Details of the Probe

General Information of Probe

Probe ID
LDPC0012
Probe Name
HRP
Synonyms
SCHEMBL15924294
Probe Type
ABPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 233.26
Lipid-water partition coefficient (xlogp) -0.2
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C13H15NO3
IUPAC Name
N-[2-(3,4-dihydroxyphenyl)ethyl]pent-4-ynamide
Canonical SMILES
C#CCCC(=O)NCCC1=CC(=C(C=C1)O)O
InChI
InChI=1S/C13H15NO3/c1-2-3-4-13(17)14-8-7-10-5-6-11(15)12(16)9-10/h1,5-6,9,15-16H,3-4,7-8H2,(H,14,17)
InChIKey
QTFKCGYVLHYGNP-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

46 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) LDTP02000 8.42  LDD0347 
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) LDTP02000 8.42  LDD0347 
Acyl-CoA (8-3)-desaturase (FADS1) LDTP00968 21.93  LDD0347 
Acyl-CoA (8-3)-desaturase (FADS1) LDTP00968 21.93  LDD0347 
Dehydrodolichyl diphosphate synthase complex subunit NUS1 (NUS1) LDTP10245 4.12  LDD0347 
Dehydrodolichyl diphosphate synthase complex subunit NUS1 (NUS1) LDTP10245 4.12  LDD0347 
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15) LDTP05874 7.90  LDD0347 
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15) LDTP05874 7.90  LDD0347 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 7.87  LDD0347 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 7.87  LDD0347 
Glycerol-3-phosphate phosphatase (PGP) LDTP00089 4.51  LDD0347 
Glycerol-3-phosphate phosphatase (PGP) LDTP00089 4.51  LDD0347 
Glycerophosphodiester phosphodiesterase 1 (GDE1) LDTP12886 4.89  LDD0347 
Glycerophosphodiester phosphodiesterase 1 (GDE1) LDTP12886 4.89  LDD0347 
Heme oxygenase 2 (HMOX2) LDTP03540 19.53  LDD0347 
Heme oxygenase 2 (HMOX2) LDTP03540 19.53  LDD0347 
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) LDTP09188 6.62  LDD0347 
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) LDTP09188 6.62  LDD0347 
Lysophosphatidylserine lipase ABHD12 (ABHD12) LDTP08799 5.56  LDD0347 
Lysophosphatidylserine lipase ABHD12 (ABHD12) LDTP08799 5.56  LDD0347 
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) LDTP01004 8.34  LDD0347 
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) LDTP01004 8.34  LDD0347 
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) LDTP06104 4.89  LDD0347 
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) LDTP06104 4.89  LDD0347 
Phosphatidylserine synthase 1 (PTDSS1) LDTP04203 5.52  LDD0347 
Phosphatidylserine synthase 1 (PTDSS1) LDTP04203 5.52  LDD0347 
Protein disulfide-isomerase A5 (PDIA5) LDTP06145 4.74  LDD0347 
Protein disulfide-isomerase A5 (PDIA5) LDTP06145 4.74  LDD0347 
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (TYW1) LDTP16105 4.44  LDD0347 
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (TYW1) LDTP16105 4.44  LDD0347 
Serine palmitoyltransferase 2 (SPTLC2) LDTP00598 23.13  LDD0347 
Serine palmitoyltransferase 2 (SPTLC2) LDTP00598 23.13  LDD0347 
Serine/threonine-protein kinase VRK2 (VRK2) LDTP08378 16.09  LDD0347 
Serine/threonine-protein kinase VRK2 (VRK2) LDTP08378 16.09  LDD0347 
Signal peptidase complex subunit 2 (SPCS2) LDTP06270 20.63  LDD0347 
Signal peptidase complex subunit 2 (SPCS2) LDTP06270 20.63  LDD0347 
Sphingolipid delta(4)-desaturase DES1 (DEGS1) LDTP00544 4.91  LDD0347 
Sphingolipid delta(4)-desaturase DES1 (DEGS1) LDTP00544 4.91  LDD0347 
Thioredoxin domain-containing protein 12 (TXNDC12) LDTP01707 6.65  LDD0347 
Thioredoxin domain-containing protein 12 (TXNDC12) LDTP01707 6.65  LDD0347 
Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) LDTP07227 27.81  LDD0347 
Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) LDTP07227 27.81  LDD0347 
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) LDTP02935 5.55  LDD0347 
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) LDTP02935 5.55  LDD0347 
Ubiquitin carboxyl-terminal hydrolase 33 (USP33) LDTP09517 25.85  LDD0347 
Ubiquitin carboxyl-terminal hydrolase 33 (USP33) LDTP09517 25.85  LDD0347 
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⏷ Show the Full List of 46 Enzyme
36 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily B member 14 (DNAJB14) LDTP09352 8.91  LDD0347 
DnaJ homolog subfamily B member 14 (DNAJB14) LDTP09352 8.91  LDD0347 
Extended synaptotagmin-1 (ESYT1) LDTP11161 4.02  LDD0347 
Extended synaptotagmin-1 (ESYT1) LDTP11161 4.02  LDD0347 
Guided entry of tail-anchored proteins factor CAMLG (CAMLG) LDTP04227 6.99  LDD0347 
Guided entry of tail-anchored proteins factor CAMLG (CAMLG) LDTP04227 6.99  LDD0347 
Integrin beta-1 (ITGB1) LDTP02122 5.74  LDD0347 
Integrin beta-1 (ITGB1) LDTP02122 5.74  LDD0347 
Macoilin (MACO1) LDTP08897 12.19  LDD0347 
Macoilin (MACO1) LDTP08897 12.19  LDD0347 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 9.12  LDD0347 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 9.12  LDD0347 
mRNA export factor GLE1 (GLE1) LDTP06902 7.18  LDD0347 
mRNA export factor GLE1 (GLE1) LDTP06902 7.18  LDD0347 
Nuclear pore complex protein Nup153 (NUP153) LDTP04309 9.83  LDD0347 
Nuclear pore complex protein Nup153 (NUP153) LDTP04309 9.83  LDD0347 
Nucleoporin NUP35 (NUP35) LDTP09204 5.17  LDD0347 
Nucleoporin NUP35 (NUP35) LDTP09204 5.17  LDD0347 
Protein Aster-A (GRAMD1A) LDTP10181 8.35  LDD0347 
Protein Aster-A (GRAMD1A) LDTP10181 8.35  LDD0347 
Protein transport protein Sec61 subunit beta (SEC61B) LDTP04866 4.16  LDD0347 
Protein transport protein Sec61 subunit beta (SEC61B) LDTP04866 4.16  LDD0347 
Reticulon-1 (RTN1) LDTP06633 35.42  LDD0347 
Reticulon-1 (RTN1) LDTP06633 35.42  LDD0347 
Stromal interaction molecule 2 (STIM2) LDTP13018 17.45  LDD0347 
Stromal interaction molecule 2 (STIM2) LDTP13018 17.45  LDD0347 
SUN domain-containing protein 1 (SUN1) LDTP01454 5.22  LDD0347 
SUN domain-containing protein 1 (SUN1) LDTP01454 5.22  LDD0347 
Syntaxin-17 (STX17) LDTP04770 12.46  LDD0347 
Syntaxin-17 (STX17) LDTP04770 12.46  LDD0347 
Transport and Golgi organization protein 1 homolog (MIA3) LDTP07002 4.63  LDD0347 
Transport and Golgi organization protein 1 homolog (MIA3) LDTP07002 4.63  LDD0347 
Vezatin (VEZT) LDTP12191 47.08  LDD0347 
Vezatin (VEZT) LDTP12191 47.08  LDD0347 
Zinc finger FYVE domain-containing protein 16 (ZFYVE16) LDTP08040 6.96  LDD0347 
Zinc finger FYVE domain-containing protein 16 (ZFYVE16) LDTP08040 6.96  LDD0347 
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⏷ Show the Full List of 36 Transporter and channel
4 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) LDTP02970 6.46  LDD0347 
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) LDTP02970 6.46  LDD0347 
Transcription regulator protein BACH1 (BACH1) LDTP00461 8.12  LDD0347 
Transcription regulator protein BACH1 (BACH1) LDTP00461 8.12  LDD0347 
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54 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
A-kinase anchor protein 1, mitochondrial (AKAP1) LDTP09837 9.66  LDD0347 
A-kinase anchor protein 1, mitochondrial (AKAP1) LDTP09837 9.66  LDD0347 
A-kinase anchor protein 12 (AKAP12) LDTP05382 8.58  LDD0347 
A-kinase anchor protein 12 (AKAP12) LDTP05382 8.58  LDD0347 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 17.08  LDD0347 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 17.08  LDD0347 
BAG family molecular chaperone regulator 5 (BAG5) LDTP13507 4.68  LDD0347 
BAG family molecular chaperone regulator 5 (BAG5) LDTP13507 4.68  LDD0347 
CDGSH iron-sulfur domain-containing protein 2 (CISD2) LDTP08902 9.90  LDD0347 
CDGSH iron-sulfur domain-containing protein 2 (CISD2) LDTP08902 9.90  LDD0347 
Cell division cycle-associated protein 2 (CDCA2) LDTP07345 6.77  LDD0347 
Cell division cycle-associated protein 2 (CDCA2) LDTP07345 6.77  LDD0347 
Collagen alpha-2(IV) chain (COL4A2) LDTP02282 4.19  LDD0347 
Collagen alpha-2(IV) chain (COL4A2) LDTP02282 4.19  LDD0347 
Inner nuclear membrane protein Man1 (LEMD3) LDTP13913 5.67  LDD0347 
Inner nuclear membrane protein Man1 (LEMD3) LDTP13913 5.67  LDD0347 
Laminin subunit beta-1 (LAMB1) LDTP02230 6.61  LDD0347 
Laminin subunit beta-1 (LAMB1) LDTP02230 6.61  LDD0347 
Laminin subunit gamma-1 (LAMC1) LDTP02535 10.97  LDD0347 
Laminin subunit gamma-1 (LAMC1) LDTP02535 10.97  LDD0347 
LIM domain-containing protein 1 (LIMD1) LDTP13241 5.38  LDD0347 
LIM domain-containing protein 1 (LIMD1) LDTP13241 5.38  LDD0347 
Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) LDTP14217 5.48  LDD0347 
Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) LDTP14217 5.48  LDD0347 
MAP7 domain-containing protein 3 (MAP7D3) LDTP08535 4.43  LDD0347 
MAP7 domain-containing protein 3 (MAP7D3) LDTP08535 4.43  LDD0347 
Nesprin-2 (SYNE2) LDTP09702 21.98  LDD0347 
Nesprin-2 (SYNE2) LDTP09702 21.98  LDD0347 
Nicastrin (NCSTN) LDTP09787 5.40  LDD0347 
Nicastrin (NCSTN) LDTP09787 5.40  LDD0347 
Protein ITPRID2 (ITPRID2) LDTP03426 9.03  LDD0347 
Protein ITPRID2 (ITPRID2) LDTP03426 9.03  LDD0347 
Protein transport protein Sec16A (SEC16A) LDTP00512 21.06  LDD0347 
Protein transport protein Sec16A (SEC16A) LDTP00512 21.06  LDD0347 
Reticulon-3 (RTN3) LDTP01522 34.04  LDD0347 
Reticulon-3 (RTN3) LDTP01522 34.04  LDD0347 
Tetratricopeptide repeat protein 1 (TTC1) LDTP15840 4.78  LDD0347 
Tetratricopeptide repeat protein 1 (TTC1) LDTP15840 4.78  LDD0347 
Transducin beta-like protein 2 (TBL2) LDTP16285 4.58  LDD0347 
Transducin beta-like protein 2 (TBL2) LDTP16285 4.58  LDD0347 
Transforming acidic coiled-coil-containing protein 1 (TACC1) LDTP01210 109.46  LDD0347 
Transforming acidic coiled-coil-containing protein 1 (TACC1) LDTP01210 109.46  LDD0347 
Transforming acidic coiled-coil-containing protein 3 (TACC3) LDTP14228 4.19  LDD0347 
Transforming acidic coiled-coil-containing protein 3 (TACC3) LDTP14228 4.19  LDD0347 
Transmembrane protein 209 (TMEM209) LDTP18272 16.69  LDD0347 
Transmembrane protein 209 (TMEM209) LDTP18272 16.69  LDD0347 
Trinucleotide repeat-containing gene 6A protein (TNRC6A) LDTP09137 4.18  LDD0347 
Trinucleotide repeat-containing gene 6A protein (TNRC6A) LDTP09137 4.18  LDD0347 
UBX domain-containing protein 4 (UBXN4) LDTP09806 38.06  LDD0347 
UBX domain-containing protein 4 (UBXN4) LDTP09806 38.06  LDD0347 
Uncharacterized protein FAM241A (FAM241A) LDTP19744 4.07  LDD0347 
Uncharacterized protein FAM241A (FAM241A) LDTP19744 4.07  LDD0347 
Vesicle-trafficking protein SEC22a (SEC22A) LDTP10431 4.08  LDD0347 
Vesicle-trafficking protein SEC22a (SEC22A) LDTP10431 4.08  LDD0347 
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⏷ Show the Full List of 54 Other

Full Information of The Labelling Profiles of This Probe

Quantification: Probe vs DMSO
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
15 uM
Quantitative Method
LFQ
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Interaction Atlas ID
 LDD0347 
Download The Altas

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348