Details of the Target

General Information of Target

Target ID LDTP03837
Target Name Signal recognition particle 14 kDa protein (SRP14)
Gene Name SRP14
Gene ID 6727
Synonyms
Signal recognition particle 14 kDa protein; SRP14; 18 kDa Alu RNA-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLLESEQFLTELTRLFQKCRTSGSVYITLKKYDGRTKPIPKKGTVEGFEPADNKCLLRA
TDGKKKISTVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKNKTKKTKAAAAAAAAAPAAA
ATAPTTAATTAATAAQ
Target Bioclass
Transporter and channel
Family
SRP14 family
Subcellular location
Cytoplasm
Function
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Uniprot ID
P37108
Ensemble ID
ENST00000267884.11
HGNC ID
HGNC:11299

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		10.00  LDD0452  [1]
C-Sul
 Probe Info  		4.01  LDD0066  [2]
TH211
 Probe Info  		Y27(20.00)  LDD0257  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K74(1.68); K78(3.19)  LDD0277  [5]
OPA-S-S-alkyne
 Probe Info  		K55(1.02)  LDD3494  [6]
P11
 Probe Info  		1.25  LDD0210  [7]
ATP probe
 Probe Info  		K31(0.00); K32(0.00); K55(0.00); K43(0.00)  LDD0199  [8]
1d-yne
 Probe Info  		N.A.  LDD0358  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [10]
BTD
 Probe Info  		N.A.  LDD0004  [11]
IPM
 Probe Info  		N.A.  LDD0025  [12]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
DBIA
 Probe Info  		C56(0.42)  LDD2236  [13]
NHS
 Probe Info  		N.A.  LDD0010  [11]
SF
 Probe Info  		N.A.  LDD0028  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [9]
NAIA_5
 Probe Info  		C20(0.00); C56(0.00)  LDD2223  [16]
HHS-475
 Probe Info  		Y27(0.59)  LDD2238  [17]
HHS-482
 Probe Info  		Y27(0.86)  LDD2239  [17]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C191
 Probe Info  		9.58  LDD1868  [18]
C193
 Probe Info  		4.92  LDD1869  [18]
DA-2
 Probe Info  		N.A.  LDD0071  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C56(0.52)  LDD2142  [20]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C56(0.79)  LDD2112  [20]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C56(0.92)  LDD2117  [20]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C56(1.02)  LDD2103  [20]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C56(1.09)  LDD2131  [20]
 LDCM0520  AKOS000195272 MDA-MB-231 C56(0.65)  LDD2113  [20]
 LDCM0498  BS-3668 MDA-MB-231 C56(0.54)  LDD2091  [20]
 LDCM0089  C30 HEK-293T 1.25  LDD0210  [7]
 LDCM0625  F8 Ramos C56(1.70)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C56(0.42)  LDD2189  [21]
 LDCM0574  Fragment12 Ramos C56(0.48)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C56(0.45)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C56(0.74)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C56(0.34)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C56(0.48)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C56(1.07)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C56(0.80)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C56(0.64)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C56(1.09)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C56(0.59)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C56(0.56)  LDD2201  [21]
 LDCM0468  Fragment33 Ramos C56(0.65)  LDD2202  [21]
 LDCM0596  Fragment38 Ramos C56(0.74)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C56(0.84)  LDD2184  [21]
 LDCM0610  Fragment52 Ramos C56(0.67)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C56(0.78)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C56(0.34)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C56(0.32)  LDD2188  [21]
 LDCM0022  KB02 Ramos C56(0.37)  LDD2182  [21]
 LDCM0023  KB03 Ramos C56(0.69)  LDD2183  [21]
 LDCM0024  KB05 Ramos C56(0.23)  LDD2185  [21]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C56(0.96)  LDD2102  [20]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C56(0.63)  LDD2121  [20]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C56(0.97)  LDD2090  [20]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C56(1.07); C20(0.04)  LDD2096  [20]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C56(0.69)  LDD2097  [20]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C56(0.90)  LDD2098  [20]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C56(0.98)  LDD2099  [20]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C56(0.47)  LDD2100  [20]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C56(0.98)  LDD2101  [20]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C56(0.48)  LDD2104  [20]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C56(1.34)  LDD2105  [20]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C56(0.44)  LDD2106  [20]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C56(0.94)  LDD2107  [20]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C56(0.80)  LDD2108  [20]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C56(0.79)  LDD2109  [20]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C56(0.85)  LDD2110  [20]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C56(0.58)  LDD2114  [20]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C56(0.60)  LDD2115  [20]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C56(1.03)  LDD2120  [20]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C56(1.09)  LDD2122  [20]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C56(1.32)  LDD2124  [20]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C56(0.92)  LDD2125  [20]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C56(1.47)  LDD2126  [20]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C56(0.90)  LDD2127  [20]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C56(1.37)  LDD2128  [20]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C56(0.44)  LDD2134  [20]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C56(1.14)  LDD2135  [20]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C56(0.68)  LDD2136  [20]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C56(0.79)  LDD2140  [20]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C56(0.57)  LDD2141  [20]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C56(1.04)  LDD2143  [20]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C56(4.29)  LDD2144  [20]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C56(3.33)  LDD2145  [20]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C56(1.01)  LDD2146  [20]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C56(2.73)  LDD2147  [20]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C56(0.50)  LDD2148  [20]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C56(1.39); C20(1.06)  LDD2149  [20]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C56(0.35)  LDD2150  [20]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C56(1.25)  LDD2151  [20]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C56(1.56)  LDD2153  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sperm protein associated with the nucleus on the X chromosome N2 (SPANXN2) SPAN-X family Q5MJ10
Signal recognition particle 9 kDa protein (SRP9) SRP9 family P49458
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ELL-associated factor 1 (EAF1) EAF family Q96JC9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Global profiling of phosphorylation-dependent changes in cysteine reactivity. Nat Methods. 2022 Mar;19(3):341-352. doi: 10.1038/s41592-022-01398-2. Epub 2022 Feb 28.
Mass spectrometry data entry: PXD026730
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
20 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578