General Information of Experiment

Probe Name P1  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
LFQ
In Vivo Experiment Model Model Type Living cell
Derived Tissue Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cells (HeLa)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 32 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04876  Actin, cytoplasmic 1 (ACTB) 10.0
 LDTP00314  ATP-dependent RNA helicase DDX3X (DDX3X) 10.0
 LDTP04886  Cell division control protein 42 homolog (CDC42) 10.0
 LDTP05460  Elongation factor 1-alpha 2 (EEF1A2) 10.0
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) 10.0
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 10.0
 LDTP02333  Glutathione S-transferase P (GSTP1) 10.0
 LDTP03764  Myosin-9 (MYH9) 10.0
 LDTP02924  Probable ATP-dependent RNA helicase DDX5 (DDX5) 10.0
 LDTP12444  Xaa-Pro aminopeptidase 1 (XPNPEP1) 10.0
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) 7.7
 LDTP02616  Creatine kinase B-type (CKB) 5.8
 LDTP08190  E3 ubiquitin-protein ligase RNF180 (RNF180) 5.3
 LDTP03242  Adenosylhomocysteinase (AHCY) 4.0
 LDTP03908  Malate dehydrogenase, mitochondrial (MDH2) 4.0
 LDTP03166  Ubiquitin-like modifier-activating enzyme 1 (UBA1) 3.6
 LDTP02008  Fructose-bisphosphate aldolase A (ALDOA) 3.1
 LDTP06192  Neutral alpha-glucosidase AB (GANAB) 3.1
 LDTP03976  Aldo-keto reductase family 1 member C3 (AKR1C3) 2.9
 LDTP02733  Pyruvate kinase PKM (PKM) 2.9
 LDTP05550  ATP-dependent RNA helicase A (DHX9) 2.8
 LDTP07932  Probable ATP-dependent RNA helicase DDX46 (DDX46) 2.6
 LDTP04878  Eukaryotic initiation factor 4A-I (EIF4A1) 2.6
 LDTP05911  Serine/threonine-protein kinase PRP4 homolog (PRPF4B) 2.5
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) 2.2
 LDTP02541  Heat shock cognate 71 kDa protein (HSPA8) 2.1
 LDTP01766  L-lactate dehydrogenase A chain (LDHA) 2.1
 LDTP01124  Probable phospholipid-transporting ATPase IIA (ATP9A) 2.1
 LDTP03487  Transketolase (TKT) 2.0
 LDTP01807  Argininosuccinate synthase (ASS1) 1.7
 LDTP04851  Triosephosphate isomerase (TPI1) 1.6
 LDTP02672  Elongation factor 2 (EEF2) 1.6
Transporter and channel
Click to Show/Hide to Show 16 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00362  Astrotactin-1 (ASTN1) 10.0
 LDTP05252  Clathrin heavy chain 1 (CLTC) 10.0
 LDTP05292  Fatty acid-binding protein 5 (FABP5) 10.0
 LDTP03107  Filamin-A (FLNA) 10.0
 LDTP03837  Signal recognition particle 14 kDa protein (SRP14) 10.0
 LDTP04391  T-complex protein 1 subunit delta (CCT4) 10.0
 LDTP05832  Urea transporter 1 (SLC14A1) 10.0
 LDTP02815  Desmoplakin (DSP) 7.7
 LDTP02307  Annexin A5 (ANXA5) 7.0
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) 6.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 2.0
 LDTP03385  14-3-3 protein theta (YWHAQ) 1.9
 LDTP04969  14-3-3 protein epsilon (YWHAE) 1.7
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) 1.6
 LDTP02199  Annexin A2 (ANXA2) 1.5
 LDTP02256  Amino acid transporter heavy chain SLC3A2 (SLC3A2) 1.5
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03212  Splicing factor, proline- and glutamine-rich (SFPQ) 10.0
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP17677  Olfactory receptor 8H2 (OR8H2) 2.5
Other
Click to Show/Hide to Show 42 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03283  Elongation factor 1-beta (EEF1B2) 10.0
 LDTP05421  Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) 10.0
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 10.0
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) 10.0
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) 10.0
 LDTP02125  Keratin, type II cytoskeletal 8 (KRT8) 10.0
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) 10.0
 LDTP03658  Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) 10.0
 LDTP03346  Moesin (MSN) 10.0
 LDTP01993  Muellerian-inhibiting factor (AMH) 10.0
 LDTP02595  Polyadenylate-binding protein 1 (PABPC1) 10.0
 LDTP03364  Polypyrimidine tract-binding protein 1 (PTBP1) 10.0
 LDTP17266  Pre-mRNA-splicing factor 38B (PRPF38B) 10.0
 LDTP01932  Prelamin-A/C (LMNA) 10.0
 LDTP04355  Rab GDP dissociation inhibitor beta (GDI2) 10.0
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1) 10.0
 LDTP06381  Ryanodine receptor 3 (RYR3) 10.0
 LDTP10650  Serpin B11 (SERPINB11) 10.0
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) 10.0
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) 10.0
 LDTP04249  T-complex protein 1 subunit gamma (CCT3) 10.0
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 10.0
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) 8.6
 LDTP06598  Fascin (FSCN1) 7.0
 LDTP01534  Luc7-like protein 3 (LUC7L3) 5.3
 LDTP17734  Testis-expressed protein 9 (TEX9) 5.2
 LDTP05014  Small ribosomal subunit protein eS26 (RPS26) 4.2
 LDTP14045  Disheveled-associated activator of morphogenesis 1 (DAAM1) 3.9
 LDTP00843  Alpha-actinin-4 (ACTN4) 3.5
 LDTP02297  Vimentin (VIM) 3.1
 LDTP09562  Splicing factor U2AF 26 kDa subunit (U2AF1L4) 2.8
 LDTP04966  Small ribosomal subunit protein uS9 (RPS16) 2.6
 LDTP05023  Large ribosomal subunit protein eL31 (RPL31) 2.5
 LDTP12388  Putative RNA-binding protein Luc7-like 1 (LUC7L) 1.9
 LDTP04106  Large ribosomal subunit protein uL18 (RPL5) 1.9
 LDTP03367  Elongation factor 1-gamma (EEF1G) 1.9
 LDTP19229  Cilia- and flagella- associated protein 210 (CFAP210) 1.9
 LDTP06128  RNA-binding protein 39 (RBM39) 1.8
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) 1.7
 LDTP02205  Tubulin beta chain (TUBB) 1.6
 LDTP03999  Large ribosomal subunit protein uL29 (RPL35) 1.5
 LDTP02164  Nucleophosmin (NPM1) 1.5

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.