Details of the Target

General Information of Target

Target ID LDTP06588
Target Name Drebrin (DBN1)
Gene Name DBN1
Gene ID 1627
Synonyms
D0S117E; Drebrin; Developmentally-regulated brain protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFEN
QKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNASS
VEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQF
WEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQ
TLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERV
ASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVT
SSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAED
LMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWP
GNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPP
ATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQ
SQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections. Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS. Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines. Involved in memory-related synaptic plasticity in the hippocampus.
Uniprot ID
Q16643
Ensemble ID
ENST00000292385.9
HGNC ID
HGNC:2695

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
W1
 Probe Info  		16.89  LDD0235  [2]
FBP2
 Probe Info  		2.13  LDD0323  [3]
TH211
 Probe Info  		Y163(11.70)  LDD0257  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K173(0.62); K238(9.64); K271(4.05); K295(6.25)  LDD0277  [6]
BTD
 Probe Info  		C98(4.28); C96(6.28)  LDD1699  [7]
OPA-S-S-alkyne
 Probe Info  		K248(0.86)  LDD3494  [8]
Probe 1
 Probe Info  		Y163(12.79)  LDD3495  [9]
DBIA
 Probe Info  		C70(1.98)  LDD3310  [10]
AHL-Pu-1
 Probe Info  		C308(20.00)  LDD0168  [11]
5E-2FA
 Probe Info  		H9(0.00); H235(0.00); H57(0.00)  LDD2235  [12]
ATP probe
 Probe Info  		N.A.  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C68(0.00); C96(0.00); C98(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C613(0.00); C68(0.00); C96(0.00); C98(0.00)  LDD0037  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [17]
WYneN
 Probe Info  		N.A.  LDD0021  [18]
ENE
 Probe Info  		N.A.  LDD0006  [18]
IPM
 Probe Info  		C308(0.00); C96(0.00)  LDD0005  [18]
NPM
 Probe Info  		N.A.  LDD0016  [18]
SF
 Probe Info  		K165(0.00); Y163(0.00)  LDD0028  [19]
VSF
 Probe Info  		C96(0.00); C613(0.00)  LDD0007  [18]
Phosphinate-6
 Probe Info  		C96(0.00); C308(0.00)  LDD0018  [20]
1c-yne
 Probe Info  		K165(0.00); K271(0.00); K79(0.00)  LDD0228  [21]
Acrolein
 Probe Info  		C613(0.00); C68(0.00); C98(0.00)  LDD0217  [22]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [22]
Methacrolein
 Probe Info  		C98(0.00); C613(0.00); C68(0.00); C96(0.00)  LDD0218  [22]
AOyne
 Probe Info  		8.20  LDD0443  [23]
NAIA_5
 Probe Info  		N.A.  LDD2223  [24]
HHS-465
 Probe Info  		K165(0.00); Y163(0.00)  LDD2240  [25]
HHS-475
 Probe Info  		Y163(1.01)  LDD2238  [26]
HHS-482
 Probe Info  		Y163(0.87)  LDD2239  [26]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe12
 Probe Info  		20.00  LDD0473  [27]
FFF probe13
 Probe Info  		7.33  LDD0475  [27]
FFF probe2
 Probe Info  		5.06  LDD0463  [27]
FFF probe3
 Probe Info  		20.00  LDD0464  [27]
FFF probe6
 Probe Info  		5.62  LDD0468  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C96(0.95); C98(0.97)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C308(0.35); C96(1.07); C98(0.99)  LDD2112  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C308(1.18); C96(1.04); C68(0.95)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C308(1.17); C96(0.99); C98(1.00)  LDD2152  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C96(0.98)  LDD2131  [7]
 LDCM0025  4SU-RNA HEK-293T C308(20.00)  LDD0168  [11]
 LDCM0026  4SU-RNA+native RNA DM93 C632(2.49); C613(2.59)  LDD0171  [11]
 LDCM0214  AC1 HEK-293T C308(0.93); C96(0.97); C613(0.96); C68(0.95)  LDD1507  [28]
 LDCM0215  AC10 HEK-293T C308(1.00); C96(0.93); C98(1.24); C613(0.97)  LDD1508  [28]
 LDCM0226  AC11 HEK-293T C308(1.01); C96(1.25); C613(0.97); C68(0.94)  LDD1509  [28]
 LDCM0237  AC12 HEK-293T C308(0.97); C96(0.91); C613(0.98); C68(0.86)  LDD1510  [28]
 LDCM0259  AC14 HEK-293T C308(1.22); C96(0.91); C613(0.96); C68(1.01)  LDD1512  [28]
 LDCM0270  AC15 HEK-293T C308(1.03); C96(0.92); C613(1.02); C68(0.95)  LDD1513  [28]
 LDCM0276  AC17 HEK-293T C308(1.13); C96(1.10); C613(0.99); C68(0.92)  LDD1515  [28]
 LDCM0277  AC18 HEK-293T C308(0.91); C96(1.01); C98(1.05); C613(0.97)  LDD1516  [28]
 LDCM0278  AC19 HEK-293T C308(0.94); C96(1.01); C613(1.29); C68(0.72)  LDD1517  [28]
 LDCM0279  AC2 HEK-293T C308(0.96); C96(0.89); C98(1.30); C613(0.92)  LDD1518  [28]
 LDCM0280  AC20 HEK-293T C308(1.03); C96(1.02); C613(1.02); C68(0.93)  LDD1519  [28]
 LDCM0281  AC21 HEK-293T C308(1.10); C96(1.04); C98(1.14); C613(1.01)  LDD1520  [28]
 LDCM0282  AC22 HEK-293T C308(1.07); C96(0.97); C613(0.92); C68(1.01)  LDD1521  [28]
 LDCM0283  AC23 HEK-293T C308(1.07); C96(1.08); C613(0.99); C68(1.00)  LDD1522  [28]
 LDCM0284  AC24 HEK-293T C308(1.08); C96(0.98); C613(0.84); C68(0.92)  LDD1523  [28]
 LDCM0285  AC25 HEK-293T C308(1.05); C96(1.07); C613(1.02); C68(0.99)  LDD1524  [28]
 LDCM0286  AC26 HEK-293T C308(1.00); C96(0.95); C98(1.16); C613(1.01)  LDD1525  [28]
 LDCM0287  AC27 HEK-293T C308(1.04); C96(1.07); C613(1.16); C68(1.04)  LDD1526  [28]
 LDCM0288  AC28 HEK-293T C308(1.01); C96(0.94); C613(1.03); C68(0.95)  LDD1527  [28]
 LDCM0289  AC29 HEK-293T C308(1.08); C96(1.03); C98(1.00); C613(1.09)  LDD1528  [28]
 LDCM0290  AC3 HEK-293T C308(1.01); C96(1.14); C613(1.02); C68(0.97)  LDD1529  [28]
 LDCM0291  AC30 HEK-293T C308(0.99); C96(0.96); C613(1.00); C68(1.01)  LDD1530  [28]
 LDCM0292  AC31 HEK-293T C308(0.99); C96(1.00); C613(1.08); C68(0.98)  LDD1531  [28]
 LDCM0293  AC32 HEK-293T C308(0.99); C96(0.93); C613(1.08); C68(0.98)  LDD1532  [28]
 LDCM0294  AC33 HEK-293T C308(1.15); C96(1.02); C613(0.95); C68(0.91)  LDD1533  [28]
 LDCM0295  AC34 HEK-293T C308(0.98); C96(0.86); C98(1.38); C613(1.03)  LDD1534  [28]
 LDCM0296  AC35 HEK-293T C308(1.11); C96(1.25); C613(1.08); C68(0.98)  LDD1535  [28]
 LDCM0297  AC36 HEK-293T C308(0.99); C96(0.90); C613(1.03); C68(1.00)  LDD1536  [28]
 LDCM0298  AC37 HEK-293T C308(0.96); C96(0.90); C98(1.56); C613(1.17)  LDD1537  [28]
 LDCM0299  AC38 HEK-293T C308(1.12); C96(0.89); C613(0.83); C68(1.02)  LDD1538  [28]
 LDCM0300  AC39 HEK-293T C308(1.08); C96(0.94); C613(1.00); C68(0.96)  LDD1539  [28]
 LDCM0301  AC4 HEK-293T C308(0.91); C96(0.89); C613(0.92); C68(0.99)  LDD1540  [28]
 LDCM0302  AC40 HEK-293T C308(1.07); C96(0.85); C613(1.00); C68(0.93)  LDD1541  [28]
 LDCM0303  AC41 HEK-293T C308(1.15); C96(0.99); C613(0.92); C68(0.90)  LDD1542  [28]
 LDCM0304  AC42 HEK-293T C308(1.02); C96(0.88); C98(1.57); C613(1.00)  LDD1543  [28]
 LDCM0305  AC43 HEK-293T C308(1.03); C96(1.27); C613(1.07); C68(1.04)  LDD1544  [28]
 LDCM0306  AC44 HEK-293T C308(0.98); C96(0.88); C613(1.01); C68(0.96)  LDD1545  [28]
 LDCM0307  AC45 HEK-293T C308(1.05); C96(0.94); C98(1.40); C613(1.18)  LDD1546  [28]
 LDCM0308  AC46 HEK-293T C308(1.05); C96(0.91); C613(0.97); C68(1.00)  LDD1547  [28]
 LDCM0309  AC47 HEK-293T C308(1.03); C96(0.87); C613(0.92); C68(0.99)  LDD1548  [28]
 LDCM0310  AC48 HEK-293T C308(1.06); C96(0.87); C613(0.84); C68(0.97)  LDD1549  [28]
 LDCM0311  AC49 HEK-293T C308(1.05); C96(1.06); C613(1.01); C68(0.85)  LDD1550  [28]
 LDCM0312  AC5 HEK-293T C308(0.93); C96(0.90); C98(1.11); C613(1.04)  LDD1551  [28]
 LDCM0313  AC50 HEK-293T C308(1.01); C96(0.93); C98(1.62); C613(1.02)  LDD1552  [28]
 LDCM0314  AC51 HEK-293T C308(1.01); C96(1.19); C613(1.03); C68(1.00)  LDD1553  [28]
 LDCM0315  AC52 HEK-293T C308(0.99); C96(0.92); C613(1.05); C68(0.93)  LDD1554  [28]
 LDCM0316  AC53 HEK-293T C308(0.94); C96(0.95); C98(1.38); C613(1.02)  LDD1555  [28]
 LDCM0317  AC54 HEK-293T C308(0.97); C96(0.93); C613(0.95); C68(1.03)  LDD1556  [28]
 LDCM0318  AC55 HEK-293T C308(0.95); C96(0.98); C613(0.92); C68(0.96)  LDD1557  [28]
 LDCM0319  AC56 HEK-293T C308(1.04); C96(0.94); C613(0.84); C68(0.95)  LDD1558  [28]
 LDCM0320  AC57 HEK-293T C308(1.03); C96(0.99); C613(0.92); C68(0.93)  LDD1559  [28]
 LDCM0321  AC58 HEK-293T C308(0.92); C96(0.84); C98(1.27); C613(0.97)  LDD1560  [28]
 LDCM0322  AC59 HEK-293T C308(0.89); C96(1.21); C613(1.10); C68(1.03)  LDD1561  [28]
 LDCM0323  AC6 HEK-293T C308(0.94); C96(0.93); C613(1.01); C68(0.99)  LDD1562  [28]
 LDCM0324  AC60 HEK-293T C308(1.02); C96(0.89); C613(0.96); C68(0.86)  LDD1563  [28]
 LDCM0325  AC61 HEK-293T C308(0.92); C96(0.96); C98(1.18); C613(1.11)  LDD1564  [28]
 LDCM0326  AC62 HEK-293T C308(0.92); C96(0.93); C613(1.01); C68(0.99)  LDD1565  [28]
 LDCM0327  AC63 HEK-293T C308(1.01); C96(0.92); C613(0.99); C68(1.01)  LDD1566  [28]
 LDCM0328  AC64 HEK-293T C308(0.90); C96(0.92); C613(0.93); C68(0.96)  LDD1567  [28]
 LDCM0334  AC7 HEK-293T C308(0.95); C96(0.92); C613(0.99); C68(0.97)  LDD1568  [28]
 LDCM0345  AC8 HEK-293T C308(0.93); C96(0.90); C613(0.81); C68(0.93)  LDD1569  [28]
 LDCM0545  Acetamide MDA-MB-231 C96(0.74)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C96(1.05); C98(1.03)  LDD2113  [7]
 LDCM0248  AKOS034007472 HEK-293T C308(0.96); C96(0.89); C98(1.32); C613(0.98)  LDD1511  [28]
 LDCM0356  AKOS034007680 HEK-293T C308(1.17); C96(1.02); C613(0.97); C68(0.92)  LDD1570  [28]
 LDCM0275  AKOS034007705 HEK-293T C308(1.04); C96(0.93); C613(0.86); C68(0.91)  LDD1514  [28]
 LDCM0156  Aniline NCI-H1299 11.84  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C613(1.53); C632(1.16)  LDD2214  [29]
 LDCM0108  Chloroacetamide HeLa H57(0.00); C68(0.00); C98(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C96(1.16); C308(0.41)  LDD2227  [24]
 LDCM0367  CL1 HEK-293T C308(1.13); C96(0.87); C613(0.98); C68(1.07)  LDD1571  [28]
 LDCM0368  CL10 HEK-293T C308(1.64); C96(0.70); C613(0.94); C68(0.99)  LDD1572  [28]
 LDCM0369  CL100 HEK-293T C308(0.93); C96(1.04); C613(0.99); C68(1.00)  LDD1573  [28]
 LDCM0370  CL101 HEK-293T C308(0.89); C96(0.99); C613(0.92); C68(0.99)  LDD1574  [28]
 LDCM0371  CL102 HEK-293T C308(0.97); C96(0.92); C98(1.04); C613(1.00)  LDD1575  [28]
 LDCM0372  CL103 HEK-293T C308(1.03); C96(1.06); C613(1.14); C68(0.95)  LDD1576  [28]
 LDCM0373  CL104 HEK-293T C308(0.87); C96(1.07); C613(0.98); C68(0.99)  LDD1577  [28]
 LDCM0374  CL105 HEK-293T C308(0.99); C96(1.05); C613(1.00); C68(1.01)  LDD1578  [28]
 LDCM0375  CL106 HEK-293T C308(1.04); C96(1.05); C98(1.01); C613(1.07)  LDD1579  [28]
 LDCM0376  CL107 HEK-293T C308(1.01); C96(0.99); C613(0.97); C68(0.99)  LDD1580  [28]
 LDCM0377  CL108 HEK-293T C308(0.98); C96(1.05); C613(0.92); C68(1.02)  LDD1581  [28]
 LDCM0378  CL109 HEK-293T C308(0.92); C96(0.94); C613(0.86); C68(1.05)  LDD1582  [28]
 LDCM0379  CL11 HEK-293T C308(1.41); C96(0.85); C613(1.10); C68(0.89)  LDD1583  [28]
 LDCM0380  CL110 HEK-293T C308(1.05); C96(0.94); C98(0.98); C613(0.98)  LDD1584  [28]
 LDCM0381  CL111 HEK-293T C308(1.02); C96(1.06); C613(0.97); C68(0.99)  LDD1585  [28]
 LDCM0382  CL112 HEK-293T C308(1.02); C96(1.10); C613(0.96); C68(0.93)  LDD1586  [28]
 LDCM0383  CL113 HEK-293T C308(1.09); C96(0.94); C613(0.92); C68(1.00)  LDD1587  [28]
 LDCM0384  CL114 HEK-293T C308(1.02); C96(0.87); C98(1.16); C613(0.97)  LDD1588  [28]
 LDCM0385  CL115 HEK-293T C308(0.97); C96(1.09); C613(1.03); C68(0.97)  LDD1589  [28]
 LDCM0386  CL116 HEK-293T C308(1.03); C96(1.17); C613(0.93); C68(0.96)  LDD1590  [28]
 LDCM0387  CL117 HEK-293T C308(1.03); C96(0.93); C613(0.94); C68(1.03)  LDD1591  [28]
 LDCM0388  CL118 HEK-293T C308(0.95); C96(0.95); C98(1.15); C613(1.15)  LDD1592  [28]
 LDCM0389  CL119 HEK-293T C308(0.98); C96(1.11); C613(0.91); C68(1.01)  LDD1593  [28]
 LDCM0390  CL12 HEK-293T C308(1.41); C96(0.79); C613(1.00); C68(0.84)  LDD1594  [28]
 LDCM0391  CL120 HEK-293T C308(0.93); C96(1.10); C613(0.90); C68(0.97)  LDD1595  [28]
 LDCM0392  CL121 HEK-293T C308(0.96); C96(1.01); C613(0.96); C68(1.02)  LDD1596  [28]
 LDCM0393  CL122 HEK-293T C308(0.90); C96(0.99); C98(1.09); C613(1.00)  LDD1597  [28]
 LDCM0394  CL123 HEK-293T C308(0.87); C96(1.07); C613(0.87); C68(0.98)  LDD1598  [28]
 LDCM0395  CL124 HEK-293T C308(0.92); C96(1.12); C613(0.77); C68(1.02)  LDD1599  [28]
 LDCM0396  CL125 HEK-293T C308(0.89); C96(0.97); C613(1.07); C68(1.03)  LDD1600  [28]
 LDCM0397  CL126 HEK-293T C308(0.83); C96(0.88); C98(1.17); C613(1.13)  LDD1601  [28]
 LDCM0398  CL127 HEK-293T C308(0.75); C96(1.04); C613(0.90); C68(1.00)  LDD1602  [28]
 LDCM0399  CL128 HEK-293T C308(0.80); C96(1.04); C613(0.98); C68(1.05)  LDD1603  [28]
 LDCM0400  CL13 HEK-293T C308(0.96); C96(0.92); C613(1.18); C68(0.89)  LDD1604  [28]
 LDCM0401  CL14 HEK-293T C308(1.12); C96(0.90); C98(1.11); C613(1.10)  LDD1605  [28]
 LDCM0402  CL15 HEK-293T C308(1.01); C96(1.02); C613(0.93); C68(0.82)  LDD1606  [28]
 LDCM0403  CL16 HEK-293T C308(1.07); C96(1.14); C613(0.99); C68(0.94)  LDD1607  [28]
 LDCM0404  CL17 HEK-293T C308(1.10); C96(0.85); C613(0.91); C68(0.78)  LDD1608  [28]
 LDCM0405  CL18 HEK-293T C308(1.00); C96(0.87); C98(1.04); C613(1.02)  LDD1609  [28]
 LDCM0406  CL19 HEK-293T C308(1.14); C96(1.25); C613(1.16); C68(0.86)  LDD1610  [28]
 LDCM0407  CL2 HEK-293T C308(1.05); C96(0.82); C98(1.01); C613(1.03)  LDD1611  [28]
 LDCM0408  CL20 HEK-293T C308(1.24); C96(0.92); C613(1.04); C68(0.85)  LDD1612  [28]
 LDCM0409  CL21 HEK-293T C308(1.33); C96(0.86); C98(1.44); C613(1.23)  LDD1613  [28]
 LDCM0410  CL22 HEK-293T C308(1.50); C96(0.87); C613(1.10); C68(1.05)  LDD1614  [28]
 LDCM0411  CL23 HEK-293T C308(1.41); C96(0.88); C613(1.18); C68(0.92)  LDD1615  [28]
 LDCM0412  CL24 HEK-293T C308(1.35); C96(0.84); C613(1.13); C68(0.95)  LDD1616  [28]
 LDCM0413  CL25 HEK-293T C308(0.93); C96(0.87); C613(0.84); C68(0.94)  LDD1617  [28]
 LDCM0414  CL26 HEK-293T C308(0.98); C96(1.02); C98(1.01); C613(1.18)  LDD1618  [28]
 LDCM0415  CL27 HEK-293T C308(0.96); C96(1.06); C613(1.10); C68(0.91)  LDD1619  [28]
 LDCM0416  CL28 HEK-293T C308(1.05); C96(1.12); C613(0.97); C68(0.92)  LDD1620  [28]
 LDCM0417  CL29 HEK-293T C308(1.04); C96(1.09); C613(1.12); C68(0.94)  LDD1621  [28]
 LDCM0418  CL3 HEK-293T C308(1.07); C96(1.04); C613(0.88); C68(0.88)  LDD1622  [28]
 LDCM0419  CL30 HEK-293T C308(1.09); C96(0.96); C98(1.06); C613(0.96)  LDD1623  [28]
 LDCM0420  CL31 HEK-293T C308(1.14); C96(1.19); C613(1.05); C68(0.86)  LDD1624  [28]
 LDCM0421  CL32 HEK-293T C308(1.07); C96(0.97); C613(1.06); C68(0.85)  LDD1625  [28]
 LDCM0422  CL33 HEK-293T C308(1.18); C96(0.87); C98(0.81); C613(0.95)  LDD1626  [28]
 LDCM0423  CL34 HEK-293T C308(1.32); C96(0.96); C613(1.03); C68(1.02)  LDD1627  [28]
 LDCM0424  CL35 HEK-293T C308(1.38); C96(1.04); C613(1.06); C68(1.01)  LDD1628  [28]
 LDCM0425  CL36 HEK-293T C308(1.22); C96(0.91); C613(0.99); C68(0.98)  LDD1629  [28]
 LDCM0426  CL37 HEK-293T C308(0.93); C96(0.89); C613(0.89); C68(1.04)  LDD1630  [28]
 LDCM0428  CL39 HEK-293T C308(0.92); C96(1.00); C613(0.95); C68(0.99)  LDD1632  [28]
 LDCM0429  CL4 HEK-293T C308(0.97); C96(1.09); C613(0.93); C68(0.90)  LDD1633  [28]
 LDCM0430  CL40 HEK-293T C308(1.07); C96(1.06); C613(1.03); C68(1.01)  LDD1634  [28]
 LDCM0431  CL41 HEK-293T C308(1.16); C96(0.96); C613(1.04); C68(0.87)  LDD1635  [28]
 LDCM0432  CL42 HEK-293T C308(0.91); C96(0.94); C98(1.36); C613(0.94)  LDD1636  [28]
 LDCM0433  CL43 HEK-293T C308(1.11); C96(1.07); C613(1.00); C68(0.90)  LDD1637  [28]
 LDCM0434  CL44 HEK-293T C308(1.11); C96(0.97); C613(1.04); C68(0.90)  LDD1638  [28]
 LDCM0435  CL45 HEK-293T C308(1.26); C96(0.99); C98(1.18); C613(1.06)  LDD1639  [28]
 LDCM0436  CL46 HEK-293T C308(1.51); C96(0.94); C613(1.25); C68(0.98)  LDD1640  [28]
 LDCM0437  CL47 HEK-293T C308(1.42); C96(0.97); C613(1.06); C68(1.01)  LDD1641  [28]
 LDCM0438  CL48 HEK-293T C308(1.21); C96(0.90); C613(1.01); C68(0.99)  LDD1642  [28]
 LDCM0439  CL49 HEK-293T C308(0.93); C96(0.82); C613(0.84); C68(1.04)  LDD1643  [28]
 LDCM0440  CL5 HEK-293T C308(1.12); C96(0.97); C613(1.01); C68(0.79)  LDD1644  [28]
 LDCM0441  CL50 HEK-293T C308(1.07); C96(0.89); C98(1.10); C613(0.99)  LDD1645  [28]
 LDCM0443  CL52 HEK-293T C308(1.09); C96(1.14); C613(0.97); C68(0.97)  LDD1646  [28]
 LDCM0444  CL53 HEK-293T C308(1.11); C96(0.85); C613(0.82); C68(0.89)  LDD1647  [28]
 LDCM0445  CL54 HEK-293T C308(0.94); C96(0.81); C98(1.64); C613(0.98)  LDD1648  [28]
 LDCM0446  CL55 HEK-293T C308(1.24); C96(1.30); C613(1.05); C68(0.89)  LDD1649  [28]
 LDCM0447  CL56 HEK-293T C308(1.14); C96(0.83); C613(1.02); C68(0.88)  LDD1650  [28]
 LDCM0448  CL57 HEK-293T C308(1.19); C96(0.85); C98(1.30); C613(1.05)  LDD1651  [28]
 LDCM0449  CL58 HEK-293T C308(1.54); C96(0.88); C613(0.91); C68(1.05)  LDD1652  [28]
 LDCM0450  CL59 HEK-293T C308(1.25); C96(0.94); C613(1.05); C68(0.93)  LDD1653  [28]
 LDCM0451  CL6 HEK-293T C308(0.96); C96(0.82); C98(1.16); C613(0.92)  LDD1654  [28]
 LDCM0452  CL60 HEK-293T C308(1.32); C96(0.80); C613(1.05); C68(0.94)  LDD1655  [28]
 LDCM0453  CL61 HEK-293T C308(0.97); C96(0.87); C613(0.94); C68(1.01)  LDD1656  [28]
 LDCM0454  CL62 HEK-293T C308(1.09); C96(0.89); C98(1.06); C613(1.03)  LDD1657  [28]
 LDCM0455  CL63 HEK-293T C308(1.08); C96(1.10); C613(1.01); C68(1.03)  LDD1658  [28]
 LDCM0456  CL64 HEK-293T C308(0.98); C96(1.04); C613(0.86); C68(0.97)  LDD1659  [28]
 LDCM0457  CL65 HEK-293T C308(1.09); C96(0.95); C613(1.05); C68(0.93)  LDD1660  [28]
 LDCM0458  CL66 HEK-293T C308(1.06); C96(0.85); C98(1.34); C613(1.05)  LDD1661  [28]
 LDCM0459  CL67 HEK-293T C308(1.07); C96(1.24); C613(1.15); C68(0.90)  LDD1662  [28]
 LDCM0460  CL68 HEK-293T C308(1.08); C96(0.85); C613(1.01); C68(0.89)  LDD1663  [28]
 LDCM0461  CL69 HEK-293T C308(1.08); C96(0.92); C98(1.37); C613(1.11)  LDD1664  [28]
 LDCM0462  CL7 HEK-293T C308(0.99); C96(1.15); C613(0.99); C68(0.90)  LDD1665  [28]
 LDCM0463  CL70 HEK-293T C308(1.47); C96(0.89); C613(1.05); C68(1.06)  LDD1666  [28]
 LDCM0464  CL71 HEK-293T C308(1.18); C96(0.96); C613(1.03); C68(0.96)  LDD1667  [28]
 LDCM0465  CL72 HEK-293T C308(1.29); C96(0.82); C613(0.87); C68(0.88)  LDD1668  [28]
 LDCM0466  CL73 HEK-293T C308(0.91); C96(0.87); C613(0.96); C68(1.10)  LDD1669  [28]
 LDCM0467  CL74 HEK-293T C308(0.96); C96(0.97); C98(1.08); C613(1.09)  LDD1670  [28]
 LDCM0469  CL76 HEK-293T C308(0.96); C96(1.10); C613(0.91); C68(1.05)  LDD1672  [28]
 LDCM0470  CL77 HEK-293T C308(1.01); C96(0.98); C613(0.97); C68(0.89)  LDD1673  [28]
 LDCM0471  CL78 HEK-293T C308(0.95); C96(0.93); C98(1.05); C613(0.98)  LDD1674  [28]
 LDCM0472  CL79 HEK-293T C308(1.06); C96(1.21); C613(1.07); C68(0.91)  LDD1675  [28]
 LDCM0473  CL8 HEK-293T C308(0.85); C96(0.67); C613(0.80); C68(0.81)  LDD1676  [28]
 LDCM0474  CL80 HEK-293T C308(0.98); C96(0.89); C613(1.01); C68(0.97)  LDD1677  [28]
 LDCM0475  CL81 HEK-293T C308(1.01); C96(1.02); C98(1.27); C613(1.14)  LDD1678  [28]
 LDCM0476  CL82 HEK-293T C308(1.24); C96(0.92); C613(1.05); C68(1.11)  LDD1679  [28]
 LDCM0477  CL83 HEK-293T C308(1.12); C96(0.91); C613(0.93); C68(1.00)  LDD1680  [28]
 LDCM0478  CL84 HEK-293T C308(1.12); C96(0.84); C613(1.12); C68(0.95)  LDD1681  [28]
 LDCM0479  CL85 HEK-293T C308(0.86); C96(0.87); C613(0.90); C68(1.04)  LDD1682  [28]
 LDCM0480  CL86 HEK-293T C308(0.69); C96(0.87); C98(1.24); C613(1.06)  LDD1683  [28]
 LDCM0481  CL87 HEK-293T C308(0.76); C96(1.11); C613(0.92); C68(0.98)  LDD1684  [28]
 LDCM0482  CL88 HEK-293T C308(0.79); C96(1.07); C613(1.08); C68(0.97)  LDD1685  [28]
 LDCM0483  CL89 HEK-293T C308(0.86); C96(0.88); C613(0.92); C68(0.89)  LDD1686  [28]
 LDCM0484  CL9 HEK-293T C308(1.34); C96(0.89); C98(1.74); C613(1.00)  LDD1687  [28]
 LDCM0485  CL90 HEK-293T C308(0.80); C96(0.67); C98(1.11); C613(0.82)  LDD1688  [28]
 LDCM0486  CL91 HEK-293T C308(0.77); C96(1.32); C613(0.99); C68(0.91)  LDD1689  [28]
 LDCM0487  CL92 HEK-293T C308(0.99); C96(0.78); C613(0.92); C68(0.87)  LDD1690  [28]
 LDCM0488  CL93 HEK-293T C308(1.06); C96(0.81); C98(1.44); C613(1.09)  LDD1691  [28]
 LDCM0489  CL94 HEK-293T C308(1.32); C96(0.84); C613(0.95); C68(1.03)  LDD1692  [28]
 LDCM0490  CL95 HEK-293T C308(1.00); C96(0.76); C613(1.03); C68(0.96)  LDD1693  [28]
 LDCM0491  CL96 HEK-293T C308(0.89); C96(0.76); C613(1.08); C68(0.93)  LDD1694  [28]
 LDCM0492  CL97 HEK-293T C308(0.97); C96(0.95); C613(0.86); C68(1.01)  LDD1695  [28]
 LDCM0493  CL98 HEK-293T C308(1.03); C96(0.92); C98(1.10); C613(1.06)  LDD1696  [28]
 LDCM0494  CL99 HEK-293T C308(0.99); C96(1.05); C613(0.98); C68(1.00)  LDD1697  [28]
 LDCM0495  E2913 HEK-293T C308(1.04); C96(1.08); C613(0.91); C68(0.80)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C308(1.17); C96(1.02)  LDD1702  [7]
 LDCM0468  Fragment33 HEK-293T C308(0.88); C96(1.06); C613(0.80); C68(0.95)  LDD1671  [28]
 LDCM0427  Fragment51 HEK-293T C308(0.95); C96(0.89); C98(1.05); C613(1.07)  LDD1631  [28]
 LDCM0107  IAA HeLa H57(0.00); C68(0.00); H235(0.00); C98(0.00)  LDD0221  [22]
 LDCM0022  KB02 HEK-293T C308(1.04); C96(1.00); C613(0.91); C68(1.11)  LDD1492  [28]
 LDCM0023  KB03 HEK-293T C308(1.06); C96(1.03); C613(1.03); C68(1.18)  LDD1497  [28]
 LDCM0024  KB05 COLO792 C70(1.98)  LDD3310  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C96(0.99)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C96(0.75)  LDD2121  [7]
 LDCM0109  NEM HeLa H57(0.00); H235(0.00)  LDD0223  [22]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C96(0.65); C98(1.01)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C308(0.91)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C96(0.98); C98(1.08)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C96(0.94)  LDD2096  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C96(2.24); C98(1.33)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C308(0.92); C96(0.99); C98(0.94); C68(1.33)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C96(1.28); C98(1.05)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C96(0.42)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C96(0.87); C98(0.98)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C96(0.80); C98(0.95)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C308(0.56)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C308(1.30); C96(1.06); C98(1.14); C68(1.53)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C96(0.78); C98(0.86)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C308(1.52); C96(0.98); C98(0.62); C68(0.72)  LDD2109  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C308(1.50); C96(0.69)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C96(0.58); C98(0.73)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C96(0.57)  LDD2115  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C96(1.05)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C96(1.09); C98(0.59)  LDD2118  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C96(0.70); C98(0.73)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C96(1.02); C98(0.73)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C308(0.90); C96(0.67); C98(0.90); C68(1.03)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C96(1.43); C98(1.34)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C96(0.83); C98(0.90); C68(0.97)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C96(1.74)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C308(0.80); C96(0.74); C68(1.11)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C96(0.64); C98(0.75)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C308(0.95); C96(0.37)  LDD2129  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C96(0.99)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C96(0.38); C98(0.84)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C96(1.02); C98(1.32); C68(1.32)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C96(0.62); C98(0.69); C68(0.99)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C98(1.71); C308(0.90); C96(0.82)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C308(0.91); C98(1.11); C68(0.92)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C96(0.83); C98(0.57)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C96(1.03); C98(0.93)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C308(1.70); C96(1.87); C98(1.51); C68(1.73)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C308(0.89); C96(0.78)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C96(3.38)  LDD2147  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C96(1.23)  LDD2149  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C96(2.52); C98(2.74)  LDD2151  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C96(2.10)  LDD2153  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C96(1.98); C96(1.04)  LDD2206  [30]
 LDCM0628  OTUB2-COV-1 HEK-293T C96(0.94); C96(0.58)  LDD2207  [30]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) PTEN phosphatase protein family P60484
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-X-C chemokine receptor type 4 (CXCR4) G-protein coupled receptor 1 family P61073
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Progranulin (GRN) Granulin family P28799
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Afadin (AFDN) . P55196
MYND-type zinc finger-containing chromatin reader ZMYND8 (ZMYND8) . Q9ULU4
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
26 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
30 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.