Details of the Probe

General Information of Probe

Probe ID
LDPC0012
Probe Name
HRP
Synonyms
SCHEMBL15924294
Probe Type
ABPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 233.26
Lipid-water partition coefficient (xlogp) -0.2
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C13H15NO3
IUPAC Name
N-[2-(3,4-dihydroxyphenyl)ethyl]pent-4-ynamide
Canonical SMILES
C#CCCC(=O)NCCC1=CC(=C(C=C1)O)O
InChI
InChI=1S/C13H15NO3/c1-2-3-4-13(17)14-8-7-10-5-6-11(15)12(16)9-10/h1,5-6,9,15-16H,3-4,7-8H2,(H,14,17)
InChIKey
QTFKCGYVLHYGNP-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

23 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) LDTP02000 8.42  LDD0347 
Acyl-CoA (8-3)-desaturase (FADS1) LDTP00968 21.93  LDD0347 
Dehydrodolichyl diphosphate synthase complex subunit NUS1 (NUS1) LDTP10245 4.12  LDD0347 
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15) LDTP05874 7.90  LDD0347 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 7.87  LDD0347 
Glycerol-3-phosphate phosphatase (PGP) LDTP00089 4.51  LDD0347 
Glycerophosphodiester phosphodiesterase 1 (GDE1) LDTP12886 4.89  LDD0347 
Heme oxygenase 2 (HMOX2) LDTP03540 19.53  LDD0347 
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) LDTP09188 6.62  LDD0347 
Lysophosphatidylserine lipase ABHD12 (ABHD12) LDTP08799 5.56  LDD0347 
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) LDTP01004 8.34  LDD0347 
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) LDTP06104 4.89  LDD0347 
Phosphatidylserine synthase 1 (PTDSS1) LDTP04203 5.52  LDD0347 
Protein disulfide-isomerase A5 (PDIA5) LDTP06145 4.74  LDD0347 
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (TYW1) LDTP16105 4.44  LDD0347 
Serine palmitoyltransferase 2 (SPTLC2) LDTP00598 23.13  LDD0347 
Serine/threonine-protein kinase VRK2 (VRK2) LDTP08378 16.09  LDD0347 
Signal peptidase complex subunit 2 (SPCS2) LDTP06270 20.63  LDD0347 
Sphingolipid delta(4)-desaturase DES1 (DEGS1) LDTP00544 4.91  LDD0347 
Thioredoxin domain-containing protein 12 (TXNDC12) LDTP01707 6.65  LDD0347 
Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) LDTP07227 27.81  LDD0347 
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) LDTP02935 5.55  LDD0347 
Ubiquitin carboxyl-terminal hydrolase 33 (USP33) LDTP09517 25.85  LDD0347 
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⏷ Show the Full List of 23 Enzyme
18 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily B member 14 (DNAJB14) LDTP09352 8.91  LDD0347 
Extended synaptotagmin-1 (ESYT1) LDTP11161 4.02  LDD0347 
Guided entry of tail-anchored proteins factor CAMLG (CAMLG) LDTP04227 6.99  LDD0347 
Integrin beta-1 (ITGB1) LDTP02122 5.74  LDD0347 
Macoilin (MACO1) LDTP08897 12.19  LDD0347 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 9.12  LDD0347 
mRNA export factor GLE1 (GLE1) LDTP06902 7.18  LDD0347 
Nuclear pore complex protein Nup153 (NUP153) LDTP04309 9.83  LDD0347 
Nucleoporin NUP35 (NUP35) LDTP09204 5.17  LDD0347 
Protein Aster-A (GRAMD1A) LDTP10181 8.35  LDD0347 
Protein transport protein Sec61 subunit beta (SEC61B) LDTP04866 4.16  LDD0347 
Reticulon-1 (RTN1) LDTP06633 35.42  LDD0347 
Stromal interaction molecule 2 (STIM2) LDTP13018 17.45  LDD0347 
SUN domain-containing protein 1 (SUN1) LDTP01454 5.22  LDD0347 
Syntaxin-17 (STX17) LDTP04770 12.46  LDD0347 
Transport and Golgi organization protein 1 homolog (MIA3) LDTP07002 4.63  LDD0347 
Vezatin (VEZT) LDTP12191 47.08  LDD0347 
Zinc finger FYVE domain-containing protein 16 (ZFYVE16) LDTP08040 6.96  LDD0347 
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⏷ Show the Full List of 18 Transporter and channel
2 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) LDTP02970 6.46  LDD0347 
Transcription regulator protein BACH1 (BACH1) LDTP00461 8.12  LDD0347 
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27 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
A-kinase anchor protein 1, mitochondrial (AKAP1) LDTP09837 9.66  LDD0347 
A-kinase anchor protein 12 (AKAP12) LDTP05382 8.58  LDD0347 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 17.08  LDD0347 
BAG family molecular chaperone regulator 5 (BAG5) LDTP13507 4.68  LDD0347 
CDGSH iron-sulfur domain-containing protein 2 (CISD2) LDTP08902 9.90  LDD0347 
Cell division cycle-associated protein 2 (CDCA2) LDTP07345 6.77  LDD0347 
Collagen alpha-2(IV) chain (COL4A2) LDTP02282 4.19  LDD0347 
Inner nuclear membrane protein Man1 (LEMD3) LDTP13913 5.67  LDD0347 
Laminin subunit beta-1 (LAMB1) LDTP02230 6.61  LDD0347 
Laminin subunit gamma-1 (LAMC1) LDTP02535 10.97  LDD0347 
LIM domain-containing protein 1 (LIMD1) LDTP13241 5.38  LDD0347 
Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) LDTP14217 5.48  LDD0347 
MAP7 domain-containing protein 3 (MAP7D3) LDTP08535 4.43  LDD0347 
Nesprin-2 (SYNE2) LDTP09702 21.98  LDD0347 
Nicastrin (NCSTN) LDTP09787 5.40  LDD0347 
Protein ITPRID2 (ITPRID2) LDTP03426 9.03  LDD0347 
Protein transport protein Sec16A (SEC16A) LDTP00512 21.06  LDD0347 
Reticulon-3 (RTN3) LDTP01522 34.04  LDD0347 
Tetratricopeptide repeat protein 1 (TTC1) LDTP15840 4.78  LDD0347 
Transducin beta-like protein 2 (TBL2) LDTP16285 4.58  LDD0347 
Transforming acidic coiled-coil-containing protein 1 (TACC1) LDTP01210 109.46  LDD0347 
Transforming acidic coiled-coil-containing protein 3 (TACC3) LDTP14228 4.19  LDD0347 
Transmembrane protein 209 (TMEM209) LDTP18272 16.69  LDD0347 
Trinucleotide repeat-containing gene 6A protein (TNRC6A) LDTP09137 4.18  LDD0347 
UBX domain-containing protein 4 (UBXN4) LDTP09806 38.06  LDD0347 
Uncharacterized protein FAM241A (FAM241A) LDTP19744 4.07  LDD0347 
Vesicle-trafficking protein SEC22a (SEC22A) LDTP10431 4.08  LDD0347 
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⏷ Show the Full List of 27 Other

Full Information of The Labelling Profiles of This Probe

Quantification: Probe vs DMSO
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
15 uM
Quantitative Method
LFQ
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Interaction Atlas ID
 LDD0347 
Download The Altas

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348