Details of the Target

General Information of Target

Target ID LDTP05272
Target Name Splicing factor U2AF 35 kDa subunit (U2AF1)
Gene Name U2AF1
Gene ID 102724594
Synonyms
U2AF35; U2AFBP; Splicing factor U2AF 35 kDa subunit; U2 auxiliary factor 35 kDa subunit; U2 small nuclear RNA auxiliary factor 1; U2 snRNP auxiliary factor small subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQ
SADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRRE
EDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRE
LRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
Target Bioclass
Other
Family
Splicing factor SR family
Subcellular location
Nucleus
Function
Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.
Uniprot ID
Q01081
Ensemble ID
ENST00000291552.9
HGNC ID
HGNC:12453

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
W1
 Probe Info  		10.12  LDD0235  [2]
TH211
 Probe Info  		Y114(20.00); Y158(20.00); Y78(8.31)  LDD0257  [3]
TH216
 Probe Info  		Y158(20.00)  LDD0259  [3]
IPM
 Probe Info  		C18(0.00); C163(0.00); C169(0.00); C102(0.00)  LDD0241  [2]
Probe 1
 Probe Info  		Y158(36.03)  LDD3495  [4]
BTD
 Probe Info  		C18(2.71); C163(1.88)  LDD1700  [5]
AHL-Pu-1
 Probe Info  		C67(2.41)  LDD0168  [6]
DBIA
 Probe Info  		C163(0.88)  LDD0078  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
IA-alkyne
 Probe Info  		C163(0.00); C18(0.00); C67(0.00)  LDD0032  [9]
IPIAA_H
 Probe Info  		C18(0.00); C163(0.00)  LDD0030  [10]
IPIAA_L
 Probe Info  		C102(0.00); C163(0.00); C18(0.00); C67(0.00)  LDD0031  [10]
ATP probe
 Probe Info  		N.A.  LDD0035  [11]
Compound 10
 Probe Info  		C102(0.00); C163(0.00); C169(0.00); C18(0.00)  LDD2216  [12]
Compound 11
 Probe Info  		C163(0.00); C169(0.00)  LDD2213  [12]
TFBX
 Probe Info  		C169(0.00); C18(0.00); C102(0.00)  LDD0148  [13]
Phosphinate-6
 Probe Info  		C33(0.00); C163(0.00); C18(0.00); C169(0.00)  LDD0018  [14]
AOyne
 Probe Info  		13.90  LDD0443  [15]
NAIA_5
 Probe Info  		C67(0.00); C18(0.00); C169(0.00); C33(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		5.80  LDD0475  [17]
STS-1
 Probe Info  		N.A.  LDD0136  [18]
STS-2
 Probe Info  		N.A.  LDD0138  [18]
VE-P
 Probe Info  		N.A.  LDD0396  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C18(1.03)  LDD2112  [5]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C18(0.81)  LDD2130  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C18(1.25); C163(1.04); C33(0.28)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C18(1.50); C163(1.32)  LDD2152  [5]
 LDCM0025  4SU-RNA HEK-293T C67(2.41)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C67(3.34)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C163(1.35); C169(0.70); C18(0.92)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C163(0.93); C169(0.73); C18(0.95)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C163(0.66); C169(0.87); C18(0.71)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C163(0.62); C169(0.85); C18(0.69)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C163(0.53); C169(0.93); C18(0.72)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C163(0.41); C169(0.97); C18(0.56)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C163(0.52); C169(1.21); C18(0.63)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C163(0.45); C169(0.89); C18(0.63)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C163(0.49); C169(0.91); C18(0.57)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C163(0.46); C169(1.25); C18(0.72)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C163(0.89); C169(0.86); C18(0.89)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C163(0.57); C169(1.27); C18(0.87)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C163(0.73); C169(0.79); C18(0.94)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C163(0.57); C169(0.94); C18(0.82)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C163(0.49); C169(1.08); C18(0.79)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C163(0.47); C169(0.96); C18(0.72)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C102(0.97); C163(1.07); C169(1.03); C18(0.99)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C102(0.56); C163(0.80); C169(1.11); C18(0.84)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C102(0.41); C163(0.64); C169(0.96); C18(0.80)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C102(0.37); C163(0.62); C169(0.85); C18(0.75)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C102(0.65); C163(0.86); C169(0.80); C18(0.88)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C102(0.75); C163(0.87); C169(0.85); C18(0.99)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C102(0.61); C163(0.84); C169(0.77); C18(0.89)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C163(1.57); C169(1.02); C18(1.05)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C102(0.60); C163(0.78); C169(1.34); C18(0.95)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C102(1.41); C163(0.90); C169(1.28); C18(1.01)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C102(0.81); C163(1.07); C169(1.03); C18(1.05)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C102(1.03); C163(1.24); C169(1.62); C18(1.06)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C102(1.09); C163(1.00); C169(1.07); C18(1.00)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C102(0.74); C163(0.87); C169(1.18); C18(1.04)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C102(0.45); C163(0.67); C169(1.22); C18(0.85)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C102(0.44); C163(0.73); C169(1.07); C18(0.89)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C163(0.69); C169(0.94); C18(0.70)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C163(0.89); C169(0.68); C18(0.91)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C163(0.84); C169(0.68); C18(0.75)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C163(0.94); C169(0.68); C18(0.85)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C163(0.84); C169(0.50); C18(0.81)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C163(0.80); C169(0.63); C18(0.75)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C163(0.61); C169(0.53); C18(0.68)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C163(0.56); C169(0.61); C18(0.72)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C163(0.79); C169(0.49); C18(0.81)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C163(0.81); C169(0.53); C18(0.86)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C163(0.53); C169(0.50); C18(0.78)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C163(0.55); C169(0.35); C18(0.71)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C163(1.27); C169(1.06); C18(0.98)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C163(0.51); C169(0.32); C18(0.71)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C163(0.56); C169(0.37); C18(0.73)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C163(1.14); C169(0.43); C18(0.98)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C102(0.71); C169(0.85); C163(0.94); C18(0.98)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C102(0.29); C18(0.74); C169(1.07); C163(1.08)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C102(0.51); C18(0.87); C169(0.91); C163(1.03)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C102(0.51); C169(0.76); C18(0.85); C163(0.98)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C102(0.26); C18(0.77); C169(0.85); C163(1.28)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C102(0.24); C169(0.82); C18(0.83); C163(1.17)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C102(0.35); C18(0.84); C169(0.86); C163(0.96)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C18(0.88); C163(0.89); C169(1.06)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C102(0.52); C169(0.71); C18(0.99); C163(1.46)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C169(0.78); C102(0.97); C163(0.99); C18(1.14)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C102(0.30); C169(0.81); C18(0.94); C163(0.94)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C102(0.24); C169(0.61); C163(0.94); C18(0.95)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C102(0.37); C163(0.89); C169(0.78); C18(0.87)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C102(0.36); C163(0.97); C169(0.74); C18(0.89)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C102(0.67); C163(1.12); C169(0.77); C18(1.14)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C102(0.78); C163(0.92); C169(0.60); C18(1.10)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C102(0.86); C169(0.87); C18(1.03); C163(1.04)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C18(0.76); C163(0.80); C102(0.91); C169(1.04)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C102(0.80); C169(0.84); C18(0.87); C163(1.02)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C169(0.53); C18(0.81); C163(1.18)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C18(0.93); C169(0.94); C163(0.97); C102(1.26)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C169(0.84); C163(0.93); C18(0.96); C102(1.00)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C169(0.82); C102(0.99); C18(1.04); C163(1.07)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C169(0.92); C18(0.93); C163(0.98); C102(1.09)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C163(0.89); C18(1.00); C169(1.05); C102(1.15)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C102(0.76); C18(1.12); C163(1.13); C169(1.18)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C102(0.71); C169(0.79); C163(1.02); C18(1.10)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C163(0.74); C102(0.81); C18(0.93); C169(0.94)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C102(0.76); C169(0.81); C163(0.84); C18(1.08)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C102(0.73); C163(0.76); C169(0.77); C18(0.95)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C169(0.54); C18(0.80); C163(1.46)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C163(0.66); C102(0.69); C169(0.76); C18(0.90)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C169(0.67); C102(0.72); C163(0.94); C18(0.99)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C169(0.53); C102(0.62); C163(0.63); C18(0.90)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C163(0.61); C102(0.77); C169(0.80); C18(0.92)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C163(0.60); C102(0.67); C169(0.73); C18(0.81)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C163(1.25); C102(1.28); C18(1.34); C169(1.59)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C163(1.10); C102(1.12); C18(1.40); C169(1.90)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C163(0.99); C102(1.26); C18(1.31); C169(1.70)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C102(1.06); C163(1.10); C18(1.20); C169(1.72)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C102(0.86); C163(0.99); C18(1.09); C169(1.57)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C169(0.52); C18(0.74); C163(1.36)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C102(0.80); C163(0.86); C18(0.97); C169(1.62)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C163(0.94); C102(1.00); C169(1.14); C18(1.18)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C102(0.84); C163(0.91); C18(0.94); C169(1.53)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C163(0.90); C102(1.06); C18(1.07); C169(1.28)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C102(0.84); C163(0.91); C18(0.98); C169(1.27)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C102(0.74); C163(0.91); C18(0.91); C169(1.18)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C169(0.87); C102(0.99); C163(1.00); C18(1.12)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C169(0.88); C163(0.93); C102(1.03); C18(1.17)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C169(0.84); C102(0.99); C163(1.14); C18(1.26)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C163(0.73); C169(0.78); C18(0.86); C102(0.88)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C169(0.48); C18(0.78); C163(1.23)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C163(0.64); C102(0.71); C18(0.93); C169(0.95)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C18(1.29); C163(1.39); C169(1.48); C102(1.54)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C102(0.84); C163(0.93); C169(1.03); C18(1.16)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C163(0.80); C102(0.85); C18(0.86); C169(0.93)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C163(0.77); C102(0.79); C18(0.89); C169(0.98)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C102(0.75); C169(0.80); C163(0.84); C18(0.84)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C163(0.70); C102(0.84); C169(0.88); C18(0.89)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C169(0.62); C18(0.64); C102(0.96); C163(1.21)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C18(0.65); C169(0.71); C102(0.91); C163(0.96)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C18(0.57); C169(0.63); C102(1.02); C163(1.15)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C169(0.85); C18(0.90); C163(1.02)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C18(0.68); C169(0.76); C102(0.86); C163(1.16)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C169(0.62); C18(0.79); C102(0.98); C163(1.24)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C169(0.63); C18(0.63); C102(1.00); C163(1.15)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C18(0.73); C169(0.73); C102(0.95); C163(1.07)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C169(0.57); C18(0.60); C102(1.16); C163(1.16)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C169(0.52); C18(0.60); C102(0.93); C163(0.97)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C169(0.59); C18(0.66); C163(0.85); C102(0.95)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C169(0.56); C18(0.57); C102(1.04); C163(1.07)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C163(1.03); C18(1.16); C169(1.64)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C163(0.83); C18(1.13); C169(1.88)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C169(0.91); C18(0.96); C163(1.11)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C163(0.82); C18(0.88); C169(1.24)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C18(1.08); C163(1.17); C169(1.86)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C163(0.84); C18(0.98); C169(1.13)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C163(0.71); C18(0.90); C169(1.21)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C163(0.79); C18(1.03); C169(1.54)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C163(0.78); C18(0.93); C169(1.11)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C163(0.84); C18(1.00); C169(1.46)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C163(0.78); C18(1.11); C169(1.51)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C163(1.11); C169(1.21); C18(1.28)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C163(0.90); C18(1.10); C169(1.18)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C169(0.90); C18(1.00); C163(1.07)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C163(1.04); C18(1.08); C169(1.50)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C169(1.29); C163(1.37); C18(1.52)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C163(0.86); C18(0.99); C169(1.24)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C169(0.53); C18(0.64); C163(0.86)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C169(0.62); C18(0.69); C163(0.81)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C169(0.55); C18(0.88); C163(0.94)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C169(0.59); C18(0.74); C163(0.75)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C169(0.51); C163(0.87); C18(1.03)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C169(0.57); C163(0.78); C18(0.83)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C169(0.52); C18(0.70); C163(0.86)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C169(0.36); C163(0.70); C18(1.01)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C169(0.62); C18(0.68); C163(0.98)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C169(0.48); C18(0.71); C163(1.06)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C169(0.52); C163(0.90); C18(0.96)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C169(0.41); C18(0.86); C163(1.06)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C169(0.55); C163(0.78); C18(0.96)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C169(0.42); C18(0.74); C163(1.04)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C169(0.48); C18(0.70); C163(0.79)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C163(0.38); C18(0.51); C169(0.75)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C169(0.71); C163(0.78); C18(0.82)  LDD0683  [7]
 LDCM0545  Acetamide MDA-MB-231 C163(0.47)  LDD2138  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C18(1.05)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C163(1.16); C169(0.90); C18(1.04)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C169(0.77); C18(0.93); C163(1.03)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C18(0.67); C163(0.81); C169(0.96)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 11.94  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C163(0.88)  LDD0078  [7]
 LDCM0498  BS-3668 MDA-MB-231 C18(0.97); C163(0.67)  LDD2091  [5]
 LDCM0632  CL-Sc Hep-G2 C18(1.27); C169(1.00)  LDD2227  [16]
 LDCM0367  CL1 HCT 116 C163(1.00); C18(1.02); C169(1.03)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C163(0.77); C169(0.84); C18(0.92)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C169(0.61); C18(0.84); C163(1.56)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C18(0.90); C163(1.07); C169(1.85)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C18(1.04); C163(1.09); C169(1.45)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C18(1.07); C169(1.23); C163(1.97)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C18(1.02); C169(1.12); C163(1.84)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C102(0.74); C18(0.79); C163(0.91); C169(0.91)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C102(0.45); C18(0.67); C163(0.82); C169(1.03)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C102(0.46); C18(0.69); C163(0.95); C169(0.98)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C102(0.42); C18(0.65); C169(0.79); C163(0.81)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C102(0.68); C18(0.80); C163(0.80); C169(0.83)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C169(0.70); C163(0.74); C18(0.95)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C169(0.50); C102(0.51); C18(0.62); C163(0.94)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C169(0.47); C163(0.85); C18(0.86); C102(0.87)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C102(0.81); C169(0.83); C18(1.04); C163(1.08)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C102(0.63); C169(0.65); C163(0.71); C18(0.92)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C102(0.61); C169(0.73); C163(0.75); C18(1.09)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C102(0.70); C163(0.71); C169(0.75); C18(0.97)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C163(0.74); C102(0.77); C169(0.77); C18(1.02)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C102(0.66); C163(0.74); C18(0.85); C169(2.07)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C102(0.82); C163(0.90); C18(1.06); C169(1.08)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C102(0.86); C169(0.98); C163(1.01); C18(1.02)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C163(0.76); C169(0.77); C18(0.78)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C163(0.93); C102(1.08); C18(1.11); C169(1.18)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C163(0.73); C102(0.85); C169(0.92); C18(1.15)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C163(0.78); C102(0.99); C18(1.03); C169(1.04)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C163(0.63); C102(0.70); C169(0.70); C18(0.81)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C163(0.76); C102(0.78); C169(0.82); C18(0.84)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C169(0.74); C102(0.88); C18(0.94); C163(1.16)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C163(0.85); C18(0.96); C102(1.04); C169(1.57)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C169(0.68); C18(0.93); C163(0.95); C102(1.05)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C169(0.56); C18(0.61); C102(0.84); C163(1.04)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C163(0.85); C18(0.87); C169(1.08)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C163(0.93); C169(1.01); C18(1.02)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C163(0.80); C18(0.86); C169(0.90)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C169(0.80); C163(0.95); C18(1.04)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C18(0.80); C169(0.97); C163(1.04)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C18(0.97); C169(1.24); C163(1.52)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C169(0.82); C18(0.86); C163(0.99)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C163(1.03); C18(1.12); C169(1.20)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C169(0.72); C163(0.90); C18(0.90)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C169(0.68); C163(0.69); C18(0.75)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C169(0.72); C163(0.93); C18(1.08)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C169(0.80); C163(0.95); C18(1.04)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C163(0.98); C169(0.60); C18(1.03)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C163(0.86); C169(0.56); C18(1.08)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C163(0.94); C169(0.73); C18(1.14)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C163(0.92); C169(0.63); C18(1.12)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C163(1.01); C169(0.68); C18(1.08)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C163(0.90); C169(0.74); C18(1.18)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C163(0.96); C169(1.20); C18(1.12)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C163(1.13); C169(0.99); C18(1.24)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C102(20.00); C163(0.80); C169(0.73); C18(1.06)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C102(0.93); C163(0.77); C169(0.79); C18(1.13)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C102(0.48); C163(0.68); C169(0.58); C18(0.81)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C102(0.52); C163(0.61); C169(0.77); C18(0.92)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C102(0.64); C163(0.67); C169(0.68); C18(0.83)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C102(0.76); C163(0.61); C169(1.17); C18(0.84)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C102(0.46); C163(0.70); C169(0.82); C18(0.73)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C102(0.42); C163(0.70); C169(0.83); C18(0.94)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C163(0.77); C169(0.78); C18(0.90)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C102(0.46); C163(0.57); C169(0.64); C18(0.80)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C102(0.61); C163(0.71); C169(1.23); C18(1.05)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C102(0.52); C163(0.73); C169(1.27); C18(0.93)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C102(0.49); C163(0.74); C169(1.12); C18(0.89)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C102(0.53); C163(0.78); C169(0.95); C18(0.89)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C102(0.55); C163(0.66); C169(0.56); C18(0.89)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C163(1.21); C169(0.60); C18(1.06)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C163(0.96); C169(0.73); C18(1.24)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C163(1.28); C169(1.12); C18(1.43)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C163(1.20); C169(0.63); C18(1.05)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C163(0.85); C169(1.11); C18(1.01)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C163(1.18); C169(1.00); C18(1.27)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C163(0.97); C169(0.53); C18(1.06)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C163(0.74); C169(0.76); C18(1.00)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C163(1.08); C169(2.25); C18(1.07)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C163(1.32); C169(1.18); C18(1.01)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C163(1.28); C169(1.10); C18(0.97)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C163(1.03); C169(1.38); C18(1.11)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C163(1.00); C169(1.08); C18(0.83)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C163(1.23); C169(1.01); C18(0.87)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C163(1.30); C169(0.88); C18(0.94)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C163(0.87); C169(0.89); C18(0.95)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C163(1.38); C169(0.80); C18(0.97)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C102(0.81); C163(1.05); C169(1.14); C18(0.94)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C102(0.71); C163(1.00); C169(1.30); C18(0.91)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C102(0.99); C163(0.93); C169(1.51); C18(0.86)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C102(0.88); C163(0.80); C169(1.35); C18(0.72)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C102(0.93); C163(1.02); C169(1.41); C18(0.91)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C102(1.05); C163(0.74); C169(1.27); C18(0.68)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C102(0.93); C163(0.93); C169(2.80); C18(0.86)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C102(0.98); C163(0.83); C169(1.72); C18(0.80)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C102(0.95); C163(1.30); C169(1.41); C18(0.92)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C163(0.90); C169(0.80); C18(0.88)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C102(1.01); C163(0.82); C169(1.10); C18(0.99)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C102(0.76); C163(0.85); C169(1.30); C18(0.81)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C102(0.96); C163(1.01); C169(1.27); C18(0.89)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C102(0.93); C163(0.79); C169(1.40); C18(0.71)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C102(0.85); C163(0.85); C169(1.75); C18(0.78)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C163(0.90); C169(1.05); C18(0.85)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C163(0.68); C169(1.01); C18(0.92)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C163(0.82); C169(0.83); C18(0.80)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C163(0.79); C169(0.95); C18(0.56)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C163(0.60); C169(0.82); C18(0.68)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C163(1.30); C169(0.86); C18(0.93)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C163(0.80); C169(0.83); C18(0.73)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C163(0.66); C169(1.07); C18(0.59)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C163(0.85); C169(0.98); C18(0.52)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C163(0.84); C169(1.13); C18(0.60)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C163(0.76); C169(1.03); C18(0.75)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C163(2.04); C169(1.16); C18(0.93)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C163(0.75); C169(1.08); C18(0.64)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C163(0.75); C169(1.42); C18(0.61)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C163(0.86); C169(1.01); C18(0.64)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C163(0.89); C169(0.75); C18(0.89)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C163(0.68); C169(0.83); C18(0.72)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C163(0.84); C169(0.84); C18(0.85)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C163(1.20); C169(1.05); C18(0.81)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C163(1.68); C169(0.86); C18(0.85)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C163(1.26); C169(0.83); C18(0.83)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C163(1.45); C169(0.66); C18(0.72)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C163(1.71); C169(0.70); C18(0.89)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C163(1.27); C169(0.61); C18(0.84)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C163(1.23); C169(0.54); C18(0.73)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C163(1.48); C169(0.57); C18(0.83)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C163(0.97); C169(0.90); C18(0.89); C102(0.99)  LDD1698  [20]
 LDCM0625  F8 Ramos C18(0.83); C169(1.88)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C18(0.40); C169(0.26)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C18(2.23); C169(0.39)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C18(0.56); C169(0.11)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C18(1.00)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C18(0.31); C169(0.43)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C18(0.39); C169(0.09)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C18(0.73); C169(0.14)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C18(0.62); C169(0.28)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C18(0.82); C169(0.37)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C18(1.03); C169(1.46)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C18(0.74); C169(0.19)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C18(0.81); C169(0.33)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C18(0.45); C169(0.08)  LDD2201  [21]
 LDCM0468  Fragment33 HCT 116 C102(0.94); C163(0.98); C169(1.14); C18(0.87)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C18(1.28)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C18(0.67); C169(0.71)  LDD2184  [21]
 LDCM0427  Fragment51 HCT 116 C102(0.78); C163(0.54); C169(0.84); C18(0.69)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C18(0.99); C169(0.28)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C18(0.80); C169(0.15)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C18(0.59); C169(0.36)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C18(0.38); C169(0.07)  LDD2188  [21]
 LDCM0022  KB02 HCT 116 C18(1.06); C102(1.01); C163(1.23)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C18(1.64); C102(1.29); C163(1.96)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C18(1.54); C102(1.16); C163(1.15)  LDD0082  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C33(0.09)  LDD2121  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C18(1.36); C163(1.21); C33(0.23)  LDD2093  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C18(0.46); C33(0.86)  LDD2096  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C18(0.61); C33(0.80)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C18(1.24); C163(0.99); C33(0.36)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C18(0.45)  LDD2100  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C33(0.68)  LDD2104  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C18(1.55); C163(1.10); C33(0.53)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C18(0.48)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C18(0.75); C163(0.83); C33(0.22); C169(1.47)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C163(1.12); C33(0.30)  LDD2111  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C33(0.80)  LDD2116  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C33(0.75)  LDD2118  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C18(1.80)  LDD2119  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C18(0.77)  LDD2120  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C33(0.82)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C18(0.87); C163(1.00); C169(1.25)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C18(0.94); C163(0.86)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C18(1.13); C163(1.20); C33(0.42)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C18(0.89)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C18(1.49); C163(1.30); C33(0.21)  LDD2129  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C18(0.84)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C18(2.05); C163(1.45); C33(0.44)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C18(1.76); C163(1.16)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C18(0.91); C163(0.94)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C18(2.71); C163(1.88)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C18(1.05); C163(0.84)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C18(0.28); C33(0.89)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C18(0.76)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C18(1.40)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C18(1.22); C163(1.05); C33(0.19)  LDD2146  [5]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C18(1.46)  LDD2147  [5]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C33(0.99)  LDD2149  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C163(0.57); C33(0.05)  LDD2150  [5]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C33(0.98)  LDD2151  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C18(3.23)  LDD2206  [22]
 LDCM0628  OTUB2-COV-1 HEK-293T C18(1.09)  LDD2207  [22]
 LDCM0131  RA190 MM1.R C67(1.16); C102(1.05)  LDD0304  [23]
 LDCM0021  THZ1 HCT 116 C18(0.97); C163(1.56); C169(0.84)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carnosine N-methyltransferase (CARNMT1) Carnosine N-methyltransferase family Q8N4J0
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (JMJD6) JMJD6 family Q6NYC1
SRSF protein kinase 1 (SRPK1) CMGC Ser/Thr protein kinase family Q96SB4
SRSF protein kinase 2 (SRPK2) CMGC Ser/Thr protein kinase family P78362
Dual specificity protein kinase CLK2 (CLK2) CMGC Ser/Thr protein kinase family P49760
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-2 complex subunit beta (AP2B1) Adaptor complexes large subunit family P63010
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
Keratin, type II cytoskeletal 1 (KRT1) Intermediate filament family P04264
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
NF-kappa-B-activating protein (NKAP) NKAP family Q8N5F7
Serine/arginine repetitive matrix protein 4 (SRRM4) NSR100 family A7MD48
Serine/arginine-rich splicing factor 1 (SRSF1) Splicing factor SR family Q07955
Serine/arginine-rich splicing factor 2 (SRSF2) Splicing factor SR family Q01130
Serine/arginine-rich splicing factor 3 (SRSF3) Splicing factor SR family P84103
Splicing factor U2AF 65 kDa subunit (U2AF2) Splicing factor SR family P26368
Transformer-2 protein homolog beta (TRA2B) Splicing factor SR family P62995
Corepressor interacting with RBPJ 1 (CIR1) . Q86X95
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
SAP domain-containing ribonucleoprotein (SARNP) . P82979
Splicing factor 3B subunit 2 (SF3B2) . Q13435

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
19 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
23 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.