Probe Name	W1					Probe Info
Probe concentration	20 uM
Criteria	Quantification: Probe vs DMSO
Quantitative Method	SILAC
In Vivo Experiment Model	Model Type			Living cell
	Derived Tissue			Liver
	Disease Model		Hepatoblastoma [ICD-11:DB91]
	Model Name		Human hepatoblastoma cells (Hep-G2)

Target ID	Target Name					Binding Ratio
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)					62.0
LDTP04671	Trifunctional enzyme subunit beta, mitochondrial (HADHB)					58.8
LDTP03515	Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3)					55.0
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)					51.6
LDTP12319	Serine--tRNA ligase, mitochondrial (SARS2)					49.4
LDTP12688	ATP-dependent RNA helicase DDX18 (DDX18)					42.0
LDTP01283	U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200)					35.8
LDTP12227	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2)					35.0
LDTP12814	Probable ATP-dependent RNA helicase DDX56 (DDX56)					32.0
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)					31.3
LDTP02860	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2)					30.6
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)					25.7
LDTP03764	Myosin-9 (MYH9)					23.4
LDTP10878	Parkinson disease protein 7 (PARK7)					23.0
LDTP14842	Glycerol kinase 3 (GK3)					22.5
LDTP05809	Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2)					22.3
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)					22.1
LDTP03540	Heme oxygenase 2 (HMOX2)					22.1
LDTP06270	Signal peptidase complex subunit 2 (SPCS2)					21.9
LDTP04438	Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1)					21.8
LDTP02067	Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1)					21.8
LDTP03401	Multifunctional protein CAD (CAD)					21.5
LDTP02188	Protein disulfide-isomerase (P4HB)					21.3
LDTP05918	Histone deacetylase 1 (HDAC1)					21.1
LDTP03911	Replication factor C subunit 3 (RFC3)					20.9
LDTP11297	Guanine nucleotide-binding protein-like 3 (GNL3)					20.7
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)					19.7
LDTP04253	Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1)					19.4
LDTP16274	Acyl-coenzyme A thioesterase 9, mitochondrial (ACOT9)					19.2
LDTP13989	Peptidyl-tRNA hydrolase 2, mitochondrial (PTRH2)					18.5
LDTP09962	Ubiquitin carboxyl-terminal hydrolase 7 (USP7)					18.2
LDTP03221	Glycine dehydrogenase (decarboxylating), mitochondrial (GLDC)					18.1
LDTP11107	Serine/threonine-protein phosphatase CPPED1 (CPPED1)					18.0
LDTP13272	Septin-9 (SEPTIN9)					17.7
LDTP03610	Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1)					17.5
LDTP03626	Peroxiredoxin-2 (PRDX2)					17.3
LDTP11127	ADP-dependent glucokinase (ADPGK)					17.0
LDTP04310	E3 SUMO-protein ligase RanBP2 (RANBP2)					16.8
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)					16.2
LDTP02074	Aldehyde dehydrogenase, mitochondrial (ALDH2)					16.1
LDTP04398	Ras-related protein Rab-5C (RAB5C)					15.9
LDTP11690	RNA cytidine acetyltransferase (NAT10)					15.8
LDTP03560	Aldehyde dehydrogenase X, mitochondrial (ALDH1B1)					14.7
LDTP00314	ATP-dependent RNA helicase DDX3X (DDX3X)					14.4
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)					14.2
LDTP09899	Probable ATP-dependent RNA helicase DDX17 (DDX17)					14.2
LDTP11321	Acetyl-CoA acetyltransferase, cytosolic (ACAT2)					14.2
LDTP03522	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A)					14.0
LDTP05652	Aspartyl/asparaginyl beta-hydroxylase (ASPH)					13.8
LDTP02616	Creatine kinase B-type (CKB)					13.6
LDTP02568	DNA topoisomerase 2-alpha (TOP2A)					13.0
LDTP04349	Sulfotransferase 1A1 (SULT1A1)					12.7
LDTP02175	Epoxide hydrolase 1 (EPHX1)					12.6
LDTP03289	Low molecular weight phosphotyrosine protein phosphatase (ACP1)					12.4
LDTP00982	Long-chain-fatty-acid--CoA ligase 4 (ACSL4)					12.2
LDTP05503	Peroxiredoxin-1 (PRDX1)					12.1
LDTP04542	Thimet oligopeptidase (THOP1)					12.0
LDTP08629	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (FTSJ3)					11.7
LDTP07932	Probable ATP-dependent RNA helicase DDX46 (DDX46)					11.6
LDTP04531	Hexokinase-2 (HK2)					11.5
LDTP08017	Endoplasmic reticulum metallopeptidase 1 (ERMP1)					11.4
LDTP03316	DNA replication licensing factor MCM3 (MCM3)					11.4
LDTP05136	DNA-dependent protein kinase catalytic subunit (PRKDC)					11.3
LDTP04878	Eukaryotic initiation factor 4A-I (EIF4A1)					11.3
LDTP02752	Aspartate--tRNA ligase, cytoplasmic (DARS1)					11.2
LDTP04601	Arginine--tRNA ligase, cytoplasmic (RARS1)					11.1
LDTP10318	Ubiquitin thioesterase OTUB1 (OTUB1)					11.1
LDTP12469	Nucleolar RNA helicase 2 (DDX21)					10.9
LDTP05946	Cullin-1 (CUL1)					10.7
LDTP13056	Leucine--tRNA ligase, cytoplasmic (LARS1)					10.7
LDTP01584	Phosphoacetylglucosamine mutase (PGM3)					10.7
LDTP01767	Aldehyde dehydrogenase 1A1 (ALDH1A1)					10.6
LDTP04135	Glutamine--tRNA ligase (QARS1)					10.6
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)					10.6
LDTP06192	Neutral alpha-glucosidase AB (GANAB)					10.2
LDTP00684	ATP-dependent RNA helicase DHX15 (DHX15)					10.2
LDTP00606	Phosphomannomutase 2 (PMM2)					10.2
LDTP06145	Protein disulfide-isomerase A5 (PDIA5)					10.1

Target ID	Target Name					Binding Ratio
LDTP04071	Voltage-dependent anion-selective channel protein 2 (VDAC2)					68.1
LDTP13824	Voltage-dependent anion-selective channel protein 3 (VDAC3)					47.0
LDTP05511	Cytoskeleton-associated protein 4 (CKAP4)					35.5
LDTP02122	Integrin beta-1 (ITGB1)					34.7
LDTP01525	Mitochondrial proton/calcium exchanger protein (LETM1)					33.5
LDTP05238	Solute carrier family 25 member 3 (SLC25A3)					27.6
LDTP13416	Stomatin-like protein 2, mitochondrial (STOML2)					25.5
LDTP13490	Apoptotic chromatin condensation inducer in the nucleus (ACIN1)					21.0
LDTP02256	Amino acid transporter heavy chain SLC3A2 (SLC3A2)					20.2
LDTP02057	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1)					20.1
LDTP08769	Nuclear pore complex protein Nup93 (NUP93)					19.5
LDTP04082	Ran GTPase-activating protein 1 (RANGAP1)					18.7
LDTP06660	MICOS complex subunit MIC60 (IMMT)					17.1
LDTP00014	Extended synaptotagmin-2 (ESYT2)					16.8
LDTP04501	Importin subunit alpha-1 (KPNA2)					16.1
LDTP02087	ADP/ATP translocase 2 (SLC25A5)					14.8
LDTP13319	V-type proton ATPase subunit H (ATP6V1H)					14.5
LDTP04391	T-complex protein 1 subunit delta (CCT4)					14.4
LDTP12966	Vesicle-associated membrane protein-associated protein A (VAPA)					14.4
LDTP12090	Sideroflexin-1 (SFXN1)					14.2
LDTP02612	Nucleoprotein TPR (TPR)					13.9
LDTP13393	Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13)					13.5
LDTP15845	Transmembrane 9 superfamily member 2 (TM9SF2)					13.0
LDTP13174	Mitochondrial dicarboxylate carrier (SLC25A10)					12.3
LDTP04866	Protein transport protein Sec61 subunit beta (SEC61B)					12.3
LDTP01197	Filamin-B (FLNB)					10.7
LDTP10989	Copine-1 (CPNE1)					10.7
LDTP02609	ADP/ATP translocase 3 (SLC25A6)					10.6
LDTP14031	Talin-1 (TLN1)					10.4

Target ID	Target Name					Binding Ratio
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)					22.5
LDTP08097	Interferon regulatory factor 2-binding protein 2 (IRF2BP2)					11.5

Target ID	Target Name					Binding Ratio
LDTP01970	Serotransferrin (TF)					75.4
LDTP04241	Nuclear autoantigenic sperm protein (NASP)					66.2
LDTP04809	Epiplakin (EPPK1)					33.6
LDTP05867	Treacle protein (TCOF1)					30.4
LDTP06385	Scaffold attachment factor B1 (SAFB)					29.4
LDTP10889	Perilipin-2 (PLIN2)					28.7
LDTP02389	Complement C4-B (C4B; C4B_2)					27.3
LDTP15762	Zinc finger RNA-binding protein (ZFR)					27.0
LDTP01815	Complement C3 (C3)					27.0
LDTP17065	Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2)					26.9
LDTP05525	KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1)					26.5
LDTP01208	Pre-mRNA-processing factor 40 homolog A (PRPF40A)					26.5
LDTP04126	F-actin-capping protein subunit alpha-2 (CAPZA2)					26.4
LDTP04439	Glypican-3 (GPC3)					25.9
LDTP01963	Albumin (ALB)					23.4
LDTP06952	DBIRD complex subunit ZNF326 (ZNF326)					23.3
LDTP08760	Cell cycle and apoptosis regulator protein 2 (CCAR2)					22.7
LDTP10864	Calponin-2 (CNN2)					22.1
LDTP03014	Inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2)					21.0
LDTP13746	Serine/arginine repetitive matrix protein 2 (SRRM2)					20.6
LDTP05898	Sequestosome-1 (SQSTM1)					20.4
LDTP09281	WD repeat-containing protein 36 (WDR36)					20.2
LDTP03209	Transcription elongation factor A protein 1 (TCEA1)					19.6
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)					19.1
LDTP06310	Early endosome antigen 1 (EEA1)					19.0
LDTP05997	Beta-1-syntrophin (SNTB1)					18.7
LDTP03404	Microtubule-associated protein 4 (MAP4)					18.2
LDTP03065	Lamin-B1 (LMNB1)					17.8
LDTP11066	Methylosome protein WDR77 (WDR77)					17.6
LDTP01319	Eukaryotic translation initiation factor 3 subunit G (EIF3G)					17.4
LDTP12591	Kinesin light chain 4 (KLC4)					17.4
LDTP12412	Reticulon-4 (RTN4)					17.3
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)					17.2
LDTP06450	ELAV-like protein 1 (ELAVL1)					17.1
LDTP01683	BAG family molecular chaperone regulator 2 (BAG2)					17.1
LDTP02934	T-complex protein 1 subunit alpha (TCP1)					17.0
LDTP06588	Drebrin (DBN1)					16.9
LDTP03557	Leukocyte elastase inhibitor (SERPINB1)					16.8
LDTP10585	Non-structural maintenance of chromosomes element 3 homolog (NSMCE3)					15.3
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)					15.0
LDTP06330	Plectin (PLEC)					14.8
LDTP13044	Ribosome-binding protein 1 (RRBP1)					14.8
LDTP11144	Endoplasmic reticulum resident protein 44 (ERP44)					14.7
LDTP03364	Polypyrimidine tract-binding protein 1 (PTBP1)					14.7
LDTP00551	Actin-related protein 2/3 complex subunit 2 (ARPC2)					14.7
LDTP04917	Proteasome activator complex subunit 3 (PSME3)					14.5
LDTP04875	Myosin light polypeptide 6 (MYL6)					14.4
LDTP01964	Alpha-fetoprotein (AFP)					14.3
LDTP02263	Signal recognition particle receptor subunit alpha (SRPRA)					14.0
LDTP04500	Heterogeneous nuclear ribonucleoprotein M (HNRNPM)					13.9
LDTP11443	Polymerase delta-interacting protein 3 (POLDIP3)					13.4
LDTP05197	Serine/arginine-rich splicing factor 3 (SRSF3)					13.3
LDTP01511	Elongator complex protein 1 (ELP1)					13.3
LDTP09081	SERPINE1 mRNA-binding protein 1 (SERBP1)					13.2
LDTP09920	Golgi apparatus protein 1 (GLG1)					13.1
LDTP08018	Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1)					13.0
LDTP01677	Double-stranded RNA-binding protein Staufen homolog 1 (STAU1)					12.9
LDTP00313	Nucleolar protein 56 (NOP56)					12.6
LDTP11625	Ribosome biogenesis protein WDR12 (WDR12)					12.0
LDTP05688	Interleukin enhancer-binding factor 2 (ILF2)					12.0
LDTP06393	Splicing factor 3A subunit 1 (SF3A1)					11.8
LDTP04718	Eukaryotic translation initiation factor 3 subunit B (EIF3B)					11.8
LDTP05239	Vigilin (HDLBP)					11.8
LDTP05767	TAR DNA-binding protein 43 (TARDBP)					11.8
LDTP01252	Cold shock domain-containing protein E1 (CSDE1)					11.8
LDTP12883	Constitutive coactivator of PPAR-gamma-like protein 1 (FAM120A)					11.7
LDTP01932	Prelamin-A/C (LMNA)					11.6
LDTP02692	Plastin-3 (PLS3)					11.6
LDTP04571	Coatomer subunit alpha (COPA)					11.6
LDTP09938	Far upstream element-binding protein 2 (KHSRP)					11.5
LDTP04201	T-complex protein 1 subunit epsilon (CCT5)					11.4
LDTP05800	Serine/arginine-rich splicing factor 9 (SRSF9)					11.0
LDTP11870	BolA-like protein 2 (BOLA2; BOLA2B)					11.0
LDTP02341	Galectin-1 (LGALS1)					10.9
LDTP05697	Heat shock protein 75 kDa, mitochondrial (TRAP1)					10.8
LDTP02191	Asialoglycoprotein receptor 1 (ASGR1)					10.8
LDTP11324	RNA-binding protein 4 (RBM4)					10.8
LDTP06083	Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)					10.8
LDTP03030	Annexin A7 (ANXA7)					10.8
LDTP03509	Endoplasmic reticulum resident protein 29 (ERP29)					10.7
LDTP03615	Heterogeneous nuclear ribonucleoprotein H (HNRNPH1)					10.6
LDTP05932	Ras GTPase-activating-like protein IQGAP2 (IQGAP2)					10.5
LDTP05677	Splicing factor 3A subunit 3 (SF3A3)					10.5
LDTP04714	Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2)					10.4
LDTP06128	RNA-binding protein 39 (RBM39)					10.2
LDTP13192	Tight junction protein ZO-2 (TJP2)					10.2
LDTP05272	Splicing factor U2AF 35 kDa subunit (U2AF1)					10.1
LDTP03886	Alpha-taxilin (TXLNA)					10.0

1	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.