Details of the Target

General Information of Target

Target ID LDTP06310
Target Name Early endosome antigen 1 (EEA1)
Gene Name EEA1
Gene ID 8411
Synonyms
ZFYVE2; Early endosome antigen 1; Endosome-associated protein p162; Zinc finger FYVE domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRRILQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHY
EAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQ
QQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYD
EERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNM
TLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL
TQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSL
HRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH
SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ
HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS
LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD
QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA
QRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLS
LEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI
VSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTE
LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ
LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN
INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN
YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL
KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI
TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV
KKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSS
QRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL
DNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNI
FCAECSAKNALTPSSKKPVRVCDACFNDLQG
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
Uniprot ID
Q15075
Ensemble ID
ENST00000322349.13
HGNC ID
HGNC:3185

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
W1
 Probe Info  		18.97  LDD0235  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K1013(0.93); K1081(7.20); K1084(10.00); K1151(8.88)  LDD0277  [3]
OPA-S-S-alkyne
 Probe Info  		K583(3.77)  LDD3494  [4]
Probe 1
 Probe Info  		Y262(174.11); Y318(36.75); Y550(99.37); Y1036(9.25)  LDD3495  [5]
Sulforaphane-probe2
 Probe Info  		2.70  LDD0042  [6]
HHS-475
 Probe Info  		Y1036(0.17); Y1021(1.12); Y286(1.25)  LDD0264  [7]
Acrolein
 Probe Info  		N.A.  LDD0222  [8]
DBIA
 Probe Info  		C1382(1.01); C1385(1.01); C346(0.88)  LDD0078  [9]
5E-2FA
 Probe Info  		H72(0.00); H599(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		K485(0.00); K487(0.00); K1340(0.00)  LDD0199  [11]
m-APA
 Probe Info  		H72(0.00); H599(0.00)  LDD2231  [10]
CY4
 Probe Info  		N.A.  LDD0247  [12]
N1
 Probe Info  		E1189(0.00); K1197(0.00); R1191(0.00)  LDD0245  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		C1299(0.00); C704(0.00)  LDD0036  [13]
Lodoacetamide azide
 Probe Info  		C346(0.00); C1299(0.00); C704(0.00)  LDD0037  [13]
BTD
 Probe Info  		N.A.  LDD0004  [14]
IPM
 Probe Info  		N.A.  LDD0147  [15]
NHS
 Probe Info  		N.A.  LDD0010  [14]
TFBX
 Probe Info  		C255(0.00); C1299(0.00); C894(0.00)  LDD0148  [15]
VSF
 Probe Info  		N.A.  LDD0007  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
NAIA_5
 Probe Info  		C255(0.00); C704(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		6.92  LDD1779  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1134(0.83); C255(1.50)  LDD2142  [18]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1134(1.17); C704(0.68); C255(0.67)  LDD2112  [18]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1134(1.08); C704(1.06); C255(0.99)  LDD2117  [18]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C255(1.47)  LDD2152  [18]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1134(0.97)  LDD2103  [18]
 LDCM0214  AC1 HCT 116 C346(1.37)  LDD0531  [9]
 LDCM0215  AC10 HEK-293T C346(0.83)  LDD0813  [9]
 LDCM0216  AC100 HEK-293T C346(1.11)  LDD0814  [9]
 LDCM0217  AC101 HEK-293T C346(0.89)  LDD0815  [9]
 LDCM0218  AC102 HEK-293T C346(0.94)  LDD0816  [9]
 LDCM0219  AC103 HEK-293T C346(0.88)  LDD0817  [9]
 LDCM0220  AC104 HEK-293T C346(0.98)  LDD0818  [9]
 LDCM0221  AC105 HEK-293T C346(0.92)  LDD0819  [9]
 LDCM0222  AC106 HEK-293T C346(0.87)  LDD0820  [9]
 LDCM0223  AC107 HEK-293T C346(0.91)  LDD0821  [9]
 LDCM0224  AC108 HEK-293T C346(0.82)  LDD0822  [9]
 LDCM0225  AC109 HEK-293T C346(0.92)  LDD0823  [9]
 LDCM0226  AC11 HEK-293T C346(0.85)  LDD0824  [9]
 LDCM0227  AC110 HEK-293T C346(1.05)  LDD0825  [9]
 LDCM0228  AC111 HEK-293T C346(1.29)  LDD0826  [9]
 LDCM0229  AC112 HEK-293T C346(1.08)  LDD0827  [9]
 LDCM0230  AC113 HCT 116 C346(1.05)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C346(0.95)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C346(0.90)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C346(0.97)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C346(1.18)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C346(1.06)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C346(0.91)  LDD0553  [9]
 LDCM0237  AC12 HEK-293T C346(0.83)  LDD0835  [9]
 LDCM0238  AC120 HCT 116 C346(0.90)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C346(1.04)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C346(0.93)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C346(1.51)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C346(0.98)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C346(0.88)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C346(0.95)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C346(1.09)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C346(0.73)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C346(0.60)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C346(0.70)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C346(0.60)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C346(0.65)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C346(0.79)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C346(0.44)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C346(0.42)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C346(0.91)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C346(0.64)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C346(0.53)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C346(0.42)  LDD0575  [9]
 LDCM0259  AC14 HEK-293T C346(0.94)  LDD0857  [9]
 LDCM0260  AC140 HCT 116 C346(0.64)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C346(0.47)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C346(0.72)  LDD0579  [9]
 LDCM0270  AC15 HEK-293T C346(1.06)  LDD0868  [9]
 LDCM0276  AC17 HCT 116 C346(1.11)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C346(1.02)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C346(0.97)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C346(1.90)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C346(1.13)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C346(1.30)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C346(1.18)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C346(0.92)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C346(1.41)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C346(1.31)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C346(1.18)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C346(1.43)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C346(1.11)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C346(1.14)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C346(1.53)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C346(1.33)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C346(1.22)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C346(1.35)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C346(1.34)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C346(1.52)  LDD0612  [9]
 LDCM0296  AC35 PaTu 8988t C1361(0.93)  LDD1175  [9]
 LDCM0297  AC36 PaTu 8988t C1361(1.04)  LDD1176  [9]
 LDCM0298  AC37 PaTu 8988t C1361(1.40)  LDD1177  [9]
 LDCM0299  AC38 PaTu 8988t C1361(1.27)  LDD1178  [9]
 LDCM0300  AC39 PaTu 8988t C1361(1.35)  LDD1179  [9]
 LDCM0301  AC4 HCT 116 C346(1.28)  LDD0618  [9]
 LDCM0302  AC40 PaTu 8988t C1361(1.65)  LDD1181  [9]
 LDCM0303  AC41 PaTu 8988t C1361(1.49)  LDD1182  [9]
 LDCM0304  AC42 PaTu 8988t C1361(1.32)  LDD1183  [9]
 LDCM0305  AC43 PaTu 8988t C1361(1.28)  LDD1184  [9]
 LDCM0306  AC44 PaTu 8988t C1361(2.62)  LDD1185  [9]
 LDCM0307  AC45 PaTu 8988t C1361(1.94)  LDD1186  [9]
 LDCM0308  AC46 PaTu 8988t C1361(0.82)  LDD1187  [9]
 LDCM0309  AC47 PaTu 8988t C1361(1.15)  LDD1188  [9]
 LDCM0310  AC48 PaTu 8988t C1361(1.08)  LDD1189  [9]
 LDCM0311  AC49 PaTu 8988t C1361(1.42)  LDD1190  [9]
 LDCM0312  AC5 HCT 116 C346(1.33)  LDD0629  [9]
 LDCM0313  AC50 PaTu 8988t C1361(1.59)  LDD1192  [9]
 LDCM0314  AC51 PaTu 8988t C1361(0.27)  LDD1193  [9]
 LDCM0315  AC52 PaTu 8988t C1361(1.15)  LDD1194  [9]
 LDCM0316  AC53 PaTu 8988t C1361(1.94)  LDD1195  [9]
 LDCM0317  AC54 PaTu 8988t C1361(2.13)  LDD1196  [9]
 LDCM0318  AC55 PaTu 8988t C1361(1.23)  LDD1197  [9]
 LDCM0319  AC56 PaTu 8988t C1361(1.31)  LDD1198  [9]
 LDCM0320  AC57 HEK-293T C346(0.80)  LDD0918  [9]
 LDCM0321  AC58 HEK-293T C346(0.86)  LDD0919  [9]
 LDCM0322  AC59 HEK-293T C346(0.82)  LDD0920  [9]
 LDCM0323  AC6 HEK-293T C346(0.84)  LDD0921  [9]
 LDCM0324  AC60 HEK-293T C346(0.77)  LDD0922  [9]
 LDCM0325  AC61 HEK-293T C346(1.41)  LDD0923  [9]
 LDCM0326  AC62 HEK-293T C346(1.18)  LDD0924  [9]
 LDCM0327  AC63 HEK-293T C346(1.17)  LDD0925  [9]
 LDCM0328  AC64 HEK-293T C346(1.10)  LDD0926  [9]
 LDCM0329  AC65 HEK-293T C346(1.19)  LDD0927  [9]
 LDCM0330  AC66 HEK-293T C346(1.02)  LDD0928  [9]
 LDCM0331  AC67 HEK-293T C346(1.07)  LDD0929  [9]
 LDCM0332  AC68 HEK-293T C346(1.31)  LDD0930  [9]
 LDCM0333  AC69 HEK-293T C346(1.06)  LDD0931  [9]
 LDCM0334  AC7 HEK-293T C346(0.96)  LDD0932  [9]
 LDCM0335  AC70 HEK-293T C346(0.94)  LDD0933  [9]
 LDCM0336  AC71 HEK-293T C346(1.02)  LDD0934  [9]
 LDCM0337  AC72 HEK-293T C346(1.00)  LDD0935  [9]
 LDCM0338  AC73 HEK-293T C346(1.21)  LDD0936  [9]
 LDCM0339  AC74 HEK-293T C346(0.90)  LDD0937  [9]
 LDCM0340  AC75 HEK-293T C346(1.04)  LDD0938  [9]
 LDCM0341  AC76 HEK-293T C346(1.35)  LDD0939  [9]
 LDCM0342  AC77 HEK-293T C346(1.13)  LDD0940  [9]
 LDCM0343  AC78 HEK-293T C346(1.42)  LDD0941  [9]
 LDCM0344  AC79 HEK-293T C346(0.99)  LDD0942  [9]
 LDCM0345  AC8 HEK-293T C346(1.15)  LDD0943  [9]
 LDCM0346  AC80 HEK-293T C346(1.04)  LDD0944  [9]
 LDCM0347  AC81 HEK-293T C346(1.11)  LDD0945  [9]
 LDCM0348  AC82 HEK-293T C346(1.44)  LDD0946  [9]
 LDCM0349  AC83 HEK-293T C346(0.88)  LDD0947  [9]
 LDCM0350  AC84 HEK-293T C346(1.03)  LDD0948  [9]
 LDCM0351  AC85 HEK-293T C346(1.14)  LDD0949  [9]
 LDCM0352  AC86 HEK-293T C346(0.75)  LDD0950  [9]
 LDCM0353  AC87 HEK-293T C346(1.10)  LDD0951  [9]
 LDCM0354  AC88 HEK-293T C346(1.43)  LDD0952  [9]
 LDCM0355  AC89 HEK-293T C346(0.97)  LDD0953  [9]
 LDCM0357  AC90 HEK-293T C346(0.83)  LDD0955  [9]
 LDCM0358  AC91 HEK-293T C346(0.76)  LDD0956  [9]
 LDCM0359  AC92 HEK-293T C346(0.67)  LDD0957  [9]
 LDCM0360  AC93 HEK-293T C346(0.71)  LDD0958  [9]
 LDCM0361  AC94 HEK-293T C346(0.96)  LDD0959  [9]
 LDCM0362  AC95 HEK-293T C346(0.77)  LDD0960  [9]
 LDCM0363  AC96 HEK-293T C346(0.75)  LDD0961  [9]
 LDCM0364  AC97 HEK-293T C346(1.40)  LDD0962  [9]
 LDCM0365  AC98 HEK-293T C346(0.83)  LDD0963  [9]
 LDCM0366  AC99 HEK-293T C346(0.67)  LDD0964  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C346(0.79)  LDD2113  [18]
 LDCM0248  AKOS034007472 HEK-293T C346(0.88)  LDD0846  [9]
 LDCM0356  AKOS034007680 HEK-293T C346(1.04)  LDD0954  [9]
 LDCM0275  AKOS034007705 HEK-293T C346(0.95)  LDD0873  [9]
 LDCM0020  ARS-1620 HCC44 C1382(1.01); C1385(1.01); C346(0.88)  LDD0078  [9]
 LDCM0498  BS-3668 MDA-MB-231 C1134(0.51)  LDD2091  [18]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HCT 116 C346(0.68)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C346(0.78)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C346(1.15)  LDD0686  [9]
 LDCM0370  CL101 HEK-293T C346(1.18)  LDD0968  [9]
 LDCM0371  CL102 HEK-293T C346(1.14)  LDD0969  [9]
 LDCM0372  CL103 HEK-293T C346(1.08)  LDD0970  [9]
 LDCM0373  CL104 HEK-293T C346(0.91)  LDD0971  [9]
 LDCM0374  CL105 HCT 116 C346(0.95)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C346(0.85)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C346(1.20)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C346(0.99)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C346(1.06)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C346(0.68)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C346(1.06)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C346(1.04)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C346(1.08)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C346(1.38)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C346(1.18)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C346(1.31)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C346(1.47)  LDD0703  [9]
 LDCM0387  CL117 PaTu 8988t C1361(1.06)  LDD1266  [9]
 LDCM0388  CL118 PaTu 8988t C1361(1.38)  LDD1267  [9]
 LDCM0389  CL119 PaTu 8988t C1361(1.13)  LDD1268  [9]
 LDCM0390  CL12 HCT 116 C346(1.06)  LDD0707  [9]
 LDCM0391  CL120 PaTu 8988t C1361(1.21)  LDD1270  [9]
 LDCM0392  CL121 PaTu 8988t C1361(1.10)  LDD1271  [9]
 LDCM0393  CL122 PaTu 8988t C1361(1.19)  LDD1272  [9]
 LDCM0394  CL123 PaTu 8988t C1361(1.43)  LDD1273  [9]
 LDCM0395  CL124 PaTu 8988t C1361(1.06)  LDD1274  [9]
 LDCM0396  CL125 HEK-293T C346(0.99)  LDD0994  [9]
 LDCM0397  CL126 HEK-293T C346(0.97)  LDD0995  [9]
 LDCM0398  CL127 HEK-293T C346(0.78)  LDD0996  [9]
 LDCM0399  CL128 HEK-293T C346(0.83)  LDD0997  [9]
 LDCM0400  CL13 HCT 116 C346(0.81)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C346(0.75)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C346(1.00)  LDD0719  [9]
 LDCM0403  CL16 HEK-293T C346(0.95)  LDD1001  [9]
 LDCM0404  CL17 HEK-293T C346(1.07)  LDD1002  [9]
 LDCM0405  CL18 HEK-293T C346(1.11)  LDD1003  [9]
 LDCM0406  CL19 HEK-293T C346(0.86)  LDD1004  [9]
 LDCM0407  CL2 HCT 116 C346(0.89)  LDD0724  [9]
 LDCM0408  CL20 HEK-293T C346(1.02)  LDD1006  [9]
 LDCM0409  CL21 HEK-293T C346(1.26)  LDD1007  [9]
 LDCM0410  CL22 HEK-293T C346(1.04)  LDD1008  [9]
 LDCM0411  CL23 HEK-293T C346(1.18)  LDD1009  [9]
 LDCM0412  CL24 HEK-293T C346(0.97)  LDD1010  [9]
 LDCM0413  CL25 HEK-293T C346(1.06)  LDD1011  [9]
 LDCM0414  CL26 HEK-293T C346(1.08)  LDD1012  [9]
 LDCM0415  CL27 HEK-293T C346(1.06)  LDD1013  [9]
 LDCM0416  CL28 HEK-293T C346(1.05)  LDD1014  [9]
 LDCM0417  CL29 HEK-293T C346(0.95)  LDD1015  [9]
 LDCM0418  CL3 HCT 116 C346(0.70)  LDD0735  [9]
 LDCM0419  CL30 HEK-293T C346(1.39)  LDD1017  [9]
 LDCM0420  CL31 HEK-293T C346(1.16)  LDD1018  [9]
 LDCM0421  CL32 HEK-293T C346(1.49)  LDD1019  [9]
 LDCM0422  CL33 HEK-293T C346(1.49)  LDD1020  [9]
 LDCM0423  CL34 HEK-293T C346(1.08)  LDD1021  [9]
 LDCM0424  CL35 HEK-293T C346(1.53)  LDD1022  [9]
 LDCM0425  CL36 HEK-293T C346(1.30)  LDD1023  [9]
 LDCM0426  CL37 HEK-293T C346(1.14)  LDD1024  [9]
 LDCM0428  CL39 HEK-293T C346(1.95)  LDD1026  [9]
 LDCM0429  CL4 HCT 116 C346(0.93)  LDD0746  [9]
 LDCM0430  CL40 HEK-293T C346(1.48)  LDD1028  [9]
 LDCM0431  CL41 HEK-293T C346(1.81)  LDD1029  [9]
 LDCM0432  CL42 HEK-293T C346(1.77)  LDD1030  [9]
 LDCM0433  CL43 HEK-293T C346(1.59)  LDD1031  [9]
 LDCM0434  CL44 HEK-293T C346(1.44)  LDD1032  [9]
 LDCM0435  CL45 HEK-293T C346(1.78)  LDD1033  [9]
 LDCM0436  CL46 HCT 116 C346(0.81)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C346(0.84)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C346(0.88)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C346(0.77)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C346(0.71)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C346(0.89)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C346(0.92)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C346(0.79)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C346(0.85)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C346(0.76)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C346(0.65)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C346(0.75)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C346(0.83)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C346(0.75)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C346(0.87)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C346(1.01)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C346(0.74)  LDD0769  [9]
 LDCM0453  CL61 HEK-293T C346(1.53)  LDD1051  [9]
 LDCM0454  CL62 HEK-293T C346(1.36)  LDD1052  [9]
 LDCM0455  CL63 HEK-293T C346(1.58)  LDD1053  [9]
 LDCM0456  CL64 HEK-293T C346(1.05)  LDD1054  [9]
 LDCM0457  CL65 HEK-293T C346(1.36)  LDD1055  [9]
 LDCM0458  CL66 HEK-293T C346(1.41)  LDD1056  [9]
 LDCM0459  CL67 HEK-293T C346(1.14)  LDD1057  [9]
 LDCM0460  CL68 HEK-293T C346(1.55)  LDD1058  [9]
 LDCM0461  CL69 HEK-293T C346(1.28)  LDD1059  [9]
 LDCM0462  CL7 HCT 116 C346(1.03)  LDD0779  [9]
 LDCM0463  CL70 HEK-293T C346(1.28)  LDD1061  [9]
 LDCM0464  CL71 HEK-293T C346(1.84)  LDD1062  [9]
 LDCM0465  CL72 HEK-293T C346(1.13)  LDD1063  [9]
 LDCM0466  CL73 HEK-293T C346(1.55)  LDD1064  [9]
 LDCM0467  CL74 HEK-293T C346(2.32)  LDD1065  [9]
 LDCM0469  CL76 HEK-293T C346(0.93)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C346(0.89); C704(0.94)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C346(0.92); C1377(0.82)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C346(0.99)  LDD1675  [19]
 LDCM0473  CL8 HCT 116 C346(0.82)  LDD0790  [9]
 LDCM0474  CL80 HEK-293T C346(0.90); C1377(0.79)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C346(1.07)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C346(0.93); C1377(0.99)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C346(1.06); C704(1.28); C1377(0.91)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C346(1.01)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C346(0.89)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C346(0.95)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C346(0.97)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C346(0.73)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C346(0.83); C704(0.97)  LDD1686  [19]
 LDCM0484  CL9 HCT 116 C346(0.85)  LDD0801  [9]
 LDCM0485  CL90 HEK-293T C346(0.89); C1377(0.97)  LDD1688  [19]
 LDCM0486  CL91 HCT 116 C346(1.91)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C346(1.26)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C346(0.98)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C346(1.33)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C346(1.23)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C346(1.80)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C346(2.35)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C346(1.06)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C346(1.26)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C346(1.05)  LDD1698  [19]
 LDCM0468  Fragment33 HEK-293T C346(2.01)  LDD1066  [9]
 LDCM0427  Fragment51 HEK-293T C346(1.34)  LDD1025  [9]
 LDCM0116  HHS-0101 DM93 Y1036(0.17); Y1021(1.12); Y286(1.25)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y286(0.74); Y1021(0.81); Y1036(1.99)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y286(0.45); Y1021(0.83); Y1036(1.95)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y1021(0.78); Y286(1.20); Y1036(3.15)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y116(0.11); Y286(0.58); Y1036(0.84); Y1021(0.95)  LDD0268  [7]
 LDCM0022  KB02 HCT 116 C1382(1.37); C1385(1.37)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C1382(1.17); C1385(1.17)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C1382(1.35); C1385(1.35)  LDD0082  [9]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1134(1.10)  LDD2102  [18]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C1134(1.21); C255(0.98)  LDD2090  [18]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1134(0.84); C255(0.67)  LDD2092  [18]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1134(1.72); C255(1.22)  LDD2093  [18]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1134(1.23); C255(2.47)  LDD2094  [18]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1134(0.28); C1102(0.48)  LDD2096  [18]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C1134(0.75); C255(0.79)  LDD2097  [18]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1134(0.64); C255(0.56)  LDD2098  [18]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C704(0.80); C255(0.99)  LDD2099  [18]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1134(0.88); C255(0.50)  LDD2100  [18]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1134(0.66); C255(1.05)  LDD2101  [18]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1134(0.95); C255(0.55)  LDD2104  [18]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1134(1.39)  LDD2105  [18]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C1134(0.81); C255(0.40)  LDD2106  [18]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1134(0.92); C704(0.99); C255(0.85); C346(0.84)  LDD2107  [18]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1134(0.84)  LDD2108  [18]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1134(0.80); C255(0.96)  LDD2109  [18]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C255(0.72)  LDD2110  [18]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1134(1.14); C255(1.17)  LDD2111  [18]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1134(0.97); C255(0.79)  LDD2114  [18]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C255(0.69)  LDD2115  [18]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C1134(0.23)  LDD2116  [18]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1134(0.23); C255(0.62); C1102(0.74)  LDD2118  [18]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C255(2.34)  LDD2119  [18]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1134(0.99); C255(0.86)  LDD2120  [18]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1134(0.20); C1102(0.72)  LDD2122  [18]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1134(0.78); C255(0.72)  LDD2123  [18]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1134(0.31); C255(0.74)  LDD2124  [18]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C255(1.12)  LDD2125  [18]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C255(0.58); C1102(0.73)  LDD2126  [18]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1134(1.02); C704(1.14); C255(1.16)  LDD2127  [18]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1134(0.99); C255(0.90)  LDD2128  [18]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1134(0.99); C704(0.74); C255(0.73)  LDD2129  [18]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1134(0.41); C255(0.34)  LDD2133  [18]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C255(0.38)  LDD2134  [18]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1134(0.58); C704(0.63)  LDD2135  [18]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1134(1.01); C704(1.01)  LDD2136  [18]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1134(1.05); C255(1.07)  LDD2137  [18]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C255(1.97); C1134(0.93)  LDD1700  [18]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1134(0.79); C255(0.93)  LDD2140  [18]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1134(0.78); C704(0.62); C255(0.96)  LDD2141  [18]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1134(1.22); C255(1.05)  LDD2143  [18]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1134(3.24)  LDD2144  [18]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1134(0.99); C255(0.87)  LDD2146  [18]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C1134(3.38); C255(3.51)  LDD2147  [18]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1134(0.29); C255(0.41); C346(0.51)  LDD2148  [18]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C1134(0.25)  LDD2149  [18]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1134(0.61)  LDD2150  [18]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C1134(0.57)  LDD2151  [18]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C1134(1.38)  LDD2153  [18]
 LDCM0003  Sulforaphane MCF-7 2.70  LDD0042  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Ras-related protein Rab-22A (RAB22A) Rab family Q9UL26
Ras-related protein Rab-5A (RAB5A) Rab family P20339
Ras-related protein Rab-5B (RAB5B) Rab family P61020
Ras-related protein Rab-5C (RAB5C) Rab family P51148
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger FYVE domain-containing protein 16 (ZFYVE16) . Q7Z3T8
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sterile alpha motif domain-containing protein 9 (SAMD9) . Q5K651

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Inositol 13-bisphosphate . DB02942

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402