Details of the Target

General Information of Target

Target ID LDTP02612
Target Name Nucleoprotein TPR (TPR)
Gene Name TPR
Gene ID 7175
Synonyms
Nucleoprotein TPR; Megator; NPC-associated intranuclear protein; Translocated promoter region protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKR
LSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL
EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE
KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM
NGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS
NELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLL
SATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN
KYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSS
VLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSY
RNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQ
MQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVI
ESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDF
ASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVR
AENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQ
IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKE
IATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTS
NVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQD
DKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQN
KYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKD
EVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEIL
RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHE
ELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGM
LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKA
EIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRR
YKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENL
QKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAA
KSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREH
QERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSK
VTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPV
FGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEV
VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLK
SVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQGDYTPMEDSEETSQSLQIDL
GPLQSDQQTTTSSQDGQGKGDDVIVIDSDDEEEDDDENDGEHEDYEEDEEDDDDDEDDTG
MGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAADSQNSGEG
NTGAAESSFSQEVSREQQPSSASERQAPRAPQSPRRPPHPLPPRLTIHAPPQELGPPVQR
IQMTRRQSVGRGLQLTPGIGGMQQHFFDDEDRTVPSTPTLVVPHRTDGFAEAIHSPQVAG
VPRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYETPLFLAHEEESGGRSVPTTPLQVAA
PVTVFTESTTSDASEHASQSVPMVTTSTGTLSTTNETATGDDGDEVFVEAESEGISSEAG
LEIDSQQEEEPVQASDESDLPSTSQDPPSSSSVDTSSSQPKPFRRVRLQTTLRQGVRGRQ
FNRQRGVSHAMGGRGGINRGNIN
Target Bioclass
Transporter and channel
Family
TPR family
Subcellular location
Nucleus
Function
Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export. Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases.
Uniprot ID
P12270
Ensemble ID
ENST00000367478.9
HGNC ID
HGNC:12017

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.L222R; p.R1749S DBIA    Probe Info 
CAL148 SNV: p.R1407K DBIA    Probe Info 
COLO320 SNV: p.T1822N DBIA    Probe Info 
EFO21 SNV: p.L767F .
FTC133 SNV: p.D612G DBIA    Probe Info 
HCC1419 SNV: p.Q1517R DBIA    Probe Info 
HCC15 SNV: p.L1186F DBIA    Probe Info 
HCT15 SNV: p.R179Ter; p.L1625I .
HEC1 SNV: p.I101N DBIA    Probe Info 
HT115 SNV: p.I678M; p.E1577Ter .
HUH7 SNV: p.E1247D DBIA    Probe Info 
IGR1 SNV: p.E912K DBIA    Probe Info 
IM95 Insertion: p.D2128Ter DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.G2000C DBIA    Probe Info 
J82 SNV: p.K877E DBIA    Probe Info 
JHH7 SNV: p.L791F .
JURKAT Deletion: p.F2127LfsTer65 Compound 10    Probe Info 
KYSE150 SNV: p.G2360V DBIA    Probe Info 
KYSE510 SNV: p.T716I DBIA    Probe Info 
LS513 SNV: p.S1824G .
MCC13 SNV: p.K153R DBIA    Probe Info 
MDAMB231 SNV: p.D1959Y .
MFE319 SNV: p.T750A DBIA    Probe Info 
NCIH1048 SNV: p.Y682H DBIA    Probe Info 
NCIH2052 SNV: p.E1281K DBIA    Probe Info 
NCIH358 Deletion: p.K1549RfsTer10
SNV: p.K1549Ter		 DBIA    Probe Info 
NCIH716 SNV: p.K956R .
REH SNV: p.T1677A; p.T2315A DBIA    Probe Info 
SHP77 Substitution: p.D936Y DBIA    Probe Info 
SKMEL30 Deletion: p.A2045del DBIA    Probe Info 
WM793 SNV: p.D1593E DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		2.49  LDD0215  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
W1
 Probe Info  		13.89  LDD0235  [3]
TH211
 Probe Info  		Y682(14.16); Y422(9.56); Y735(9.53)  LDD0257  [4]
TH216
 Probe Info  		Y422(20.00); Y682(9.79)  LDD0259  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [5]
Probe 1
 Probe Info  		Y54(23.41); Y140(66.40); Y289(37.93); Y725(11.78)  LDD3495  [6]
AHL-Pu-1
 Probe Info  		C1149(2.87)  LDD0168  [7]
HHS-475
 Probe Info  		Y422(0.61); Y965(0.87); Y735(0.89); Y402(1.19)  LDD0264  [8]
HHS-465
 Probe Info  		Y402(3.04); Y735(9.04)  LDD2237  [9]
DBIA
 Probe Info  		C1127(0.92)  LDD0078  [10]
5E-2FA
 Probe Info  		H327(0.00); H191(0.00); H629(0.00); H2088(0.00)  LDD2235  [11]
ATP probe
 Probe Info  		K854(0.00); K1571(0.00); K315(0.00); K260(0.00)  LDD0199  [12]
m-APA
 Probe Info  		H2125(0.00); H629(0.00); H2088(0.00); H2154(0.00)  LDD2231  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1127(0.00); C1068(0.00); C224(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
Lodoacetamide azide
 Probe Info  		C1127(0.00); C224(0.00); C1068(0.00)  LDD0037  [13]
BTD
 Probe Info  		N.A.  LDD0004  [15]
TFBX
 Probe Info  		N.A.  LDD0027  [16]
WYneO
 Probe Info  		N.A.  LDD0022  [15]
1d-yne
 Probe Info  		K390(0.00); K1037(0.00)  LDD0356  [17]
Compound 10
 Probe Info  		N.A.  LDD2216  [18]
Compound 11
 Probe Info  		N.A.  LDD2213  [18]
ENE
 Probe Info  		N.A.  LDD0006  [15]
IPM
 Probe Info  		C1127(0.00); C224(0.00)  LDD0005  [15]
NHS
 Probe Info  		K421(0.00); K748(0.00); K1571(0.00); K773(0.00)  LDD0010  [15]
SF
 Probe Info  		N.A.  LDD0028  [19]
STPyne
 Probe Info  		K854(0.00); K1571(0.00); K433(0.00); K723(0.00)  LDD0009  [15]
VSF
 Probe Info  		C1127(0.00); C224(0.00)  LDD0007  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [20]
1c-yne
 Probe Info  		K1248(0.00); K1128(0.00); K351(0.00); K366(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		H1341(0.00); H1160(0.00); H276(0.00); H1112(0.00)  LDD0217  [21]
Crotonaldehyde
 Probe Info  		C1068(0.00); C1127(0.00); H743(0.00); H1341(0.00)  LDD0219  [21]
Methacrolein
 Probe Info  		N.A.  LDD0218  [21]
NAIA_5
 Probe Info  		C1127(0.00); C1149(0.00); C224(0.00); C1068(0.00)  LDD2223  [22]
HHS-482
 Probe Info  		Y965(0.82)  LDD2239  [9]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [23]
FFF probe14
 Probe Info  		20.00  LDD0477  [23]
FFF probe2
 Probe Info  		9.02  LDD0463  [23]
FFF probe3
 Probe Info  		20.00  LDD0464  [23]
FFF probe6
 Probe Info  		5.02  LDD0467  [23]
JN0003
 Probe Info  		12.86  LDD0469  [23]
VE-P
 Probe Info  		N.A.  LDD0396  [24]
EN
 Probe Info  		1.51  LDD0418  [25]
OEA-DA
 Probe Info  		4.18  LDD0046  [26]
STS-1
 Probe Info  		N.A.  LDD0068  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C224(0.79); C75(0.29)  LDD2142  [28]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C224(0.91)  LDD2112  [28]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C224(1.16); C1127(1.23); C75(0.96)  LDD2117  [28]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C224(1.12); C1127(1.42); C1068(1.56); C75(2.17)  LDD2152  [28]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C224(0.86); C1127(0.80); C1068(0.68)  LDD2103  [28]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1068(0.35)  LDD2132  [28]
 LDCM0025  4SU-RNA HEK-293T C1149(2.87)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C224(2.54); C1149(2.42); C1127(2.53)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C1068(0.71); C1127(1.11)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C1068(0.80); C1127(1.22); C224(0.34)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C1068(0.92); C1127(0.92)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C1068(0.38); C1127(0.92)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C1068(0.33); C1127(0.92)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C1068(0.35); C1127(1.12)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C1068(0.33); C1127(1.01)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C1068(0.47); C1127(1.01)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C1068(0.47); C1127(1.09)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C1068(0.28); C1127(1.12)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C1068(0.26); C1127(0.88)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C1068(0.25); C1127(0.76)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C1068(0.67); C1127(1.11); C224(0.25)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C1068(0.27); C1127(0.80)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C1068(0.23); C1127(0.85)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C1068(0.37); C1127(0.94)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C1068(1.04); C1127(0.99); C224(0.83)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C1068(1.18); C1127(1.22); C224(1.29)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C1068(1.17); C1127(1.41); C224(1.16)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C1068(1.39); C1127(1.37); C224(1.17)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C1068(1.33); C1127(1.27); C224(1.05)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C1068(1.24); C1127(1.17); C224(1.06)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C1068(1.17); C1127(1.26); C224(1.25)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C1068(0.70); C1127(0.99); C224(0.24)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C1068(1.13); C1127(1.13); C224(1.11)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C1068(1.16); C1127(1.14); C224(0.90)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C1068(1.03); C1127(1.25); C224(1.07)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C1068(1.08); C1127(0.97); C224(0.88)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C1068(0.90); C1127(1.03); C224(0.90)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C1068(1.14); C1127(1.13); C224(1.02)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C1068(1.11); C1127(1.43); C224(1.09)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C1068(1.36); C1127(1.24); C224(1.09)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C1068(1.24); C1127(1.14)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C1068(1.12); C1127(0.92)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C1068(0.95); C1127(0.99)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C1068(0.74); C1127(0.75)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C1068(0.86); C1127(0.71)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C1068(0.88); C1127(1.00)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C1068(1.01); C1127(0.87)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C1068(1.15); C1127(1.10)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C1068(0.95); C1127(0.91)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C1068(0.79); C1127(0.87)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C1068(0.97); C1127(0.86)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C1068(1.09); C1127(0.89)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C1068(0.74); C1127(1.06); C224(0.38)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C1068(0.90); C1127(0.84)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C1068(0.93); C1127(0.99)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C1068(0.83); C1127(0.89)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C1068(1.10); C1127(1.14)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C1127(1.22); C1068(1.44)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C1068(1.32); C1127(1.35)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C1068(1.40); C1127(1.67)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C1127(1.27); C1068(1.60)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C1127(1.74); C1068(1.85)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C1127(1.42); C1068(1.50)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C224(0.39); C1068(0.70); C1127(1.19)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C1127(1.14); C1068(1.22)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C1127(1.23); C1068(1.35)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C1068(1.28); C1127(1.28)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C1068(1.71); C1127(1.98)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C1068(1.49); C1127(1.35)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C1068(1.38); C1127(1.62)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C1068(1.11); C1127(1.29)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C1068(1.10); C1127(1.11)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C1127(1.00); C1068(1.13)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C1127(0.78); C1068(1.16)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C1127(0.85); C1068(1.03)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C1068(0.73); C1127(0.88)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C1127(1.07); C1068(1.12)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C1127(0.96); C1068(1.53)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C1127(1.09); C1068(1.16)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C1068(0.98); C1127(1.01)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C1068(0.93); C1127(1.00)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C1127(0.91); C224(1.02); C1068(1.20)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C1127(1.04); C224(1.04); C1068(1.26)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C224(0.99); C1127(1.00); C1068(1.28)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C224(0.91); C1127(1.03); C1068(1.32)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C224(1.14); C1068(1.25); C1127(1.26)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C1068(0.83); C1127(0.99)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C224(1.17); C1068(1.21); C1127(1.34)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C1127(0.98); C224(1.06); C1068(1.15)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C224(1.21); C1127(1.38); C1068(1.55)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C1127(1.07); C224(1.15); C1068(1.48)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C1127(1.18); C224(1.41); C1068(1.57)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C1127(0.83); C1068(0.97)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C1127(0.98); C1068(1.07)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C1127(0.95); C1068(1.09)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C1068(1.04); C1127(1.24)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C1127(1.09); C1068(1.16)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C1068(0.77); C1127(1.17)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C1127(1.09); C1068(1.24)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C1068(0.97); C1127(1.20)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C1068(0.97); C1127(1.17)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C1068(0.93); C1127(1.25)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C1068(0.91); C1127(1.11)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C1127(1.20); C1068(1.22)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C1068(0.93); C1127(1.06)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C1068(1.02); C1127(1.16)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C1068(0.91); C1127(1.08)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C1068(1.29); C1127(2.05)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C1068(0.86); C1127(1.19)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C1068(0.94); C1127(1.97)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C1068(0.76); C1127(0.97)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C1068(0.89); C1127(1.14)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C1068(0.91); C1127(1.46)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C1068(0.89); C1127(1.45)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C1068(1.02); C1127(1.80)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C1068(1.45); C1127(2.84)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C1127(1.35); C1068(1.66)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C1068(1.39); C1127(1.44)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C1127(1.29); C1068(1.46)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C224(0.93); C1068(0.98); C1127(1.26)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C1127(1.19); C1068(1.52)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C1068(1.21); C1127(1.26)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C1127(1.50); C1068(1.59)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C1127(1.38); C1068(1.40)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C1127(1.35); C1068(1.52)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C1068(0.86); C1127(0.96)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C1068(0.82); C1127(0.89)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C1068(0.99); C1127(1.12)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C1127(1.15); C1068(1.21)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C1127(1.33); C1068(1.38)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C224(0.80); C1068(0.93); C1127(1.04)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C1127(1.46); C1068(1.57)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C1127(1.09); C1068(1.24)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C1068(1.23); C1127(1.53)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C1127(1.58); C1068(1.61)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C1127(1.43); C1068(1.47)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C1127(1.61); C1068(2.11)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C1127(1.22); C1068(1.30)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C1068(1.30); C1127(1.54)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C1127(1.25); C1068(1.36)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C1068(1.06); C1127(1.34)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C1068(0.96); C224(1.10); C1127(1.20)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C1068(1.22); C1127(1.27)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C1068(1.10); C1127(1.12)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C1127(1.64); C1068(1.86)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C1068(1.11); C1127(1.35); C224(2.35)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C1068(1.10); C1127(1.20); C224(1.63)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C1068(1.08); C1127(1.15); C224(1.21)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C1068(0.88); C1127(1.22); C224(1.30)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C1068(0.84); C224(0.88); C1127(1.06)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C1068(0.88); C1127(1.07); C224(1.27)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C1068(1.08); C1127(1.14); C224(1.52)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C224(0.71); C1068(0.93); C1127(1.16)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C1068(1.22); C1127(1.38); C224(2.23)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C1068(1.25); C1127(1.27); C224(1.48)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C1068(0.93); C224(1.13); C1127(1.30)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C224(1.21); C1068(1.36); C1127(1.40)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C224(0.92); C1068(1.09); C1127(1.10)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C1068(1.32); C1127(1.36); C224(1.37)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C1068(0.96); C1127(1.25); C224(1.51)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C1068(0.31); C1127(1.55)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C1068(0.42); C1127(0.87)  LDD0683  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C224(0.80); C1127(0.79); C1068(0.84); C75(0.79)  LDD2113  [28]
 LDCM0248  AKOS034007472 HCT 116 C1068(0.70); C1127(0.98); C224(0.39)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C224(0.46); C1068(0.85); C1127(1.13)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C224(0.47); C1068(0.89); C1127(1.99)  LDD0592  [10]
 LDCM0020  ARS-1620 HCC44 C1127(0.92)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C1068(0.31)  LDD2091  [28]
 LDCM0108  Chloroacetamide HeLa H276(0.00); H1341(0.00); C1127(0.00); H282(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C1068(1.34); C224(0.94)  LDD2227  [22]
 LDCM0367  CL1 HCT 116 C1068(0.92); C1127(0.97)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C1068(1.28); C1127(1.60)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C1068(0.72); C1127(1.31)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C1068(0.82); C224(1.05); C1127(1.19)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C224(0.60); C1068(0.67); C1127(0.95)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C224(0.53); C1068(0.69); C1127(0.95)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C224(0.64); C1068(0.70); C1127(1.06)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C1127(1.05); C1068(1.29)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C1127(0.90); C1068(1.66)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C1127(1.08); C1068(1.60)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C1127(1.00); C1068(1.54)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C1127(0.99); C1068(1.26)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C1068(1.52); C1127(1.78)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C1127(0.87); C1068(1.39)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C1127(0.94); C1068(1.16)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C1127(0.93); C1068(1.00); C224(1.10)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C1127(1.24); C1068(1.40); C224(1.61)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C1068(1.02); C1127(1.23); C224(1.60)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C224(1.12); C1068(1.20); C1127(1.22)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C224(1.15); C1068(1.23); C1127(1.25)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C1127(1.17); C1068(2.10)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C1068(1.09); C1127(1.23)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C1068(1.12); C1127(1.32)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C1127(1.81); C1068(2.39)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C1068(1.01); C1127(1.15)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C1068(0.78); C1127(1.04)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C1068(0.96); C1127(1.14)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C1068(0.96); C1127(1.41)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C1068(1.02); C1127(1.60)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C1068(0.97); C1127(1.15)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C1127(1.11); C1068(1.27)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C1068(0.85); C1127(1.20)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C1127(1.43); C1068(1.52)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C1127(1.27); C1068(1.28)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C1127(0.94); C1068(1.08)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C1068(1.07); C1127(1.25)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C1068(1.15); C1127(1.18); C224(1.44)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C1068(0.92); C1127(0.99); C224(1.56)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C1127(1.17); C1068(1.19); C224(1.68)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C1068(1.25); C1127(1.29); C224(1.58)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C1127(0.89); C1068(0.92)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C1127(1.45); C224(1.51); C1068(1.56)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C1127(1.56); C1068(1.71); C224(1.99)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C224(1.92); C1127(2.89); C1068(3.95)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C224(1.22); C1127(1.55); C1068(1.60)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C1068(2.16); C1127(1.99); C224(1.68)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C1068(1.51); C1127(1.60); C224(1.50)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C1068(1.29); C1127(1.39); C224(1.45)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C1068(1.37); C1127(1.49); C224(1.51)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C1068(1.47); C1127(1.44); C224(1.57)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C1068(2.10); C1127(1.54); C224(1.54)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C1068(0.87); C1127(0.93)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C1068(1.27); C1127(1.10); C224(1.18)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C1068(1.23); C1127(1.28)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C1068(1.38); C1127(1.27)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C1068(1.12); C1127(1.05)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C1068(1.69); C1127(1.54)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C1068(1.82); C1127(1.57)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C1068(1.26); C1127(1.30)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C1068(1.93); C1127(1.64)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C1068(2.01); C1127(1.48)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C1068(1.11); C1127(1.00)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C1068(1.45); C1127(1.40)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C1068(1.40); C1127(1.34)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C1068(3.10); C1127(2.51)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C1068(2.34); C1127(1.78)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C1068(2.09); C1127(1.58)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C1068(1.97); C1127(1.87)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C1068(0.75); C1127(1.14)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C1068(0.96); C1127(1.16)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C1068(0.81); C1127(1.19)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C1068(0.78); C1127(0.95)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C1068(1.27); C1127(1.15)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C1068(0.73); C1127(1.01)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C1068(0.79); C1127(1.03)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C1068(0.74); C1127(1.05)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C1068(0.82); C1127(0.94)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C1068(0.83); C1127(1.27)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C1068(0.66); C1127(1.00)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C1068(0.83); C1127(1.20)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C1068(0.81); C1127(1.06)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C1068(0.88); C1127(1.08)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C1068(0.68); C1127(0.93)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C1068(1.03); C1127(1.03)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C1068(0.79); C1127(1.17)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C1068(1.01); C1127(1.10); C224(0.81)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C1068(1.13); C1127(1.33); C224(0.81)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C1068(1.19); C1127(1.32); C224(1.00)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C1068(1.20); C1127(1.81); C224(0.72)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C1068(0.99); C1127(1.29); C224(0.80)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C1068(1.51); C1127(2.22); C224(0.79)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C1068(1.33); C1127(1.52); C224(0.99)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C1068(1.15); C1127(1.37); C224(1.87)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C1068(0.88); C1127(1.13); C224(0.86)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C1068(1.24); C1127(1.29)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C1068(0.98); C1127(1.29); C224(1.19)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C1068(1.06); C1127(1.47); C224(1.00)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C1068(1.04); C1127(1.33); C224(1.02)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C1068(1.05); C1127(1.33); C224(1.13)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C1068(1.19); C1127(1.46); C224(1.02)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C1068(0.99); C1127(0.97)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C1068(0.98); C1127(1.24)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C1068(1.64); C1127(1.47)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C1068(1.82); C1127(1.22)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C1068(1.70); C1127(1.63)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C1068(0.80); C1127(1.08)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C1068(0.88); C1127(1.01)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C1068(1.42); C1127(1.67)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C1068(1.66); C1127(1.12)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C1068(2.02); C1127(1.61)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C1068(0.93); C1127(0.91)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C1068(0.84); C1127(0.81)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C1068(0.83); C1127(0.94)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C1068(1.17); C1127(1.20)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C1068(2.14); C1127(1.93)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C1068(1.23); C1127(1.29)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C1068(0.74); C1127(0.79)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C1068(1.04); C1127(1.23)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C1068(1.05); C1127(1.16)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C1068(0.87); C1127(1.13)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C1068(0.91); C1127(1.31)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C1068(0.77); C1127(1.36)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C1068(0.94); C1127(1.25)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C1068(0.74); C1127(0.99)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C1068(0.88); C1127(1.41)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C1068(0.80); C1127(1.15)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C1068(0.91); C1127(0.94); C224(0.97)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1127(1.07); C224(0.49)  LDD1702  [28]
 LDCM0163  Entinostat Hep-G2 1.51  LDD0418  [25]
 LDCM0572  Fragment10 Ramos C1068(0.36)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C224(1.73)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C1068(0.33)  LDD2191  [30]
 LDCM0576  Fragment14 Ramos C224(1.23)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C1068(0.32)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C1068(1.41)  LDD2195  [30]
 LDCM0590  Fragment32 Ramos C1068(0.55)  LDD2201  [30]
 LDCM0468  Fragment33 HCT 116 C1068(1.15); C1127(1.56); C224(1.10)  LDD0785  [10]
 LDCM0566  Fragment4 Ramos C1068(2.02); C224(0.94)  LDD2184  [30]
 LDCM0427  Fragment51 HCT 116 C1068(3.05); C1127(2.40)  LDD0744  [10]
 LDCM0569  Fragment7 Ramos C224(0.84)  LDD2186  [30]
 LDCM0116  HHS-0101 DM93 Y422(0.61); Y965(0.87); Y735(0.89); Y402(1.19)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y422(0.39); Y965(0.71); Y735(0.81); Y402(0.98)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y422(0.74); Y965(0.95); Y402(1.01); Y735(1.32)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y402(0.82); Y965(0.94); Y735(1.00); Y422(1.22)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y965(0.58); Y735(0.74); Y402(1.03); Y422(1.85)  LDD0268  [8]
 LDCM0107  IAA HeLa H629(0.00); H907(0.00); H1112(0.00); H276(0.00)  LDD0221  [21]
 LDCM0022  KB02 HCT 116 C1127(1.53)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C1127(1.27)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C1127(1.48)  LDD0082  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C224(0.84); C1127(0.93); C1068(0.73)  LDD2102  [28]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C224(0.46); C1127(1.04); C1068(0.32)  LDD2121  [28]
 LDCM0109  NEM HeLa H191(0.00); H629(0.00); H282(0.00); H253(0.00)  LDD0223  [21]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C1127(0.88); C1068(0.36)  LDD2089  [28]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C224(1.13); C1068(1.15)  LDD2090  [28]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C224(0.93); C1068(0.77)  LDD2092  [28]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C224(0.98); C1127(0.91); C1068(0.55)  LDD2093  [28]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C224(1.07); C1127(2.45); C1068(1.96)  LDD2094  [28]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C224(3.43); C1068(0.77)  LDD2096  [28]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C1068(0.99)  LDD2097  [28]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C224(1.02); C1127(0.55); C1068(0.52)  LDD2098  [28]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C224(0.95); C1127(0.98); C1068(0.72); C75(1.00)  LDD2099  [28]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C224(0.70); C1127(0.23); C1068(0.38); C75(0.31)  LDD2100  [28]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1127(1.09); C1068(1.05); C75(1.13)  LDD2101  [28]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C224(0.84); C1127(0.26); C1068(0.50)  LDD2104  [28]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C224(1.43); C1127(0.99); C1068(1.35); C75(1.35)  LDD2105  [28]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C224(0.58)  LDD2106  [28]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C224(1.17); C1127(0.84); C1068(0.97); C75(0.91)  LDD2107  [28]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C224(0.67); C1127(0.28); C1068(0.32)  LDD2108  [28]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C224(0.88); C1127(0.88); C1068(0.60)  LDD2109  [28]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C224(1.33); C1127(0.65)  LDD2110  [28]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C224(1.04); C1127(1.42); C1068(0.71)  LDD2111  [28]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C224(0.73); C1068(0.43); C75(0.36)  LDD2114  [28]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C1127(0.38); C1068(0.34)  LDD2115  [28]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C224(1.85); C1068(0.79)  LDD2116  [28]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C224(3.06); C1068(0.76)  LDD2118  [28]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1068(1.80); C75(1.94)  LDD2119  [28]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C224(0.82); C1068(0.84)  LDD2120  [28]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C224(3.19); C1068(0.84)  LDD2122  [28]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C224(0.75); C1127(0.82); C1068(0.55)  LDD2123  [28]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C224(1.29); C1068(0.68)  LDD2124  [28]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1127(0.89); C1068(0.66); C75(0.89)  LDD2125  [28]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C224(2.78); C1068(0.31)  LDD2126  [28]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1127(0.99); C1068(1.02); C75(1.27)  LDD2127  [28]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1068(0.70)  LDD2128  [28]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C224(0.79); C1127(0.79); C1068(0.44)  LDD2129  [28]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1068(0.37); C75(0.51)  LDD2133  [28]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C224(0.63); C1127(0.47); C1068(0.49); C75(0.46)  LDD2134  [28]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C224(0.69); C1127(1.58); C1068(0.53); C75(1.19)  LDD2135  [28]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C224(1.18); C1068(0.90)  LDD2136  [28]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C224(0.95); C1068(1.13); C75(1.03)  LDD2137  [28]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C224(1.01); C1068(0.99)  LDD1700  [28]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C224(0.81); C1127(0.83); C1068(0.50); C75(0.87)  LDD2140  [28]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C224(0.76); C1127(0.47); C1068(0.59); C75(0.43)  LDD2141  [28]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C224(0.99); C1068(1.27)  LDD2143  [28]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1127(2.11); C1068(2.84); C75(2.84)  LDD2144  [28]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C224(6.21); C1127(0.91); C1068(1.37)  LDD2145  [28]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C224(0.74); C1127(1.07); C1068(0.54); C75(0.95)  LDD2146  [28]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C224(3.43); C1068(5.79)  LDD2147  [28]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1127(0.55); C1068(0.39); C75(0.47)  LDD2148  [28]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C224(2.33); C1068(0.58)  LDD2149  [28]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C224(0.44); C1127(0.61); C1068(0.45); C75(0.38)  LDD2150  [28]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C1068(0.96)  LDD2151  [28]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C224(1.11); C1127(1.41)  LDD2153  [28]
 LDCM0021  THZ1 HCT 116 C1127(1.15); C1068(0.77)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) MAD1 family Q9Y6D9

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
25 Expanding the "minimalist" small molecule tagging approach to different bioactive compounds. Org Biomol Chem. 2019 Mar 13;17(11):3010-3017. doi: 10.1039/c8ob03175d.
26 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
27 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
28 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578