Details of the Target

General Information of Target

Target ID LDTP04866
Target Name Protein transport protein Sec61 subunit beta (SEC61B)
Gene Name SEC61B
Gene ID 10952
Synonyms
Protein transport protein Sec61 subunit beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGPTPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYT
EDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS
Target Bioclass
Transporter and channel
Family
SEC61-beta family
Subcellular location
Endoplasmic reticulum membrane
Function
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER.
Uniprot ID
P60468
Ensemble ID
ENST00000223641.5
HGNC ID
HGNC:16993

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.66  LDD0402  [1]
DA-P2
 Probe Info  		5.09  LDD0348  [2]
HRP
 Probe Info  		4.16  LDD0347  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
TG42
 Probe Info  		5.46  LDD0326  [4]
W1
 Probe Info  		12.30  LDD0235  [5]
TH211
 Probe Info  		Y59(6.09)  LDD0260  [6]
YN-4
 Probe Info  		100.00  LDD0445  [7]
STPyne
 Probe Info  		K20(9.27); K35(7.63)  LDD0277  [8]
BTD
 Probe Info  		C39(3.50)  LDD1699  [9]
ONAyne
 Probe Info  		N.A.  LDD0273  [8]
Probe 1
 Probe Info  		Y59(10.51)  LDD3495  [10]
DA-P3
 Probe Info  		5.01  LDD0179  [2]
AHL-Pu-1
 Probe Info  		C39(2.30)  LDD0168  [11]
EA-probe
 Probe Info  		N.A.  LDD0440  [12]
DBIA
 Probe Info  		C39(4.13)  LDD0209  [13]
ATP probe
 Probe Info  		N.A.  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [15]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [16]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [15]
ATP probe
 Probe Info  		N.A.  LDD0035  [17]
WYneN
 Probe Info  		N.A.  LDD0021  [18]
WYneO
 Probe Info  		N.A.  LDD0022  [18]
Compound 10
 Probe Info  		N.A.  LDD2216  [19]
ENE
 Probe Info  		N.A.  LDD0006  [18]
IPM
 Probe Info  		N.A.  LDD0005  [18]
TFBX
 Probe Info  		N.A.  LDD0148  [20]
VSF
 Probe Info  		N.A.  LDD0007  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [21]
Ox-W18
 Probe Info  		N.A.  LDD2175  [22]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [23]
Methacrolein
 Probe Info  		N.A.  LDD0218  [23]
AOyne
 Probe Info  		10.90  LDD0443  [24]
NAIA_5
 Probe Info  		N.A.  LDD2223  [25]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0139  [26]
Alk-rapa
 Probe Info  		5.78  LDD0213  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C39(1.00)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C39(1.10)  LDD2112  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C39(0.49)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C39(1.38)  LDD2152  [9]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C39(1.01)  LDD2103  [9]
 LDCM0025  4SU-RNA HEK-293T C39(2.30)  LDD0168  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C39(2.24)  LDD0169  [11]
 LDCM0214  AC1 HEK-293T C39(1.21)  LDD1507  [28]
 LDCM0215  AC10 HEK-293T C39(1.55)  LDD1508  [28]
 LDCM0226  AC11 HEK-293T C39(1.11)  LDD1509  [28]
 LDCM0237  AC12 HEK-293T C39(1.35)  LDD1510  [28]
 LDCM0259  AC14 HEK-293T C39(1.24)  LDD1512  [28]
 LDCM0270  AC15 HEK-293T C39(1.31)  LDD1513  [28]
 LDCM0276  AC17 HEK-293T C39(1.26)  LDD1515  [28]
 LDCM0277  AC18 HEK-293T C39(1.20)  LDD1516  [28]
 LDCM0278  AC19 HEK-293T C39(1.84)  LDD1517  [28]
 LDCM0279  AC2 HEK-293T C39(1.10)  LDD1518  [28]
 LDCM0280  AC20 HEK-293T C39(1.38)  LDD1519  [28]
 LDCM0281  AC21 HEK-293T C39(1.05)  LDD1520  [28]
 LDCM0282  AC22 HEK-293T C39(1.16)  LDD1521  [28]
 LDCM0283  AC23 HEK-293T C39(1.33)  LDD1522  [28]
 LDCM0284  AC24 HEK-293T C39(1.20)  LDD1523  [28]
 LDCM0285  AC25 HEK-293T C39(1.28)  LDD1524  [28]
 LDCM0286  AC26 HEK-293T C39(1.21)  LDD1525  [28]
 LDCM0287  AC27 HEK-293T C39(1.49)  LDD1526  [28]
 LDCM0288  AC28 HEK-293T C39(1.25)  LDD1527  [28]
 LDCM0289  AC29 HEK-293T C39(1.00)  LDD1528  [28]
 LDCM0290  AC3 HEK-293T C39(1.12)  LDD1529  [28]
 LDCM0291  AC30 HEK-293T C39(1.18)  LDD1530  [28]
 LDCM0292  AC31 HEK-293T C39(1.23)  LDD1531  [28]
 LDCM0293  AC32 HEK-293T C39(1.03)  LDD1532  [28]
 LDCM0294  AC33 HEK-293T C39(1.32)  LDD1533  [28]
 LDCM0295  AC34 HEK-293T C39(1.19)  LDD1534  [28]
 LDCM0296  AC35 HEK-293T C39(1.16)  LDD1535  [28]
 LDCM0297  AC36 HEK-293T C39(1.44)  LDD1536  [28]
 LDCM0298  AC37 HEK-293T C39(1.09)  LDD1537  [28]
 LDCM0299  AC38 HEK-293T C39(1.22)  LDD1538  [28]
 LDCM0300  AC39 HEK-293T C39(1.40)  LDD1539  [28]
 LDCM0301  AC4 HEK-293T C39(1.09)  LDD1540  [28]
 LDCM0302  AC40 HEK-293T C39(1.13)  LDD1541  [28]
 LDCM0303  AC41 HEK-293T C39(1.28)  LDD1542  [28]
 LDCM0304  AC42 HEK-293T C39(1.67)  LDD1543  [28]
 LDCM0305  AC43 HEK-293T C39(1.27)  LDD1544  [28]
 LDCM0306  AC44 HEK-293T C39(1.30)  LDD1545  [28]
 LDCM0307  AC45 HEK-293T C39(1.03)  LDD1546  [28]
 LDCM0308  AC46 HEK-293T C39(1.27)  LDD1547  [28]
 LDCM0309  AC47 HEK-293T C39(1.20)  LDD1548  [28]
 LDCM0310  AC48 HEK-293T C39(1.22)  LDD1549  [28]
 LDCM0311  AC49 HEK-293T C39(1.44)  LDD1550  [28]
 LDCM0312  AC5 HEK-293T C39(0.96)  LDD1551  [28]
 LDCM0313  AC50 HEK-293T C39(1.39)  LDD1552  [28]
 LDCM0314  AC51 HEK-293T C39(1.29)  LDD1553  [28]
 LDCM0315  AC52 HEK-293T C39(1.36)  LDD1554  [28]
 LDCM0316  AC53 HEK-293T C39(1.03)  LDD1555  [28]
 LDCM0317  AC54 HEK-293T C39(1.21)  LDD1556  [28]
 LDCM0318  AC55 HEK-293T C39(1.41)  LDD1557  [28]
 LDCM0319  AC56 HEK-293T C39(1.13)  LDD1558  [28]
 LDCM0320  AC57 HEK-293T C39(1.20)  LDD1559  [28]
 LDCM0321  AC58 HEK-293T C39(1.04)  LDD1560  [28]
 LDCM0322  AC59 HEK-293T C39(1.27)  LDD1561  [28]
 LDCM0323  AC6 HEK-293T C39(1.09)  LDD1562  [28]
 LDCM0324  AC60 HEK-293T C39(1.07)  LDD1563  [28]
 LDCM0325  AC61 HEK-293T C39(1.14)  LDD1564  [28]
 LDCM0326  AC62 HEK-293T C39(1.12)  LDD1565  [28]
 LDCM0327  AC63 HEK-293T C39(1.22)  LDD1566  [28]
 LDCM0328  AC64 HEK-293T C39(1.18)  LDD1567  [28]
 LDCM0334  AC7 HEK-293T C39(1.27)  LDD1568  [28]
 LDCM0345  AC8 HEK-293T C39(1.07)  LDD1569  [28]
 LDCM0520  AKOS000195272 MDA-MB-231 C39(1.17)  LDD2113  [9]
 LDCM0248  AKOS034007472 HEK-293T C39(1.02)  LDD1511  [28]
 LDCM0356  AKOS034007680 HEK-293T C39(1.32)  LDD1570  [28]
 LDCM0275  AKOS034007705 HEK-293T C39(1.22)  LDD1514  [28]
 LDCM0156  Aniline NCI-H1299 13.08  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C39(1.18)  LDD2171  [29]
 LDCM0632  CL-Sc Hep-G2 C39(20.00)  LDD2227  [25]
 LDCM0368  CL10 HEK-293T C39(0.74)  LDD1572  [28]
 LDCM0371  CL102 HEK-293T C39(0.74)  LDD1575  [28]
 LDCM0372  CL103 HEK-293T C39(1.34)  LDD1576  [28]
 LDCM0375  CL106 HEK-293T C39(0.62)  LDD1579  [28]
 LDCM0376  CL107 HEK-293T C39(1.31)  LDD1580  [28]
 LDCM0379  CL11 HEK-293T C39(0.54)  LDD1583  [28]
 LDCM0380  CL110 HEK-293T C39(0.68)  LDD1584  [28]
 LDCM0381  CL111 HEK-293T C39(1.27)  LDD1585  [28]
 LDCM0384  CL114 HEK-293T C39(0.83)  LDD1588  [28]
 LDCM0385  CL115 HEK-293T C39(1.36)  LDD1589  [28]
 LDCM0388  CL118 HEK-293T C39(0.62)  LDD1592  [28]
 LDCM0389  CL119 HEK-293T C39(1.29)  LDD1593  [28]
 LDCM0390  CL12 HEK-293T C39(0.55)  LDD1594  [28]
 LDCM0393  CL122 HEK-293T C39(0.63)  LDD1597  [28]
 LDCM0394  CL123 HEK-293T C39(1.15)  LDD1598  [28]
 LDCM0397  CL126 HEK-293T C39(1.15)  LDD1601  [28]
 LDCM0398  CL127 HEK-293T C39(1.03)  LDD1602  [28]
 LDCM0401  CL14 HEK-293T C39(0.85)  LDD1605  [28]
 LDCM0402  CL15 HEK-293T C39(1.21)  LDD1606  [28]
 LDCM0404  CL17 HEK-293T C39(1.14)  LDD1608  [28]
 LDCM0405  CL18 HEK-293T C39(1.08)  LDD1609  [28]
 LDCM0406  CL19 HEK-293T C39(1.02)  LDD1610  [28]
 LDCM0407  CL2 HEK-293T C39(1.20)  LDD1611  [28]
 LDCM0408  CL20 HEK-293T C39(0.66)  LDD1612  [28]
 LDCM0409  CL21 HEK-293T C39(0.73)  LDD1613  [28]
 LDCM0410  CL22 HEK-293T C39(0.72)  LDD1614  [28]
 LDCM0411  CL23 HEK-293T C39(0.56)  LDD1615  [28]
 LDCM0412  CL24 HEK-293T C39(0.49)  LDD1616  [28]
 LDCM0414  CL26 HEK-293T C39(0.82)  LDD1618  [28]
 LDCM0415  CL27 HEK-293T C39(1.24)  LDD1619  [28]
 LDCM0417  CL29 HEK-293T C39(1.18)  LDD1621  [28]
 LDCM0418  CL3 HEK-293T C39(1.00)  LDD1622  [28]
 LDCM0419  CL30 HEK-293T C39(0.95)  LDD1623  [28]
 LDCM0420  CL31 HEK-293T C39(1.05)  LDD1624  [28]
 LDCM0421  CL32 HEK-293T C39(0.91)  LDD1625  [28]
 LDCM0422  CL33 HEK-293T C39(0.59)  LDD1626  [28]
 LDCM0423  CL34 HEK-293T C39(0.72)  LDD1627  [28]
 LDCM0424  CL35 HEK-293T C39(0.47)  LDD1628  [28]
 LDCM0425  CL36 HEK-293T C39(0.53)  LDD1629  [28]
 LDCM0428  CL39 HEK-293T C39(1.20)  LDD1632  [28]
 LDCM0431  CL41 HEK-293T C39(1.22)  LDD1635  [28]
 LDCM0432  CL42 HEK-293T C39(0.88)  LDD1636  [28]
 LDCM0433  CL43 HEK-293T C39(0.84)  LDD1637  [28]
 LDCM0434  CL44 HEK-293T C39(0.84)  LDD1638  [28]
 LDCM0435  CL45 HEK-293T C39(0.81)  LDD1639  [28]
 LDCM0436  CL46 HEK-293T C39(0.71)  LDD1640  [28]
 LDCM0437  CL47 HEK-293T C39(0.54)  LDD1641  [28]
 LDCM0438  CL48 HEK-293T C39(0.38)  LDD1642  [28]
 LDCM0440  CL5 HEK-293T C39(0.98)  LDD1644  [28]
 LDCM0441  CL50 HEK-293T C39(0.84)  LDD1645  [28]
 LDCM0444  CL53 HEK-293T C39(1.24)  LDD1647  [28]
 LDCM0445  CL54 HEK-293T C39(1.51)  LDD1648  [28]
 LDCM0446  CL55 HEK-293T C39(0.80)  LDD1649  [28]
 LDCM0447  CL56 HEK-293T C39(0.76)  LDD1650  [28]
 LDCM0448  CL57 HEK-293T C39(0.82)  LDD1651  [28]
 LDCM0449  CL58 HEK-293T C39(0.82)  LDD1652  [28]
 LDCM0450  CL59 HEK-293T C39(0.61)  LDD1653  [28]
 LDCM0451  CL6 HEK-293T C39(0.91)  LDD1654  [28]
 LDCM0452  CL60 HEK-293T C39(0.53)  LDD1655  [28]
 LDCM0454  CL62 HEK-293T C39(0.93)  LDD1657  [28]
 LDCM0455  CL63 HEK-293T C39(1.20)  LDD1658  [28]
 LDCM0457  CL65 HEK-293T C39(1.27)  LDD1660  [28]
 LDCM0458  CL66 HEK-293T C39(1.08)  LDD1661  [28]
 LDCM0459  CL67 HEK-293T C39(0.98)  LDD1662  [28]
 LDCM0460  CL68 HEK-293T C39(0.73)  LDD1663  [28]
 LDCM0461  CL69 HEK-293T C39(0.66)  LDD1664  [28]
 LDCM0462  CL7 HEK-293T C39(0.79)  LDD1665  [28]
 LDCM0463  CL70 HEK-293T C39(0.80)  LDD1666  [28]
 LDCM0464  CL71 HEK-293T C39(0.81)  LDD1667  [28]
 LDCM0465  CL72 HEK-293T C39(0.62)  LDD1668  [28]
 LDCM0467  CL74 HEK-293T C39(0.84)  LDD1670  [28]
 LDCM0470  CL77 HEK-293T C39(1.14)  LDD1673  [28]
 LDCM0471  CL78 HEK-293T C39(1.26)  LDD1674  [28]
 LDCM0472  CL79 HEK-293T C39(1.13)  LDD1675  [28]
 LDCM0473  CL8 HEK-293T C39(0.70)  LDD1676  [28]
 LDCM0474  CL80 HEK-293T C39(0.94)  LDD1677  [28]
 LDCM0475  CL81 HEK-293T C39(0.80)  LDD1678  [28]
 LDCM0476  CL82 HEK-293T C39(0.91)  LDD1679  [28]
 LDCM0477  CL83 HEK-293T C39(0.62)  LDD1680  [28]
 LDCM0478  CL84 HEK-293T C39(0.74)  LDD1681  [28]
 LDCM0480  CL86 HEK-293T C39(1.14)  LDD1683  [28]
 LDCM0481  CL87 HEK-293T C39(1.07)  LDD1684  [28]
 LDCM0483  CL89 HEK-293T C39(1.07)  LDD1686  [28]
 LDCM0484  CL9 HEK-293T C39(0.66)  LDD1687  [28]
 LDCM0485  CL90 HEK-293T C39(0.86)  LDD1688  [28]
 LDCM0486  CL91 HEK-293T C39(0.84)  LDD1689  [28]
 LDCM0487  CL92 HEK-293T C39(1.03)  LDD1690  [28]
 LDCM0488  CL93 HEK-293T C39(0.85)  LDD1691  [28]
 LDCM0489  CL94 HEK-293T C39(0.96)  LDD1692  [28]
 LDCM0490  CL95 HEK-293T C39(0.75)  LDD1693  [28]
 LDCM0491  CL96 HEK-293T C39(0.95)  LDD1694  [28]
 LDCM0493  CL98 HEK-293T C39(0.89)  LDD1696  [28]
 LDCM0494  CL99 HEK-293T C39(0.99)  LDD1697  [28]
 LDCM0027  Dopamine HEK-293T 5.01  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C39(1.31)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C39(3.65)  LDD1702  [9]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [12]
 LDCM0625  F8 Ramos C39(1.14)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C39(2.02)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C39(1.92)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C39(0.91)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C39(0.54)  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C39(1.06)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C39(2.26)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C39(0.43)  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C39(0.82)  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C39(0.43)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C39(0.57)  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C39(0.82)  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C39(0.43)  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C39(1.41)  LDD2201  [30]
 LDCM0468  Fragment33 HEK-293T C39(1.22)  LDD1671  [28]
 LDCM0596  Fragment38 Ramos C39(0.62)  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C39(0.99)  LDD2184  [30]
 LDCM0427  Fragment51 HEK-293T C39(0.88)  LDD1631  [28]
 LDCM0610  Fragment52 Ramos C39(0.52)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C39(0.57)  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C39(1.32)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C39(1.68)  LDD2188  [30]
 LDCM0015  HNE MDA-MB-231 C39(1.11)  LDD0346  [30]
 LDCM0022  KB02 Ramos C39(2.42)  LDD2182  [30]
 LDCM0023  KB03 Jurkat C39(4.13)  LDD0209  [13]
 LDCM0024  KB05 COLO792 C39(5.58)  LDD3310  [31]
 LDCM0030  Luteolin HEK-293T 4.88  LDD0182  [2]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C39(0.97)  LDD2102  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C39(0.31)  LDD2121  [9]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C39(0.21)  LDD2089  [9]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C39(1.26)  LDD2090  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C39(0.79)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C39(1.33)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C39(1.03)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C39(0.67)  LDD2096  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C39(0.85)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C39(0.94)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C39(1.33)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C39(0.85)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C39(1.06)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C39(1.66)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C39(1.14)  LDD2106  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C39(0.73)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C39(0.86)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C39(0.73)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C39(3.95)  LDD2110  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C39(0.89)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C39(1.10)  LDD2114  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C39(1.05)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C39(1.00)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C39(2.29)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C39(1.01)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C39(1.01)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C39(0.79)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C39(0.85)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C39(0.80)  LDD2125  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C39(0.69)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C39(1.29)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C39(0.97)  LDD2129  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C39(0.94)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C39(1.01)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C39(1.03)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C39(1.03)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C39(0.77)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C39(0.55)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C39(1.05)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C39(2.53)  LDD2144  [9]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C39(6.90)  LDD2145  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C39(0.71)  LDD2146  [9]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C39(4.85)  LDD2147  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C39(0.54)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C39(0.95)  LDD2149  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C39(1.79)  LDD2153  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C39(0.36)  LDD2206  [32]
 LDCM0628  OTUB2-COV-1 HEK-293T C39(1.19)  LDD2207  [32]
 LDCM0029  Quercetin HEK-293T 4.67  LDD0181  [2]
 LDCM0131  RA190 MM1.R C39(1.42)  LDD0304  [33]
 LDCM0090  Rapamycin JHH-7 5.78  LDD0213  [27]
 LDCM0021  THZ1 HCT 116 C39(1.18)  LDD2173  [29]
 LDCM0110  W12 Hep-G2 C39(14.24)  LDD0237  [5]
 LDCM0111  W14 Hep-G2 C39(11.79)  LDD0238  [5]
 LDCM0113  W17 Hep-G2 C39(5.71)  LDD0240  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell receptor-associated protein 31 (BCAP31) BCAP29/BCAP31 family P51572

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
13 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
25 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
26 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
27 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
31 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
32 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
33 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.