Details of the Target

General Information of Target

Target ID LDTP03626
Target Name Peroxiredoxin-2 (PRDX2)
Gene Name PRDX2
Gene ID 7001
Synonyms
NKEFB; TDPX1; Peroxiredoxin-2; EC 1.11.1.24; Natural killer cell-enhancing factor B; NKEF-B; PRP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Thioredoxin-dependent peroxiredoxin 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSN
RAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKT
DEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGS
DTIKPNVDDSKEYFSKHN
Target Bioclass
Enzyme
Family
Peroxiredoxin family, AhpC/Prx1 subfamily
Subcellular location
Cytoplasm
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
Uniprot ID
P32119
Ensemble ID
ENST00000301522.3
HGNC ID
HGNC:9353
ChEMBL ID
CHEMBL4295744

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MOLT4 Deletion: p.R91GfsTer9 IA-alkyne    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		5.22  LDD0215  [1]
Jackson_1
 Probe Info  		10.64  LDD0122  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
SAA-alkyne
 Probe Info  		1.07  LDD0252  [4]
W1
 Probe Info  		17.29  LDD0235  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
STPyne
 Probe Info  		K10(5.36); K177(5.26); K184(5.88); K26(2.20)  LDD0277  [7]
AZ-9
 Probe Info  		E113(1.03); E122(0.98); D22(1.03)  LDD2208  [8]
ONAyne
 Probe Info  		K10(0.00); K16(0.00)  LDD0273  [7]
OPA-S-S-alkyne
 Probe Info  		K119(2.00); K196(2.99); K92(6.57)  LDD3494  [9]
Probe 1
 Probe Info  		Y115(41.34); Y126(66.16)  LDD3495  [10]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [11]
THZ1-DTB
 Probe Info  		C172(1.14)  LDD0460  [11]
AHL-Pu-1
 Probe Info  		C70(2.34)  LDD0171  [12]
EA-probe
 Probe Info  		N.A.  LDD0440  [13]
HHS-475
 Probe Info  		Y164(3.19)  LDD0265  [14]
DBIA
 Probe Info  		C172(0.70)  LDD0532  [15]
5E-2FA
 Probe Info  		N.A.  LDD2235  [16]
ATP probe
 Probe Info  		K16(0.00); K177(0.00); K184(0.00); K119(0.00)  LDD0199  [17]
m-APA
 Probe Info  		N.A.  LDD2231  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C70(0.00); C172(0.00); C51(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [19]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [20]
IPIAA_L
 Probe Info  		C172(0.00); C70(0.00)  LDD0031  [20]
Lodoacetamide azide
 Probe Info  		C70(0.00); C172(0.00); C51(0.00)  LDD0037  [18]
IPM
 Probe Info  		N.A.  LDD0025  [21]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [21]
1d-yne
 Probe Info  		K177(0.00); K92(0.00)  LDD0356  [22]
Compound 10
 Probe Info  		N.A.  LDD2216  [23]
Compound 11
 Probe Info  		N.A.  LDD2213  [23]
NHS
 Probe Info  		K26(0.00); K16(0.00); K135(0.00)  LDD0010  [24]
SF
 Probe Info  		K34(0.00); K92(0.00); K10(0.00)  LDD0028  [25]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [26]
Ox-W18
 Probe Info  		N.A.  LDD2175  [27]
1c-yne
 Probe Info  		K184(0.00); K177(0.00)  LDD0228  [22]
Acrolein
 Probe Info  		C172(0.00); H168(0.00)  LDD0217  [28]
Methacrolein
 Probe Info  		C172(0.00); H168(0.00)  LDD0218  [28]
AOyne
 Probe Info  		15.00  LDD0443  [29]
NAIA_5
 Probe Info  		C70(0.00); C51(0.00); C172(0.00)  LDD2223  [30]
HHS-465
 Probe Info  		K10(0.00); K135(0.00); K16(0.00); K26(0.00)  LDD2240  [31]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe12
 Probe Info  		6.14  LDD0473  [32]
FFF probe13
 Probe Info  		12.48  LDD0475  [32]
FFF probe14
 Probe Info  		5.32  LDD0477  [32]
STS-1
 Probe Info  		N.A.  LDD0068  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C70(2.34)  LDD0171  [12]
 LDCM0214  AC1 HEK-293T C172(1.03)  LDD0812  [15]
 LDCM0215  AC10 HCT 116 C172(0.70)  LDD0532  [15]
 LDCM0216  AC100 PaTu 8988t C172(0.95)  LDD1095  [15]
 LDCM0217  AC101 PaTu 8988t C172(0.98)  LDD1096  [15]
 LDCM0218  AC102 PaTu 8988t C172(0.97)  LDD1097  [15]
 LDCM0219  AC103 PaTu 8988t C172(1.63)  LDD1098  [15]
 LDCM0220  AC104 PaTu 8988t C172(0.91)  LDD1099  [15]
 LDCM0221  AC105 PaTu 8988t C172(0.96)  LDD1100  [15]
 LDCM0222  AC106 PaTu 8988t C172(0.81)  LDD1101  [15]
 LDCM0223  AC107 PaTu 8988t C172(1.06)  LDD1102  [15]
 LDCM0224  AC108 PaTu 8988t C172(1.22)  LDD1103  [15]
 LDCM0225  AC109 PaTu 8988t C172(0.95)  LDD1104  [15]
 LDCM0226  AC11 HCT 116 C172(0.76)  LDD0543  [15]
 LDCM0227  AC110 PaTu 8988t C172(1.43)  LDD1106  [15]
 LDCM0228  AC111 PaTu 8988t C172(1.14)  LDD1107  [15]
 LDCM0229  AC112 PaTu 8988t C172(1.00)  LDD1108  [15]
 LDCM0230  AC113 HCT 116 C172(1.28)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C172(1.24)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C172(1.66)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C172(2.20)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C172(1.24)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C172(1.04)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C172(1.05)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C172(0.95)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C172(1.93)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C172(0.92)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C172(1.25)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C172(1.10)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C172(1.08)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C172(0.94)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C172(1.49)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C172(1.71)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C172(0.87)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C172(0.90)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C172(0.80)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C172(1.15)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C172(0.67)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C172(0.70)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C172(0.77)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C172(0.83)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C172(0.98)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C172(0.80)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C172(0.77)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C172(0.88)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C172(0.77)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C172(0.94)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C172(0.95)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C172(0.63)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C172(1.01)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C172(0.91)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C172(0.81)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C172(0.66)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C172(0.93)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C172(0.68)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C172(0.76)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C172(0.86)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C172(1.08)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C172(0.96)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C172(0.79)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C172(0.73)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C172(0.83)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C172(0.91)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C172(0.91)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C172(0.86)  LDD2161  [15]
 LDCM0276  AC17 HCT 116 C172(1.17)  LDD0593  [15]
 LDCM0277  AC18 HCT 116 C172(0.90)  LDD0594  [15]
 LDCM0278  AC19 HCT 116 C172(1.23)  LDD0595  [15]
 LDCM0279  AC2 HEK-293T C172(1.19)  LDD0877  [15]
 LDCM0280  AC20 HCT 116 C172(1.11)  LDD0597  [15]
 LDCM0281  AC21 HCT 116 C172(1.05)  LDD0598  [15]
 LDCM0282  AC22 HCT 116 C172(1.10)  LDD0599  [15]
 LDCM0283  AC23 HCT 116 C172(0.85)  LDD0600  [15]
 LDCM0284  AC24 HCT 116 C172(1.16)  LDD0601  [15]
 LDCM0285  AC25 HCT 116 C172(0.99)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C172(0.93)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C172(0.85)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C172(0.93)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C172(0.98)  LDD0606  [15]
 LDCM0290  AC3 HEK-293T C172(0.93)  LDD0888  [15]
 LDCM0291  AC30 HCT 116 C172(0.93)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C172(0.86)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C172(0.76)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C172(1.10)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C172(0.91)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C172(1.50)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C172(1.16)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C172(1.04)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C172(1.05)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C172(1.03)  LDD0617  [15]
 LDCM0301  AC4 HEK-293T C172(1.00)  LDD0899  [15]
 LDCM0302  AC40 HCT 116 C172(0.93)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C172(1.13)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C172(0.95)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C172(1.08)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C172(0.85)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C172(0.77)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C172(1.29)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C172(1.30)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C172(1.17)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C172(1.19)  LDD0628  [15]
 LDCM0312  AC5 HEK-293T C172(1.01)  LDD0910  [15]
 LDCM0313  AC50 HCT 116 C172(1.32)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C172(0.93)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C172(1.25)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C172(1.26)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C172(1.33)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C172(1.49)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C172(1.40)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C172(1.10)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C172(0.82)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C172(1.00)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C172(0.77)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C172(1.06)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C172(0.94)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C172(1.18)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C172(1.43)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C172(1.25)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C172(1.19)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C172(1.06)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C172(1.41)  LDD0648  [15]
 LDCM0334  AC7 HCT 116 C172(0.61)  LDD0651  [15]
 LDCM0345  AC8 HCT 116 C172(0.75)  LDD0662  [15]
 LDCM0349  AC83 HCT 116 C172(1.06)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C172(1.01)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C172(1.02)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C172(1.14)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C172(1.01)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C172(1.07)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C172(1.00)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C172(1.24)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C172(1.17)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C172(1.08)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C172(1.11)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C172(1.33)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C172(1.28)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C172(1.29)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C172(1.24)  LDD0681  [15]
 LDCM0365  AC98 PaTu 8988t C172(0.88)  LDD1244  [15]
 LDCM0366  AC99 PaTu 8988t C172(0.91)  LDD1245  [15]
 LDCM0248  AKOS034007472 HCT 116 C172(0.83)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C172(0.79)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C172(0.95)  LDD0592  [15]
 LDCM0108  Chloroacetamide HeLa C172(0.00); H168(0.00)  LDD0222  [28]
 LDCM0632  CL-Sc Hep-G2 C172(0.46)  LDD2227  [30]
 LDCM0367  CL1 HCT 116 C172(0.92)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C172(1.26)  LDD0685  [15]
 LDCM0369  CL100 HEK-293T C172(0.98)  LDD0967  [15]
 LDCM0370  CL101 HCT 116 C172(1.04)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C172(0.94)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C172(0.98)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C172(1.09)  LDD0690  [15]
 LDCM0374  CL105 HCT 116 C172(1.03)  LDD0691  [15]
 LDCM0375  CL106 HCT 116 C172(1.07)  LDD0692  [15]
 LDCM0376  CL107 HCT 116 C172(1.06)  LDD0693  [15]
 LDCM0377  CL108 HCT 116 C172(1.33)  LDD0694  [15]
 LDCM0378  CL109 HCT 116 C172(1.20)  LDD0695  [15]
 LDCM0379  CL11 HCT 116 C172(0.79)  LDD0696  [15]
 LDCM0380  CL110 HCT 116 C172(1.07)  LDD0697  [15]
 LDCM0381  CL111 HCT 116 C172(1.22)  LDD0698  [15]
 LDCM0382  CL112 HCT 116 C172(0.61)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C172(1.05)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C172(0.65)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C172(1.03)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C172(0.97)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C172(1.30)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C172(0.94)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C172(1.41)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C172(1.25)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C172(1.41)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C172(0.75)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C172(0.78)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C172(0.86)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C172(1.16)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C172(1.23)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C172(0.78)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C172(0.98)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C172(1.06)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C172(0.99)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C172(1.34)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C172(1.19)  LDD0719  [15]
 LDCM0403  CL16 HEK-293T C172(0.78)  LDD1001  [15]
 LDCM0404  CL17 HCT 116 C172(1.37)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C172(1.48)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C172(1.10)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C172(1.19)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C172(1.34)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C172(1.19)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C172(0.94)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C172(0.80)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C172(1.04)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C172(1.13)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C172(1.13)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C172(1.09)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C172(1.18)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C172(1.08)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C172(1.11)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C172(1.14)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C172(1.03)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C172(1.00)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C172(1.02)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C172(1.23)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C172(0.95)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C172(1.01)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C172(1.08)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C172(1.06)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C172(1.14)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C172(0.73)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C172(1.02)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C172(1.15)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C172(1.20)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C172(1.03)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C172(0.70)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C172(1.01)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C172(0.91)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C172(0.86)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C172(1.02)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C172(1.06)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C172(1.03)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C172(0.87)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C172(0.94)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C172(0.90)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C172(1.00)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C172(0.97)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C172(0.89)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C172(0.85)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C172(0.98)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C172(1.07)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C172(1.27)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C172(1.07)  LDD0769  [15]
 LDCM0453  CL61 HEK-293T C172(0.83); C70(1.10); C51(1.11)  LDD1656  [34]
 LDCM0454  CL62 HEK-293T C172(0.94); C70(1.01); C51(1.27)  LDD1657  [34]
 LDCM0455  CL63 HEK-293T C172(0.92); C70(0.96)  LDD1658  [34]
 LDCM0456  CL64 HEK-293T C172(0.81); C70(0.88); C51(0.90)  LDD1659  [34]
 LDCM0457  CL65 HEK-293T C172(0.86); C70(0.94); C51(1.00)  LDD1660  [34]
 LDCM0458  CL66 HEK-293T C172(1.05); C70(0.86); C51(0.95)  LDD1661  [34]
 LDCM0459  CL67 HEK-293T C172(0.98); C70(1.01)  LDD1662  [34]
 LDCM0460  CL68 HEK-293T C172(0.98); C70(0.85); C51(1.02)  LDD1663  [34]
 LDCM0461  CL69 HEK-293T C172(1.11); C70(0.96); C51(0.76)  LDD1664  [34]
 LDCM0462  CL7 HCT 116 C172(1.05)  LDD0779  [15]
 LDCM0463  CL70 HEK-293T C172(0.96); C70(1.08)  LDD1666  [34]
 LDCM0464  CL71 HEK-293T C172(1.23); C70(1.17); C51(1.26)  LDD1667  [34]
 LDCM0465  CL72 HEK-293T C172(1.05); C70(1.15); C51(1.20)  LDD1668  [34]
 LDCM0466  CL73 HEK-293T C172(0.86); C70(0.93); C51(1.10)  LDD1669  [34]
 LDCM0467  CL74 HEK-293T C172(0.93); C70(0.97); C51(1.09)  LDD1670  [34]
 LDCM0469  CL76 HCT 116 C172(0.87)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C172(0.81)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C172(0.97)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C172(0.91)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C172(0.63)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C172(0.90)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C172(1.39)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C172(0.91)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C172(0.66)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C172(0.87)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C172(0.72)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C172(0.69)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C172(0.71)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C172(0.69)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C172(0.79)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C172(0.76)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C172(0.63)  LDD0802  [15]
 LDCM0486  CL91 HEK-293T C172(1.39)  LDD1084  [15]
 LDCM0487  CL92 HEK-293T C172(1.48)  LDD1085  [15]
 LDCM0488  CL93 HEK-293T C172(0.99)  LDD1086  [15]
 LDCM0489  CL94 HEK-293T C172(1.35)  LDD1087  [15]
 LDCM0490  CL95 HEK-293T C172(1.21)  LDD1088  [15]
 LDCM0491  CL96 HEK-293T C172(1.84)  LDD1089  [15]
 LDCM0492  CL97 HEK-293T C172(1.32)  LDD1090  [15]
 LDCM0493  CL98 HEK-293T C172(1.02)  LDD1091  [15]
 LDCM0494  CL99 HEK-293T C172(1.02)  LDD1092  [15]
 LDCM0495  E2913 HEK-293T C172(0.97); C70(0.90)  LDD1698  [34]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C172(0.58)  LDD1702  [35]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [13]
 LDCM0468  Fragment33 HEK-293T C172(0.89); C70(1.00)  LDD1671  [34]
 LDCM0427  Fragment51 HCT 116 C172(0.89)  LDD0744  [15]
 LDCM0117  HHS-0201 DM93 Y164(3.19)  LDD0265  [14]
 LDCM0107  IAA HeLa C172(0.00); H168(0.00)  LDD0221  [28]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [11]
 LDCM0022  KB02 HEK-293T C172(1.01); C70(0.94)  LDD1492  [34]
 LDCM0023  KB03 HEK-293T C172(0.98); C70(1.00)  LDD1497  [34]
 LDCM0024  KB05 SK-HEP1 C172(2.00)  LDD3424  [36]
 LDCM0109  NEM HeLa N.A.  LDD0223  [28]
 LDCM0627  NUDT7-COV-1 HEK-293T C172(0.89)  LDD2206  [37]
 LDCM0628  OTUB2-COV-1 HEK-293T C172(0.34)  LDD2207  [37]
 LDCM0021  THZ1 HeLa S3 C172(1.14)  LDD0460  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Thioredoxin (TXN) Thioredoxin family P10599
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal transducer and activator of transcription 3 (STAT3) Transcription factor STAT family P40763

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Copper . DB09130
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
3-sulfino-l-alanine Small molecular drug DB02153
N-carbamoyl-alanine . DB04048

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1. J Proteome Res. 2023 Jul 7;22(7):2450-2459. doi: 10.1021/acs.jproteome.3c00188. Epub 2023 Jun 22.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
14 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
17 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
18 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
19 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
24 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
25 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
26 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
27 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
28 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
29 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
30 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
31 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
32 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
33 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
34 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
35 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
36 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
37 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.