Details of the Target

General Information of Target

Target ID LDTP05023
Target Name Large ribosomal subunit protein eL31 (RPL31)
Gene Name RPL31
Gene ID 6160
Synonyms
Large ribosomal subunit protein eL31; 60S ribosomal protein L31
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPAKKGGEKKKGRSAINEVVTREYTINIHKRIHGVGFKKRAPRALKEIRKFAMKEMGTP
DVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTYVPVTTFKNLQTV
NVDEN
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eL31 family
Subcellular location
Cytoplasm
Function Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Uniprot ID
P62899
Ensemble ID
ENST00000264258.8
HGNC ID
HGNC:10334

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		2.48  LDD0452  [1]
P2
 Probe Info  		4.28  LDD0453  [1]
P3
 Probe Info  		1.79  LDD0454  [1]
A-EBA
 Probe Info  		3.69  LDD0215  [2]
C-Sul
 Probe Info  		7.12  LDD0066  [3]
TH211
 Probe Info  		Y25(20.00)  LDD0257  [4]
TH214
 Probe Info  		Y25(20.00)  LDD0258  [4]
TH216
 Probe Info  		Y103(20.00); Y108(20.00); Y25(6.36)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
ONAyne
 Probe Info  		K31(10.00); K70(5.00); K75(0.72)  LDD0274  [6]
STPyne
 Probe Info  		K101(0.84); K31(6.67); K39(10.00); K70(10.00)  LDD0277  [6]
AZ-9
 Probe Info  		E19(0.95)  LDD2208  [7]
OPA-S-S-alkyne
 Probe Info  		K31(1.97); K75(2.92); K70(12.86)  LDD3494  [8]
HHS-482
 Probe Info  		Y103(1.79); Y108(0.81)  LDD0285  [9]
HHS-475
 Probe Info  		Y103(0.62)  LDD0264  [10]
HHS-465
 Probe Info  		Y108(5.15)  LDD2237  [11]
ATP probe
 Probe Info  		K75(0.00); K31(0.00); K55(0.00); K70(0.00)  LDD0199  [12]
ATP probe
 Probe Info  		K75(0.00); K31(0.00)  LDD0035  [13]
1d-yne
 Probe Info  		K115(0.00); K101(0.00)  LDD0356  [14]
SF
 Probe Info  		Y25(0.00); K91(0.00); Y108(0.00)  LDD0028  [15]
Ox-W18
 Probe Info  		N.A.  LDD2175  [16]
1c-yne
 Probe Info  		K55(0.00); K101(0.00); K115(0.00)  LDD0228  [14]
Acrolein
 Probe Info  		H34(0.00); H30(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
Methacrolein
 Probe Info  		N.A.  LDD0218  [17]
W1
 Probe Info  		N.A.  LDD0236  [18]
MPP-AC
 Probe Info  		N.A.  LDD0428  [19]
TPP-AC
 Probe Info  		N.A.  LDD0427  [19]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H30(0.00); H34(0.00)  LDD0222  [17]
 LDCM0116  HHS-0101 DM93 Y103(0.62)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y103(0.80)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y103(0.82)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y103(0.71)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y103(0.56)  LDD0268  [10]
 LDCM0107  IAA HeLa H30(0.00); H34(0.00)  LDD0221  [17]
 LDCM0123  JWB131 DM93 Y103(1.79); Y108(0.81)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y103(1.45)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y103(1.86)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y103(6.13)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y103(5.25); Y108(2.78)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y103(2.50)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y103(1.63)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y103(2.19)  LDD0292  [9]
 LDCM0109  NEM HeLa H30(0.00); H34(0.00)  LDD0223  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gelsolin (GSN) Villin/gelsolin family P06396
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
20 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.