T C499(1.06); C562(1.04)  LDD0885  [12]
 LDCM0288  AC28 HEK-293T C499(1.07); C562(2.27)  LDD0886  [12]
 LDCM0289  AC29 HEK-293T C499(1.22); C562(1.17)  LDD0887  [12]
 LDCM0290  AC3 HEK-293T C499(0.95)  LDD0888  [12]
 LDCM0291  AC30 HEK-293T C499(1.17); C562(0.91)  LDD0889  [12]
 LDCM0292  AC31 HEK-293T C499(1.11); C562(0.88)  LDD0890  [12]
 LDCM0293  AC32 HEK-293T C499(0.99); C562(0.79)  LDD0891  [12]
 LDCM0294  AC33 HEK-293T C499(1.11); C562(0.94)  LDD0892  [12]
 LDCM0295  AC34 HEK-293T C499(1.14); C562(0.86)  LDD0893  [12]
 LDCM0296  AC35 HEK-293T C562(1.05)  LDD0894  [12]
 LDCM0297  AC36 HEK-293T C562(1.04)  LDD0895  [12]
 LDCM0298  AC37 HEK-293T C562(1.00)  LDD0896  [12]
 LDCM0299  AC38 HEK-293T C562(1.16)  LDD0897  [12]
 LDCM0300  AC39 HEK-293T C562(1.36)  LDD0898  [12]
 LDCM0301  AC4 HEK-293T C499(1.04)  LDD0899  [12]
 LDCM0302  AC40 HEK-293T C562(0.96)  LDD0900  [12]
 LDCM0303  AC41 HEK-293T C562(1.22)  LDD0901  [12]
 LDCM0304  AC42 HEK-293T C562(1.10)  LDD0902  [12]
 LDCM0305  AC43 HEK-293T C562(1.09)  LDD0903  [12]
 LDCM0306  AC44 HEK-293T C562(1.26)  LDD0904  [12]
 LDCM0307  AC45 HEK-293T C562(1.29)  LDD0905  [12]
 LDCM0308  AC46 HEK-293T C499(1.13); C562(1.01)  LDD0906  [12]
 LDCM0309  AC47 HEK-293T C499(1.02); C562(1.03)  LDD0907  [12]
 LDCM0310  AC48 HEK-293T C499(1.20); C562(1.13)  LDD0908  [12]
 LDCM0311  AC49 HEK-293T C499(1.35); C562(1.31)  LDD0909  [12]
 LDCM0312  AC5 HEK-293T C499(1.02)  LDD0910  [12]
 LDCM0313  AC50 HEK-293T C499(1.61); C562(1.13)  LDD0911  [12]
 LDCM0314  AC51 HEK-293T C499(1.44); C562(1.22)  LDD0912  [12]
 LDCM0315  AC52 HEK-293T C499(1.58); C562(1.08)  LDD0913  [12]
 LDCM0316  AC53 HEK-293T C499(1.08); C562(0.96)  LDD0914  [12]
 LDCM0317  AC54 HEK-293T C499(1.41); C562(1.14)  LDD0915  [12]
 LDCM0318  AC55 HEK-293T C499(1.45); C562(1.18)  LDD0916  [12]
 LDCM0319  AC56 HEK-293T C499(1.54); C562(1.17)  LDD0917  [12]
 LDCM0320  AC57 HEK-293T C499(1.00); C562(1.08)  LDD0918  [12]
 LDCM0321  AC58 HEK-293T C499(1.01); C562(1.00)  LDD0919  [12]
 LDCM0322  AC59 HEK-293T C499(1.00); C562(1.00)  LDD0920  [12]
 LDCM0323  AC6 HEK-293T C499(1.24)  LDD0921  [12]
 LDCM0324  AC60 HEK-293T C499(0.93); C562(1.43)  LDD0922  [12]
 LDCM0325  AC61 HEK-293T C499(1.14); C562(1.21)  LDD0923  [12]
 LDCM0326  AC62 HEK-293T C499(0.96); C562(1.08)  LDD0924  [12]
 LDCM0327  AC63 HEK-293T C499(1.06); C562(1.18)  LDD0925  [12]
 LDCM0328  AC64 HEK-293T C499(0.89); C562(1.16)  LDD0926  [12]
 LDCM0329  AC65 HEK-293T C499(1.22); C562(1.14)  LDD0927  [12]
 LDCM0330  AC66 HEK-293T C499(0.99); C562(1.10)  LDD0928  [12]
 LDCM0331  AC67 HEK-293T C499(1.21); C562(1.12)  LDD0929  [12]
 LDCM0332  AC68 HEK-293T C499(0.91); C562(0.68)  LDD0930  [12]
 LDCM0333  AC69 HEK-293T C499(1.02); C562(1.15)  LDD0931  [12]
 LDCM0334  AC7 HEK-293T C499(1.66)  LDD0932  [12]
 LDCM0335  AC70 HEK-293T C499(1.17); C562(0.82)  LDD0933  [12]
 LDCM0336  AC71 HEK-293T C499(1.09); C562(0.91)  LDD0934  [12]
 LDCM0337  AC72 HEK-293T C499(1.18); C562(0.79)  LDD0935  [12]
 LDCM0338  AC73 HEK-293T C499(1.07); C562(0.82)  LDD0936  [12]
 LDCM0339  AC74 HEK-293T C499(1.19); C562(0.79)  LDD0937  [12]
 LDCM0340  AC75 HEK-293T C499(1.45); C562(0.65)  LDD0938  [12]
 LDCM0341  AC76 HEK-293T C499(1.02); C562(0.60)  LDD0939  [12]
 LDCM0342  AC77 HEK-293T C499(1.17); C562(0.96)  LDD0940  [12]
 LDCM0343  AC78 HEK-293T C499(1.29); C562(0.66)  LDD0941  [12]
 LDCM0344  AC79 HEK-293T C499(1.14); C562(0.76)  LDD0942  [12]
 LDCM0345  AC8 HEK-293T C499(1.59)  LDD0943  [12]
 LDCM0346  AC80 HEK-293T C499(1.37); C562(0.78)  LDD0944  [12]
 LDCM0347  AC81 HEK-293T C499(1.14); C562(0.77)  LDD0945  [12]
 LDCM0348  AC82 HEK-293T C499(1.68); C562(1.47)  LDD0946  [12]
 LDCM0349  AC83 HEK-293T C499(0.96); C562(0.88)  LDD0947  [12]
 LDCM0350  AC84 HEK-293T C499(1.65); C562(1.09)  LDD0948  [12]
 LDCM0351  AC85 HEK-293T C499(1.30); C562(0.99)  LDD0949  [12]
 LDCM0352  AC86 HEK-293T C499(1.20); C562(0.97)  LDD0950  [12]
 LDCM0353  AC87 HEK-293T C499(1.06); C562(0.96)  LDD0951  [12]
 LDCM0354  AC88 HEK-293T C499(1.08); C562(1.32)  LDD0952  [12]
 LDCM0355  AC89 HEK-293T C499(1.45); C562(1.10)  LDD0953  [12]
 LDCM0357  AC90 HEK-293T C499(1.21); C562(0.93)  LDD0955  [12]
 LDCM0358  AC91 HEK-293T C499(1.00); C562(0.91)  LDD0956  [12]
 LDCM0359  AC92 HEK-293T C499(1.40); C562(1.05)  LDD0957  [12]
 LDCM0360  AC93 HEK-293T C499(1.17); C562(0.94)  LDD0958  [12]
 LDCM0361  AC94 HEK-293T C499(1.22); C562(1.22)  LDD0959  [12]
 LDCM0362  AC95 HEK-293T C499(1.29); C562(0.98)  LDD0960  [12]
 LDCM0363  AC96 HEK-293T C499(1.26); C562(1.00)  LDD0961  [12]
 LDCM0364  AC97 HEK-293T C499(2.13); C562(1.25)  LDD0962  [12]
 LDCM0365  AC98 HEK-293T C499(1.00); C562(1.16)  LDD0963  [12]
 LDCM0366  AC99 HEK-293T C499(1.24); C562(1.10)  LDD0964  [12]
 LDCM0248  AKOS034007472 HEK-293T C499(0.95)  LDD0846  [12]
 LDCM0356  AKOS034007680 HEK-293T C499(1.43)  LDD0954  [12]
 LDCM0275  AKOS034007705 HEK-293T C499(1.10)  LDD0873  [12]
 LDCM0156  Aniline NCI-H1299 12.48  LDD0403  [1]
 LDCM0089  C30 HEK-293T 1.46  LDD0210  [5]
 LDCM0087  Capsaicin HEK-293T 7.84  LDD0185  [2]
 LDCM0630  CCW28-3 231MFP C288(1.37)  LDD2214  [29]
 LDCM0632  CL-Sc Hep-G2 C499(20.00)  LDD2227  [19]
 LDCM0367  CL1 HEK-293T C562(1.41)  LDD0965  [12]
 LDCM0368  CL10 HEK-293T C562(2.07)  LDD0966  [12]
 LDCM0369  CL100 HEK-293T C499(1.17)  LDD0967  [12]
 LDCM0370  CL101 HEK-293T C499(1.78)  LDD0968  [12]
 LDCM0371  CL102 HEK-293T C499(1.54)  LDD0969  [12]
 LDCM0372  CL103 HEK-293T C499(1.33)  LDD0970  [12]
 LDCM0373  CL104 HEK-293T C499(1.15)  LDD0971  [12]
 LDCM0374  CL105 HEK-293T C562(0.83); C405(1.04); C558(1.00); C504(0.95)  LDD1578  [28]
 LDCM0375  CL106 HEK-293T C562(1.08); C405(0.95); C558(0.81); C504(0.87)  LDD1579  [28]
 LDCM0376  CL107 HEK-293T C562(1.08); C405(0.88); C558(1.04); C504(0.98)  LDD1580  [28]
 LDCM0377  CL108 HEK-293T C562(0.98); C405(1.02); C504(0.92); C499(1.01)  LDD1581  [28]
 LDCM0378  CL109 HEK-293T C562(0.94); C405(0.97); C558(0.90); C504(0.93)  LDD1582  [28]
 LDCM0379  CL11 HEK-293T C562(1.80)  LDD0977  [12]
 LDCM0380  CL110 HEK-293T C562(0.99); C405(0.97); C558(1.00); C504(0.91)  LDD1584  [28]
 LDCM0381  CL111 HEK-293T C562(1.00); C405(0.96); C558(0.94); C504(0.95)  LDD1585  [28]
 LDCM0382  CL112 HEK-293T C499(1.22); C562(0.86)  LDD0980  [12]
 LDCM0383  CL113 HEK-293T C499(1.01); C562(0.89)  LDD0981  [12]
 LDCM0384  CL114 HEK-293T C499(1.35); C562(0.95)  LDD0982  [12]
 LDCM0385  CL115 HEK-293T C499(1.35); C562(0.99)  LDD0983  [12]
 LDCM0386  CL116 HEK-293T C499(1.22); C562(0.88)  LDD0984  [12]
 LDCM0387  CL117 HEK-293T C562(1.15)  LDD0985  [12]
 LDCM0388  CL118 HEK-293T C562(1.07)  LDD0986  [12]
 LDCM0389  CL119 HEK-293T C562(1.10)  LDD0987  [12]
 LDCM0390  CL12 HEK-293T C562(1.26)  LDD0988  [12]
 LDCM0391  CL120 HEK-293T C562(1.28)  LDD0989  [12]
 LDCM0392  CL121 HEK-293T C499(1.69); C562(1.08)  LDD0990  [12]
 LDCM0393  CL122 HEK-293T C499(1.34); C562(1.11)  LDD0991  [12]
 LDCM0394  CL123 HEK-293T C499(0.99); C562(0.91)  LDD0992  [12]
 LDCM0395  CL124 HEK-293T C499(1.44); C562(0.95)  LDD0993  [12]
 LDCM0396  CL125 HEK-293T C499(1.01); C562(0.98)  LDD0994  [12]
 LDCM0397  CL126 HEK-293T C499(0.89); C562(1.12)  LDD0995  [12]
 LDCM0398  CL127 HEK-293T C499(0.88); C562(1.16)  LDD0996  [12]
 LDCM0399  CL128 HEK-293T C499(0.88); C562(1.11)  LDD0997  [12]
 LDCM0400  CL13 HEK-293T C562(1.23)  LDD0998  [12]
 LDCM0401  CL14 HEK-293T C562(1.23)  LDD0999  [12]
 LDCM0402  CL15 HEK-293T C562(1.24)  LDD1000  [12]
 LDCM0403  CL16 HEK-293T C499(1.26); C562(0.95)  LDD1001  [12]
 LDCM0404  CL17 HEK-293T C499(0.83); C562(1.53)  LDD1002  [12]
 LDCM0405  CL18 HEK-293T C499(1.13); C562(0.90)  LDD1003  [12]
 LDCM0406  CL19 HEK-293T C499(1.04); C562(0.89)  LDD1004  [12]
 LDCM0407  CL2 HEK-293T C562(1.13)  LDD1005  [12]
 LDCM0408  CL20 HEK-293T C499(0.85); C562(1.01)  LDD1006  [12]
 LDCM0409  CL21 HEK-293T C499(1.08); C562(1.27)  LDD1007  [12]
 LDCM0410  CL22 HEK-293T C499(1.15); C562(1.82)  LDD1008  [12]
 LDCM0411  CL23 HEK-293T C499(0.86); C562(1.08)  LDD1009  [12]
 LDCM0412  CL24 HEK-293T C499(0.85); C562(1.91)  LDD1010  [12]
 LDCM0413  CL25 HEK-293T C499(1.10); C562(1.86)  LDD1011  [12]
 LDCM0414  CL26 HEK-293T C499(0.91); C562(0.76)  LDD1012  [12]
 LDCM0415  CL27 HEK-293T C499(0.95); C562(1.37)  LDD1013  [12]
 LDCM0416  CL28 HEK-293T C499(0.87); C562(1.00)  LDD1014  [12]
 LDCM0417  CL29 HEK-293T C499(0.86); C562(1.07)  LDD1015  [12]
 LDCM0418  CL3 HEK-293T C562(1.38)  LDD1016  [12]
 LDCM0419  CL30 HEK-293T C499(1.33); C562(1.47)  LDD1017  [12]
 LDCM0420  CL31 HEK-293T C562(0.97); C405(1.09); C558(0.88); C272(1.16)  LDD1624  [28]
 LDCM0421  CL32 HEK-293T C562(1.00); C405(0.95); C558(0.98); C504(0.95)  LDD1625  [28]
 LDCM0422  CL33 HEK-293T C562(1.00); C405(1.51); C558(0.97); C272(0.76)  LDD1626  [28]
 LDCM0423  CL34 HEK-293T C562(1.03); C405(1.43); C558(0.82); C504(0.98)  LDD1627  [28]
 LDCM0424  CL35 HEK-293T C562(1.11); C405(0.94); C558(1.02); C504(0.95)  LDD1628  [28]
 LDCM0425  CL36 HEK-293T C562(1.15); C405(1.63); C558(1.08); C272(1.00)  LDD1629  [28]
 LDCM0426  CL37 HEK-293T C562(0.95); C405(0.95); C558(1.01); C504(0.94)  LDD1630  [28]
 LDCM0428  CL39 HEK-293T C562(0.97); C405(0.89); C558(1.15); C504(0.94)  LDD1632  [28]
 LDCM0429  CL4 HEK-293T C562(1.22)  LDD1027  [12]
 LDCM0430  CL40 HEK-293T C562(1.05); C405(1.06); C504(0.96); C499(1.01)  LDD1634  [28]
 LDCM0431  CL41 HEK-293T C562(1.15); C405(1.04); C558(0.86); C504(1.13)  LDD1635  [28]
 LDCM0432  CL42 HEK-293T C562(1.03); C405(1.15); C272(0.95); C504(0.91)  LDD1636  [28]
 LDCM0433  CL43 HEK-293T C562(1.19); C405(1.09); C558(0.93); C272(1.02)  LDD1637  [28]
 LDCM0434  CL44 HEK-293T C562(0.85); C405(0.94); C558(1.01); C504(0.95)  LDD1638  [28]
 LDCM0435  CL45 HEK-293T C562(0.98); C405(1.30); C558(1.04); C272(0.71)  LDD1639  [28]
 LDCM0436  CL46 HEK-293T C499(1.33)  LDD1034  [12]
 LDCM0437  CL47 HEK-293T C499(1.05)  LDD1035  [12]
 LDCM0438  CL48 HEK-293T C499(1.04)  LDD1036  [12]
 LDCM0439  CL49 HEK-293T C499(1.01)  LDD1037  [12]
 LDCM0440  CL5 HEK-293T C562(1.05)  LDD1038  [12]
 LDCM0441  CL50 HEK-293T C499(1.19)  LDD1039  [12]
 LDCM0442  CL51 HEK-293T C499(0.90)  LDD1040  [12]
 LDCM0443  CL52 HEK-293T C499(0.76)  LDD1041  [12]
 LDCM0444  CL53 HEK-293T C499(0.80)  LDD1042  [12]
 LDCM0445  CL54 HEK-293T C499(1.04)  LDD1043  [12]
 LDCM0446  CL55 HEK-293T C499(1.26)  LDD1044  [12]
 LDCM0447  CL56 HEK-293T C499(0.95)  LDD1045  [12]
 LDCM0448  CL57 HEK-293T C499(1.04)  LDD1046  [12]
 LDCM0449  CL58 HEK-293T C499(0.85)  LDD1047  [12]
 LDCM0450  CL59 HEK-293T C499(1.21)  LDD1048  [12]
 LDCM0451  CL6 HEK-293T C562(1.08)  LDD1049  [12]
 LDCM0452  CL60 HEK-293T C499(1.37)  LDD1050  [12]
 LDCM0453  CL61 HEK-293T C562(1.02); C405(0.99); C558(1.02); C504(1.05)  LDD1656  [28]
 LDCM0454  CL62 HEK-293T C562(1.04); C405(0.94); C558(1.06); C504(0.67)  LDD1657  [28]
 LDCM0455  CL63 HEK-293T C562(0.99); C405(0.95); C558(1.07); C504(0.88)  LDD1658  [28]
 LDCM0456  CL64 HEK-293T C562(1.00); C405(0.94); C504(0.89); C499(0.98)  LDD1659  [28]
 LDCM0457  CL65 HEK-293T C562(1.00); C405(0.98); C558(0.97); C504(1.00)  LDD1660  [28]
 LDCM0458  CL66 HEK-293T C562(1.01); C405(0.96); C272(1.02); C504(0.93)  LDD1661  [28]
 LDCM0459  CL67 HEK-293T C562(1.08); C405(1.08); C558(0.99); C272(1.04)  LDD1662  [28]
 LDCM0460  CL68 HEK-293T C562(1.09); C405(0.89); C558(0.85); C504(0.96)  LDD1663  [28]
 LDCM0461  CL69 HEK-293T C562(1.11); C405(1.51); C558(1.02); C272(0.96)  LDD1664  [28]
 LDCM0462  CL7 HEK-293T C562(1.41)  LDD1060  [12]
 LDCM0463  CL70 HEK-293T C562(1.05); C405(1.26); C558(0.88); C504(1.05)  LDD1666  [28]
 LDCM0464  CL71 HEK-293T C562(1.12); C405(0.92); C558(1.04); C504(0.92)  LDD1667  [28]
 LDCM0465  CL72 HEK-293T C562(1.11); C405(1.41); C558(0.83); C272(0.83)  LDD1668  [28]
 LDCM0466  CL73 HEK-293T C562(0.85); C405(1.00); C558(0.96); C504(0.99)  LDD1669  [28]
 LDCM0467  CL74 HEK-293T C562(1.17); C405(1.04); C558(0.98); C504(0.90)  LDD1670  [28]
 LDCM0469  CL76 HEK-293T C499(0.98)  LDD1067  [12]
 LDCM0470  CL77 HEK-293T C499(1.01)  LDD1068  [12]
 LDCM0471  CL78 HEK-293T C499(0.82)  LDD1069  [12]
 LDCM0472  CL79 HEK-293T C499(1.16)  LDD1070  [12]
 LDCM0473  CL8 HEK-293T C562(0.84)  LDD1071  [12]
 LDCM0474  CL80 HEK-293T C499(0.89)  LDD1072  [12]
 LDCM0475  CL81 HEK-293T C499(1.26)  LDD1073  [12]
 LDCM0476  CL82 HEK-293T C499(1.58)  LDD1074  [12]
 LDCM0477  CL83 HEK-293T C499(1.15)  LDD1075  [12]
 LDCM0478  CL84 HEK-293T C499(0.96)  LDD1076  [12]
 LDCM0479  CL85 HEK-293T C499(0.85)  LDD1077  [12]
 LDCM0480  CL86 HEK-293T C499(0.82)  LDD1078  [12]
 LDCM0481  CL87 HEK-293T C499(1.10)  LDD1079  [12]
 LDCM0482  CL88 HEK-293T C499(1.07)  LDD1080  [12]
 LDCM0483  CL89 HEK-293T C499(1.06)  LDD1081  [12]
 LDCM0484  CL9 HEK-293T C562(0.82)  LDD1082  [12]
 LDCM0485  CL90 HEK-293T C499(1.11)  LDD1083  [12]
 LDCM0486  CL91 HEK-293T C499(1.14)  LDD1084  [12]
 LDCM0487  CL92 HEK-293T C499(1.44)  LDD1085  [12]
 LDCM0488  CL93 HEK-293T C499(1.29)  LDD1086  [12]
 LDCM0489  CL94 HEK-293T C499(1.65)  LDD1087  [12]
 LDCM0490  CL95 HEK-293T C499(2.46)  LDD1088  [12]
 LDCM0491  CL96 HEK-293T C499(1.40)  LDD1089  [12]
 LDCM0492  CL97 HEK-293T C499(1.71)  LDD1090  [12]
 LDCM0493  CL98 HEK-293T C499(1.29)  LDD1091  [12]
 LDCM0494  CL99 HEK-293T C499(1.14)  LDD1092  [12]
 LDCM0634  CY-0357 Hep-G2 C562(1.33)  LDD2228  [19]
 LDCM0028  Dobutamine HEK-293T 4.68  LDD0180  [2]
 LDCM0027  Dopamine HEK-293T 7.50  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C562(1.00); C405(0.94); C558(0.84); C504(0.98)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C562(1.34)  LDD1702  [30]
 LDCM0031  Epigallocatechin gallate HEK-293T 12.66  LDD0183  [2]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [9]
 LDCM0468  Fragment33 HEK-293T C562(0.98); C405(0.94); C558(0.76); C504(0.91)  LDD1671  [28]
 LDCM0427  Fragment51 HEK-293T C562(1.23); C405(1.08); C558(0.51); C504(0.79)  LDD1631  [28]
 LDCM0116  HHS-0101 DM93 Y478(0.99); Y579(1.21); Y602(1.96)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y478(0.61); Y579(0.73); Y602(3.61)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y478(0.74); Y579(0.97)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y579(0.58); Y478(0.71); Y602(3.62)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y478(1.27); Y579(2.39); Y602(3.38)  LDD0268  [10]
 LDCM0022  KB02 HCT 116 C499(7.27); C504(7.27)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C499(5.54); C504(5.54)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C499(10.75); C504(10.75)  LDD0082  [12]
 LDCM0030  Luteolin HEK-293T 13.27  LDD0182  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C562(1.75)  LDD2206  [31]
 LDCM0628  OTUB2-COV-1 HEK-293T C562(0.89)  LDD2207  [31]
 LDCM0029  Quercetin HEK-293T 8.32  LDD0181  [2]
 LDCM0003  Sulforaphane MDA-MB-231 1.89  LDD0160  [7]
 LDCM0021  THZ1 HeLa S3 C499(1.08)  LDD0460  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Deubiquitinase DESI2 (DESI2) DeSI family Q9BSY9
OTU domain-containing protein 7B (OTUD7B) Peptidase C64 family Q6GQQ9
Ubiquitin thioesterase OTUB2 (OTUB2) Peptidase C65 family Q96DC9
Ubiquitin thioesterase otulin (OTULIN) Peptidase C65 family Q96BN8
Ubiquitin thioesterase OTU1 (YOD1) . Q5VVQ6
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) CAMP-dependent kinase regulatory chain family P10644
Ubiquitin-associated domain-containing protein 1 (UBAC1) . Q9BSL1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
6 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
7 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
27 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
30 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
31 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.