Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name P2  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
LFQ
In Vivo Experiment Model Model Type Living cell
Derived Tissue Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cells (HeLa)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 16 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04876  Actin, cytoplasmic 1 (ACTB) 10.0
 LDTP04886  Cell division control protein 42 homolog (CDC42) 10.0
 LDTP02333  Glutathione S-transferase P (GSTP1) 10.0
 LDTP03764  Myosin-9 (MYH9) 10.0
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) 6.0
 LDTP08190  E3 ubiquitin-protein ligase RNF180 (RNF180) 4.8
 LDTP02008  Fructose-bisphosphate aldolase A (ALDOA) 2.6
 LDTP06192  Neutral alpha-glucosidase AB (GANAB) 2.4
 LDTP02733  Pyruvate kinase PKM (PKM) 2.2
 LDTP02502  Thioredoxin (TXN) 2.0
 LDTP03242  Adenosylhomocysteinase (AHCY) 2.0
 LDTP01766  L-lactate dehydrogenase A chain (LDHA) 1.8
 LDTP04878  Eukaryotic initiation factor 4A-I (EIF4A1) 1.7
 LDTP04851  Triosephosphate isomerase (TPI1) 1.6
 LDTP03166  Ubiquitin-like modifier-activating enzyme 1 (UBA1) 1.6
 LDTP03976  Aldo-keto reductase family 1 member C3 (AKR1C3) 1.5
Transporter and channel
Click to Show/Hide to Show 9 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00362  Astrotactin-1 (ASTN1) 10.0
 LDTP02815  Desmoplakin (DSP) 10.0
 LDTP03107  Filamin-A (FLNA) 10.0
 LDTP06242  Importin subunit beta-1 (KPNB1) 10.0
 LDTP05832  Urea transporter 1 (SLC14A1) 10.0
 LDTP05292  Fatty acid-binding protein 5 (FABP5) 8.7
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 2.2
 LDTP02307  Annexin A5 (ANXA5) 1.7
 LDTP02256  Amino acid transporter heavy chain SLC3A2 (SLC3A2) 1.6
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP17677  Olfactory receptor 8H2 (OR8H2) 2.0
Other
Click to Show/Hide to Show 35 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03283  Elongation factor 1-beta (EEF1B2) 10.0
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) 10.0
 LDTP03658  Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) 10.0
 LDTP03346  Moesin (MSN) 10.0
 LDTP17266  Pre-mRNA-splicing factor 38B (PRPF38B) 10.0
 LDTP01932  Prelamin-A/C (LMNA) 10.0
 LDTP04355  Rab GDP dissociation inhibitor beta (GDI2) 10.0
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 10.0
 LDTP20164  Uncharacterized protein C11orf98 (C11orf98) 10.0
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) 9.6
 LDTP06598  Fascin (FSCN1) 5.0
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) 4.4
 LDTP05023  Large ribosomal subunit protein eL31 (RPL31) 4.3
 LDTP19229  Cilia- and flagella- associated protein 210 (CFAP210) 4.1
 LDTP12388  Putative RNA-binding protein Luc7-like 1 (LUC7L) 3.1
 LDTP02297  Vimentin (VIM) 3.0
 LDTP17734  Testis-expressed protein 9 (TEX9) 2.9
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) 2.9
 LDTP05014  Small ribosomal subunit protein eS26 (RPS26) 2.3
 LDTP14045  Disheveled-associated activator of morphogenesis 1 (DAAM1) 2.3
 LDTP02674  Keratin, type I cytoskeletal 10 (KRT10) 2.2
 LDTP06381  Ryanodine receptor 3 (RYR3) 1.9
 LDTP02031  Keratin, type II cytoskeletal 1 (KRT1) 1.9
 LDTP01931  Keratin, type II cytoskeletal 6A (KRT6A) 1.9
 LDTP02341  Galectin-1 (LGALS1) 1.9
 LDTP03792  Keratin, type II cytoskeletal 2 epidermal (KRT2) 1.9
 LDTP02676  Keratin, type II cytoskeletal 5 (KRT5) 1.8
 LDTP04106  Large ribosomal subunit protein uL18 (RPL5) 1.8
 LDTP03575  Protein S100-A7 (S100A7) 1.8
 LDTP01930  Keratin, type I cytoskeletal 14 (KRT14) 1.7
 LDTP05609  Ras-GEF domain-containing family member 1B (RASGEF1B) 1.6
 LDTP02308  Keratin, type I cytoskeletal 16 (KRT16) 1.6
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) 1.6
 LDTP03999  Large ribosomal subunit protein uL29 (RPL35) 1.5
 LDTP00843  Alpha-actinin-4 (ACTN4) 1.5

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.