Details of the Target

General Information of Target

Target ID LDTP04886
Target Name Cell division control protein 42 homolog (CDC42)
Gene Name CDC42
Gene ID 998
Synonyms
Cell division control protein 42 homolog; EC 3.6.5.2; G25K GTP-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG
QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR
DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPP
EPKKSRRCVLL
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rho family, CDC42 subfamily
Subcellular location
Cell membrane
Function
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. In podocytes, facilitates filopodia and podosomes formation upon DOCK11-activation. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups.
Uniprot ID
P60953
Ensemble ID
ENST00000315554.15
HGNC ID
HGNC:1736
ChEMBL ID
CHEMBL6088

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 44 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.18  LDD0402  [1]
P1
 Probe Info  		10.00  LDD0452  [2]
P2
 Probe Info  		10.00  LDD0453  [2]
P3
 Probe Info  		10.00  LDD0454  [2]
P8
 Probe Info  		10.00  LDD0455  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
TH211
 Probe Info  		Y72(20.00); Y154(11.99)  LDD0260  [4]
C-Sul
 Probe Info  		2.55  LDD0066  [5]
STPyne
 Probe Info  		K133(6.80); K135(4.25); K144(8.85); K163(5.56)  LDD0277  [6]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [7]
THZ1-DTB
 Probe Info  		C157(1.06); C105(1.00)  LDD0460  [7]
BTD
 Probe Info  		C157(1.73)  LDD1700  [8]
AHL-Pu-1
 Probe Info  		C157(2.32)  LDD0169  [9]
DBIA
 Probe Info  		C157(2.05); C18(1.09)  LDD0080  [10]
5E-2FA
 Probe Info  		N.A.  LDD2235  [11]
ATP probe
 Probe Info  		K163(0.00); K166(0.00); K153(0.00); K133(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C81(0.00); C18(0.00); C105(0.00); C157(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C157(0.00); C6(0.00)  LDD0032  [14]
IPIAA_H
 Probe Info  		C157(0.00); C81(0.00); C6(0.00)  LDD0030  [15]
IPIAA_L
 Probe Info  		C157(0.00); C81(0.00); C6(0.00)  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C105(0.00); C81(0.00); C18(0.00); C157(0.00)  LDD0037  [13]
ATP probe
 Probe Info  		K133(0.00); K153(0.00)  LDD0035  [16]
IPM
 Probe Info  		C157(0.00); C105(0.00)  LDD0025  [17]
JW-RF-010
 Probe Info  		C157(0.00); C6(0.00)  LDD0026  [17]
TFBX
 Probe Info  		C157(0.00); C6(0.00)  LDD0027  [17]
WYneN
 Probe Info  		C105(0.00); C157(0.00); C6(0.00)  LDD0021  [18]
WYneO
 Probe Info  		N.A.  LDD0022  [18]
ENE
 Probe Info  		C6(0.00); C157(0.00)  LDD0006  [18]
NHS
 Probe Info  		K133(0.00); K135(0.00)  LDD0010  [18]
PF-06672131
 Probe Info  		N.A.  LDD0152  [19]
PPMS
 Probe Info  		N.A.  LDD0008  [18]
VSF
 Probe Info  		N.A.  LDD0007  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [20]
1c-yne
 Probe Info  		N.A.  LDD0228  [21]
Acrolein
 Probe Info  		C105(0.00); C157(0.00); H104(0.00)  LDD0217  [22]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [22]
Crotonaldehyde
 Probe Info  		C157(0.00); H104(0.00)  LDD0219  [22]
Methacrolein
 Probe Info  		C105(0.00); C157(0.00)  LDD0218  [22]
W1
 Probe Info  		N.A.  LDD0236  [23]
AOyne
 Probe Info  		6.50  LDD0443  [24]
MPP-AC
 Probe Info  		N.A.  LDD0428  [25]
NAIA_5
 Probe Info  		C157(0.00); C105(0.00); C81(0.00)  LDD2223  [26]
TER-AC
 Probe Info  		N.A.  LDD0426  [25]
TPP-AC
 Probe Info  		N.A.  LDD0427  [25]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe14
 Probe Info  		20.00  LDD0477  [27]
FFF probe3
 Probe Info  		12.31  LDD0464  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C157(0.62)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C157(0.80)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C157(0.96); C105(1.27)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C105(0.95)  LDD2152  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C157(0.99)  LDD2103  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C157(0.47); C105(0.49)  LDD2132  [8]
 LDCM0025  4SU-RNA HEK-293T C157(2.11)  LDD0172  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C157(2.32)  LDD0169  [9]
 LDCM0214  AC1 HCT 116 C105(1.23); C157(1.17)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C105(0.93); C157(1.13); C18(0.90)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C105(0.80); C18(0.96)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C105(0.84); C18(1.05)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C105(0.91); C18(0.97)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C105(0.86); C18(1.02)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C105(0.89); C18(1.00)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C105(0.80); C18(1.02)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C105(0.76); C18(1.02)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C105(0.88); C18(1.03)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C105(0.76); C18(0.80)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C105(0.91); C18(0.86)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C105(0.98); C157(0.78); C18(1.12)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C105(0.76); C18(0.99)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C105(0.71); C18(0.91)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C105(0.76); C18(0.98)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C105(1.10); C157(1.49); C18(1.04)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C105(1.11); C157(1.50); C18(1.04)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C105(0.98); C157(1.21); C18(1.04)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C105(1.08); C157(1.48); C18(1.23)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C105(1.09); C157(1.29); C18(1.05)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C105(1.11); C157(1.57); C18(1.03)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C105(1.12); C157(1.54); C18(1.00)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C105(1.07); C157(1.23); C18(1.05)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C105(1.16); C157(1.78); C18(0.99)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C105(1.07); C157(1.39); C18(0.95)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C105(1.04); C157(1.44); C18(0.96)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C105(1.05); C157(1.38); C18(0.86)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C105(1.06); C157(1.54); C18(0.99)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C105(1.06); C157(1.59); C18(1.10)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C105(1.01); C157(1.54); C18(1.07)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C105(1.07); C157(1.59); C18(0.94)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C105(1.27)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C105(1.21)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C105(1.18)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C105(1.14)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C105(0.95)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C105(1.21)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C105(0.91)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C105(0.96)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C105(1.02)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C105(0.79)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C105(0.64)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C105(0.83)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C105(1.12); C157(1.33); C18(1.25)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C105(0.57)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C105(0.60)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C105(0.91)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C105(1.08); C157(0.93); C18(1.22)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C157(0.75); C18(0.96); C105(1.12)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C157(0.92); C18(0.98); C105(1.13)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C157(0.82); C105(0.97); C18(1.23)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C157(0.67); C18(0.92); C105(0.97)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C157(0.25); C105(0.46); C18(1.35)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C157(0.76); C105(0.86); C18(1.40)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C105(1.05); C157(1.22); C18(1.30)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C157(0.92); C18(1.08); C105(1.26)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C157(0.94); C18(0.99); C105(1.07)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C157(0.59); C105(0.97); C18(1.03)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C157(0.17); C105(0.30); C18(1.19)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C105(0.98); C157(0.80); C18(1.02)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C105(1.11); C157(1.09); C18(1.08)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C105(1.06); C157(1.04); C18(1.00)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C105(1.10); C157(1.07); C18(0.94)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C157(0.92); C105(1.04); C18(1.19)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C157(0.76); C105(0.94); C18(1.28)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C157(0.82); C105(1.04); C18(1.21)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C105(0.97); C157(1.21)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C157(0.59); C105(0.96); C18(1.04)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C157(0.60); C105(0.93); C18(0.99)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C157(0.83); C18(0.99); C105(1.03)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C157(0.78); C105(0.93); C18(0.95)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C157(0.97); C18(1.04); C105(1.10)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C105(0.79); C18(0.98)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C105(0.63); C18(0.96)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C105(0.66); C18(1.12)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C105(0.60); C18(1.04)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C105(0.59); C18(1.07)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C105(1.05); C157(1.35)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C105(0.51); C18(1.07)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C105(0.66); C18(1.19)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C105(0.53); C18(1.06)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C105(0.81); C18(1.12)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C105(0.79); C18(1.03)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C18(0.88); C105(0.94)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C105(0.82); C18(0.93)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C105(0.91); C18(1.17)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C105(0.95); C18(1.08)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C18(0.91); C105(0.97)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C105(1.30); C157(1.32)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C105(0.80); C18(0.83)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C105(0.85); C18(0.97)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C105(0.87); C18(1.10)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C105(0.83); C18(1.08)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C18(0.81); C105(0.84)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C18(0.77); C105(0.82)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C105(0.95); C18(1.01); C157(1.02)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C157(0.63); C105(0.90); C18(0.98)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C157(0.54); C105(0.95); C18(0.97)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C157(0.29); C105(0.67); C18(1.14)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C105(1.13); C157(1.49)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C157(0.35); C105(0.70); C18(1.12)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C157(0.94); C105(1.06); C18(1.12)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C157(0.85); C105(0.98); C18(1.03)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C157(0.58); C105(0.84); C18(1.00)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C157(0.47); C105(0.82); C18(1.05)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C157(0.26); C105(0.66); C18(0.98)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C157(0.09); C105(0.54); C18(0.97)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C105(1.03); C157(1.08); C18(1.26)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C105(0.99); C157(1.05); C18(1.22)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C157(0.81); C18(1.08); C105(1.09)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C157(0.81); C105(0.89); C18(1.03)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C157(0.91); C105(0.95); C18(1.17)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C157(0.97); C105(1.03); C18(1.14)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C157(0.73); C105(1.04); C18(1.12)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C157(0.93); C105(0.99); C18(1.34)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C157(0.72); C105(1.02); C18(1.13)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C105(0.92); C157(0.99); C18(1.64)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C105(0.96); C157(1.15); C18(1.66)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C157(0.57); C18(0.81); C105(0.96)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C105(0.91); C18(1.02); C157(1.18)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C105(0.85); C18(1.01); C157(1.23)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C157(0.99); C105(1.01); C18(1.07)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C18(0.82); C105(0.82); C157(1.39)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C18(0.88); C105(1.04); C157(1.28)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C105(0.79); C18(0.98); C157(1.22)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C18(0.65); C105(0.80); C157(1.04)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C18(0.64); C157(1.15); C105(1.19)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C18(0.67); C105(0.72); C157(1.19)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C18(0.94); C105(0.96); C157(1.17)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C105(0.82); C157(0.96); C18(1.07)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C105(0.89); C18(0.99); C157(1.24)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C105(0.75); C18(1.07); C157(1.14)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C105(1.02); C18(1.07); C157(1.11)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C105(0.91); C18(0.94); C157(1.33)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C105(0.81); C18(0.84); C157(1.09)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C18(0.60); C105(1.12); C157(1.28)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C105(0.91); C157(1.01); C18(1.04)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C105(0.87); C18(0.97); C157(1.10)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C157(0.80); C105(0.85); C18(1.11)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C105(0.82); C157(1.08); C18(1.22)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C105(0.85); C18(1.07); C157(1.44)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C105(0.83); C18(1.05); C157(1.19)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C105(0.87); C157(1.02); C18(1.22)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C105(0.81); C18(1.00); C157(1.04)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C105(0.86); C157(1.01); C18(1.07)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C157(0.67); C105(0.81); C18(1.03)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C105(0.82); C157(0.83); C18(1.16)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C105(0.86); C157(1.04); C18(1.25)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C105(0.79); C18(1.16); C157(1.33)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C105(0.94); C157(1.01); C18(1.11)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C105(0.77); C157(1.09); C18(1.13)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C18(0.52); C105(0.80)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C105(0.83); C18(0.86)  LDD0683  [10]
 LDCM0545  Acetamide MDA-MB-231 C157(0.81); C105(0.60)  LDD2138  [8]
 LDCM0248  AKOS034007472 HCT 116 C105(0.98); C157(0.97); C18(1.10)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C157(0.86); C105(0.97); C18(1.02)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C105(0.95); C157(1.19); C18(1.20)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 12.15  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C157(1.04); C105(0.93)  LDD2171  [10]
 LDCM0498  BS-3668 MDA-MB-231 C105(0.78)  LDD2091  [8]
 LDCM0108  Chloroacetamide HeLa C105(0.00); C157(0.00); C6(0.00); H104(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C105(1.39); C157(0.75)  LDD2227  [26]
 LDCM0367  CL1 HCT 116 C18(0.71); C105(0.85); C157(0.92)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C105(0.79); C157(0.88); C18(0.99)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C157(0.95); C105(1.15)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C105(0.90); C157(1.03); C18(1.31)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C105(0.86); C157(1.07); C18(1.34)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C105(1.14); C18(1.25); C157(1.39)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C105(1.07); C157(1.29); C18(1.32)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C157(0.68); C105(0.94); C18(1.01)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C157(0.57); C105(0.89); C18(0.90)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C157(0.76); C105(0.99); C18(1.00)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C157(0.83); C105(0.86); C18(1.02)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C157(0.77); C105(0.87); C18(1.12)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C105(0.70); C157(0.81); C18(0.88)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C157(0.66); C105(0.81); C18(0.99)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C157(0.65); C105(0.84); C18(1.05)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C105(0.60); C18(0.98)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C105(0.52); C18(1.09)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C105(0.55); C18(0.93)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C105(0.67); C18(0.98)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C105(0.74); C18(0.97)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C105(0.62); C18(0.75)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C105(0.88); C18(0.97)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C105(0.86); C18(1.02)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C157(0.60); C105(0.66); C18(0.77)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C105(0.86); C18(1.01)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C157(0.73); C105(0.78); C18(0.92)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C157(0.55); C105(0.87); C18(0.98)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C157(0.53); C105(0.76); C18(0.99)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C157(0.36); C105(0.67); C18(0.88)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C105(0.99); C157(1.00); C18(1.20)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C105(0.92); C157(1.00); C18(1.08)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C157(1.00); C105(1.02); C18(1.20)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C105(0.94); C157(0.98); C18(1.20)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C105(0.84); C18(0.95); C157(1.10)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C105(0.94); C18(1.00); C157(1.05)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C105(0.66); C18(0.76); C157(0.78)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C157(0.75); C105(0.94); C18(1.62)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C157(0.74); C105(0.90); C18(1.21)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C157(0.85); C105(1.01); C18(1.06)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C157(0.78); C105(0.94); C18(1.14)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C105(0.91); C18(1.01); C157(1.08)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C157(0.68); C105(0.90); C18(1.35)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C157(0.55); C105(0.69); C18(1.11)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C157(0.43); C105(0.62); C18(0.76)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C157(0.76); C105(0.97); C18(1.61)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C157(0.63); C105(0.77); C18(1.31)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C105(0.83); C157(0.57); C18(1.78)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C105(0.90); C157(0.72); C18(1.24)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C105(0.99); C157(0.85); C18(1.09)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C105(0.85); C157(0.63); C18(1.32)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C105(0.93); C157(0.69); C18(1.40)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C105(0.98); C157(1.12); C18(1.01)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C105(1.02); C157(1.04); C18(1.77)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C105(0.87); C157(0.87); C18(0.95)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C105(0.88); C157(0.77); C18(0.94)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C105(0.77); C157(0.80); C18(0.93)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C105(0.63); C157(0.34); C18(1.09)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C105(0.69); C157(0.45); C18(1.06)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C105(0.75); C157(0.46); C18(1.18)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C105(0.65); C157(0.36); C18(0.88)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C105(0.69); C157(0.46); C18(0.83)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C105(0.90); C157(1.03); C18(0.98)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C105(0.69); C157(0.54); C18(0.83)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C105(0.80); C157(0.69); C18(1.22)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C105(0.53); C157(0.11); C18(0.97)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C105(0.58); C157(0.30); C18(1.27)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C105(0.77); C157(0.47); C18(1.00)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C105(0.66); C157(0.33); C18(1.13)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C105(0.88); C18(1.08)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C105(0.87); C18(1.10)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C105(1.04); C18(1.15)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C105(0.89); C18(1.32)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C105(0.99); C157(1.14); C18(1.13)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C105(1.08); C18(1.08)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C105(0.89); C18(1.17)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C105(0.94); C18(1.24)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C105(1.03); C18(1.02)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C105(0.91); C18(1.04)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C105(0.94); C18(1.07)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C105(1.10); C18(1.20)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C105(1.00); C18(1.23)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C105(1.10); C18(1.35)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C105(1.11); C18(1.25)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C105(0.88); C157(0.99); C18(1.14)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C105(1.19); C18(1.13)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C105(1.06); C18(1.35)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C105(1.07); C18(1.01)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C105(0.96); C18(1.14)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C105(1.07); C18(1.10)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C105(1.06); C18(1.25)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C105(0.99); C18(0.99)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C105(1.10); C18(1.23)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C105(0.97); C18(1.02)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C105(0.97); C18(1.27)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C105(0.83); C157(1.08); C18(0.95)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C105(1.01); C18(1.10)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C105(0.93); C18(1.45)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C105(1.01); C18(1.23)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C105(1.02); C18(1.19)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C105(1.01); C18(1.15)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C105(0.99); C157(0.83); C18(0.98)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C105(0.79); C157(0.74); C18(0.66)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C105(0.84); C157(0.97); C18(0.90)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C105(1.04); C157(0.69); C18(1.01)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C105(0.57); C157(0.49); C18(0.78)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C105(1.05); C157(0.87); C18(0.96)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C105(1.00); C157(0.83); C18(1.01)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C105(0.99); C157(0.40); C18(0.84)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C105(0.87); C157(0.53); C18(0.68)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C105(0.97); C157(0.21); C18(0.66)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C105(0.97); C157(1.02); C18(0.87)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C105(0.98); C157(1.14); C18(0.81)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C105(0.95); C157(0.94); C18(0.79)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C105(1.03); C157(0.55); C18(0.82)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C105(1.03); C157(0.13); C18(0.80)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C105(0.92); C157(1.03); C18(0.89)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C105(0.92); C157(0.95); C18(1.16)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C105(0.76); C157(1.12)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C105(0.94); C157(1.16)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C105(1.02); C157(1.21)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C105(1.04); C157(1.14)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C105(0.90); C157(1.31)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C105(0.87); C157(1.22)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C105(0.91); C157(1.17)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C105(1.03); C157(0.92)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C105(1.22); C157(1.07)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C105(0.98); C157(0.99); C18(1.01); C81(0.97)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C105(2.40); C157(2.01)  LDD1702  [8]
 LDCM0625  F8 Ramos C157(0.62); C105(0.48)  LDD2187  [29]
 LDCM0572  Fragment10 Ramos C157(0.75); C105(0.48)  LDD2189  [29]
 LDCM0573  Fragment11 Ramos C157(0.01); C105(0.04)  LDD2190  [29]
 LDCM0574  Fragment12 Ramos C157(0.72); C105(0.58)  LDD2191  [29]
 LDCM0575  Fragment13 Ramos C157(1.03); C105(1.44)  LDD2192  [29]
 LDCM0576  Fragment14 Ramos C157(0.79); C105(0.34)  LDD2193  [29]
 LDCM0579  Fragment20 Ramos C157(0.61); C105(0.41)  LDD2194  [29]
 LDCM0580  Fragment21 Ramos C157(1.01); C105(0.44)  LDD2195  [29]
 LDCM0582  Fragment23 Ramos C157(0.50); C105(0.42)  LDD2196  [29]
 LDCM0578  Fragment27 Ramos C157(1.10); C105(1.23)  LDD2197  [29]
 LDCM0586  Fragment28 Ramos C157(0.79); C105(0.58)  LDD2198  [29]
 LDCM0588  Fragment30 Ramos C157(1.42); C105(0.70)  LDD2199  [29]
 LDCM0589  Fragment31 Ramos C157(1.22); C105(0.62)  LDD2200  [29]
 LDCM0590  Fragment32 Ramos C157(0.59); C105(0.37)  LDD2201  [29]
 LDCM0468  Fragment33 HCT 116 C105(0.97); C18(1.05)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C157(1.06); C105(2.59)  LDD2203  [29]
 LDCM0566  Fragment4 Ramos C157(0.61); C105(0.52)  LDD2184  [29]
 LDCM0427  Fragment51 HCT 116 C105(0.45); C157(0.19); C18(0.88)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C157(1.44); C105(1.60)  LDD2204  [29]
 LDCM0614  Fragment56 Ramos C157(1.64); C105(0.49)  LDD2205  [29]
 LDCM0569  Fragment7 Ramos C157(0.61); C105(0.39)  LDD2186  [29]
 LDCM0571  Fragment9 Ramos C157(0.66); C105(0.29)  LDD2188  [29]
 LDCM0107  IAA HeLa H104(0.00); C105(0.00); C6(0.00)  LDD0221  [22]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [7]
 LDCM0022  KB02 HCT 116 C157(2.05); C18(1.09)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C157(2.40); C18(1.22)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C157(2.16); C18(1.41)  LDD0082  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C157(1.01)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C157(0.69)  LDD2121  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C157(0.67); C105(0.92)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C157(1.22)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C157(0.97); C105(0.90)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C157(1.00); C105(1.66)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C157(1.43); C105(1.12)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C157(0.33)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C157(0.79)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C157(0.91)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C157(1.01); C105(2.01)  LDD2099  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C157(0.50)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C157(1.31); C105(1.14)  LDD2105  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C157(0.83); C105(1.24)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C157(0.72); C105(1.29)  LDD2109  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C157(0.73)  LDD2110  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C157(1.03)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C157(0.48); C105(0.77)  LDD2114  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C157(0.41)  LDD2116  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C157(1.14); C105(2.60)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C157(0.80)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C157(0.46)  LDD2122  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C157(0.86)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C157(0.37)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C157(0.86); C105(1.39)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C157(0.39)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C157(0.92); C105(1.39)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C157(0.98)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C105(1.38)  LDD2129  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C157(0.47); C105(0.57)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C157(1.26); C105(1.36)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C157(1.15)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C157(0.87); C105(1.35)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C157(1.73)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C157(0.78); C105(1.27)  LDD2140  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C157(0.99)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C157(1.27); C105(2.43)  LDD2144  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C157(0.85); C105(1.08)  LDD2146  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C157(0.48)  LDD2148  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C157(0.48)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C105(0.78)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C157(0.42)  LDD2151  [8]
 LDCM0021  THZ1 HeLa S3 C157(1.06); C105(1.00)  LDD0460  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phospholipid-transporting ATPase ABCA1 (ABCA1) ABCA family O95477
Serine/threonine-protein kinase MRCK alpha (CDC42BPA) AGC Ser/Thr protein kinase family Q5VT25
Protein kinase C iota type (PRKCI) AGC Ser/Thr protein kinase family P41743
MAP/microtubule affinity-regulating kinase 4 (MARK4) CAMK Ser/Thr protein kinase family Q96L34
Mitogen-activated protein kinase kinase kinase 11 (MAP3K11) STE Ser/Thr protein kinase family Q16584
Serine/threonine-protein kinase PAK 1 (PAK1) STE Ser/Thr protein kinase family Q13153
Serine/threonine-protein kinase PAK 2 (PAK2) STE Ser/Thr protein kinase family Q13177
Serine/threonine-protein kinase PAK 3 (PAK3) STE Ser/Thr protein kinase family O75914
Serine/threonine-protein kinase PAK 4 (PAK4) STE Ser/Thr protein kinase family O96013
Serine/threonine-protein kinase PAK 5 (PAK5) STE Ser/Thr protein kinase family Q9P286
Serine/threonine-protein kinase PAK 6 (PAK6) STE Ser/Thr protein kinase family Q9NQU5
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Activated CDC42 kinase 1 (TNK2) Tyr protein kinase family Q07912
GTP-binding protein Rit1 (RIT1) Ras family Q92963
Cell division control protein 42 homolog (CDC42) Rho family P60953
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenomatous polyposis coli protein (APC) Adenomatous polyposis coli (APC) family P25054
Cdc42 effector protein 1 (CDC42EP1) BORG/CEP family Q00587
Cdc42 effector protein 2 (CDC42EP2) BORG/CEP family O14613
Partitioning defective 6 homolog alpha (PARD6A) PAR6 family Q9NPB6
Partitioning defective 6 homolog beta (PARD6B) PAR6 family Q9BYG5
Partitioning defective 6 homolog gamma (PARD6G) PAR6 family Q9BYG4
Rho GDP-dissociation inhibitor 1 (ARHGDIA) Rho GDI family P52565
Actin nucleation-promoting factor WAS (WAS) . P42768
Actin nucleation-promoting factor WASL (WASL) . O00401
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) . Q9UQB8
Intersectin-1 (ITSN1) . Q15811
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1) . Q8TCU6
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) . P46940
Rho GTPase-activating protein 1 (ARHGAP1) . Q07960
Rho guanine nucleotide exchange factor 7 (ARHGEF7) . Q14155

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanosine-5'-diphosphate Small molecular drug DB04315
Aminophosphonic Acid-guanylate Ester . DB02623

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
24 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
25 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
26 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578