Details of the Target

General Information of Target

Target ID LDTP06104
Target Name Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8)
Gene Name FKBP8
Gene ID 23770
Synonyms
FKBP38; Peptidyl-prolyl cis-trans isomerase FKBP8; PPIase FKBP8; EC 5.2.1.8; 38 kDa FK506-binding protein; 38 kDa FKBP; FKBP-38; hFKBP38; FK506-binding protein 8; FKBP-8; FKBPR38; Rotamase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASCAEPSEPSAPLPAGVPPLEDFEVLDGVEDAEGEEEEEEEEEEEDDLSELPPLEDMGQ
PPAEEAEQPGALAREFLAAMEPEPAPAPAPEEWLDILGNGLLRKKTLVPGPPGSSRPVKG
QVVTVHLQTSLENGTRVQEEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYG
PQGRSPYIPPHAALCLEVTLKTAVDGPDLEMLTGQERVALANRKRECGNAHYQRADFVLA
ANSYDLAIKAITSSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLVLE
HQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQRSTE
TALYRKMLGNPSRLPAKCPGKGAWSIPWKWLFGATAVALGGVALSVVIAARN
Target Bioclass
Enzyme
Subcellular location
Mitochondrion membrane; Mitochondrion
Function
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV).
Uniprot ID
Q14318
Ensemble ID
ENST00000222308.8
HGNC ID
HGNC:3724

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Jackson_1
 Probe Info  		11.21  LDD0122  [2]
DA-P2
 Probe Info  		5.88  LDD0348  [3]
HRP
 Probe Info  		4.89  LDD0347  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
TG42
 Probe Info  		13.28  LDD0326  [5]
TH211
 Probe Info  		Y364(15.10); Y232(10.53)  LDD0260  [6]
TH216
 Probe Info  		Y364(10.49)  LDD0259  [6]
ONAyne
 Probe Info  		K352(4.55)  LDD0275  [7]
Probe 1
 Probe Info  		Y364(22.57)  LDD3495  [8]
P12
 Probe Info  		6.05  LDD0202  [9]
DA-P3
 Probe Info  		11.87  LDD0179  [3]
Alkyne-RA190
 Probe Info  		2.34  LDD0299  [10]
EA-probe
 Probe Info  		N.A.  LDD0440  [11]
DBIA
 Probe Info  		C227(16.62)  LDD0209  [12]
5E-2FA
 Probe Info  		N.A.  LDD2235  [13]
ATP probe
 Probe Info  		K314(0.00); K273(0.00); K307(0.00); K348(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C274(0.00); C295(0.00); C195(0.00); C178(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [16]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C274(0.00); C295(0.00); C178(0.00); C227(0.00)  LDD0037  [15]
BTD
 Probe Info  		N.A.  LDD0004  [18]
JW-RF-010
 Probe Info  		C274(0.00); C295(0.00)  LDD0026  [19]
NAIA_4
 Probe Info  		N.A.  LDD2226  [20]
TFBX
 Probe Info  		C295(0.00); C274(0.00)  LDD0027  [19]
1d-yne
 Probe Info  		N.A.  LDD0356  [21]
Compound 10
 Probe Info  		C274(0.00); C295(0.00)  LDD2216  [22]
Compound 11
 Probe Info  		N.A.  LDD2213  [22]
IPM
 Probe Info  		C295(0.00); C274(0.00)  LDD0005  [18]
NPM
 Probe Info  		N.A.  LDD0016  [18]
SF
 Probe Info  		Y322(0.00); K352(0.00)  LDD0028  [23]
STPyne
 Probe Info  		N.A.  LDD0009  [18]
Phosphinate-6
 Probe Info  		C195(0.00); C274(0.00); C227(0.00); C378(0.00)  LDD0018  [24]
1c-yne
 Probe Info  		N.A.  LDD0228  [21]
Acrolein
 Probe Info  		C295(0.00); H343(0.00); H301(0.00); C274(0.00)  LDD0217  [25]
Crotonaldehyde
 Probe Info  		C227(0.00); H231(0.00); H301(0.00); C295(0.00)  LDD0219  [25]
Methacrolein
 Probe Info  		C227(0.00); C295(0.00)  LDD0218  [25]
AOyne
 Probe Info  		15.00  LDD0443  [26]
NAIA_5
 Probe Info  		C274(0.00); C227(0.00); C295(0.00); C195(0.00)  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		14.93  LDD0471  [27]
FFF probe13
 Probe Info  		17.26  LDD0475  [27]
FFF probe14
 Probe Info  		17.27  LDD0477  [27]
FFF probe15
 Probe Info  		6.40  LDD0478  [27]
FFF probe2
 Probe Info  		13.94  LDD0463  [27]
FFF probe3
 Probe Info  		18.30  LDD0464  [27]
JN0003
 Probe Info  		20.00  LDD0469  [27]
STS-1
 Probe Info  		N.A.  LDD0136  [28]
STS-2
 Probe Info  		N.A.  LDD0138  [28]
SAHA-CA-8PAP
 Probe Info  		4.14  LDD0362  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C378(0.68); C227(0.88)  LDD2142  [30]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C227(1.12)  LDD2112  [30]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C378(0.63); C295(0.58)  LDD2095  [30]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C378(1.04)  LDD2130  [30]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C378(0.72); C227(1.06)  LDD2117  [30]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C295(1.36)  LDD2152  [30]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C378(1.60); C274(0.93)  LDD2103  [30]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C378(0.54); C227(0.44)  LDD2132  [30]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C378(0.70)  LDD2131  [30]
 LDCM0025  4SU-RNA HEK-293T C274(10.28)  LDD0371  [31]
 LDCM0214  AC1 HEK-293T C227(0.99); C295(0.94); C274(0.88); C195(0.92)  LDD1507  [32]
 LDCM0215  AC10 HEK-293T C227(0.95); C295(0.98); C274(0.94); C195(0.97)  LDD1508  [32]
 LDCM0226  AC11 HEK-293T C227(0.95); C295(0.99); C274(1.03); C195(1.01)  LDD1509  [32]
 LDCM0237  AC12 HEK-293T C227(1.06); C295(0.89); C274(1.05); C195(0.92)  LDD1510  [32]
 LDCM0259  AC14 HEK-293T C227(1.01); C295(0.99); C274(0.95); C195(0.89)  LDD1512  [32]
 LDCM0270  AC15 HEK-293T C227(0.97); C295(0.99); C274(0.89); C195(1.04)  LDD1513  [32]
 LDCM0276  AC17 HEK-293T C227(0.87); C295(0.91); C274(0.96); C195(0.90)  LDD1515  [32]
 LDCM0277  AC18 HEK-293T C227(1.00); C295(1.05); C274(1.02); C195(0.96)  LDD1516  [32]
 LDCM0278  AC19 HEK-293T C227(1.09); C295(1.16); C274(0.95); C195(0.96)  LDD1517  [32]
 LDCM0279  AC2 HEK-293T C227(0.96); C295(1.06); C274(0.91); C195(0.96)  LDD1518  [32]
 LDCM0280  AC20 HEK-293T C227(1.01); C295(1.02); C274(1.06); C195(0.85)  LDD1519  [32]
 LDCM0281  AC21 HEK-293T C227(0.93); C295(0.98); C274(1.07); C195(0.91)  LDD1520  [32]
 LDCM0282  AC22 HEK-293T C227(1.03); C295(1.07); C274(0.95); C195(0.97)  LDD1521  [32]
 LDCM0283  AC23 HEK-293T C227(0.94); C295(1.06); C274(0.93); C195(1.00)  LDD1522  [32]
 LDCM0284  AC24 HEK-293T C227(1.01); C295(0.97); C274(0.96); C195(1.00)  LDD1523  [32]
 LDCM0285  AC25 HEK-293T C227(0.90); C295(0.94); C274(0.97); C195(0.90)  LDD1524  [32]
 LDCM0286  AC26 HEK-293T C227(0.95); C295(0.95); C274(1.01); C195(0.98)  LDD1525  [32]
 LDCM0287  AC27 HEK-293T C227(0.98); C295(1.03); C274(1.05); C195(1.01)  LDD1526  [32]
 LDCM0288  AC28 HEK-293T C227(1.05); C295(0.89); C274(1.06); C195(0.89)  LDD1527  [32]
 LDCM0289  AC29 HEK-293T C227(0.91); C295(1.13); C274(1.00); C195(0.95)  LDD1528  [32]
 LDCM0290  AC3 HEK-293T C227(1.01); C295(0.98); C274(0.98); C195(1.05)  LDD1529  [32]
 LDCM0291  AC30 HEK-293T C227(0.97); C295(1.02); C274(1.01); C195(0.92)  LDD1530  [32]
 LDCM0292  AC31 HEK-293T C227(0.98); C295(1.04); C274(1.01); C195(0.97)  LDD1531  [32]
 LDCM0293  AC32 HEK-293T C227(1.04); C295(0.97); C274(1.03); C195(1.04)  LDD1532  [32]
 LDCM0294  AC33 HEK-293T C227(0.86); C295(0.90); C274(0.94); C195(0.95)  LDD1533  [32]
 LDCM0295  AC34 HEK-293T C227(0.95); C295(0.93); C274(0.90); C195(0.95)  LDD1534  [32]
 LDCM0296  AC35 HEK-293T C227(0.94); C295(1.10); C274(0.91); C195(1.08)  LDD1535  [32]
 LDCM0297  AC36 HEK-293T C227(1.03); C295(0.93); C274(1.05); C195(0.92)  LDD1536  [32]
 LDCM0298  AC37 HEK-293T C227(0.87); C295(1.02); C274(0.94); C195(0.99)  LDD1537  [32]
 LDCM0299  AC38 HEK-293T C227(0.99); C295(0.90); C274(0.97); C195(0.95)  LDD1538  [32]
 LDCM0300  AC39 HEK-293T C227(0.93); C295(0.95); C274(0.88); C195(1.04)  LDD1539  [32]
 LDCM0301  AC4 HEK-293T C227(0.99); C295(0.99); C274(0.99); C195(0.86)  LDD1540  [32]
 LDCM0302  AC40 HEK-293T C227(1.01); C295(0.92); C274(0.94); C195(0.96)  LDD1541  [32]
 LDCM0303  AC41 HEK-293T C227(0.89); C295(0.92); C274(0.92); C195(1.00)  LDD1542  [32]
 LDCM0304  AC42 HEK-293T C227(0.95); C295(0.88); C274(0.85); C195(0.86)  LDD1543  [32]
 LDCM0305  AC43 HEK-293T C227(0.94); C295(1.05); C274(0.97); C195(1.07)  LDD1544  [32]
 LDCM0306  AC44 HEK-293T C227(1.02); C295(0.87); C274(0.99); C195(0.99)  LDD1545  [32]
 LDCM0307  AC45 HEK-293T C227(0.87); C295(0.95); C274(0.94); C195(0.94)  LDD1546  [32]
 LDCM0308  AC46 HEK-293T C227(1.03); C295(0.97); C274(0.95); C195(0.97)  LDD1547  [32]
 LDCM0309  AC47 HEK-293T C227(1.01); C295(1.03); C274(0.93); C195(1.02)  LDD1548  [32]
 LDCM0310  AC48 HEK-293T C227(1.02); C295(1.02); C274(0.94); C195(1.03)  LDD1549  [32]
 LDCM0311  AC49 HEK-293T C227(0.88); C295(0.94); C274(0.97); C195(0.89)  LDD1550  [32]
 LDCM0312  AC5 HEK-293T C227(0.99); C295(0.99); C274(1.06); C195(0.92)  LDD1551  [32]
 LDCM0313  AC50 HEK-293T C227(0.99); C295(0.94); C274(0.91); C195(0.96)  LDD1552  [32]
 LDCM0314  AC51 HEK-293T C227(0.96); C295(0.98); C274(0.96); C195(1.05)  LDD1553  [32]
 LDCM0315  AC52 HEK-293T C227(1.04); C295(0.96); C274(1.04); C195(0.91)  LDD1554  [32]
 LDCM0316  AC53 HEK-293T C227(0.91); C295(1.01); C274(0.93); C195(1.02)  LDD1555  [32]
 LDCM0317  AC54 HEK-293T C227(0.99); C295(0.94); C274(1.00); C195(0.92)  LDD1556  [32]
 LDCM0318  AC55 HEK-293T C227(0.94); C295(1.03); C274(0.92); C195(1.02)  LDD1557  [32]
 LDCM0319  AC56 HEK-293T C227(1.01); C295(0.98); C274(0.95); C195(0.97)  LDD1558  [32]
 LDCM0320  AC57 HEK-293T C227(0.94); C295(0.87); C274(0.87); C195(0.90)  LDD1559  [32]
 LDCM0321  AC58 HEK-293T C227(1.02); C295(0.93); C274(0.98); C195(0.92)  LDD1560  [32]
 LDCM0322  AC59 HEK-293T C227(1.02); C295(1.02); C274(0.93); C195(1.03)  LDD1561  [32]
 LDCM0323  AC6 HEK-293T C227(1.13); C295(0.98); C274(1.03); C195(0.87)  LDD1562  [32]
 LDCM0324  AC60 HEK-293T C227(1.03); C295(0.84); C274(0.99); C195(0.95)  LDD1563  [32]
 LDCM0325  AC61 HEK-293T C227(0.91); C295(0.92); C274(0.95); C195(0.89)  LDD1564  [32]
 LDCM0326  AC62 HEK-293T C227(1.08); C295(0.88); C274(0.94); C195(0.83)  LDD1565  [32]
 LDCM0327  AC63 HEK-293T C227(1.01); C295(0.97); C274(0.82); C195(0.97)  LDD1566  [32]
 LDCM0328  AC64 HEK-293T C227(1.00); C295(0.96); C274(0.90); C195(0.96)  LDD1567  [32]
 LDCM0334  AC7 HEK-293T C227(0.98); C295(1.06); C274(0.88); C195(1.11)  LDD1568  [32]
 LDCM0345  AC8 HEK-293T C227(1.04); C295(0.95); C274(0.93); C195(0.99)  LDD1569  [32]
 LDCM0545  Acetamide MDA-MB-231 C378(0.40); C295(0.69); C227(0.34); C274(0.29)  LDD2138  [30]
 LDCM0520  AKOS000195272 MDA-MB-231 C295(0.56); C227(0.92)  LDD2113  [30]
 LDCM0248  AKOS034007472 HEK-293T C227(0.93); C295(1.01); C274(0.99); C195(0.98)  LDD1511  [32]
 LDCM0356  AKOS034007680 HEK-293T C227(0.94); C295(0.94); C274(0.94); C195(0.95)  LDD1570  [32]
 LDCM0275  AKOS034007705 HEK-293T C227(1.02); C295(0.98); C274(0.93); C195(0.99)  LDD1514  [32]
 LDCM0156  Aniline NCI-H1299 12.75  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C378(0.35); C227(0.74)  LDD2091  [30]
 LDCM0088  C45 HEK-293T 6.05  LDD0202  [9]
 LDCM0087  Capsaicin HEK-293T 9.87  LDD0185  [3]
 LDCM0108  Chloroacetamide HeLa C227(0.00); H343(0.00); H301(0.00)  LDD0222  [25]
 LDCM0632  CL-Sc Hep-G2 C227(20.00); C227(2.56); C274(0.99); C295(0.93)  LDD2227  [20]
 LDCM0367  CL1 HEK-293T C227(0.88); C295(1.04); C274(0.99); C195(0.87)  LDD1571  [32]
 LDCM0368  CL10 HEK-293T C227(0.95); C295(1.03); C274(1.17); C195(0.72)  LDD1572  [32]
 LDCM0369  CL100 HEK-293T C227(1.00); C295(0.97); C274(1.07); C195(0.96)  LDD1573  [32]
 LDCM0370  CL101 HEK-293T C227(0.96); C295(0.91); C274(0.96); C195(0.91)  LDD1574  [32]
 LDCM0371  CL102 HEK-293T C227(0.97); C295(0.88); C274(0.88); C195(0.84)  LDD1575  [32]
 LDCM0372  CL103 HEK-293T C227(0.79); C295(1.01); C274(0.99); C195(0.95)  LDD1576  [32]
 LDCM0373  CL104 HEK-293T C227(0.95); C295(0.99); C274(0.99); C195(0.98)  LDD1577  [32]
 LDCM0374  CL105 HEK-293T C227(0.93); C295(0.94); C274(1.06); C195(0.86)  LDD1578  [32]
 LDCM0375  CL106 HEK-293T C227(0.94); C295(0.96); C274(1.05); C195(0.86)  LDD1579  [32]
 LDCM0376  CL107 HEK-293T C227(0.84); C295(0.99); C274(1.01); C195(0.98)  LDD1580  [32]
 LDCM0377  CL108 HEK-293T C227(0.91); C295(0.90); C274(1.05); C195(1.02)  LDD1581  [32]
 LDCM0378  CL109 HEK-293T C227(0.91); C295(0.90); C274(0.99); C195(0.85)  LDD1582  [32]
 LDCM0379  CL11 HEK-293T C227(0.95); C295(1.23); C274(1.00); C195(0.94)  LDD1583  [32]
 LDCM0380  CL110 HEK-293T C227(0.93); C295(0.90); C274(0.99); C195(0.87)  LDD1584  [32]
 LDCM0381  CL111 HEK-293T C227(0.84); C295(1.09); C274(1.02); C195(1.00)  LDD1585  [32]
 LDCM0382  CL112 HEK-293T C227(0.90); C295(0.96); C274(1.07); C195(0.93)  LDD1586  [32]
 LDCM0383  CL113 HEK-293T C227(1.00); C295(0.93); C274(1.03); C195(0.96)  LDD1587  [32]
 LDCM0384  CL114 HEK-293T C227(0.97); C295(0.91); C274(0.95); C195(0.90)  LDD1588  [32]
 LDCM0385  CL115 HEK-293T C227(0.90); C295(0.93); C274(0.96); C195(1.02)  LDD1589  [32]
 LDCM0386  CL116 HEK-293T C227(0.94); C295(0.90); C274(0.97); C195(0.97)  LDD1590  [32]
 LDCM0387  CL117 HEK-293T C227(0.99); C295(0.87); C274(1.01); C195(1.04)  LDD1591  [32]
 LDCM0388  CL118 HEK-293T C227(0.98); C295(0.92); C274(0.95); C195(0.93)  LDD1592  [32]
 LDCM0389  CL119 HEK-293T C227(0.92); C295(0.98); C274(0.99); C195(1.01)  LDD1593  [32]
 LDCM0390  CL12 HEK-293T C227(1.03); C295(1.10); C274(1.04); C195(0.94)  LDD1594  [32]
 LDCM0391  CL120 HEK-293T C227(0.95); C295(0.97); C274(0.92); C195(0.99)  LDD1595  [32]
 LDCM0392  CL121 HEK-293T C227(0.96); C295(1.03); C274(1.01); C195(0.96)  LDD1596  [32]
 LDCM0393  CL122 HEK-293T C227(0.94); C295(0.92); C274(1.01); C195(0.94)  LDD1597  [32]
 LDCM0394  CL123 HEK-293T C227(0.81); C295(0.96); C274(0.98); C195(0.87)  LDD1598  [32]
 LDCM0395  CL124 HEK-293T C227(0.94); C295(0.90); C274(1.01); C195(0.94)  LDD1599  [32]
 LDCM0396  CL125 HEK-293T C227(1.04); C295(0.95); C274(0.98); C195(0.89)  LDD1600  [32]
 LDCM0397  CL126 HEK-293T C227(1.03); C295(0.96); C274(0.98); C195(0.92)  LDD1601  [32]
 LDCM0398  CL127 HEK-293T C227(1.01); C295(1.04); C274(0.96); C195(0.90)  LDD1602  [32]
 LDCM0399  CL128 HEK-293T C227(1.12); C295(0.90); C274(0.97); C195(0.96)  LDD1603  [32]
 LDCM0400  CL13 HEK-293T C227(0.94); C295(1.01); C274(1.06); C195(0.94)  LDD1604  [32]
 LDCM0401  CL14 HEK-293T C227(0.93); C295(0.96); C274(0.97); C195(0.92)  LDD1605  [32]
 LDCM0402  CL15 HEK-293T C227(0.69); C295(1.09); C274(1.01); C195(0.89)  LDD1606  [32]
 LDCM0403  CL16 HEK-293T C227(0.83); C295(0.96); C274(1.05); C195(1.06)  LDD1607  [32]
 LDCM0404  CL17 HEK-293T C227(0.75); C295(0.93); C274(0.86); C195(0.85)  LDD1608  [32]
 LDCM0405  CL18 HEK-293T C227(0.94); C295(1.11); C274(0.93); C195(0.96)  LDD1609  [32]
 LDCM0406  CL19 HEK-293T C227(0.87); C295(1.21); C274(1.06); C195(1.03)  LDD1610  [32]
 LDCM0407  CL2 HEK-293T C227(1.00); C295(1.06); C274(0.95); C195(0.90)  LDD1611  [32]
 LDCM0408  CL20 HEK-293T C227(1.11); C295(1.02); C274(1.12); C195(0.91)  LDD1612  [32]
 LDCM0409  CL21 HEK-293T C227(0.81); C295(0.87); C274(1.11); C195(0.87)  LDD1613  [32]
 LDCM0410  CL22 HEK-293T C227(1.04); C295(1.12); C274(1.05); C195(0.98)  LDD1614  [32]
 LDCM0411  CL23 HEK-293T C227(1.07); C295(1.27); C274(0.97); C195(1.02)  LDD1615  [32]
 LDCM0412  CL24 HEK-293T C227(1.07); C295(1.16); C274(1.11); C195(1.00)  LDD1616  [32]
 LDCM0413  CL25 HEK-293T C227(1.00); C295(0.97); C274(1.08); C195(0.67)  LDD1617  [32]
 LDCM0414  CL26 HEK-293T C227(1.04); C295(1.00); C274(1.06); C195(0.94)  LDD1618  [32]
 LDCM0415  CL27 HEK-293T C227(0.83); C295(1.03); C274(1.01); C195(0.97)  LDD1619  [32]
 LDCM0416  CL28 HEK-293T C227(0.90); C295(0.95); C274(0.93); C195(0.90)  LDD1620  [32]
 LDCM0417  CL29 HEK-293T C227(0.95); C295(0.99); C274(1.00); C195(0.97)  LDD1621  [32]
 LDCM0418  CL3 HEK-293T C227(0.83); C295(1.15); C274(0.99); C195(0.99)  LDD1622  [32]
 LDCM0419  CL30 HEK-293T C227(0.98); C295(1.09); C274(1.11); C195(0.98)  LDD1623  [32]
 LDCM0420  CL31 HEK-293T C227(0.95); C295(1.26); C274(1.12); C195(0.99)  LDD1624  [32]
 LDCM0421  CL32 HEK-293T C227(1.06); C295(1.27); C274(1.19); C195(0.96)  LDD1625  [32]
 LDCM0422  CL33 HEK-293T C227(0.88); C295(1.05); C274(1.11); C195(0.82)  LDD1626  [32]
 LDCM0423  CL34 HEK-293T C227(1.07); C295(1.14); C274(1.13); C195(0.97)  LDD1627  [32]
 LDCM0424  CL35 HEK-293T C227(1.07); C295(1.29); C274(1.02); C195(0.97)  LDD1628  [32]
 LDCM0425  CL36 HEK-293T C227(1.04); C295(1.11); C274(1.15); C195(1.04)  LDD1629  [32]
 LDCM0426  CL37 HEK-293T C227(1.02); C295(1.02); C274(1.04); C195(0.93)  LDD1630  [32]
 LDCM0428  CL39 HEK-293T C227(0.82); C295(1.08); C274(0.99); C195(1.03)  LDD1632  [32]
 LDCM0429  CL4 HEK-293T C227(0.94); C295(1.08); C274(1.08); C195(0.94)  LDD1633  [32]
 LDCM0430  CL40 HEK-293T C227(0.95); C295(0.96); C274(1.02); C195(1.01)  LDD1634  [32]
 LDCM0431  CL41 HEK-293T C227(0.90); C295(0.96); C274(0.93); C195(0.94)  LDD1635  [32]
 LDCM0432  CL42 HEK-293T C227(1.03); C295(1.09); C274(1.10); C195(0.99)  LDD1636  [32]
 LDCM0433  CL43 HEK-293T C227(0.96); C295(1.20); C274(1.12); C195(0.97)  LDD1637  [32]
 LDCM0434  CL44 HEK-293T C227(1.03); C295(1.02); C274(1.15); C195(0.90)  LDD1638  [32]
 LDCM0435  CL45 HEK-293T C227(0.94); C295(1.02); C274(1.08); C195(0.94)  LDD1639  [32]
 LDCM0436  CL46 HEK-293T C227(1.10); C295(1.11); C274(1.23); C195(0.95)  LDD1640  [32]
 LDCM0437  CL47 HEK-293T C227(1.00); C295(1.19); C274(1.07); C195(1.09)  LDD1641  [32]
 LDCM0438  CL48 HEK-293T C227(1.07); C295(1.07); C274(1.17); C195(1.05)  LDD1642  [32]
 LDCM0439  CL49 HEK-293T C227(1.03); C295(0.96); C274(1.07); C195(1.03)  LDD1643  [32]
 LDCM0440  CL5 HEK-293T C227(0.95); C295(0.98); C274(0.95); C195(0.95)  LDD1644  [32]
 LDCM0441  CL50 HEK-293T C227(1.06); C295(0.99); C274(0.94); C195(0.95)  LDD1645  [32]
 LDCM0443  CL52 HEK-293T C227(0.99); C295(1.00); C274(0.89); C195(0.98)  LDD1646  [32]
 LDCM0444  CL53 HEK-293T C227(0.86); C295(0.88); C274(0.86); C195(0.88)  LDD1647  [32]
 LDCM0445  CL54 HEK-293T C227(0.87); C295(1.00); C274(0.93); C195(0.83)  LDD1648  [32]
 LDCM0446  CL55 HEK-293T C227(1.01); C295(1.10); C274(0.95); C195(1.04)  LDD1649  [32]
 LDCM0447  CL56 HEK-293T C227(1.08); C295(0.95); C274(1.08); C195(0.95)  LDD1650  [32]
 LDCM0448  CL57 HEK-293T C227(1.00); C295(1.05); C274(1.03); C195(0.85)  LDD1651  [32]
 LDCM0449  CL58 HEK-293T C227(1.06); C295(1.01); C274(1.07); C195(0.88)  LDD1652  [32]
 LDCM0450  CL59 HEK-293T C227(1.06); C295(1.28); C274(1.00); C195(1.06)  LDD1653  [32]
 LDCM0451  CL6 HEK-293T C227(0.96); C295(1.03); C274(0.98); C195(0.84)  LDD1654  [32]
 LDCM0452  CL60 HEK-293T C227(1.08); C295(1.04); C274(1.06); C195(1.08)  LDD1655  [32]
 LDCM0453  CL61 HEK-293T C227(1.05); C295(0.99); C274(1.02); C195(1.00)  LDD1656  [32]
 LDCM0454  CL62 HEK-293T C227(1.07); C295(0.93); C274(0.94); C195(0.93)  LDD1657  [32]
 LDCM0455  CL63 HEK-293T C227(0.93); C295(1.00); C274(0.99); C195(1.09)  LDD1658  [32]
 LDCM0456  CL64 HEK-293T C227(0.88); C295(0.98); C274(1.01); C195(0.91)  LDD1659  [32]
 LDCM0457  CL65 HEK-293T C227(0.93); C295(0.93); C274(0.92); C195(1.01)  LDD1660  [32]
 LDCM0458  CL66 HEK-293T C227(0.95); C295(1.02); C274(0.93); C195(0.99)  LDD1661  [32]
 LDCM0459  CL67 HEK-293T C227(1.00); C295(1.24); C274(1.00); C195(1.04)  LDD1662  [32]
 LDCM0460  CL68 HEK-293T C227(1.03); C295(0.97); C274(1.14); C195(0.91)  LDD1663  [32]
 LDCM0461  CL69 HEK-293T C227(1.01); C295(1.02); C274(1.10); C195(1.00)  LDD1664  [32]
 LDCM0462  CL7 HEK-293T C227(0.94); C295(1.36); C274(0.98); C195(0.96)  LDD1665  [32]
 LDCM0463  CL70 HEK-293T C227(1.10); C295(1.07); C274(1.02); C195(0.97)  LDD1666  [32]
 LDCM0464  CL71 HEK-293T C227(1.04); C295(1.16); C274(1.02); C195(1.03)  LDD1667  [32]
 LDCM0465  CL72 HEK-293T C227(1.07); C295(1.05); C274(1.08); C195(1.10)  LDD1668  [32]
 LDCM0466  CL73 HEK-293T C227(0.97); C295(1.01); C274(1.03); C195(0.92)  LDD1669  [32]
 LDCM0467  CL74 HEK-293T C227(1.06); C295(0.89); C274(0.97); C195(0.97)  LDD1670  [32]
 LDCM0469  CL76 HEK-293T C227(0.99); C295(0.90); C274(0.94); C195(0.94)  LDD1672  [32]
 LDCM0470  CL77 HEK-293T C227(0.92); C295(0.85); C274(1.04); C195(0.83)  LDD1673  [32]
 LDCM0471  CL78 HEK-293T C227(0.97); C295(1.01); C274(1.03); C195(0.92)  LDD1674  [32]
 LDCM0472  CL79 HEK-293T C227(0.99); C295(1.14); C274(1.06); C195(1.08)  LDD1675  [32]
 LDCM0473  CL8 HEK-293T C227(0.93); C295(1.18); C274(1.09); C195(0.64)  LDD1676  [32]
 LDCM0474  CL80 HEK-293T C227(1.13); C295(0.91); C274(1.12); C195(0.94)  LDD1677  [32]
 LDCM0475  CL81 HEK-293T C227(0.93); C295(1.01); C274(1.16); C195(1.03)  LDD1678  [32]
 LDCM0476  CL82 HEK-293T C227(1.04); C295(1.13); C274(1.05); C195(0.94)  LDD1679  [32]
 LDCM0477  CL83 HEK-293T C227(1.04); C295(1.17); C274(0.91); C195(0.99)  LDD1680  [32]
 LDCM0478  CL84 HEK-293T C227(0.99); C295(1.03); C274(1.03); C195(0.98)  LDD1681  [32]
 LDCM0479  CL85 HEK-293T C227(1.15); C295(0.96); C274(1.08); C195(0.95)  LDD1682  [32]
 LDCM0480  CL86 HEK-293T C227(1.11); C295(0.89); C274(0.97); C195(0.91)  LDD1683  [32]
 LDCM0481  CL87 HEK-293T C227(1.10); C295(1.06); C274(1.08); C195(1.01)  LDD1684  [32]
 LDCM0482  CL88 HEK-293T C227(1.10); C295(1.00); C274(0.93); C195(1.01)  LDD1685  [32]
 LDCM0483  CL89 HEK-293T C227(1.02); C295(0.90); C274(0.99); C195(0.96)  LDD1686  [32]
 LDCM0484  CL9 HEK-293T C227(0.94); C295(1.18); C274(1.14); C195(0.92)  LDD1687  [32]
 LDCM0485  CL90 HEK-293T C227(0.91); C295(0.87); C274(1.05); C195(0.76)  LDD1688  [32]
 LDCM0486  CL91 HEK-293T C227(1.05); C295(1.00); C274(1.06); C195(1.05)  LDD1689  [32]
 LDCM0487  CL92 HEK-293T C227(1.05); C295(0.90); C274(1.04); C195(0.88)  LDD1690  [32]
 LDCM0488  CL93 HEK-293T C227(0.99); C295(0.99); C274(1.04); C195(0.86)  LDD1691  [32]
 LDCM0489  CL94 HEK-293T C227(1.07); C295(1.03); C274(1.03); C195(0.86)  LDD1692  [32]
 LDCM0490  CL95 HEK-293T C227(0.98); C295(1.08); C274(0.97); C195(0.81)  LDD1693  [32]
 LDCM0491  CL96 HEK-293T C227(1.04); C295(1.02); C274(0.99); C195(0.95)  LDD1694  [32]
 LDCM0492  CL97 HEK-293T C227(0.96); C295(0.97); C274(0.94); C195(0.89)  LDD1695  [32]
 LDCM0493  CL98 HEK-293T C227(0.99); C295(0.93); C274(0.98); C195(0.85)  LDD1696  [32]
 LDCM0494  CL99 HEK-293T C227(1.00); C295(1.00); C274(0.98); C195(0.97)  LDD1697  [32]
 LDCM0028  Dobutamine HEK-293T 9.47  LDD0180  [3]
 LDCM0027  Dopamine HEK-293T 11.87  LDD0179  [3]
 LDCM0495  E2913 HEK-293T C227(0.92); C295(0.94); C274(0.92); C195(0.95)  LDD1698  [32]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C274(3.60); C227(2.35); C178(0.79)  LDD1702  [30]
 LDCM0031  Epigallocatechin gallate HEK-293T 6.09  LDD0183  [3]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [11]
 LDCM0625  F8 Ramos C227(1.32); C295(1.31); C274(1.07)  LDD2187  [33]
 LDCM0572  Fragment10 Ramos C227(1.17); C295(1.04); C274(1.60)  LDD2189  [33]
 LDCM0573  Fragment11 Ramos C227(0.37); C295(2.03); C274(0.08)  LDD2190  [33]
 LDCM0574  Fragment12 Ramos C227(0.92); C295(0.98); C274(2.39)  LDD2191  [33]
 LDCM0575  Fragment13 Ramos C227(0.91); C295(0.92); C274(1.18)  LDD2192  [33]
 LDCM0576  Fragment14 Ramos C227(1.57); C295(1.94); C274(2.51)  LDD2193  [33]
 LDCM0579  Fragment20 Ramos C227(1.47); C295(1.74); C274(6.33)  LDD2194  [33]
 LDCM0580  Fragment21 Ramos C227(1.18); C295(0.82); C274(1.22)  LDD2195  [33]
 LDCM0582  Fragment23 Ramos C227(0.66); C295(0.75); C274(0.99)  LDD2196  [33]
 LDCM0578  Fragment27 Ramos C227(1.07); C295(0.85); C274(0.88)  LDD2197  [33]
 LDCM0586  Fragment28 Ramos C227(0.69); C295(0.90); C274(0.74)  LDD2198  [33]
 LDCM0588  Fragment30 Ramos C227(1.12); C295(1.12); C274(1.63)  LDD2199  [33]
 LDCM0589  Fragment31 Ramos C227(0.86); C295(0.98); C274(1.22)  LDD2200  [33]
 LDCM0590  Fragment32 Ramos C227(0.87); C295(1.00); C274(1.60)  LDD2201  [33]
 LDCM0468  Fragment33 HEK-293T C227(0.83); C295(0.94); C274(0.99); C195(0.97)  LDD1671  [32]
 LDCM0596  Fragment38 Ramos C227(1.38); C295(0.81); C274(1.11)  LDD2203  [33]
 LDCM0566  Fragment4 Ramos C227(0.89); C295(1.36); C274(3.11)  LDD2184  [33]
 LDCM0427  Fragment51 HEK-293T C227(1.05); C295(1.02); C274(1.02); C195(0.97)  LDD1631  [32]
 LDCM0610  Fragment52 Ramos C227(0.91); C295(1.52); C274(1.71)  LDD2204  [33]
 LDCM0614  Fragment56 Ramos C227(1.62); C295(1.03); C274(1.42)  LDD2205  [33]
 LDCM0569  Fragment7 Ramos C227(1.20); C295(1.72); C274(2.08)  LDD2186  [33]
 LDCM0571  Fragment9 Ramos C227(0.97); C295(1.68); C274(5.17)  LDD2188  [33]
 LDCM0107  IAA HeLa H343(0.00); H301(0.00); H231(0.00)  LDD0221  [25]
 LDCM0022  KB02 HEK-293T C227(0.98); C295(0.95); C274(0.90); C195(1.07)  LDD1492  [32]
 LDCM0023  KB03 Jurkat C227(16.62)  LDD0209  [12]
 LDCM0024  KB05 G361 C275(6.30); C296(2.73)  LDD3311  [34]
 LDCM0030  Luteolin HEK-293T 10.49  LDD0182  [3]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C378(1.75)  LDD2102  [30]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C378(0.38); C295(1.16); C227(0.47)  LDD2121  [30]
 LDCM0109  NEM HeLa H301(0.00); H343(0.00)  LDD0223  [25]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C378(0.76); C295(0.78); C227(0.73); C274(0.49)  LDD2089  [30]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C378(2.66)  LDD2090  [30]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C378(1.07); C274(0.91)  LDD2092  [30]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C378(0.97); C295(1.26); C274(0.74)  LDD2093  [30]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C378(1.75); C227(0.84); C274(1.37)  LDD2094  [30]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C378(0.51)  LDD2096  [30]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C295(0.57); C227(3.00)  LDD2097  [30]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C378(3.18); C295(1.14)  LDD2098  [30]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C378(0.33)  LDD2099  [30]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C295(0.94)  LDD2100  [30]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C295(0.85)  LDD2101  [30]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C378(0.68); C227(1.08)  LDD2104  [30]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C378(4.17); C274(1.73)  LDD2105  [30]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C378(0.42)  LDD2106  [30]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C378(0.53); C227(0.75)  LDD2107  [30]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C378(0.50); C295(1.00); C227(0.75)  LDD2108  [30]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C295(0.93); C274(0.33)  LDD2109  [30]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C378(0.34); C227(0.94)  LDD2114  [30]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C295(0.60); C227(1.21)  LDD2115  [30]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C378(0.63); C274(1.04)  LDD2116  [30]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C378(0.55); C274(1.25)  LDD2118  [30]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C295(1.31); C227(1.97)  LDD2119  [30]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C378(0.99)  LDD2120  [30]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C378(0.82); C274(0.64)  LDD2122  [30]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C378(0.34); C178(1.06)  LDD2123  [30]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C378(0.50)  LDD2124  [30]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C378(0.46); C295(1.03); C227(0.83); C274(0.81)  LDD2125  [30]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C378(0.65); C227(1.15)  LDD2127  [30]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C227(1.00); C274(0.80)  LDD2129  [30]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C227(0.98)  LDD2134  [30]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C378(0.53); C227(1.09)  LDD2135  [30]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C378(0.46); C178(1.21)  LDD2137  [30]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C378(0.76)  LDD1700  [30]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C378(0.32)  LDD2140  [30]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C378(0.69); C295(0.95)  LDD2141  [30]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C378(0.84)  LDD2143  [30]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C378(0.35); C295(1.22); C274(0.64)  LDD2146  [30]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C295(0.60)  LDD2148  [30]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C378(0.59); C274(1.04)  LDD2149  [30]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C378(0.34); C227(0.35)  LDD2150  [30]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C378(9.20)  LDD2153  [30]
 LDCM0627  NUDT7-COV-1 HEK-293T C227(4.49); C378(1.18); C274(1.09); C295(0.93)  LDD2206  [35]
 LDCM0628  OTUB2-COV-1 HEK-293T C378(1.93); C274(1.77); C227(1.66); C274(1.61)  LDD2207  [35]
 LDCM0029  Quercetin HEK-293T 19.84  LDD0181  [3]
 LDCM0131  RA190 MM1.R 2.34  LDD0299  [10]
 LDCM0096  SAHA K562 4.14  LDD0362  [29]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
Heat shock protein HSP 90-alpha (HSP90AA1) Heat shock protein 90 family P07900
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Egl nine homolog 1 (EGLN1) . Q9GZT9
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) . Q14318
Plasma membrane ascorbate-dependent reductase CYBRD1 (CYBRD1) . Q53TN4
Thioredoxin-related transmembrane protein 1 (TMX1) . Q9H3N1
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
UDP-sugar transporter protein SLC35A5 (SLC35A5) Nucleotide-sugar transporter family Q9BS91
Solute carrier family 35 member B1 (SLC35B1) Nucleotide-sugar transporter family P78383
Peroxisome assembly protein 12 (PEX12) Pex2/pex10/pex12 family O00623
Cardiac phospholamban (PLN) Phospholamban family P26678
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Protrudin (ZFYVE27) . Q5T4F4
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-X-C chemokine receptor type 2 (CXCR2) G-protein coupled receptor 1 family P25025
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Membrane protein FAM174A (FAM174A) FAM174 family Q8TBP5
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (FKBP6) FKBP6 family O75344
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Transmembrane protein 43 (TMEM43) TMEM43 family Q9BTV4
Transmembrane protein 45B (TMEM45B) TMEM45 family Q96B21
Zinc finger protein-like 1 (ZFPL1) ZFPL1 family O95159
Transmembrane protein 254 (TMEM254) . Q8TBM7
Transmembrane protein 80 (TMEM80) . Q96HE8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
10 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
23 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
29 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
30 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
31 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
33 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
34 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
35 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.