Details of the Target

General Information of Target

Target ID LDTP06192
Target Name Neutral alpha-glucosidase AB (GANAB)
Gene Name GANAB
Gene ID 23193
Synonyms
G2AN; KIAA0088; Neutral alpha-glucosidase AB; EC 3.2.1.207; Alpha-glucosidase 2; Glucosidase II subunit alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVAAVAARRRRSWASLVLAFLGVCLGITLAVDRSNFKTCEESSFCKRQRSIRPGLSPY
RALLDSLQLGPDSLTVHLIHEVTKVLLVLELQGLQKNMTRFRIDELEPRRPRYRVPDVLV
ADPPIARLSVSGRDENSVELTMAEGPYKIILTARPFRLDLLEDRSLLLSVNARGLLEFEH
QRAPRVSQGSKDPAEGDGAQPEETPRDGDKPEETQGKAEKDEPGAWEETFKTHSDSKPYG
PMSVGLDFSLPGMEHVYGIPEHADNLRLKVTEGGEPYRLYNLDVFQYELYNPMALYGSVP
VLLAHNPHRDLGIFWLNAAETWVDISSNTAGKTLFGKMMDYLQGSGETPQTDVRWMSETG
IIDVFLLLGPSISDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHN
LPCDVIWLDIEHADGKRYFTWDPSRFPQPRTMLERLASKRRKLVAIVDPHIKVDSGYRVH
EELRNLGLYVKTRDGSDYEGWCWPGSAGYPDFTNPTMRAWWANMFSYDNYEGSAPNLFVW
NDMNEPSVFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLRQRSGGMERPFVL
ARAFFAGSQRFGAVWTGDNTAEWDHLKISIPMCLSLGLVGLSFCGADVGGFFKNPEPELL
VRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQHNDIIRDALGQRYSLLPFWYTLLYQAHR
EGIPVMRPLWVQYPQDVTTFNIDDQYLLGDALLVHPVSDSGAHGVQVYLPGQGEVWYDIQ
SYQKHHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSECMKDDPITLFVALSPQGTA
QGELFLDDGHTFNYQTRQEFLLRRFSFSGNTLVSSSADPEGHFETPIWIERVVIIGAGKP
AAVVLQTKGSPESRLSFQHDPETSVLVLRKPGINVASDWSIHLR
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 31 family
Subcellular location
Endoplasmic reticulum
Function
Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia.
Uniprot ID
Q14697
Ensemble ID
ENST00000346178.8
HGNC ID
HGNC:4138
ChEMBL ID
CHEMBL2519

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.I29T DBIA    Probe Info 
FTC133 SNV: p.R173Ter DBIA    Probe Info 
GB1 SNV: p.I894R .
HCT15 SNV: p.G764C .
HEC1 SNV: p.V832A DBIA    Probe Info 
HEC1B SNV: p.Y379H; p.V832A IA-alkyne    Probe Info 
HEPG2 Insertion: p.P251CfsTer17 .
HT1197 SNV: p.S533L .
JURKAT SNV: p.G592R .
K562 SNV: p.D494G FFF probe13    Probe Info 
MCC26 SNV: p.V614L .
MFE319 Deletion: p.L23Ter DBIA    Probe Info 
MOLT4 SNV: p.M543I IA-alkyne    Probe Info 
NCIH1155 SNV: p.A646V DBIA    Probe Info 
NCIH2286 SNV: p.G312V .
OVK18 Deletion: p.L23Ter DBIA    Probe Info 
SAOS2 SNV: p.D192V .
SNU1 SNV: p.D197E .
SUPT1 SNV: p.A668V DBIA    Probe Info 
SW1271 Deletion: p.K332RfsTer7 .
UMUC3 SNV: p.R450S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 51 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		3.06  LDD0452  [1]
P2
 Probe Info  		2.42  LDD0453  [1]
P3
 Probe Info  		2.04  LDD0450  [1]
P8
 Probe Info  		10.00  LDD0455  [1]
CHEMBL5175495
 Probe Info  		6.73  LDD0196  [2]
W1
 Probe Info  		10.25  LDD0235  [3]
C-Sul
 Probe Info  		4.51  LDD0066  [4]
TH211
 Probe Info  		Y489(12.15); Y578(7.02); Y113(6.20)  LDD0257  [5]
TH216
 Probe Info  		Y113(20.00)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
ONAyne
 Probe Info  		K472(10.00)  LDD0274  [7]
BTD
 Probe Info  		C41(3.72)  LDD1699  [8]
OPA-S-S-alkyne
 Probe Info  		K491(1.12); K269(2.12); K48(3.47); K191(4.19)  LDD3494  [9]
Probe 1
 Probe Info  		Y113(9.14); Y341(9.75); Y438(15.08); Y477(73.34)  LDD3495  [10]
DBIA
 Probe Info  		C524(0.97)  LDD3310  [11]
THZ1-DTB
 Probe Info  		C423(1.04); C502(1.05)  LDD0460  [12]
AZ-9
 Probe Info  		10.00  LDD2154  [13]
Jackson_14
 Probe Info  		2.08  LDD0123  [14]
AHL-Pu-1
 Probe Info  		C822(5.60)  LDD0168  [15]
HHS-482
 Probe Info  		Y341(2.04)  LDD0285  [16]
HHS-475
 Probe Info  		Y563(0.68); Y792(0.79); Y341(0.85)  LDD0264  [17]
HHS-465
 Probe Info  		Y563(10.00); Y792(5.37)  LDD2237  [18]
5E-2FA
 Probe Info  		H678(0.00); H693(0.00); H882(0.00); H785(0.00)  LDD2235  [19]
ATP probe
 Probe Info  		K191(0.00); K472(0.00)  LDD0199  [20]
4-Iodoacetamidophenylacetylene
 Probe Info  		C502(0.00); C822(0.00); C423(0.00); C644(0.00)  LDD0038  [21]
IA-alkyne
 Probe Info  		C41(0.00); C502(0.00)  LDD0032  [22]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [23]
IPIAA_L
 Probe Info  		C423(0.00); C502(0.00)  LDD0031  [23]
Lodoacetamide azide
 Probe Info  		C502(0.00); C822(0.00); C423(0.00); C644(0.00)  LDD0037  [21]
ATP probe
 Probe Info  		K48(0.00); K39(0.00)  LDD0035  [24]
IPM
 Probe Info  		C47(0.00); C41(0.00)  LDD0025  [25]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [25]
NAIA_4
 Probe Info  		C423(0.00); C502(0.00); C822(0.00)  LDD2226  [26]
TFBX
 Probe Info  		C47(0.00); C41(0.00)  LDD0027  [25]
WYneN
 Probe Info  		N.A.  LDD0021  [27]
1d-yne
 Probe Info  		N.A.  LDD0356  [28]
NHS
 Probe Info  		K191(0.00); K220(0.00); K899(0.00)  LDD0010  [27]
PF-06672131
 Probe Info  		N.A.  LDD0152  [29]
SF
 Probe Info  		K472(0.00); Y792(0.00); K899(0.00)  LDD0028  [30]
STPyne
 Probe Info  		N.A.  LDD0009  [27]
Phosphinate-6
 Probe Info  		C41(0.00); C822(0.00)  LDD0018  [31]
Ox-W18
 Probe Info  		W687(0.00); W615(0.00); W623(0.00); W939(0.00)  LDD2175  [32]
1c-yne
 Probe Info  		K191(0.00); K930(0.00); K337(0.00)  LDD0228  [28]
Acrolein
 Probe Info  		H180(0.00); H678(0.00); H470(0.00); H676(0.00)  LDD0217  [33]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [33]
Crotonaldehyde
 Probe Info  		H678(0.00); H676(0.00); H568(0.00); H180(0.00)  LDD0219  [33]
Methacrolein
 Probe Info  		C41(0.00); H678(0.00); H676(0.00); C822(0.00)  LDD0218  [33]
m-APA
 Probe Info  		N.A.  LDD0405  [34]
NAIA_5
 Probe Info  		C423(0.00); C502(0.00); C822(0.00); C47(0.00)  LDD2223  [26]
TER-AC
 Probe Info  		N.A.  LDD0426  [35]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.32  LDD0471  [36]
FFF probe13
 Probe Info  		9.84  LDD0475  [36]
FFF probe2
 Probe Info  		5.80  LDD0463  [36]
FFF probe3
 Probe Info  		7.30  LDD0464  [36]
STS-1
 Probe Info  		N.A.  LDD0136  [37]
STS-2
 Probe Info  		N.A.  LDD0138  [37]
VE-P
 Probe Info  		N.A.  LDD0396  [38]
DA-2
 Probe Info  		N.A.  LDD0070  [39]
OEA-DA
 Probe Info  		3.50  LDD0046  [40]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C41(0.76)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C41(0.84)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C47(0.97); C41(0.78)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C47(0.89); C41(0.82)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C47(0.94); C41(1.13)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C47(1.21); C41(1.28)  LDD2152  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C47(0.47); C41(0.62)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C47(0.75); C41(0.46)  LDD2131  [8]
 LDCM0025  4SU-RNA HEK-293T C822(5.60)  LDD0168  [15]
 LDCM0026  4SU-RNA+native RNA HEK-293T C822(2.21)  LDD0169  [15]
 LDCM0214  AC1 HEK-293T C502(1.01); C423(0.94); C822(1.20); C41(0.97)  LDD1507  [41]
 LDCM0215  AC10 HEK-293T C502(1.06); C423(1.02); C822(1.27); C41(1.04)  LDD1508  [41]
 LDCM0226  AC11 HEK-293T C502(0.91); C423(1.07); C822(1.18); C41(0.96)  LDD1509  [41]
 LDCM0237  AC12 HEK-293T C502(1.03); C423(1.04); C822(1.32); C41(1.03)  LDD1510  [41]
 LDCM0259  AC14 HEK-293T C502(1.10); C423(1.10); C822(1.03); C41(0.99)  LDD1512  [41]
 LDCM0270  AC15 HEK-293T C502(1.01); C423(1.06); C822(1.10); C41(1.03)  LDD1513  [41]
 LDCM0276  AC17 HEK-293T C502(1.02); C423(0.92); C822(1.09); C41(1.02)  LDD1515  [41]
 LDCM0277  AC18 HEK-293T C502(0.94); C423(1.05); C822(1.16); C41(1.10)  LDD1516  [41]
 LDCM0278  AC19 HEK-293T C502(0.89); C423(1.01); C822(1.13); C41(0.92)  LDD1517  [41]
 LDCM0279  AC2 HEK-293T C502(1.06); C423(1.01); C822(1.41); C41(1.00)  LDD1518  [41]
 LDCM0280  AC20 HEK-293T C502(1.04); C423(1.04); C822(1.49); C41(1.02)  LDD1519  [41]
 LDCM0281  AC21 HEK-293T C502(1.06); C423(1.02); C822(1.07); C41(1.08)  LDD1520  [41]
 LDCM0282  AC22 HEK-293T C502(1.06); C423(1.00); C822(1.28); C41(1.06)  LDD1521  [41]
 LDCM0283  AC23 HEK-293T C502(1.00); C423(1.00); C822(1.15); C41(0.98)  LDD1522  [41]
 LDCM0284  AC24 HEK-293T C502(1.00); C423(1.00); C822(1.01); C41(0.99)  LDD1523  [41]
 LDCM0285  AC25 HEK-293T C502(1.07); C423(0.94); C822(1.27); C41(1.01)  LDD1524  [41]
 LDCM0286  AC26 HEK-293T C502(1.05); C423(1.01); C822(1.14); C41(1.03)  LDD1525  [41]
 LDCM0287  AC27 HEK-293T C502(0.94); C423(1.02); C822(1.18); C41(1.07)  LDD1526  [41]
 LDCM0288  AC28 HEK-293T C502(1.13); C423(0.97); C822(1.45); C41(1.03)  LDD1527  [41]
 LDCM0289  AC29 HEK-293T C502(1.05); C423(1.08); C822(1.02); C41(1.12)  LDD1528  [41]
 LDCM0290  AC3 HEK-293T C502(0.94); C423(1.11); C822(1.13); C41(0.97)  LDD1529  [41]
 LDCM0291  AC30 HEK-293T C502(1.05); C423(1.02); C822(1.27); C41(1.08)  LDD1530  [41]
 LDCM0292  AC31 HEK-293T C502(1.05); C423(1.04); C822(1.22); C41(1.02)  LDD1531  [41]
 LDCM0293  AC32 HEK-293T C502(1.04); C423(0.98); C822(1.18); C41(0.98)  LDD1532  [41]
 LDCM0294  AC33 HEK-293T C502(0.97); C423(1.01); C822(1.17); C41(0.89)  LDD1533  [41]
 LDCM0295  AC34 HEK-293T C502(1.04); C423(0.98); C822(1.14); C41(0.97)  LDD1534  [41]
 LDCM0296  AC35 HEK-293T C502(0.97); C423(1.08); C822(1.17); C41(0.90)  LDD1535  [41]
 LDCM0297  AC36 HEK-293T C502(1.13); C423(0.98); C822(1.56); C41(0.99)  LDD1536  [41]
 LDCM0298  AC37 HEK-293T C502(1.04); C423(1.08); C822(1.05); C41(1.07)  LDD1537  [41]
 LDCM0299  AC38 HEK-293T C502(1.03); C423(1.09); C822(1.26); C41(0.98)  LDD1538  [41]
 LDCM0300  AC39 HEK-293T C502(0.99); C423(1.06); C822(1.18); C41(0.93)  LDD1539  [41]
 LDCM0301  AC4 HEK-293T C502(1.09); C423(0.87); C822(1.77); C41(1.02)  LDD1540  [41]
 LDCM0302  AC40 HEK-293T C502(1.04); C423(0.98); C822(1.11); C41(0.98)  LDD1541  [41]
 LDCM0303  AC41 HEK-293T C502(0.92); C423(0.99); C822(1.19); C41(0.91)  LDD1542  [41]
 LDCM0304  AC42 HEK-293T C502(1.03); C423(1.02); C822(1.31); C41(1.00)  LDD1543  [41]
 LDCM0305  AC43 HEK-293T C502(0.94); C423(1.11); C822(1.14); C41(0.93)  LDD1544  [41]
 LDCM0306  AC44 HEK-293T C502(0.95); C423(0.99); C822(1.37); C41(0.97)  LDD1545  [41]
 LDCM0307  AC45 HEK-293T C502(1.02); C423(1.00); C822(1.18); C41(1.07)  LDD1546  [41]
 LDCM0308  AC46 HEK-293T C502(1.06); C423(1.07); C822(1.15); C41(0.97)  LDD1547  [41]
 LDCM0309  AC47 HEK-293T C502(1.00); C423(1.09); C822(1.22); C41(1.02)  LDD1548  [41]
 LDCM0310  AC48 HEK-293T C502(1.12); C423(0.94); C822(1.05); C41(0.99)  LDD1549  [41]
 LDCM0311  AC49 HEK-293T C502(0.94); C423(0.99); C822(1.22); C41(0.90)  LDD1550  [41]
 LDCM0312  AC5 HEK-293T C502(1.08); C423(1.05); C822(1.23); C41(1.01)  LDD1551  [41]
 LDCM0313  AC50 HEK-293T C502(1.03); C423(1.00); C822(1.31); C41(0.99)  LDD1552  [41]
 LDCM0314  AC51 HEK-293T C502(0.94); C423(1.03); C822(1.18); C41(0.92)  LDD1553  [41]
 LDCM0315  AC52 HEK-293T C502(1.02); C423(1.08); C822(1.37); C41(0.92)  LDD1554  [41]
 LDCM0316  AC53 HEK-293T C502(0.97); C423(1.03); C822(1.17); C41(1.04)  LDD1555  [41]
 LDCM0317  AC54 HEK-293T C502(1.02); C423(1.05); C822(1.11); C41(0.88)  LDD1556  [41]
 LDCM0318  AC55 HEK-293T C502(1.05); C423(1.02); C822(1.16); C41(0.96)  LDD1557  [41]
 LDCM0319  AC56 HEK-293T C502(1.03); C423(0.98); C822(1.12); C41(0.99)  LDD1558  [41]
 LDCM0320  AC57 HEK-293T C502(0.93); C423(1.02); C822(1.17); C41(0.94)  LDD1559  [41]
 LDCM0321  AC58 HEK-293T C502(1.01); C423(1.03); C822(1.21); C41(0.95)  LDD1560  [41]
 LDCM0322  AC59 HEK-293T C502(0.89); C423(1.01); C822(1.22); C41(0.95)  LDD1561  [41]
 LDCM0323  AC6 HEK-293T C502(1.08); C423(0.94); C822(1.08); C41(0.99)  LDD1562  [41]
 LDCM0324  AC60 HEK-293T C502(1.09); C423(0.86); C822(1.67); C41(0.96)  LDD1563  [41]
 LDCM0325  AC61 HEK-293T C502(0.99); C423(1.05); C822(1.08); C41(1.05)  LDD1564  [41]
 LDCM0326  AC62 HEK-293T C502(1.05); C423(0.91); C822(1.16); C41(0.92)  LDD1565  [41]
 LDCM0327  AC63 HEK-293T C502(0.94); C423(1.03); C822(1.28); C41(0.99)  LDD1566  [41]
 LDCM0328  AC64 HEK-293T C502(0.97); C423(0.84); C822(1.29); C41(1.06)  LDD1567  [41]
 LDCM0334  AC7 HEK-293T C502(1.07); C423(0.98); C822(1.20); C41(1.04)  LDD1568  [41]
 LDCM0345  AC8 HEK-293T C502(1.06); C423(0.94); C822(1.10); C41(1.05)  LDD1569  [41]
 LDCM0520  AKOS000195272 MDA-MB-231 C41(0.78)  LDD2113  [8]
 LDCM0248  AKOS034007472 HEK-293T C502(1.07); C423(1.02); C822(1.02); C41(1.03)  LDD1511  [41]
 LDCM0356  AKOS034007680 HEK-293T C502(1.05); C423(1.02); C822(1.09); C41(0.96)  LDD1570  [41]
 LDCM0275  AKOS034007705 HEK-293T C502(1.08); C423(0.98); C822(0.96); C41(1.03)  LDD1514  [41]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0405  [34]
 LDCM0151  AZ-11 HeLa 10.00  LDD2154  [13]
 LDCM0498  BS-3668 MDA-MB-231 C41(1.35)  LDD2091  [8]
 LDCM0108  Chloroacetamide HeLa C502(0.00); H678(0.00); H676(0.00); H470(0.00)  LDD0222  [33]
 LDCM0367  CL1 HEK-293T C502(1.04); C423(1.11); C41(0.96)  LDD1571  [41]
 LDCM0368  CL10 HEK-293T C502(0.93); C423(2.09); C822(0.60); C41(0.86)  LDD1572  [41]
 LDCM0369  CL100 HEK-293T C502(1.02); C423(1.02); C822(1.15); C41(0.94)  LDD1573  [41]
 LDCM0370  CL101 HEK-293T C502(0.99); C423(1.02); C41(0.98)  LDD1574  [41]
 LDCM0371  CL102 HEK-293T C502(0.93); C423(0.96); C822(1.33); C41(0.96)  LDD1575  [41]
 LDCM0372  CL103 HEK-293T C502(1.00); C423(1.09); C822(1.34); C41(0.97)  LDD1576  [41]
 LDCM0373  CL104 HEK-293T C502(1.09); C423(1.01); C822(1.03); C41(1.05)  LDD1577  [41]
 LDCM0374  CL105 HEK-293T C502(0.98); C423(1.03); C41(0.99)  LDD1578  [41]
 LDCM0375  CL106 HEK-293T C502(0.92); C423(0.95); C822(1.30); C41(0.98)  LDD1579  [41]
 LDCM0376  CL107 HEK-293T C502(0.98); C423(0.98); C822(1.19); C41(1.01)  LDD1580  [41]
 LDCM0377  CL108 HEK-293T C502(0.97); C423(0.96); C822(1.01); C41(1.06)  LDD1581  [41]
 LDCM0378  CL109 HEK-293T C502(1.05); C423(1.01); C41(0.99)  LDD1582  [41]
 LDCM0379  CL11 HEK-293T C502(1.00); C423(1.14); C822(0.65); C41(1.00)  LDD1583  [41]
 LDCM0380  CL110 HEK-293T C502(0.90); C423(0.92); C822(1.27); C41(0.94)  LDD1584  [41]
 LDCM0381  CL111 HEK-293T C502(1.02); C423(0.97); C822(1.14); C41(1.01)  LDD1585  [41]
 LDCM0382  CL112 HEK-293T C502(0.95); C423(1.00); C822(1.18); C41(1.04)  LDD1586  [41]
 LDCM0383  CL113 HEK-293T C502(1.03); C423(1.08); C41(0.96)  LDD1587  [41]
 LDCM0384  CL114 HEK-293T C502(0.94); C423(0.94); C822(1.47); C41(0.96)  LDD1588  [41]
 LDCM0385  CL115 HEK-293T C502(1.00); C423(0.94); C822(1.19); C41(1.01)  LDD1589  [41]
 LDCM0386  CL116 HEK-293T C502(1.03); C423(0.99); C822(1.37); C41(0.98)  LDD1590  [41]
 LDCM0387  CL117 HEK-293T C502(1.06); C423(0.99); C41(0.91)  LDD1591  [41]
 LDCM0388  CL118 HEK-293T C502(1.00); C423(1.01); C822(1.13); C41(0.97)  LDD1592  [41]
 LDCM0389  CL119 HEK-293T C502(1.10); C423(0.99); C822(1.09); C41(0.98)  LDD1593  [41]
 LDCM0390  CL12 HEK-293T C502(1.13); C423(2.18); C822(0.58); C41(1.07)  LDD1594  [41]
 LDCM0391  CL120 HEK-293T C502(1.02); C423(1.08); C822(1.25); C41(0.97)  LDD1595  [41]
 LDCM0392  CL121 HEK-293T C502(1.00); C423(0.96); C41(0.92)  LDD1596  [41]
 LDCM0393  CL122 HEK-293T C502(1.03); C423(0.92); C822(1.23); C41(0.93)  LDD1597  [41]
 LDCM0394  CL123 HEK-293T C502(0.93); C423(0.94); C822(1.17); C41(0.94)  LDD1598  [41]
 LDCM0395  CL124 HEK-293T C502(1.06); C423(0.94); C822(1.10); C41(1.00)  LDD1599  [41]
 LDCM0396  CL125 HEK-293T C502(0.99); C423(0.89); C41(0.94)  LDD1600  [41]
 LDCM0397  CL126 HEK-293T C502(0.97); C423(0.89); C822(1.46); C41(0.96)  LDD1601  [41]
 LDCM0398  CL127 HEK-293T C502(0.98); C423(0.85); C822(1.35); C41(1.03)  LDD1602  [41]
 LDCM0399  CL128 HEK-293T C502(1.02); C423(1.01); C822(1.25); C41(0.97)  LDD1603  [41]
 LDCM0400  CL13 HEK-293T C502(1.08); C423(1.03); C41(0.85)  LDD1604  [41]
 LDCM0401  CL14 HEK-293T C502(1.07); C423(1.00); C822(1.16); C41(1.00)  LDD1605  [41]
 LDCM0402  CL15 HEK-293T C502(0.92); C423(1.10); C822(1.05); C41(0.87)  LDD1606  [41]
 LDCM0403  CL16 HEK-293T C502(1.07); C423(1.00); C822(0.91); C41(0.97)  LDD1607  [41]
 LDCM0404  CL17 HEK-293T C502(0.95); C423(1.14); C822(1.02); C41(0.79)  LDD1608  [41]
 LDCM0405  CL18 HEK-293T C502(1.16); C423(1.04); C822(0.95); C41(1.11)  LDD1609  [41]
 LDCM0406  CL19 HEK-293T C502(1.09); C423(1.32); C822(0.82); C41(0.96)  LDD1610  [41]
 LDCM0407  CL2 HEK-293T C502(1.13); C423(0.89); C822(1.21); C41(0.98)  LDD1611  [41]
 LDCM0408  CL20 HEK-293T C502(1.05); C423(2.28); C822(0.62); C41(1.00)  LDD1612  [41]
 LDCM0409  CL21 HEK-293T C502(1.01); C423(0.97); C822(0.62); C41(1.10)  LDD1613  [41]
 LDCM0410  CL22 HEK-293T C502(0.99); C423(2.21); C822(0.59); C41(1.00)  LDD1614  [41]
 LDCM0411  CL23 HEK-293T C502(1.07); C423(1.10); C822(0.55); C41(1.10)  LDD1615  [41]
 LDCM0412  CL24 HEK-293T C502(1.13); C423(2.52); C822(0.48); C41(1.03)  LDD1616  [41]
 LDCM0413  CL25 HEK-293T C502(1.00); C423(1.03); C41(0.85)  LDD1617  [41]
 LDCM0414  CL26 HEK-293T C502(0.92); C423(0.97); C822(1.06); C41(0.98)  LDD1618  [41]
 LDCM0415  CL27 HEK-293T C502(1.02); C423(1.02); C822(1.06); C41(0.99)  LDD1619  [41]
 LDCM0416  CL28 HEK-293T C502(1.02); C423(1.07); C822(0.95); C41(0.98)  LDD1620  [41]
 LDCM0417  CL29 HEK-293T C502(1.04); C423(1.07); C822(0.94); C41(1.00)  LDD1621  [41]
 LDCM0418  CL3 HEK-293T C502(0.99); C423(1.14); C822(1.13); C41(0.97)  LDD1622  [41]
 LDCM0419  CL30 HEK-293T C502(1.03); C423(1.01); C822(0.89); C41(0.96)  LDD1623  [41]
 LDCM0420  CL31 HEK-293T C502(0.99); C423(1.19); C822(0.78); C41(0.96)  LDD1624  [41]
 LDCM0421  CL32 HEK-293T C502(1.06); C423(2.01); C822(0.65); C41(1.08)  LDD1625  [41]
 LDCM0422  CL33 HEK-293T C502(0.91); C423(1.00); C822(0.55); C41(1.02)  LDD1626  [41]
 LDCM0423  CL34 HEK-293T C502(1.05); C423(2.21); C822(0.53); C41(1.02)  LDD1627  [41]
 LDCM0424  CL35 HEK-293T C502(1.21); C423(1.09); C822(0.56); C41(1.15)  LDD1628  [41]
 LDCM0425  CL36 HEK-293T C502(1.07); C423(2.15); C822(0.49); C41(1.10)  LDD1629  [41]
 LDCM0426  CL37 HEK-293T C502(1.07); C423(0.90); C41(0.97)  LDD1630  [41]
 LDCM0428  CL39 HEK-293T C502(1.01); C423(1.05); C822(1.15); C41(1.03)  LDD1632  [41]
 LDCM0429  CL4 HEK-293T C502(0.96); C423(1.16); C822(0.97); C41(0.91)  LDD1633  [41]
 LDCM0430  CL40 HEK-293T C502(0.96); C423(1.02); C822(1.01); C41(0.98)  LDD1634  [41]
 LDCM0431  CL41 HEK-293T C502(0.93); C423(1.11); C822(0.98); C41(1.00)  LDD1635  [41]
 LDCM0432  CL42 HEK-293T C502(1.08); C423(0.95); C822(0.76); C41(1.15)  LDD1636  [41]
 LDCM0433  CL43 HEK-293T C502(1.01); C423(1.19); C822(0.76); C41(1.13)  LDD1637  [41]
 LDCM0434  CL44 HEK-293T C502(0.98); C423(1.74); C822(0.65); C41(1.06)  LDD1638  [41]
 LDCM0435  CL45 HEK-293T C502(1.00); C423(0.99); C822(0.51); C41(1.11)  LDD1639  [41]
 LDCM0436  CL46 HEK-293T C502(1.15); C423(2.13); C822(0.54); C41(1.09)  LDD1640  [41]
 LDCM0437  CL47 HEK-293T C502(1.00); C423(1.14); C822(0.57); C41(1.11)  LDD1641  [41]
 LDCM0438  CL48 HEK-293T C502(1.11); C423(1.85); C822(0.44); C41(1.09)  LDD1642  [41]
 LDCM0439  CL49 HEK-293T C502(1.09); C423(1.02); C41(0.95)  LDD1643  [41]
 LDCM0440  CL5 HEK-293T C502(1.00); C423(1.09); C822(1.02); C41(0.85)  LDD1644  [41]
 LDCM0441  CL50 HEK-293T C502(1.03); C423(1.00); C822(1.21); C41(0.89)  LDD1645  [41]
 LDCM0443  CL52 HEK-293T C502(0.98); C423(0.99); C822(0.95); C41(0.95)  LDD1646  [41]
 LDCM0444  CL53 HEK-293T C502(0.98); C423(1.15); C822(1.02); C41(0.84)  LDD1647  [41]
 LDCM0445  CL54 HEK-293T C502(1.02); C423(1.03); C822(0.98); C41(1.00)  LDD1648  [41]
 LDCM0446  CL55 HEK-293T C502(1.12); C423(1.21); C822(0.77); C41(0.93)  LDD1649  [41]
 LDCM0447  CL56 HEK-293T C502(1.09); C423(1.94); C822(0.69); C41(1.02)  LDD1650  [41]
 LDCM0448  CL57 HEK-293T C502(1.05); C423(1.02); C822(0.68); C41(1.09)  LDD1651  [41]
 LDCM0449  CL58 HEK-293T C502(1.12); C423(2.13); C822(0.55); C41(0.95)  LDD1652  [41]
 LDCM0450  CL59 HEK-293T C502(1.11); C423(1.08); C822(0.60); C41(1.08)  LDD1653  [41]
 LDCM0451  CL6 HEK-293T C502(1.04); C423(1.00); C822(0.98); C41(0.99)  LDD1654  [41]
 LDCM0452  CL60 HEK-293T C502(1.09); C423(2.26); C822(0.49); C41(1.03)  LDD1655  [41]
 LDCM0453  CL61 HEK-293T C502(1.09); C423(0.97); C41(0.90)  LDD1656  [41]
 LDCM0454  CL62 HEK-293T C502(0.97); C423(0.95); C822(1.38); C41(0.91)  LDD1657  [41]
 LDCM0455  CL63 HEK-293T C502(1.01); C423(0.93); C822(1.13); C41(0.98)  LDD1658  [41]
 LDCM0456  CL64 HEK-293T C502(0.99); C423(0.97); C822(1.03); C41(0.87)  LDD1659  [41]
 LDCM0457  CL65 HEK-293T C502(1.00); C423(1.07); C822(1.04); C41(0.95)  LDD1660  [41]
 LDCM0458  CL66 HEK-293T C502(1.07); C423(1.06); C822(0.94); C41(1.03)  LDD1661  [41]
 LDCM0459  CL67 HEK-293T C502(1.00); C423(1.08); C822(0.95); C41(0.91)  LDD1662  [41]
 LDCM0460  CL68 HEK-293T C502(1.00); C423(1.91); C822(0.67); C41(1.01)  LDD1663  [41]
 LDCM0461  CL69 HEK-293T C502(1.11); C423(0.98); C822(0.61); C41(1.08)  LDD1664  [41]
 LDCM0462  CL7 HEK-293T C502(1.10); C423(1.19); C822(0.90); C41(0.88)  LDD1665  [41]
 LDCM0463  CL70 HEK-293T C502(1.12); C423(1.90); C822(0.55); C41(0.99)  LDD1666  [41]
 LDCM0464  CL71 HEK-293T C502(1.07); C423(1.14); C822(0.66); C41(0.99)  LDD1667  [41]
 LDCM0465  CL72 HEK-293T C502(1.12); C423(2.04); C822(0.55); C41(0.93)  LDD1668  [41]
 LDCM0466  CL73 HEK-293T C502(1.09); C423(0.92); C41(0.98)  LDD1669  [41]
 LDCM0467  CL74 HEK-293T C502(1.05); C423(0.91); C822(1.46); C41(1.03)  LDD1670  [41]
 LDCM0469  CL76 HEK-293T C502(1.02); C423(0.99); C822(1.00); C41(0.96)  LDD1672  [41]
 LDCM0470  CL77 HEK-293T C502(0.92); C423(1.08); C822(1.08); C41(0.91)  LDD1673  [41]
 LDCM0471  CL78 HEK-293T C502(1.03); C423(1.03); C822(0.83); C41(1.01)  LDD1674  [41]
 LDCM0472  CL79 HEK-293T C502(1.03); C423(1.13); C822(0.87); C41(1.00)  LDD1675  [41]
 LDCM0473  CL8 HEK-293T C502(0.84); C423(1.56); C822(0.80); C41(0.89)  LDD1676  [41]
 LDCM0474  CL80 HEK-293T C502(1.06); C423(1.68); C822(0.76); C41(1.11)  LDD1677  [41]
 LDCM0475  CL81 HEK-293T C502(1.10); C423(0.97); C822(0.59); C41(1.04)  LDD1678  [41]
 LDCM0476  CL82 HEK-293T C502(1.08); C423(1.65); C822(0.60); C41(1.11)  LDD1679  [41]
 LDCM0477  CL83 HEK-293T C502(0.96); C423(1.16); C822(0.66); C41(1.12)  LDD1680  [41]
 LDCM0478  CL84 HEK-293T C502(1.10); C423(1.62); C822(0.60); C41(1.09)  LDD1681  [41]
 LDCM0479  CL85 HEK-293T C502(1.02); C423(0.97); C41(0.90)  LDD1682  [41]
 LDCM0480  CL86 HEK-293T C502(0.99); C423(0.77); C822(1.53); C41(0.97)  LDD1683  [41]
 LDCM0481  CL87 HEK-293T C502(0.87); C423(0.85); C822(1.34); C41(0.96)  LDD1684  [41]
 LDCM0482  CL88 HEK-293T C502(1.09); C423(1.13); C822(1.40); C41(0.97)  LDD1685  [41]
 LDCM0483  CL89 HEK-293T C502(0.96); C423(0.95); C822(1.22); C41(0.95)  LDD1686  [41]
 LDCM0484  CL9 HEK-293T C502(1.10); C423(1.09); C822(0.60); C41(1.16)  LDD1687  [41]
 LDCM0485  CL90 HEK-293T C502(0.93); C423(1.08); C822(0.98); C41(0.87)  LDD1688  [41]
 LDCM0486  CL91 HEK-293T C502(1.00); C423(1.19); C822(0.94); C41(0.89)  LDD1689  [41]
 LDCM0487  CL92 HEK-293T C502(1.03); C423(1.06); C822(1.08); C41(0.92)  LDD1690  [41]
 LDCM0488  CL93 HEK-293T C502(1.01); C423(0.98); C822(0.66); C41(1.07)  LDD1691  [41]
 LDCM0489  CL94 HEK-293T C502(0.98); C423(1.59); C822(0.71); C41(0.95)  LDD1692  [41]
 LDCM0490  CL95 HEK-293T C502(0.90); C423(1.09); C822(0.87); C41(0.91)  LDD1693  [41]
 LDCM0491  CL96 HEK-293T C502(1.02); C423(1.12); C822(0.99); C41(1.00)  LDD1694  [41]
 LDCM0492  CL97 HEK-293T C502(0.96); C423(1.01); C41(0.92)  LDD1695  [41]
 LDCM0493  CL98 HEK-293T C502(0.98); C423(0.91); C822(1.33); C41(0.99)  LDD1696  [41]
 LDCM0494  CL99 HEK-293T C502(0.96); C423(0.84); C822(1.22); C41(1.01)  LDD1697  [41]
 LDCM0495  E2913 HEK-293T C502(0.99); C423(1.01); C822(1.19); C41(0.91)  LDD1698  [41]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C41(2.84); C47(1.67)  LDD1702  [8]
 LDCM0625  F8 Ramos C502(0.82)  LDD2187  [42]
 LDCM0572  Fragment10 Ramos C502(0.68)  LDD2189  [42]
 LDCM0574  Fragment12 Ramos C502(0.64)  LDD2191  [42]
 LDCM0575  Fragment13 Ramos C502(0.54)  LDD2192  [42]
 LDCM0576  Fragment14 Ramos C502(1.03)  LDD2193  [42]
 LDCM0579  Fragment20 Ramos C502(0.58)  LDD2194  [42]
 LDCM0580  Fragment21 Ramos C502(0.47)  LDD2195  [42]
 LDCM0582  Fragment23 Ramos C502(1.07)  LDD2196  [42]
 LDCM0578  Fragment27 Ramos C502(0.96)  LDD2197  [42]
 LDCM0588  Fragment30 Ramos C502(0.48)  LDD2199  [42]
 LDCM0589  Fragment31 Ramos C502(0.53)  LDD2200  [42]
 LDCM0590  Fragment32 Ramos C502(0.69)  LDD2201  [42]
 LDCM0468  Fragment33 HEK-293T C502(0.93); C423(1.01); C822(1.14); C41(0.99)  LDD1671  [41]
 LDCM0596  Fragment38 Ramos C502(1.24)  LDD2203  [42]
 LDCM0566  Fragment4 Ramos C502(0.89)  LDD2184  [42]
 LDCM0427  Fragment51 HEK-293T C502(1.02); C423(0.85); C822(1.15); C41(0.95)  LDD1631  [41]
 LDCM0610  Fragment52 Ramos C502(0.25)  LDD2204  [42]
 LDCM0614  Fragment56 Ramos C502(0.71)  LDD2205  [42]
 LDCM0569  Fragment7 Ramos C502(0.96)  LDD2186  [42]
 LDCM0571  Fragment9 Ramos C502(0.49)  LDD2188  [42]
 LDCM0116  HHS-0101 DM93 Y563(0.68); Y792(0.79); Y341(0.85)  LDD0264  [17]
 LDCM0117  HHS-0201 DM93 Y563(0.69); Y792(0.71); Y341(0.93)  LDD0265  [17]
 LDCM0118  HHS-0301 DM93 Y563(0.68); Y341(0.68); Y792(1.85)  LDD0266  [17]
 LDCM0119  HHS-0401 DM93 Y341(0.80); Y563(0.96); Y792(3.43)  LDD0267  [17]
 LDCM0120  HHS-0701 DM93 Y563(0.28); Y341(0.36); Y792(0.68)  LDD0268  [17]
 LDCM0107  IAA HeLa H678(0.00); H676(0.00); H180(0.00); H470(0.00)  LDD0221  [33]
 LDCM0123  JWB131 DM93 Y341(2.04)  LDD0285  [16]
 LDCM0124  JWB142 DM93 Y341(1.65); Y489(2.38)  LDD0286  [16]
 LDCM0125  JWB146 DM93 Y341(0.95); Y489(0.89)  LDD0287  [16]
 LDCM0126  JWB150 DM93 Y489(3.99)  LDD0288  [16]
 LDCM0127  JWB152 DM93 Y341(1.93); Y489(2.74)  LDD0289  [16]
 LDCM0129  JWB202 DM93 Y341(0.89); Y489(0.95)  LDD0291  [16]
 LDCM0130  JWB211 DM93 Y341(0.79); Y489(0.57)  LDD0292  [16]
 LDCM0022  KB02 HEK-293T C502(0.98); C423(1.03); C822(1.07); C41(0.93)  LDD1492  [41]
 LDCM0023  KB03 HEK-293T C502(1.02); C423(0.97); C822(0.93); C41(1.02)  LDD1497  [41]
 LDCM0024  KB05 COLO792 C524(0.97)  LDD3310  [11]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C47(1.32)  LDD2121  [8]
 LDCM0109  NEM HeLa H625(0.00); H470(0.00); H180(0.00); H678(0.00)  LDD0223  [33]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C41(1.27)  LDD2089  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C47(1.23); C41(0.89)  LDD2093  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C47(0.78)  LDD2097  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C47(1.56); C41(1.36)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C41(0.61)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C47(2.44); C41(2.18)  LDD2101  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C41(0.86)  LDD2105  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C47(1.10); C41(0.99)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C41(0.86)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C47(2.02); C41(1.29)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C47(1.26); C41(0.95)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C41(0.56)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C47(0.50); C41(0.64)  LDD2115  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C47(3.10); C41(1.59)  LDD2119  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C41(1.03)  LDD2123  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C47(1.00); C41(0.89)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C41(0.95)  LDD2127  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C47(1.12); C41(0.97)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C47(0.64); C41(0.58)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C47(0.58); C41(0.57)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C41(0.98)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C47(1.39); C41(1.41)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C47(1.07); C41(0.97)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C41(1.84); C47(1.62)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C41(1.15)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C41(0.73)  LDD2141  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C47(2.48); C41(1.90)  LDD2144  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C41(2.59)  LDD2145  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C41(1.12)  LDD2146  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C41(0.53)  LDD2148  [8]
 LDCM0628  OTUB2-COV-1 HEK-293T C502(0.31)  LDD2207  [43]
 LDCM0131  RA190 MM1.R C502(1.28)  LDD0304  [44]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.08  LDD0123  [14]
 LDCM0021  THZ1 HeLa S3 C423(1.04); C502(1.05)  LDD0460  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glucosidase 2 subunit beta (PRKCSH) . P14314

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Miglitol Small molecular drug DB00491

References

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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD042888
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Mass spectrometry data entry: PXD047840
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD028853
22 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
23 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
24 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD036569
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD033004
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Mass spectrometry data entry: PXD001377 , PXD005252
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD027578
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