Details of the Target

General Information of Target

Target ID LDTP03999
Target Name Large ribosomal subunit protein uL29 (RPL35)
Gene Name RPL35
Gene ID 11224
Synonyms
Large ribosomal subunit protein uL29; 60S ribosomal protein L35
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAKIKARDLRGKKKEELLKQLDDLKVELSQLRVAKVTGGAASKLSKIRVVRKSIARVLTV
INQTQKENLRKFYKGKKYKPLDLRPKKTRAMRRRLNKHEENLKTKKQQRKERLYPLRKYA
VKA
Target Bioclass
Other
Family
Universal ribosomal protein uL29 family
Subcellular location
Cytoplasm
Function Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Uniprot ID
P42766
Ensemble ID
ENST00000348462.6
HGNC ID
HGNC:10344

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		1.54  LDD0452  [1]
P2
 Probe Info  		1.51  LDD0453  [1]
A-EBA
 Probe Info  		5.73  LDD0215  [2]
C-Sul
 Probe Info  		4.59  LDD0066  [3]
TH211
 Probe Info  		Y78(19.73)  LDD0257  [4]
TH214
 Probe Info  		Y78(11.08)  LDD0258  [4]
TH216
 Probe Info  		Y78(20.00)  LDD0259  [4]
ONAyne
 Probe Info  		K35(0.00); K66(0.00); K97(0.00); K25(0.00)  LDD0273  [5]
Probe 1
 Probe Info  		Y78(33.86)  LDD3495  [6]
HHS-482
 Probe Info  		Y78(0.91)  LDD0285  [7]
AMP probe
 Probe Info  		K66(0.00); K43(0.00)  LDD0200  [8]
ATP probe
 Probe Info  		K66(0.00); K43(0.00); K97(0.00); K35(0.00)  LDD0199  [8]
1d-yne
 Probe Info  		K66(0.00); K13(0.00); K14(0.00)  LDD0356  [9]
NHS
 Probe Info  		N.A.  LDD0010  [10]
SF
 Probe Info  		K66(0.00); Y78(0.00); K79(0.00); K43(0.00)  LDD0028  [11]
STPyne
 Probe Info  		K66(0.00); K25(0.00)  LDD0009  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
HHS-475
 Probe Info  		Y78(1.16)  LDD2238  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0123  JWB131 DM93 Y78(0.91)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y78(0.62)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y78(1.72)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y78(3.89)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y78(1.97)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y78(0.82)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y78(0.28)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y78(0.82)  LDD0292  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.