Details of the Target

General Information of Target

Target ID LDTP02568
Target Name DNA topoisomerase 2-alpha (TOP2A)
Gene Name TOP2A
Gene ID 7153
Synonyms
TOP2; DNA topoisomerase 2-alpha; EC 5.6.2.2; DNA topoisomerase II, alpha isozyme
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE
ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG
TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM
DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Type II topoisomerase family
Subcellular location
Cytoplasm
Function
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. May play a role in regulating the period length of BMAL1 transcriptional oscillation.
TTD ID
T17048
Uniprot ID
P11388
DrugMap ID
TTCGY2K
Ensemble ID
ENST00000423485.6
HGNC ID
HGNC:11989
ChEMBL ID
CHEMBL1806

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.S1449C DBIA    Probe Info 
HCT116 Insertion: p.Q657TfsTer4 .
HT115 SNV: p.S527Ter; p.S1425F DBIA    Probe Info 
IGROV1 SNV: p.H605Q .
IM95 Deletion: p.T1205HfsTer19 DBIA    Probe Info 
JURKAT SNV: p.R804Ter; p.R815Q; p.I1481N Compound 10    Probe Info 
KMS12BM SNV: p.A318P DBIA    Probe Info 
LS180 Deletion: p.T1205HfsTer19 DBIA    Probe Info 
MOLT4 SNV: p.R268H; p.S1491F IA-alkyne    Probe Info 
NCIH1048 Deletion: p.Q1453KfsTer3 DBIA    Probe Info 
P31FUJ SNV: p.L944S DBIA    Probe Info 
RKO Insertion: p.T620KfsTer7
SNV: p.Y613C;p.K1489E		 DBIA    Probe Info 
TGBC1TKB SNV: p.T530A DBIA    Probe Info 
YSCCC SNV: p.S497C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY4
 Probe Info  		100.00  LDD0244  [1]
W1
 Probe Info  		13.05  LDD0235  [2]
TH211
 Probe Info  		Y151(13.68)  LDD0257  [3]
STPyne
 Probe Info  		K1058(6.25); K1070(10.00); K1091(1.89); K251(10.00)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
Probe 1
 Probe Info  		Y518(23.52); Y522(12.08)  LDD3495  [5]
BTD
 Probe Info  		C1145(1.37); C392(1.28)  LDD1700  [6]
AHL-Pu-1
 Probe Info  		C455(2.96); C392(2.03); C216(2.82)  LDD0168  [7]
DBIA
 Probe Info  		C170(4.82)  LDD0209  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
m-APA
 Probe Info  		H1398(0.00); H1499(0.00)  LDD2233  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C405(0.00); C216(0.00); C170(0.00); C455(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C455(0.00); C216(0.00); C392(0.00)  LDD0032  [12]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [13]
Lodoacetamide azide
 Probe Info  		C405(0.00); C216(0.00); C455(0.00); C392(0.00)  LDD0037  [11]
IPM
 Probe Info  		N.A.  LDD0025  [14]
NAIA_4
 Probe Info  		C170(0.00); C405(0.00); C455(0.00)  LDD2226  [15]
TFBX
 Probe Info  		C392(0.00); C455(0.00)  LDD0027  [14]
WYneO
 Probe Info  		N.A.  LDD0022  [16]
Compound 10
 Probe Info  		C170(0.00); C392(0.00); C455(0.00); C733(0.00)  LDD2216  [17]
NHS
 Probe Info  		N.A.  LDD0010  [16]
SF
 Probe Info  		Y960(0.00); Y518(0.00); Y481(0.00); Y830(0.00)  LDD0028  [18]
VSF
 Probe Info  		N.A.  LDD0007  [16]
1c-yne
 Probe Info  		K123(0.00); K254(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		C455(0.00); H325(0.00); C392(0.00); C1145(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info  		C455(0.00); H290(0.00); C392(0.00); H325(0.00)  LDD0219  [20]
Methacrolein
 Probe Info  		C455(0.00); C392(0.00); C1145(0.00)  LDD0218  [20]
NAIA_5
 Probe Info  		C405(0.00); C427(0.00); C170(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		12.52  LDD0475  [21]
FFF probe2
 Probe Info  		12.35  LDD0463  [21]
FFF probe3
 Probe Info  		12.81  LDD0464  [21]
JN0003
 Probe Info  		12.54  LDD0469  [21]
STS-1
 Probe Info  		N.A.  LDD0136  [22]
STS-2
 Probe Info  		N.A.  LDD0138  [22]
VE-P
 Probe Info  		N.A.  LDD0396  [23]
DA-2
 Probe Info  		N.A.  LDD0072  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C392(0.74); C1145(1.02)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C392(0.75)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C392(0.65)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C392(0.74)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C392(0.87); C1145(0.99); C455(0.98)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C392(1.26); C1145(1.34)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C392(0.92); C1145(1.16)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C392(0.50)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C392(0.62)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C455(2.96); C392(2.03); C216(2.82)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C405(3.87); C216(7.05)  LDD0169  [7]
 LDCM0214  AC1 HEK-293T C392(0.96); C455(0.89); C300(1.13); C733(0.86)  LDD1507  [25]
 LDCM0215  AC10 HEK-293T C392(1.02); C455(1.47); C300(0.93); C733(0.90)  LDD1508  [25]
 LDCM0226  AC11 HEK-293T C392(1.01); C455(1.12); C300(1.00); C733(0.80)  LDD1509  [25]
 LDCM0237  AC12 HEK-293T C392(0.93); C455(1.10); C300(1.02); C733(0.82)  LDD1510  [25]
 LDCM0259  AC14 HEK-293T C392(1.01); C455(1.12); C300(1.00); C733(0.90)  LDD1512  [25]
 LDCM0270  AC15 HEK-293T C392(1.05); C455(1.09); C300(0.99); C733(0.85)  LDD1513  [25]
 LDCM0276  AC17 HEK-293T C392(1.03); C455(0.99); C300(1.03); C733(0.89)  LDD1515  [25]
 LDCM0277  AC18 HEK-293T C392(0.96); C455(0.88); C300(0.90); C733(1.04)  LDD1516  [25]
 LDCM0278  AC19 HEK-293T C392(1.04); C455(1.26); C300(0.91); C733(0.87)  LDD1517  [25]
 LDCM0279  AC2 HEK-293T C392(1.11); C455(0.92); C300(0.99); C733(0.89)  LDD1518  [25]
 LDCM0280  AC20 HEK-293T C392(0.93); C455(1.04); C300(0.94); C733(0.99)  LDD1519  [25]
 LDCM0281  AC21 HEK-293T C392(1.01); C455(1.08); C300(0.97); C733(1.02)  LDD1520  [25]
 LDCM0282  AC22 HEK-293T C392(1.01); C455(1.05); C300(0.96); C733(1.01)  LDD1521  [25]
 LDCM0283  AC23 HEK-293T C392(1.04); C455(1.06); C300(0.97); C733(0.87)  LDD1522  [25]
 LDCM0284  AC24 HEK-293T C392(0.98); C455(1.09); C300(1.03); C733(0.94)  LDD1523  [25]
 LDCM0285  AC25 HEK-293T C392(1.03); C455(0.96); C300(0.91); C733(0.87)  LDD1524  [25]
 LDCM0286  AC26 HEK-293T C392(1.07); C455(1.17); C300(0.89); C733(0.90)  LDD1525  [25]
 LDCM0287  AC27 HEK-293T C392(0.99); C455(1.10); C300(1.07); C733(0.82)  LDD1526  [25]
 LDCM0288  AC28 HEK-293T C392(1.01); C455(0.97); C300(1.00); C733(0.98)  LDD1527  [25]
 LDCM0289  AC29 HEK-293T C392(1.01); C455(1.04); C300(0.94); C733(1.00)  LDD1528  [25]
 LDCM0290  AC3 HEK-293T C392(1.05); C455(1.05); C300(1.06); C733(0.83)  LDD1529  [25]
 LDCM0291  AC30 HEK-293T C392(1.02); C455(1.14); C300(0.96); C733(0.87)  LDD1530  [25]
 LDCM0292  AC31 HEK-293T C392(1.04); C455(1.01); C300(0.98); C733(0.92)  LDD1531  [25]
 LDCM0293  AC32 HEK-293T C392(1.01); C455(1.02); C300(1.01); C733(0.92)  LDD1532  [25]
 LDCM0294  AC33 HEK-293T C392(1.01); C455(0.97); C300(0.99); C733(0.92)  LDD1533  [25]
 LDCM0295  AC34 HEK-293T C392(1.00); C455(1.05); C300(0.95); C733(0.95)  LDD1534  [25]
 LDCM0296  AC35 HEK-293T C392(1.02); C455(1.15); C300(1.02); C733(0.85)  LDD1535  [25]
 LDCM0297  AC36 HEK-293T C392(0.94); C455(1.13); C300(0.93); C733(0.86)  LDD1536  [25]
 LDCM0298  AC37 HEK-293T C392(1.01); C455(0.98); C300(1.09); C733(1.00)  LDD1537  [25]
 LDCM0299  AC38 HEK-293T C392(1.03); C455(1.10); C300(1.01); C733(0.95)  LDD1538  [25]
 LDCM0300  AC39 HEK-293T C392(1.08); C455(1.11); C300(0.98); C733(0.93)  LDD1539  [25]
 LDCM0301  AC4 HEK-293T C392(1.03); C455(1.01); C300(0.98); C733(0.98)  LDD1540  [25]
 LDCM0302  AC40 HEK-293T C392(0.99); C455(1.07); C300(1.01); C733(0.81)  LDD1541  [25]
 LDCM0303  AC41 HEK-293T C392(1.00); C455(0.98); C300(1.03); C733(0.85)  LDD1542  [25]
 LDCM0304  AC42 HEK-293T C392(1.03); C455(0.93); C300(0.95); C733(0.82)  LDD1543  [25]
 LDCM0305  AC43 HEK-293T C392(1.00); C455(1.15); C300(1.03); C733(0.81)  LDD1544  [25]
 LDCM0306  AC44 HEK-293T C392(0.95); C455(1.08); C300(0.98); C733(0.91)  LDD1545  [25]
 LDCM0307  AC45 HEK-293T C392(0.99); C455(1.05); C300(1.03); C733(0.94)  LDD1546  [25]
 LDCM0308  AC46 HEK-293T C392(1.02); C455(1.09); C300(0.94); C733(0.97)  LDD1547  [25]
 LDCM0309  AC47 HEK-293T C392(1.09); C455(1.05); C300(1.01); C733(0.83)  LDD1548  [25]
 LDCM0310  AC48 HEK-293T C392(0.95); C455(1.08); C300(0.98); C733(0.78)  LDD1549  [25]
 LDCM0311  AC49 HEK-293T C392(0.95); C455(1.06); C300(0.98); C733(0.85)  LDD1550  [25]
 LDCM0312  AC5 HEK-293T C392(1.01); C455(1.05); C300(0.99); C733(1.03)  LDD1551  [25]
 LDCM0313  AC50 HEK-293T C392(0.99); C455(1.12); C300(1.06); C733(1.00)  LDD1552  [25]
 LDCM0314  AC51 HEK-293T C392(1.02); C455(1.21); C300(1.00); C733(0.86)  LDD1553  [25]
 LDCM0315  AC52 HEK-293T C392(0.92); C455(1.12); C300(0.99); C733(0.91)  LDD1554  [25]
 LDCM0316  AC53 HEK-293T C392(1.00); C455(1.02); C300(1.00); C733(1.03)  LDD1555  [25]
 LDCM0317  AC54 HEK-293T C392(1.00); C455(1.11); C300(1.05); C733(0.99)  LDD1556  [25]
 LDCM0318  AC55 HEK-293T C392(1.05); C455(1.11); C300(0.98); C733(0.88)  LDD1557  [25]
 LDCM0319  AC56 HEK-293T C392(1.01); C455(1.04); C300(1.01); C733(0.87)  LDD1558  [25]
 LDCM0320  AC57 HEK-293T C392(1.05); C455(0.96); C300(0.97); C733(0.90)  LDD1559  [25]
 LDCM0321  AC58 HEK-293T C392(1.01); C455(1.19); C300(0.95); C733(0.92)  LDD1560  [25]
 LDCM0322  AC59 HEK-293T C392(1.02); C455(0.93); C300(1.01); C733(0.79)  LDD1561  [25]
 LDCM0323  AC6 HEK-293T C392(1.05); C455(0.99); C300(1.01); C733(0.88)  LDD1562  [25]
 LDCM0324  AC60 HEK-293T C392(0.98); C455(0.97); C300(0.99); C733(0.84)  LDD1563  [25]
 LDCM0325  AC61 HEK-293T C392(1.03); C455(0.99); C300(1.00); C733(0.98)  LDD1564  [25]
 LDCM0326  AC62 HEK-293T C392(0.98); C455(1.05); C300(0.97); C733(0.89)  LDD1565  [25]
 LDCM0327  AC63 HEK-293T C392(1.06); C455(1.02); C300(0.95); C733(0.87)  LDD1566  [25]
 LDCM0328  AC64 HEK-293T C392(0.98); C455(1.02); C300(0.95); C733(0.82)  LDD1567  [25]
 LDCM0334  AC7 HEK-293T C392(0.98); C455(1.02); C300(1.01); C733(0.99)  LDD1568  [25]
 LDCM0345  AC8 HEK-293T C392(0.96); C455(0.99); C300(1.03); C733(0.83)  LDD1569  [25]
 LDCM0545  Acetamide MDA-MB-231 C392(0.36)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C392(0.75); C170(0.83)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C392(1.03); C455(0.97); C300(0.99); C733(0.96)  LDD1511  [25]
 LDCM0356  AKOS034007680 HEK-293T C392(1.01); C455(1.00); C300(0.96); C733(0.84)  LDD1570  [25]
 LDCM0275  AKOS034007705 HEK-293T C392(0.98); C455(1.06); C300(0.99); C733(0.86)  LDD1514  [25]
 LDCM0498  BS-3668 MDA-MB-231 C392(0.35)  LDD2091  [6]
 LDCM0630  CCW28-3 231MFP C405(1.44)  LDD2214  [26]
 LDCM0108  Chloroacetamide HeLa C455(0.00); H290(0.00); C392(0.00); H295(0.00)  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C455(20.00); C733(1.16); C170(1.01); C427(0.65)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C392(1.37); C455(1.04); C300(1.04); C733(0.85)  LDD1571  [25]
 LDCM0368  CL10 HEK-293T C392(2.07); C455(1.11); C300(1.05); C733(1.66)  LDD1572  [25]
 LDCM0369  CL100 HEK-293T C392(1.01); C300(1.02); C733(0.94); C216(0.99)  LDD1573  [25]
 LDCM0370  CL101 HEK-293T C392(1.05); C455(1.08); C300(0.94); C733(0.83)  LDD1574  [25]
 LDCM0371  CL102 HEK-293T C392(1.55); C455(1.00); C300(0.95); C733(1.07)  LDD1575  [25]
 LDCM0372  CL103 HEK-293T C392(1.05); C455(1.16); C300(0.93); C733(0.81)  LDD1576  [25]
 LDCM0373  CL104 HEK-293T C392(0.99); C300(1.02); C733(0.95); C216(1.03)  LDD1577  [25]
 LDCM0374  CL105 HEK-293T C392(1.20); C455(1.03); C300(0.97); C733(1.00)  LDD1578  [25]
 LDCM0375  CL106 HEK-293T C392(1.29); C455(1.02); C300(1.00); C733(0.98)  LDD1579  [25]
 LDCM0376  CL107 HEK-293T C392(1.06); C455(1.15); C300(0.89); C733(0.85)  LDD1580  [25]
 LDCM0377  CL108 HEK-293T C392(0.96); C300(1.00); C733(0.87); C216(0.94)  LDD1581  [25]
 LDCM0378  CL109 HEK-293T C392(1.27); C455(0.96); C300(0.88); C733(1.04)  LDD1582  [25]
 LDCM0379  CL11 HEK-293T C392(1.31); C455(1.09); C300(1.16); C733(1.07)  LDD1583  [25]
 LDCM0380  CL110 HEK-293T C392(1.55); C455(0.95); C300(0.96); C733(1.19)  LDD1584  [25]
 LDCM0381  CL111 HEK-293T C392(1.24); C455(1.04); C300(0.87); C733(1.00)  LDD1585  [25]
 LDCM0382  CL112 HEK-293T C392(1.03); C300(1.06); C733(0.96); C216(1.07)  LDD1586  [25]
 LDCM0383  CL113 HEK-293T C392(0.95); C455(0.95); C300(0.91); C733(0.86)  LDD1587  [25]
 LDCM0384  CL114 HEK-293T C392(1.56); C455(1.07); C300(1.00); C733(0.99)  LDD1588  [25]
 LDCM0385  CL115 HEK-293T C392(0.95); C455(1.08); C300(0.96); C733(0.80)  LDD1589  [25]
 LDCM0386  CL116 HEK-293T C392(0.96); C300(1.03); C733(0.78); C216(0.97)  LDD1590  [25]
 LDCM0387  CL117 HEK-293T C392(0.99); C455(1.14); C300(0.91); C733(0.80)  LDD1591  [25]
 LDCM0388  CL118 HEK-293T C392(1.02); C455(1.01); C300(1.01); C733(0.83)  LDD1592  [25]
 LDCM0389  CL119 HEK-293T C392(1.00); C455(1.09); C300(1.01); C733(0.84)  LDD1593  [25]
 LDCM0390  CL12 HEK-293T C392(1.27); C455(0.69); C300(1.08); C733(0.90)  LDD1594  [25]
 LDCM0391  CL120 HEK-293T C392(0.98); C300(1.01); C733(0.71); C216(1.00)  LDD1595  [25]
 LDCM0392  CL121 HEK-293T C392(1.08); C455(1.00); C300(0.89); C733(0.94)  LDD1596  [25]
 LDCM0393  CL122 HEK-293T C392(1.19); C455(1.01); C300(0.96); C733(0.91)  LDD1597  [25]
 LDCM0394  CL123 HEK-293T C392(1.72); C455(1.09); C300(0.92); C733(0.89)  LDD1598  [25]
 LDCM0395  CL124 HEK-293T C392(1.16); C300(1.03); C733(0.86); C216(1.03)  LDD1599  [25]
 LDCM0396  CL125 HEK-293T C392(0.99); C455(1.11); C300(0.88); C733(0.85)  LDD1600  [25]
 LDCM0397  CL126 HEK-293T C392(1.16); C455(0.96); C300(1.05); C733(0.92)  LDD1601  [25]
 LDCM0398  CL127 HEK-293T C392(1.04); C455(1.06); C300(0.96); C733(0.79)  LDD1602  [25]
 LDCM0399  CL128 HEK-293T C392(1.01); C300(1.08); C733(0.93); C216(1.10)  LDD1603  [25]
 LDCM0400  CL13 HEK-293T C392(1.00); C455(1.12); C300(0.94); C733(0.87)  LDD1604  [25]
 LDCM0401  CL14 HEK-293T C392(1.09); C455(1.06); C300(1.05); C733(0.89)  LDD1605  [25]
 LDCM0402  CL15 HEK-293T C392(1.53); C455(1.21); C300(0.91); C733(0.95)  LDD1606  [25]
 LDCM0403  CL16 HEK-293T C392(1.05); C300(1.06); C733(0.83); C216(0.95)  LDD1607  [25]
 LDCM0404  CL17 HEK-293T C392(1.75); C455(1.01); C300(1.00); C733(1.02)  LDD1608  [25]
 LDCM0405  CL18 HEK-293T C392(1.13); C455(0.93); C300(1.03); C733(0.95)  LDD1609  [25]
 LDCM0406  CL19 HEK-293T C392(1.02); C455(1.12); C300(1.17); C733(0.87)  LDD1610  [25]
 LDCM0407  CL2 HEK-293T C392(1.05); C455(1.03); C300(1.05); C733(0.92)  LDD1611  [25]
 LDCM0408  CL20 HEK-293T C392(0.92); C455(1.17); C300(1.12); C733(0.93)  LDD1612  [25]
 LDCM0409  CL21 HEK-293T C392(1.65); C455(1.12); C300(0.97); C733(1.20)  LDD1613  [25]
 LDCM0410  CL22 HEK-293T C392(1.14); C455(1.18); C300(1.07); C733(1.00)  LDD1614  [25]
 LDCM0411  CL23 HEK-293T C392(1.09); C455(1.12); C300(1.18); C733(0.96)  LDD1615  [25]
 LDCM0412  CL24 HEK-293T C392(1.14); C455(1.09); C300(1.17); C733(0.91)  LDD1616  [25]
 LDCM0413  CL25 HEK-293T C392(1.31); C455(0.92); C300(0.96); C733(1.06)  LDD1617  [25]
 LDCM0414  CL26 HEK-293T C392(1.06); C455(1.04); C300(1.00); C733(0.89)  LDD1618  [25]
 LDCM0415  CL27 HEK-293T C392(1.03); C455(1.05); C300(1.03); C733(0.78)  LDD1619  [25]
 LDCM0416  CL28 HEK-293T C392(1.13); C300(1.07); C733(0.86); C216(0.94)  LDD1620  [25]
 LDCM0417  CL29 HEK-293T C392(1.03); C455(0.99); C300(0.99); C733(0.90)  LDD1621  [25]
 LDCM0418  CL3 HEK-293T C392(1.17); C455(1.02); C300(1.02); C733(0.84)  LDD1622  [25]
 LDCM0419  CL30 HEK-293T C392(1.01); C455(0.93); C300(1.12); C733(0.92)  LDD1623  [25]
 LDCM0420  CL31 HEK-293T C392(1.22); C455(1.37); C300(1.05); C733(1.01)  LDD1624  [25]
 LDCM0421  CL32 HEK-293T C392(0.98); C455(1.10); C300(1.04); C733(1.04)  LDD1625  [25]
 LDCM0422  CL33 HEK-293T C392(1.64); C455(1.13); C300(1.03); C733(1.38)  LDD1626  [25]
 LDCM0423  CL34 HEK-293T C392(1.35); C455(1.17); C300(1.07); C733(1.08)  LDD1627  [25]
 LDCM0424  CL35 HEK-293T C392(1.14); C455(1.06); C300(1.10); C733(1.29)  LDD1628  [25]
 LDCM0425  CL36 HEK-293T C392(1.30); C455(1.11); C300(1.08); C733(1.03)  LDD1629  [25]
 LDCM0426  CL37 HEK-293T C392(1.16); C455(0.96); C300(0.94); C733(0.88)  LDD1630  [25]
 LDCM0428  CL39 HEK-293T C392(1.27); C455(0.98); C300(0.98); C733(0.82)  LDD1632  [25]
 LDCM0429  CL4 HEK-293T C392(1.13); C300(1.07); C733(0.94); C216(1.09)  LDD1633  [25]
 LDCM0430  CL40 HEK-293T C392(0.90); C300(1.02); C733(0.86); C216(0.93)  LDD1634  [25]
 LDCM0431  CL41 HEK-293T C392(1.40); C455(0.91); C300(1.02); C733(0.96)  LDD1635  [25]
 LDCM0432  CL42 HEK-293T C392(1.04); C455(0.97); C300(1.04); C733(0.93)  LDD1636  [25]
 LDCM0433  CL43 HEK-293T C392(1.13); C455(0.95); C300(1.03); C733(0.92)  LDD1637  [25]
 LDCM0434  CL44 HEK-293T C392(1.06); C455(1.09); C300(1.04); C733(1.07)  LDD1638  [25]
 LDCM0435  CL45 HEK-293T C392(1.39); C455(0.99); C300(1.06); C733(1.12)  LDD1639  [25]
 LDCM0436  CL46 HEK-293T C392(1.15); C455(1.07); C300(1.09); C733(1.12)  LDD1640  [25]
 LDCM0437  CL47 HEK-293T C392(1.07); C455(1.05); C300(1.11); C733(1.20)  LDD1641  [25]
 LDCM0438  CL48 HEK-293T C392(1.16); C455(1.13); C300(1.14); C733(1.02)  LDD1642  [25]
 LDCM0439  CL49 HEK-293T C392(1.10); C455(1.05); C300(0.89); C733(0.80)  LDD1643  [25]
 LDCM0440  CL5 HEK-293T C392(0.99); C455(1.04); C300(1.07); C733(0.83)  LDD1644  [25]
 LDCM0441  CL50 HEK-293T C392(1.26); C455(0.97); C300(0.99); C733(0.91)  LDD1645  [25]
 LDCM0443  CL52 HEK-293T C392(0.91); C300(1.03); C733(0.99); C216(0.86)  LDD1646  [25]
 LDCM0444  CL53 HEK-293T C392(1.63); C455(0.98); C300(0.97); C733(0.96)  LDD1647  [25]
 LDCM0445  CL54 HEK-293T C392(1.62); C455(1.03); C300(0.99); C733(0.95)  LDD1648  [25]
 LDCM0446  CL55 HEK-293T C392(1.16); C455(1.37); C300(1.07); C733(0.84)  LDD1649  [25]
 LDCM0447  CL56 HEK-293T C392(1.06); C455(1.03); C300(1.05); C733(1.01)  LDD1650  [25]
 LDCM0448  CL57 HEK-293T C392(1.46); C455(1.10); C300(1.01); C733(1.09)  LDD1651  [25]
 LDCM0449  CL58 HEK-293T C392(1.38); C455(1.23); C300(1.13); C733(1.22)  LDD1652  [25]
 LDCM0450  CL59 HEK-293T C392(1.27); C455(1.13); C300(1.13); C733(0.98)  LDD1653  [25]
 LDCM0451  CL6 HEK-293T C392(1.50); C455(1.01); C300(1.03); C733(1.18)  LDD1654  [25]
 LDCM0452  CL60 HEK-293T C392(1.18); C455(1.08); C300(1.07); C733(0.88)  LDD1655  [25]
 LDCM0453  CL61 HEK-293T C392(0.92); C455(0.94); C300(0.88); C733(0.83)  LDD1656  [25]
 LDCM0454  CL62 HEK-293T C392(1.05); C455(0.94); C300(0.68); C733(0.89)  LDD1657  [25]
 LDCM0455  CL63 HEK-293T C392(0.98); C455(0.98); C300(0.99); C733(0.74)  LDD1658  [25]
 LDCM0456  CL64 HEK-293T C392(1.64); C300(1.00); C733(0.90); C216(0.93)  LDD1659  [25]
 LDCM0457  CL65 HEK-293T C392(1.01); C455(1.04); C300(0.97); C733(0.88)  LDD1660  [25]
 LDCM0458  CL66 HEK-293T C392(1.08); C455(1.14); C300(0.95); C733(0.91)  LDD1661  [25]
 LDCM0459  CL67 HEK-293T C392(1.03); C455(0.90); C300(1.08); C733(0.84)  LDD1662  [25]
 LDCM0460  CL68 HEK-293T C392(1.17); C455(1.05); C300(1.08); C733(1.03)  LDD1663  [25]
 LDCM0461  CL69 HEK-293T C392(1.34); C455(1.07); C300(1.03); C733(1.01)  LDD1664  [25]
 LDCM0462  CL7 HEK-293T C392(1.08); C455(1.10); C300(1.06); C733(0.90)  LDD1665  [25]
 LDCM0463  CL70 HEK-293T C392(1.15); C455(1.13); C300(1.16); C733(1.12)  LDD1666  [25]
 LDCM0464  CL71 HEK-293T C392(1.24); C455(1.15); C300(1.06); C733(0.99)  LDD1667  [25]
 LDCM0465  CL72 HEK-293T C392(1.02); C455(1.00); C300(1.08); C733(0.93)  LDD1668  [25]
 LDCM0466  CL73 HEK-293T C392(1.28); C455(0.89); C300(0.84); C733(0.87)  LDD1669  [25]
 LDCM0467  CL74 HEK-293T C392(1.06); C455(1.03); C300(0.96); C733(0.85)  LDD1670  [25]
 LDCM0469  CL76 HEK-293T C392(0.96); C300(1.02); C733(0.88); C216(1.07)  LDD1672  [25]
 LDCM0470  CL77 HEK-293T C392(1.58); C455(1.08); C300(0.90); C733(1.16)  LDD1673  [25]
 LDCM0471  CL78 HEK-293T C392(1.00); C455(0.93); C300(1.07); C733(1.02)  LDD1674  [25]
 LDCM0472  CL79 HEK-293T C392(1.05); C455(0.98); C300(0.98); C733(0.83)  LDD1675  [25]
 LDCM0473  CL8 HEK-293T C392(1.82); C455(1.16); C300(1.01); C733(1.69)  LDD1676  [25]
 LDCM0474  CL80 HEK-293T C392(0.93); C455(1.01); C300(1.09); C733(1.03)  LDD1677  [25]
 LDCM0475  CL81 HEK-293T C392(1.07); C455(1.13); C300(1.10); C733(1.05)  LDD1678  [25]
 LDCM0476  CL82 HEK-293T C392(1.10); C455(1.05); C300(1.00); C733(1.00)  LDD1679  [25]
 LDCM0477  CL83 HEK-293T C392(1.43); C455(1.07); C300(1.04); C733(1.03)  LDD1680  [25]
 LDCM0478  CL84 HEK-293T C392(1.49); C455(1.09); C300(1.06); C733(1.07)  LDD1681  [25]
 LDCM0479  CL85 HEK-293T C392(0.94); C455(0.98); C300(0.95); C733(0.78)  LDD1682  [25]
 LDCM0480  CL86 HEK-293T C392(1.10); C455(0.94); C300(0.97); C733(0.91)  LDD1683  [25]
 LDCM0481  CL87 HEK-293T C392(1.07); C455(1.01); C300(0.95); C733(0.79)  LDD1684  [25]
 LDCM0482  CL88 HEK-293T C392(0.92); C300(1.09); C733(0.79); C216(1.28)  LDD1685  [25]
 LDCM0483  CL89 HEK-293T C392(1.03); C455(1.00); C300(1.09); C733(0.79)  LDD1686  [25]
 LDCM0484  CL9 HEK-293T C392(1.23); C455(0.99); C300(0.99); C733(1.18)  LDD1687  [25]
 LDCM0485  CL90 HEK-293T C392(1.94); C455(1.06); C300(0.90); C733(1.12)  LDD1688  [25]
 LDCM0486  CL91 HEK-293T C392(1.10); C455(0.91); C300(1.16); C733(0.81)  LDD1689  [25]
 LDCM0487  CL92 HEK-293T C392(1.55); C455(0.98); C300(1.02); C733(0.98)  LDD1690  [25]
 LDCM0488  CL93 HEK-293T C392(1.54); C455(0.99); C300(1.08); C733(1.06)  LDD1691  [25]
 LDCM0489  CL94 HEK-293T C392(1.14); C455(1.02); C300(1.01); C733(0.94)  LDD1692  [25]
 LDCM0490  CL95 HEK-293T C392(2.32); C455(1.18); C300(0.94); C733(1.11)  LDD1693  [25]
 LDCM0491  CL96 HEK-293T C392(1.33); C455(0.99); C300(1.00); C733(0.86)  LDD1694  [25]
 LDCM0492  CL97 HEK-293T C392(1.31); C455(1.00); C300(0.98); C733(1.04)  LDD1695  [25]
 LDCM0493  CL98 HEK-293T C392(1.24); C455(1.03); C300(1.05); C733(1.03)  LDD1696  [25]
 LDCM0494  CL99 HEK-293T C392(1.01); C455(0.95); C300(0.95); C733(0.84)  LDD1697  [25]
 LDCM0495  E2913 HEK-293T C392(1.03); C455(0.96); C300(1.02); C733(0.76)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C392(2.92)  LDD1702  [6]
 LDCM0625  F8 Ramos C170(1.04); C405(1.62)  LDD2187  [27]
 LDCM0573  Fragment11 Ramos C170(5.38); C405(20.00)  LDD2190  [27]
 LDCM0576  Fragment14 Ramos C405(1.08)  LDD2193  [27]
 LDCM0586  Fragment28 Ramos C170(1.01); C405(11.89)  LDD2198  [27]
 LDCM0468  Fragment33 HEK-293T C392(1.15); C455(1.01); C300(0.93); C733(0.79)  LDD1671  [25]
 LDCM0566  Fragment4 Ramos C170(1.54)  LDD2184  [27]
 LDCM0427  Fragment51 HEK-293T C392(1.05); C455(1.00); C300(1.03); C733(0.86)  LDD1631  [25]
 LDCM0569  Fragment7 Ramos C170(1.05); C405(3.41)  LDD2186  [27]
 LDCM0107  IAA HeLa H295(0.00); C392(0.00); H325(0.00)  LDD0221  [20]
 LDCM0022  KB02 HEK-293T C392(0.78); C170(0.91); C300(1.02); C733(0.91)  LDD1492  [25]
 LDCM0023  KB03 Jurkat C170(4.82)  LDD0209  [8]
 LDCM0024  KB05 COLO792 C300(1.30)  LDD3310  [28]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C392(1.14); C1145(1.02)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C392(0.41)  LDD2121  [6]
 LDCM0109  NEM HeLa H325(0.00); H295(0.00)  LDD0223  [20]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C392(0.49)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C392(1.16); C1145(1.71)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C392(0.95); C1145(0.84)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C392(1.09); C1145(0.80)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C392(1.40); C1145(1.22)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1145(0.10)  LDD2096  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C392(0.60); C1145(1.28)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C392(0.96); C1145(1.14)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C392(0.59); C1145(0.95)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C392(1.00); C170(0.76)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C392(0.84)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C392(1.13); C1145(1.35)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C392(0.67)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C392(1.01); C1145(1.21)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C392(0.40); C1145(1.08)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C392(0.65); C1145(0.60)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C392(1.00); C1145(0.99)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C392(1.02)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C392(0.87); C170(0.42)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C1145(0.73)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1145(1.11)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C392(1.82); C1145(1.77)  LDD2119  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1145(0.53)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C392(1.03); C1145(0.79)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C392(0.32); C1145(0.78)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C392(0.89); C1145(0.65); C455(0.67); C216(0.91)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C392(0.38); C1145(0.64)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C392(0.85); C1145(0.92)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C392(1.30); C1145(1.07)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C392(1.03)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C170(0.52)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C392(1.08); C1145(1.16); C733(2.28)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C392(0.98); C1145(0.98)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C392(1.02); C1145(0.82); C216(0.97)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1145(1.37); C392(1.28)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C392(0.67); C1145(0.76)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C392(0.41)  LDD2141  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C392(2.42); C1145(2.26)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C1145(2.07); C455(0.20)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C392(1.07); C1145(0.92)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C392(0.74); C733(0.45)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C1145(0.51)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C392(0.31)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C1145(0.23)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C392(1.33); C1145(1.61)  LDD2153  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein kinase C delta type (PRKCD) AGC Ser/Thr protein kinase family Q05655
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222

The Drug(s) Related To This Target

Approved
Click To Hide/Show 22 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amsacrine Small molecular drug DB00276
Ciprofloxacin Small molecular drug DB00537
Dactinomycin Small molecular drug DB00970
Daunorubicin Small molecular drug DB00694
Dexrazoxane Small molecular drug DB00380
Doxorubicin Small molecular drug DB00997
Enoxacin Small molecular drug DB00467
Epirubicin Small molecular drug DB00445
Etoposide Small molecular drug DB00773
Finafloxacin Small molecular drug DB09047
Idarubicin Small molecular drug DB01177
Lomefloxacin Small molecular drug DB00978
Mitoxantrone Small molecular drug DB01204
Moxifloxacin Small molecular drug DB00218
Norfloxacin Small molecular drug DB01059
Ofloxacin Small molecular drug DB01165
Pefloxacin Small molecular drug DB00487
Podofilox Small molecular drug DB01179
Sparfloxacin Small molecular drug DB01208
Teniposide Small molecular drug DB00444
Trovafloxacin Small molecular drug DB00685
Valrubicin Small molecular drug DB00385
Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Annamycin Small molecular drug DCT2Q3
Camsirubicin Small molecular drug DE53JQ
Pk1 Small molecular drug D01ZMS
Investigative
Click To Hide/Show 15 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amrubicin Small molecular drug DB06263
Banoxantrone Small molecular drug DB04975
Becatecarin Small molecular drug DB06362
Declopramide Small molecular drug DB06421
Elsamitrucin Small molecular drug DB05129
Fleroxacin Small molecular drug DB04576
Genistein Small molecular drug DB01645
Lucanthone Small molecular drug DB04967
Nk314 Small molecular drug DGZ38L
13-deoxydoxorubicin . DB05706
Aldoxorubicin . DB06013
Amonafide . DB05022
Rta 744 . DB05920
Sp1049c . DB04978
Zen-012 . DB06042

References

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3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
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10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
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25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840