Details of the Target

General Information of Target

Target ID LDTP01683
Target Name BAG family molecular chaperone regulator 2 (BAG2)
Gene Name BAG2
Gene ID 9532
Synonyms
BAG family molecular chaperone regulator 2; BAG-2; Bcl-2-associated athanogene 2
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MAQAKINAKANEGRFCRSSSMADRSSRLLESLDQLELRVEALREAATAVEQEKEILLEMI
HSIQNSQDMRQISDGEREELNLTANRLMGRTLTVEVSVETIRNPQQQESLKHATRIIDEV
VNKFLDDLGNAKSHLMSLYSACSSEVPHGPVDQKFQSIVIGCALEDQKKIKRRLETLLRN
IENSDKAIKLLEHSKGAGSKTLQQNAESRFN
Target Bioclass
Other
Function
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release.
Uniprot ID
O95816
Ensemble ID
ENST00000370693.5
HGNC ID
HGNC:938

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MOLT4 SNV: p.I60T IA-alkyne    Probe Info 
TOV21G SNV: p.S26I; p.D33E DBIA    Probe Info 
YSCCC SNV: p.E119K; p.G196E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
W1
 Probe Info  		17.06  LDD0235  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
ONAyne
 Probe Info  		K111(2.19); K9(0.46)  LDD0274  [4]
STPyne
 Probe Info  		K111(5.41); K186(0.79); K189(9.59); K195(6.70)  LDD0277  [4]
AZ-9
 Probe Info  		E207(10.00)  LDD2208  [5]
BTD
 Probe Info  		C162(0.14)  LDD2096  [6]
MCL-4
 Probe Info  		1.90  LDD0049  [7]
DA-P3
 Probe Info  		11.15  LDD0179  [8]
HHS-475
 Probe Info  		Y139(1.48)  LDD0264  [9]
DBIA
 Probe Info  		C162(0.67)  LDD0531  [10]
5E-2FA
 Probe Info  		H61(0.00); H193(0.00); H112(0.00); H134(0.00)  LDD2235  [11]
ATP probe
 Probe Info  		K5(0.00); K168(0.00); K169(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C162(0.00); C142(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C162(0.00); C142(0.00)  LDD0037  [13]
IPM
 Probe Info  		C162(0.00); C16(0.00)  LDD0025  [16]
TFBX
 Probe Info  		N.A.  LDD0148  [16]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [17]
1c-yne
 Probe Info  		N.A.  LDD0228  [18]
Acrolein
 Probe Info  		C162(0.00); H61(0.00); C142(0.00)  LDD0217  [19]
Methacrolein
 Probe Info  		N.A.  LDD0218  [19]
AOyne
 Probe Info  		15.00  LDD0443  [20]
NAIA_5
 Probe Info  		C162(0.00); C142(0.00)  LDD2223  [21]
HHS-465
 Probe Info  		N.A.  LDD2240  [22]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0068  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C162(0.45)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C162(0.42)  LDD2112  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C142(2.41)  LDD0372  [24]
 LDCM0214  AC1 HCT 116 C162(0.67)  LDD0531  [10]
 LDCM0215  AC10 PaTu 8988t C162(0.68)  LDD1094  [10]
 LDCM0216  AC100 HCT 116 C162(0.51)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C162(0.52)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C162(0.46)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C162(0.41)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C162(0.39)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C162(0.47)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C162(0.45)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C162(0.43)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C162(0.65)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C162(0.72)  LDD0542  [10]
 LDCM0226  AC11 PaTu 8988t C162(0.85)  LDD1105  [10]
 LDCM0227  AC110 HCT 116 C162(0.68)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C162(0.56)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C162(0.45)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C162(0.88)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C162(0.66)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C162(0.68)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C162(0.69)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C162(0.74)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C162(0.78)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C162(0.74)  LDD0553  [10]
 LDCM0237  AC12 PaTu 8988t C162(0.75)  LDD1116  [10]
 LDCM0238  AC120 HCT 116 C162(0.67)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C162(0.88)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C162(0.79)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C162(0.72)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C162(0.77)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C162(0.88)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C162(0.66)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C162(0.68)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C162(0.89)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C162(1.06)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C162(0.92)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C162(0.96)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C162(1.39)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C162(1.30)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C162(1.20)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C162(1.15)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C162(1.01)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C162(1.12)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C162(0.89)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C162(1.10)  LDD0575  [10]
 LDCM0259  AC14 PaTu 8988t C162(0.69)  LDD1138  [10]
 LDCM0260  AC140 HCT 116 C162(1.30)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C162(1.08)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C162(1.27)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C162(0.83)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C162(0.57)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C162(0.71)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C162(0.64)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C162(0.61)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C162(0.62)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C162(0.62)  LDD0586  [10]
 LDCM0270  AC15 PaTu 8988t C162(0.58)  LDD1149  [10]
 LDCM0271  AC150 HCT 116 C162(0.68)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C162(0.76)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C162(0.55)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C162(0.61)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C162(0.60)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C162(0.60)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C162(0.85)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C162(0.77)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C162(0.88)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C162(0.94)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C162(0.85)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C162(0.86)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C162(0.86)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C162(0.81)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C162(0.95)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C162(0.89)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C162(0.95)  LDD0601  [10]
 LDCM0285  AC25 PaTu 8988t C162(0.84)  LDD1164  [10]
 LDCM0286  AC26 PaTu 8988t C162(0.78)  LDD1165  [10]
 LDCM0287  AC27 PaTu 8988t C162(0.59)  LDD1166  [10]
 LDCM0288  AC28 PaTu 8988t C162(0.49)  LDD1167  [10]
 LDCM0289  AC29 PaTu 8988t C162(0.69)  LDD1168  [10]
 LDCM0290  AC3 HCT 116 C162(0.88)  LDD0607  [10]
 LDCM0291  AC30 PaTu 8988t C162(0.82)  LDD1170  [10]
 LDCM0292  AC31 PaTu 8988t C162(1.03)  LDD1171  [10]
 LDCM0293  AC32 PaTu 8988t C162(0.73)  LDD1172  [10]
 LDCM0294  AC33 PaTu 8988t C162(0.52)  LDD1173  [10]
 LDCM0295  AC34 PaTu 8988t C162(0.76)  LDD1174  [10]
 LDCM0296  AC35 HCT 116 C162(1.01)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C162(0.90)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C162(0.89)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C162(1.03)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C162(0.86)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C162(0.68)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C162(0.82)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C162(0.72)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C162(0.83)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C162(0.74)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C162(0.76)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C162(0.76)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C162(1.08)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C162(0.88)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C162(0.73)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C162(0.84)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C162(0.66)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C162(0.96)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C162(1.01)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C162(1.06)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C162(1.00)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C162(1.12)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C162(0.89)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C162(0.98)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C162(0.62)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C162(0.71)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C162(0.65)  LDD0639  [10]
 LDCM0323  AC6 PaTu 8988t C162(0.96)  LDD1202  [10]
 LDCM0324  AC60 HCT 116 C162(0.55)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C162(0.59)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C162(0.57)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C162(0.57)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C162(0.53)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C162(0.65)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C162(0.75)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C162(0.56)  LDD0648  [10]
 LDCM0332  AC68 PaTu 8988t C162(1.01)  LDD1211  [10]
 LDCM0333  AC69 PaTu 8988t C162(0.84)  LDD1212  [10]
 LDCM0334  AC7 PaTu 8988t C162(1.33)  LDD1213  [10]
 LDCM0335  AC70 PaTu 8988t C162(0.67)  LDD1214  [10]
 LDCM0336  AC71 PaTu 8988t C162(0.85)  LDD1215  [10]
 LDCM0337  AC72 PaTu 8988t C162(1.01)  LDD1216  [10]
 LDCM0338  AC73 PaTu 8988t C162(0.85)  LDD1217  [10]
 LDCM0339  AC74 PaTu 8988t C162(0.75)  LDD1218  [10]
 LDCM0340  AC75 PaTu 8988t C162(0.77)  LDD1219  [10]
 LDCM0341  AC76 PaTu 8988t C162(0.83)  LDD1220  [10]
 LDCM0342  AC77 PaTu 8988t C162(0.75)  LDD1221  [10]
 LDCM0343  AC78 PaTu 8988t C162(0.71)  LDD1222  [10]
 LDCM0344  AC79 PaTu 8988t C162(0.77)  LDD1223  [10]
 LDCM0345  AC8 PaTu 8988t C162(0.96)  LDD1224  [10]
 LDCM0346  AC80 PaTu 8988t C162(0.67)  LDD1225  [10]
 LDCM0347  AC81 PaTu 8988t C162(0.63)  LDD1226  [10]
 LDCM0348  AC82 PaTu 8988t C162(0.79)  LDD1227  [10]
 LDCM0349  AC83 HCT 116 C162(0.77)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C162(0.71)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C162(0.77)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C162(0.86)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C162(0.93)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C162(0.85)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C162(0.82)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C162(1.03)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C162(0.90)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C162(0.85)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C162(0.86)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C162(0.81)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C162(0.95)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C162(0.84)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C162(0.90)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C162(0.31)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C162(0.56)  LDD0683  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C162(0.44)  LDD2113  [6]
 LDCM0248  AKOS034007472 PaTu 8988t C162(0.70)  LDD1127  [10]
 LDCM0356  AKOS034007680 PaTu 8988t C162(0.87)  LDD1235  [10]
 LDCM0275  AKOS034007705 PaTu 8988t C162(0.67)  LDD1154  [10]
 LDCM0156  Aniline NCI-H1299 13.02  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C162(0.00); C142(0.00); H61(0.00)  LDD0222  [19]
 LDCM0367  CL1 HCT 116 C162(1.05)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C162(1.52)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C162(0.67)  LDD0686  [10]
 LDCM0370  CL101 PaTu 8988t C162(0.75)  LDD1249  [10]
 LDCM0371  CL102 PaTu 8988t C162(0.92)  LDD1250  [10]
 LDCM0372  CL103 PaTu 8988t C162(0.83)  LDD1251  [10]
 LDCM0373  CL104 PaTu 8988t C162(0.81)  LDD1252  [10]
 LDCM0374  CL105 HCT 116 C162(0.76)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C162(0.69)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C162(0.78)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C162(0.77)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C162(0.98)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C162(1.54)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C162(0.91)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C162(0.89)  LDD0698  [10]
 LDCM0382  CL112 PaTu 8988t C162(0.83)  LDD1261  [10]
 LDCM0383  CL113 PaTu 8988t C162(0.84)  LDD1262  [10]
 LDCM0384  CL114 PaTu 8988t C162(0.60)  LDD1263  [10]
 LDCM0385  CL115 PaTu 8988t C162(0.53)  LDD1264  [10]
 LDCM0386  CL116 PaTu 8988t C162(0.67)  LDD1265  [10]
 LDCM0387  CL117 HCT 116 C162(0.88)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C162(0.84)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C162(0.85)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C162(1.99)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C162(0.86)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C162(0.88)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C162(0.97)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C162(0.81)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C162(0.93)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C162(0.86)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C162(0.74)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C162(0.75)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C162(0.64)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C162(1.25)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C162(1.16)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C162(1.23)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C162(0.77)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C162(0.70)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C162(0.75)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C162(0.80)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C162(1.13)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C162(0.74)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C162(0.71)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C162(1.14)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C162(0.96)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C162(0.91)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C162(1.00)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C162(0.80)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C162(0.93)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C162(0.71)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C162(0.83)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C162(1.16)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C162(0.80)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C162(1.04)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C162(1.41)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C162(0.71)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C162(0.65)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C162(0.75)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C162(0.82)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C162(0.90)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C162(0.75)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C162(1.02)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C162(0.82)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C162(1.04)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C162(0.66)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C162(0.70)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C162(0.67)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C162(0.58)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C162(1.69)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C162(1.37)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C162(1.41)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C162(1.18)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C162(1.42)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C162(1.34)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C162(1.74)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C162(1.54)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C162(1.31)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C162(1.57)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C162(1.38)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C162(1.06)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C162(1.44)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C162(1.37)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C162(1.12)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C162(1.25)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C162(1.06)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C162(0.95)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C162(0.91)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C162(0.86)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C162(0.77)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C162(0.88)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C162(0.70)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C162(0.69)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C162(0.73)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C162(0.95)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C162(1.36)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C162(0.73)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C162(0.76)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C162(0.92)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C162(0.77)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C162(0.75)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C162(0.75)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C162(0.76)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C162(0.83)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C162(0.69)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C162(0.89)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C162(0.71)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C162(0.72)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C162(0.69)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C162(0.70)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C162(0.73)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C162(0.77)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C162(0.86)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C162(0.74)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C162(0.76)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C162(0.65)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C162(1.22)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C162(1.13)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C162(0.90)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C162(0.95)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C162(0.87)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C162(0.68)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C162(0.72)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C162(0.77)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C162(0.76)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C162(0.66)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C162(0.70)  LDD0811  [10]
 LDCM0027  Dopamine HEK-293T 11.15  LDD0179  [8]
 LDCM0031  Epigallocatechin gallate HEK-293T 14.70  LDD0183  [8]
 LDCM0625  F8 Ramos C142(1.07)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C142(1.13)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C142(1.46)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C142(0.82)  LDD2191  [25]
 LDCM0576  Fragment14 Ramos C142(0.47)  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C142(1.02)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C142(0.99)  LDD2195  [25]
 LDCM0578  Fragment27 Ramos C142(1.35)  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C142(1.25)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C142(0.80)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C142(1.38)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C142(0.77)  LDD2201  [25]
 LDCM0468  Fragment33 HCT 116 C162(0.70)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C142(1.80)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C142(0.91)  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C162(0.99)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C142(1.53)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C142(0.71)  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C142(0.79)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C142(0.66)  LDD2188  [25]
 LDCM0116  HHS-0101 DM93 Y139(1.48)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y139(1.85)  LDD0265  [9]
 LDCM0119  HHS-0401 DM93 Y139(3.38)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y139(3.94)  LDD0268  [9]
 LDCM0107  IAA HeLa C162(0.00); H61(0.00)  LDD0221  [19]
 LDCM0022  KB02 HEK-293T C142(0.98)  LDD1492  [26]
 LDCM0023  KB03 HEK-293T C142(1.05)  LDD1497  [26]
 LDCM0024  KB05 UACC257 C162(2.90)  LDD3325  [27]
 LDCM0006  Micheliolide M9-ENL1 1.90  LDD0049  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [19]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C162(0.14)  LDD2096  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C162(0.38)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C162(0.60)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C162(0.36)  LDD2104  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C162(0.52)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C162(0.75)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C162(0.52)  LDD2108  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C162(0.57)  LDD2110  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C162(0.84)  LDD2114  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C162(0.18)  LDD2122  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C162(1.00)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C162(0.15)  LDD2126  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C162(1.04)  LDD2136  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C162(0.52)  LDD2141  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C162(0.38)  LDD2145  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock cognate 71 kDa protein (HSPA8) Heat shock protein 70 family P11142
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) AGC Ser/Thr protein kinase family P17612
Death-associated protein kinase 1 (DAPK1) CAMK Ser/Thr protein kinase family P53355
Mitogen-activated protein kinase 7 (MAPK7) CMGC Ser/Thr protein kinase family Q13164
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
RAF proto-oncogene serine/threonine-protein kinase (RAF1) TKL Ser/Thr protein kinase family P04049
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Myeloid leukemia factor 2 (MLF2) MLF family Q15773
Meiotic recombination protein REC8 homolog (REC8) Rad21 family O95072
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
BAG family molecular chaperone regulator 2 (BAG2) . O95816
DnaJ homolog subfamily C member 7 (DNAJC7) . Q99615

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
8 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
23 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
24 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840