Details of the Target

General Information of Target

Target ID LDTP00512
Target Name Protein transport protein Sec16A (SEC16A)
Gene Name SEC16A
Gene ID 9919
Synonyms
KIAA0310; SEC16; SEC16L; Protein transport protein Sec16A; SEC16 homolog A; p250
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MQPPPQTVPSGMAGPPPAGNPRSVFWASSPYRRRANNNAAVAPTTCPLQPVTDPFAFSRQ
ALQSTPLGSSSKSSPPVLQGPAPAGFSQHPGLLVPHTHARDSSQGPCEPLPGPLTQPRAH
ASPFSGALTPSAPPGPEMNRSAEVGPSSEPEVQTLPYLPHYIPGVDPETSHGGHPHGNMP
GLDRPLSRQNPHDGVVTPAASPSLPQPGLQMPGQWGPVQGGPQPSGQHRSPCPEGPVPSG
VPCATSVPHFPTPSILHQGPGHEQHSPLVAPPAALPSDGRDEVSHLQSGSHLANNSDPES
TFRQNPRIVNHWASPELRQNPGVKNEHRPASALVNPLARGDSPENRTHHPLGAGAGSGCA
PLEADSGASGALAMFFQGGETENEENLSSEKAGLSGQADFDDFCSSPGLGRPPAPTHVGA
GSLCQALLPGPSNEAAGDVWGDTASTGVPDASGSQYENVENLEFVQNQEVLPSEPLNLDP
SSPSDQFRYGPLPGPAVPRHGAVCHTGAPDATLHTVHPDSVSSSYSSRSHGRLSGSARPQ
ELVGTFIQQEVGKPEDEASGSFFKQIDSSPVGGETDETTVSQNYRGSVSQPSTPSPPKPT
GIFQTSANSSFEPVKSHLVGVKPFEADRANVVGEVRETCVRQKQCRPAAALPDASPGNLE
QPPDNMETLCAPQVCPLPLNSTTEAVHMLPHAGAPPLDTVYPAPEKRPSARTQGPVKCES
PATTLWAQSELPDFGGNVLLAPAAPALYVCAKPQPPVVQPPEEAMSGQQSRNPSSAAPVQ
SRGGIGASENLENPPKMGEEEALQSQASSGYASLLSSPPTESLQNPPVLIAQPDHSYNLA
QPINFSVSLSNSHEKNQSWREALVGDRPAVSSWALGGDSGENTSLSGIPTSSVLSLSLPS
SVAQSNFPQGSGASEMVSNQPANLLVQPPSQPVPENLVPESQKDRKAGSALPGFANSPAG
STSVVLVPPAHGTLVPDGNKANHSSHQEDTYGALDFTLSRTLENPVNVYNPSHSDSLASQ
QSVASHPRQSGPGAPNLDRFYQQVTKDAQGQPGLERAQQELVPPQQQASPPQLPKAMFSE
LSNPESLPAQGQAQNSAQSPASLVLVDAGQQLPPRPPQSSSVSLVSSGSGQAAVPSEQPW
PQPVPALAPGPPPQDLAAYYYYRPLYDAYQPQYSLPYPPEPGAASLYYQDVYSLYEPRYR
PYDGAASAYAQNYRYPEPERPSSRASHSSERPPPRQGYPEGYYSSKSGWSSQSDYYASYY
SSQYDYGDPGHWDRYHYSARVRDPRTYDRRYWCDAEYDAYRREHSAFGDRPEKRDNNWRY
DPRFTGSFDDDPDPHRDPYGEEVDRRSVHSEHSARSLHSAHSLASRRSSLSSHSHQSQIY
RSHNVAAGSYEAPLPPGSFHGDFAYGTYRSNFSSGPGFPEYGYPADTVWPAMEQVSSRPT
SPEKFSVPHVCARFGPGGQLIKVIPNLPSEGQPALVEVHSMEALLQHTSEQEEMRAFPGP
LAKDDTHKVDVINFAQNKAMKCLQNENLIDKESASLLWNFIVLLCRQNGTVVGTDIAELL
LRDHRTVWLPGKSPNEANLIDFTNEAVEQVEEEESGEAQLSFLTGGPAAAASSLERETER
FRELLLYGRKKDALESAMKNGLWGHALLLASKMDSRTHARVMTRFANSLPINDPLQTVYQ
LMSGRMPAASTCCGDEKWGDWRPHLAMVLSNLNNNMDVESRTMATMGDTLASRGLLDAAH
FCYLMAQAGFGVYTKKTTKLVLIGSNHSLPFLKFATNEAIQRTEAYEYAQSLGAETCPLP
SFQVFKFIYSCRLAEMGLATQAFHYCEAIAKSILTQPHLYSPVLISQLVQMASQLRLFDP
QLKEKPEEESLAAPTWLVHLQQVERQIKEGAGVWHQDGALPQQCPGTPSSEMEQLDRPGL
SQPGALGIANPLLAVPAPSPEHSSPSVRLLPSAPQTLPDGPLASPARVPMFPVPLPPGPL
EPGPGCVTPGPALGFLEPSGPGLPPGVPPLQERRHLLQEARSPDPGIVPQEAPVGNSLSE
LSEENFDGKFANLTPSRTVPDSEAPPGWDRADSGPTQPPLSLSPAPETKRPGQAAKKETK
EPKKGESWFFRWLPGKKKTEAYLPDDKNKSIVWDEKKNQWVNLNEPEEEKKAPPPPPTSM
PKTVQAAPPALPGPPGAPVNMYSRRAAGTRARYVDVLNPSGTQRSEPALAPADFVAPLAP
LPIPSNLFVPTPDAEEPQLPDGTGREGPAAARGLANPEPAPEPKVLSSAASLPGSELPSS
RPEGSQGGELSRCSSMSSLSREVSQHFNQAPGDLPAAGGPPSGAMPFYNPAQLAQACATS
GSSRLGRIGQRKHLVLN
Target Bioclass
Other
Family
SEC16 family
Subcellular location
Endoplasmic reticulum membrane
Function
Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Mediates the recruitment of MIA3/TANGO to ERES. Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane. Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183. Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes.
Uniprot ID
O15027
Ensemble ID
ENST00000313050.11
HGNC ID
HGNC:29006
ChEMBL ID
CHEMBL4295654

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.P1084L DBIA    Probe Info 
AU565 SNV: p.R229S DBIA    Probe Info 
COLO792 SNV: p.G421A DBIA    Probe Info 
COLO800 SNV: p.G421A DBIA    Probe Info 
EFO27 SNV: p.A1157T DBIA    Probe Info 
HCT116 Deletion: p.F563LfsTer9 .
HEC1B SNV: p.E2262K .
HS839T SNV: p.G1130C DBIA    Probe Info 
HSC3 SNV: p.N2138K; p.M2296I DBIA    Probe Info 
HT SNV: p.S1668G DBIA    Probe Info 
JURKAT SNV: p.S609N .
KMS12BM SNV: p.P2078L DBIA    Probe Info 
KYSE510 SNV: p.A511S; p.C1451F DBIA    Probe Info 
L428 SNV: p.W1140Ter DBIA    Probe Info 
LNCaP clone FGC SNV: p.S655T DBIA    Probe Info 
LU65 SNV: p.G2105C DBIA    Probe Info 
MDAMB231 SNV: p.L317R .
MELJUSO SNV: p.P15A DBIA    Probe Info 
MEWO SNV: p.S2081F DBIA    Probe Info 
MFE280 SNV: p.A1822T DBIA    Probe Info 
MFE296 SNV: p.P267H DBIA    Probe Info 
MFE319 SNV: p.Y1213H; p.E1219K; p.L1900P DBIA    Probe Info 
NCIH1155 SNV: p.G421A DBIA    Probe Info 
RKO SNV: p.G573D DBIA    Probe Info 
RT112 SNV: p.K1755N DBIA    Probe Info 
SKMEL2 SNV: p.E151G; p.P248S DBIA    Probe Info 
SNGM SNV: p.G1699R DBIA    Probe Info 
SW620 SNV: p.G421A DBIA    Probe Info 
TOV21G SNV: p.P1961T DBIA    Probe Info 
U118MG Substitution: p.P2065S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P2
 Probe Info  		35.65  LDD0348  [2]
HRP
 Probe Info  		21.06  LDD0347  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
TH211
 Probe Info  		Y1113(18.72); Y1021(7.46)  LDD0257  [4]
STPyne
 Probe Info  		K1313(2.56); K2104(3.96)  LDD0277  [5]
Probe 1
 Probe Info  		Y489(12.50); Y584(5.79); Y1041(54.99); Y1209(18.89)  LDD3495  [6]
P12
 Probe Info  		20.00  LDD0202  [7]
BTD
 Probe Info  		C1451(1.45)  LDD2093  [8]
Sulforaphane-probe2
 Probe Info  		1.94  LDD0160  [9]
AHL-Pu-1
 Probe Info  		C1619(2.85); C1115(2.01)  LDD0169  [10]
HPAP
 Probe Info  		4.32  LDD0062  [11]
EA-probe
 Probe Info  		N.A.  LDD0440  [12]
DBIA
 Probe Info  		CAmbiguous(11.06); C1293(49.02)  LDD0209  [13]
HHS-475
 Probe Info  		Y489(1.44); Y1209(1.63)  LDD0264  [14]
5E-2FA
 Probe Info  		N.A.  LDD2235  [15]
IPM
 Probe Info  		C46(0.00); C107(0.00)  LDD0025  [16]
JW-RF-010
 Probe Info  		C107(0.00); C46(0.00)  LDD0026  [16]
TFBX
 Probe Info  		C2293(0.00); C107(0.00); C1811(0.00); C46(0.00)  LDD0027  [16]
WYneN
 Probe Info  		N.A.  LDD0021  [17]
DA-P3
 Probe Info  		N.A.  LDD0178  [2]
ENE
 Probe Info  		N.A.  LDD0006  [17]
IA-alkyne
 Probe Info  		N.A.  LDD0149  [18]
PPMS
 Probe Info  		N.A.  LDD0008  [17]
VSF
 Probe Info  		C46(0.00); C2293(0.00); C107(0.00)  LDD0007  [17]
Phosphinate-6
 Probe Info  		C107(0.00); C504(0.00); C46(0.00)  LDD0018  [19]
Acrolein
 Probe Info  		C107(0.00); C1693(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info  		H1375(0.00); H1373(0.00); H1361(0.00)  LDD0219  [20]
Methacrolein
 Probe Info  		N.A.  LDD0218  [20]
AOyne
 Probe Info  		10.60  LDD0443  [21]
NAIA_5
 Probe Info  		C1522(0.00); C1545(0.00); C1742(0.00); C1826(0.00)  LDD2223  [22]
HHS-465
 Probe Info  		N.A.  LDD2240  [23]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C191
 Probe Info  		11.16  LDD1868  [24]
C231
 Probe Info  		14.93  LDD1904  [24]
C277
 Probe Info  		8.28  LDD1947  [24]
C278
 Probe Info  		47.84  LDD1948  [24]
C282
 Probe Info  		15.24  LDD1952  [24]
C284
 Probe Info  		23.75  LDD1954  [24]
C338
 Probe Info  		10.78  LDD2001  [24]
C353
 Probe Info  		6.19  LDD2014  [24]
FFF probe11
 Probe Info  		20.00  LDD0471  [25]
FFF probe13
 Probe Info  		15.39  LDD0475  [25]
FFF probe15
 Probe Info  		13.55  LDD0478  [25]
FFF probe2
 Probe Info  		20.00  LDD0463  [25]
FFF probe3
 Probe Info  		13.64  LDD0464  [25]
FFF probe9
 Probe Info  		13.10  LDD0470  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1451(1.75)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1451(1.52)  LDD2152  [8]
 LDCM0025  4SU-RNA DM93 C2159(2.91)  LDD0170  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1619(2.85); C1115(2.01)  LDD0169  [10]
 LDCM0214  AC1 HEK-293T C2293(1.24); C1451(1.07); C1293(1.04); C107(0.98)  LDD1507  [26]
 LDCM0215  AC10 HEK-293T C2293(1.19); C1451(0.97); C1293(1.08); C107(0.97)  LDD1508  [26]
 LDCM0226  AC11 HEK-293T C2293(1.17); C1451(0.94); C1293(1.02); C107(1.19)  LDD1509  [26]
 LDCM0237  AC12 HEK-293T C2293(1.10); C1451(1.02); C1293(1.03); C107(1.17)  LDD1510  [26]
 LDCM0259  AC14 HEK-293T C2293(1.08); C1451(1.00); C1293(1.06); C107(0.93)  LDD1512  [26]
 LDCM0270  AC15 HEK-293T C2293(1.09); C1451(0.95); C1293(0.98); C107(1.41)  LDD1513  [26]
 LDCM0276  AC17 HEK-293T C2293(1.16); C1451(1.03); C1293(1.11); C107(1.19)  LDD1515  [26]
 LDCM0277  AC18 HEK-293T C2293(1.17); C1451(0.94); C1293(1.00); C107(1.15)  LDD1516  [26]
 LDCM0278  AC19 HEK-293T C2293(1.73); C1451(1.19); C1293(1.28); C107(1.34)  LDD1517  [26]
 LDCM0279  AC2 HEK-293T C2293(0.98); C1451(0.99); C1293(0.98); C107(1.35)  LDD1518  [26]
 LDCM0280  AC20 HEK-293T C2293(1.12); C1451(0.98); C1293(0.97); C107(1.19)  LDD1519  [26]
 LDCM0281  AC21 HEK-293T C2293(1.08); C1451(0.99); C1293(0.95); C107(1.06)  LDD1520  [26]
 LDCM0282  AC22 HEK-293T C2293(1.03); C1451(1.01); C1293(0.99); C107(1.05)  LDD1521  [26]
 LDCM0283  AC23 HEK-293T C2293(1.09); C1451(1.00); C1293(0.95); C107(1.19)  LDD1522  [26]
 LDCM0284  AC24 HEK-293T C2293(0.96); C1451(0.97); C1293(0.99); C1522(1.01)  LDD1523  [26]
 LDCM0285  AC25 HEK-293T C2293(1.07); C1451(1.02); C1293(1.07); C107(1.03)  LDD1524  [26]
 LDCM0286  AC26 HEK-293T C2293(1.04); C1451(0.99); C1293(1.02); C107(1.12)  LDD1525  [26]
 LDCM0287  AC27 HEK-293T C2293(1.11); C1451(0.93); C1293(1.07); C107(1.13)  LDD1526  [26]
 LDCM0288  AC28 HEK-293T C2293(1.08); C1451(0.95); C1293(1.01); C107(0.92)  LDD1527  [26]
 LDCM0289  AC29 HEK-293T C2293(1.11); C1451(0.97); C1293(1.00); C107(1.08)  LDD1528  [26]
 LDCM0290  AC3 HEK-293T C2293(1.18); C1451(0.96); C1293(1.03); C107(1.02)  LDD1529  [26]
 LDCM0291  AC30 HEK-293T C2293(1.06); C1451(0.99); C1293(1.02); C107(0.86)  LDD1530  [26]
 LDCM0292  AC31 HEK-293T C2293(1.02); C1451(1.13); C1293(0.96); C107(0.88)  LDD1531  [26]
 LDCM0293  AC32 HEK-293T C2293(1.06); C1451(0.92); C1293(1.01); C1522(0.99)  LDD1532  [26]
 LDCM0294  AC33 HEK-293T C2293(1.18); C1451(1.00); C1293(1.00); C107(1.18)  LDD1533  [26]
 LDCM0295  AC34 HEK-293T C2293(1.11); C1451(0.96); C1293(1.03); C107(1.20)  LDD1534  [26]
 LDCM0296  AC35 HEK-293T C2293(1.11); C1451(0.98); C1293(1.09); C107(1.33)  LDD1535  [26]
 LDCM0297  AC36 HEK-293T C2293(1.15); C1451(1.00); C1293(1.01); C107(1.31)  LDD1536  [26]
 LDCM0298  AC37 HEK-293T C2293(1.10); C1451(0.96); C1293(0.98); C107(1.09)  LDD1537  [26]
 LDCM0299  AC38 HEK-293T C2293(1.16); C1451(1.01); C1293(1.05); C107(1.27)  LDD1538  [26]
 LDCM0300  AC39 HEK-293T C2293(1.15); C1451(1.09); C1293(0.98); C107(1.14)  LDD1539  [26]
 LDCM0301  AC4 HEK-293T C2293(1.06); C1451(1.03); C1293(1.00); C107(0.92)  LDD1540  [26]
 LDCM0302  AC40 HEK-293T C2293(1.11); C1451(0.94); C1293(1.05); C1522(1.12)  LDD1541  [26]
 LDCM0303  AC41 HEK-293T C2293(1.14); C1451(1.06); C1293(1.06); C107(1.25)  LDD1542  [26]
 LDCM0304  AC42 HEK-293T C2293(1.19); C1451(1.00); C1293(1.09); C107(1.11)  LDD1543  [26]
 LDCM0305  AC43 HEK-293T C2293(1.19); C1451(0.92); C1293(1.06); C107(1.25)  LDD1544  [26]
 LDCM0306  AC44 HEK-293T C2293(1.12); C1451(0.98); C1293(1.04); C107(1.33)  LDD1545  [26]
 LDCM0307  AC45 HEK-293T C2293(1.20); C1451(0.93); C1293(1.02); C107(1.10)  LDD1546  [26]
 LDCM0308  AC46 HEK-293T C2293(1.14); C1451(0.92); C1293(1.08); C107(1.03)  LDD1547  [26]
 LDCM0309  AC47 HEK-293T C2293(1.15); C1451(1.04); C1293(0.96); C107(1.46)  LDD1548  [26]
 LDCM0310  AC48 HEK-293T C2293(1.03); C1451(1.03); C1293(1.01); C1522(1.06)  LDD1549  [26]
 LDCM0311  AC49 HEK-293T C2293(1.31); C1451(1.04); C1293(1.08); C107(1.15)  LDD1550  [26]
 LDCM0312  AC5 HEK-293T C2293(1.06); C1451(1.01); C1293(1.03); C107(1.15)  LDD1551  [26]
 LDCM0313  AC50 HEK-293T C2293(1.14); C1451(0.95); C1293(1.00); C107(0.87)  LDD1552  [26]
 LDCM0314  AC51 HEK-293T C2293(1.13); C1451(1.01); C1293(1.05); C107(1.23)  LDD1553  [26]
 LDCM0315  AC52 HEK-293T C2293(1.17); C1451(1.06); C1293(1.01); C107(1.27)  LDD1554  [26]
 LDCM0316  AC53 HEK-293T C2293(1.12); C1451(1.00); C1293(1.01); C107(1.29)  LDD1555  [26]
 LDCM0317  AC54 HEK-293T C2293(1.17); C1451(0.96); C1293(1.05); C107(1.11)  LDD1556  [26]
 LDCM0318  AC55 HEK-293T C2293(1.16); C1451(0.99); C1293(0.96); C107(1.67)  LDD1557  [26]
 LDCM0319  AC56 HEK-293T C2293(1.18); C1451(0.91); C1293(1.04); C1522(1.07)  LDD1558  [26]
 LDCM0320  AC57 HEK-293T C2293(1.18); C1451(0.97); C1293(1.09); C107(1.07)  LDD1559  [26]
 LDCM0321  AC58 HEK-293T C2293(1.09); C1451(0.96); C1293(0.99); C107(1.38)  LDD1560  [26]
 LDCM0322  AC59 HEK-293T C2293(1.11); C1451(0.87); C1293(0.96); C107(1.28)  LDD1561  [26]
 LDCM0323  AC6 HEK-293T C2293(1.10); C1451(1.00); C1293(1.05); C107(0.88)  LDD1562  [26]
 LDCM0324  AC60 HEK-293T C2293(1.04); C1451(1.01); C1293(0.97); C107(1.12)  LDD1563  [26]
 LDCM0325  AC61 HEK-293T C2293(1.12); C1451(1.01); C1293(1.05); C107(1.16)  LDD1564  [26]
 LDCM0326  AC62 HEK-293T C2293(1.08); C1451(0.94); C1293(1.00); C107(1.00)  LDD1565  [26]
 LDCM0327  AC63 HEK-293T C2293(1.06); C1451(1.28); C1293(1.02); C107(1.98)  LDD1566  [26]
 LDCM0328  AC64 HEK-293T C2293(1.10); C1451(1.04); C1293(0.99); C1522(1.08)  LDD1567  [26]
 LDCM0334  AC7 HEK-293T C2293(1.05); C1451(1.07); C1293(0.96); C107(1.15)  LDD1568  [26]
 LDCM0345  AC8 HEK-293T C2293(1.00); C1451(0.97); C1293(1.05); C1522(1.06)  LDD1569  [26]
 LDCM0248  AKOS034007472 HEK-293T C2293(1.06); C1451(0.99); C1293(1.07); C107(1.27)  LDD1511  [26]
 LDCM0356  AKOS034007680 HEK-293T C2293(1.20); C1451(1.12); C1293(0.99); C107(1.06)  LDD1570  [26]
 LDCM0275  AKOS034007705 HEK-293T C2293(1.04); C1451(1.00); C1293(1.06); C1522(1.05)  LDD1514  [26]
 LDCM0156  Aniline NCI-H1299 11.47  LDD0403  [1]
 LDCM0088  C45 HEK-293T 20.00  LDD0202  [7]
 LDCM0108  Chloroacetamide HeLa C1826(0.00); C107(0.00); H1358(0.00)  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C504(20.00); C1797(20.00); C1826(0.94); C1293(0.79)  LDD2227  [22]
 LDCM0367  CL1 HEK-293T C2293(0.93); C1451(0.94); C1293(0.87); C107(0.89)  LDD1571  [26]
 LDCM0368  CL10 HEK-293T C2293(0.92); C1451(1.17); C1293(1.45); C107(1.03)  LDD1572  [26]
 LDCM0369  CL100 HEK-293T C2293(1.13); C1451(0.95); C1293(0.98); C107(1.23)  LDD1573  [26]
 LDCM0370  CL101 HEK-293T C2293(1.12); C1451(1.00); C1293(0.85); C107(1.09)  LDD1574  [26]
 LDCM0371  CL102 HEK-293T C2293(1.23); C1451(0.94); C1293(1.01); C107(0.93)  LDD1575  [26]
 LDCM0372  CL103 HEK-293T C2293(1.12); C1451(0.94); C1293(0.95); C107(1.09)  LDD1576  [26]
 LDCM0373  CL104 HEK-293T C2293(1.11); C1451(0.97); C1293(0.99); C107(1.13)  LDD1577  [26]
 LDCM0374  CL105 HEK-293T C2293(1.09); C1451(1.20); C1293(0.93); C107(1.20)  LDD1578  [26]
 LDCM0375  CL106 HEK-293T C2293(1.18); C1451(0.93); C1293(0.91); C107(1.02)  LDD1579  [26]
 LDCM0376  CL107 HEK-293T C2293(1.12); C1451(0.95); C1293(0.97); C107(0.98)  LDD1580  [26]
 LDCM0377  CL108 HEK-293T C2293(1.15); C1451(1.00); C1293(0.99); C107(1.25)  LDD1581  [26]
 LDCM0378  CL109 HEK-293T C2293(1.03); C1451(1.02); C1293(0.98); C107(1.04)  LDD1582  [26]
 LDCM0379  CL11 HEK-293T C2293(0.92); C1451(1.05); C1293(0.94); C107(0.82)  LDD1583  [26]
 LDCM0380  CL110 HEK-293T C2293(1.16); C1451(0.99); C1293(1.01); C107(0.96)  LDD1584  [26]
 LDCM0381  CL111 HEK-293T C2293(1.15); C1451(1.00); C1293(0.98); C107(0.99)  LDD1585  [26]
 LDCM0382  CL112 HEK-293T C2293(1.19); C1451(0.91); C1293(1.07); C107(1.14)  LDD1586  [26]
 LDCM0383  CL113 HEK-293T C2293(1.03); C1451(0.99); C1293(0.88); C107(1.20)  LDD1587  [26]
 LDCM0384  CL114 HEK-293T C2293(1.14); C1451(1.02); C1293(1.02); C107(1.15)  LDD1588  [26]
 LDCM0385  CL115 HEK-293T C2293(1.10); C1451(0.95); C1293(0.98); C107(0.95)  LDD1589  [26]
 LDCM0386  CL116 HEK-293T C2293(1.12); C1451(0.99); C1293(0.97); C107(1.20)  LDD1590  [26]
 LDCM0387  CL117 HEK-293T C2293(1.08); C1451(0.99); C1293(0.85); C107(1.28)  LDD1591  [26]
 LDCM0388  CL118 HEK-293T C2293(1.35); C1451(0.95); C1293(0.98); C107(1.13)  LDD1592  [26]
 LDCM0389  CL119 HEK-293T C2293(1.12); C1451(0.93); C1293(0.94); C107(1.02)  LDD1593  [26]
 LDCM0390  CL12 HEK-293T C2293(0.99); C1451(0.95); C1293(1.27); C1522(1.17)  LDD1594  [26]
 LDCM0391  CL120 HEK-293T C2293(1.16); C1451(0.97); C1293(1.03); C107(1.15)  LDD1595  [26]
 LDCM0392  CL121 HEK-293T C2293(1.10); C1451(0.94); C1293(0.89); C107(1.15)  LDD1596  [26]
 LDCM0393  CL122 HEK-293T C2293(1.18); C1451(0.97); C1293(0.99); C107(1.10)  LDD1597  [26]
 LDCM0394  CL123 HEK-293T C2293(1.09); C1451(1.00); C1293(1.00); C107(1.17)  LDD1598  [26]
 LDCM0395  CL124 HEK-293T C2293(1.33); C1451(1.04); C1293(1.04); C107(1.19)  LDD1599  [26]
 LDCM0396  CL125 HEK-293T C2293(1.15); C1451(1.01); C1293(0.92); C107(1.01)  LDD1600  [26]
 LDCM0397  CL126 HEK-293T C2293(1.10); C1451(0.98); C1293(1.00); C107(1.24)  LDD1601  [26]
 LDCM0398  CL127 HEK-293T C2293(1.08); C1451(1.00); C1293(1.03); C107(1.26)  LDD1602  [26]
 LDCM0399  CL128 HEK-293T C2293(1.17); C1451(1.05); C1293(1.01); C107(1.27)  LDD1603  [26]
 LDCM0400  CL13 HEK-293T C2293(1.14); C1451(1.16); C1293(0.94); C107(1.22)  LDD1604  [26]
 LDCM0401  CL14 HEK-293T C2293(1.06); C1451(0.92); C1293(1.00); C107(0.96)  LDD1605  [26]
 LDCM0402  CL15 HEK-293T C2293(1.22); C1451(1.11); C1293(1.04); C107(1.12)  LDD1606  [26]
 LDCM0403  CL16 HEK-293T C2293(1.08); C1451(0.97); C1293(1.05); C107(1.24)  LDD1607  [26]
 LDCM0404  CL17 HEK-293T C2293(1.21); C1451(1.05); C1293(1.20); C107(1.20)  LDD1608  [26]
 LDCM0405  CL18 HEK-293T C2293(1.06); C1451(0.98); C1293(1.06); C107(1.01)  LDD1609  [26]
 LDCM0406  CL19 HEK-293T C2293(1.15); C1451(0.99); C1293(1.23); C107(1.15)  LDD1610  [26]
 LDCM0407  CL2 HEK-293T C2293(1.00); C1451(0.94); C1293(1.00); C107(0.87)  LDD1611  [26]
 LDCM0408  CL20 HEK-293T C2293(1.11); C1451(0.95); C1293(1.19); C107(1.25)  LDD1612  [26]
 LDCM0409  CL21 HEK-293T C2293(1.07); C1451(0.97); C1293(1.15); C107(0.90)  LDD1613  [26]
 LDCM0410  CL22 HEK-293T C2293(0.97); C1451(0.90); C1293(1.22); C107(1.05)  LDD1614  [26]
 LDCM0411  CL23 HEK-293T C2293(1.01); C1451(0.87); C1293(0.91); C107(1.52)  LDD1615  [26]
 LDCM0412  CL24 HEK-293T C2293(1.01); C1451(0.88); C1293(1.13); C1522(1.17)  LDD1616  [26]
 LDCM0413  CL25 HEK-293T C2293(1.02); C1451(1.00); C1293(0.90); C107(1.33)  LDD1617  [26]
 LDCM0414  CL26 HEK-293T C2293(1.17); C1451(0.90); C1293(1.01); C107(1.06)  LDD1618  [26]
 LDCM0415  CL27 HEK-293T C2293(1.09); C1451(0.97); C1293(0.95); C107(1.06)  LDD1619  [26]
 LDCM0416  CL28 HEK-293T C2293(1.09); C1451(0.98); C1293(0.94); C107(1.19)  LDD1620  [26]
 LDCM0417  CL29 HEK-293T C2293(1.06); C1451(0.98); C1293(1.09); C107(1.07)  LDD1621  [26]
 LDCM0418  CL3 HEK-293T C2293(1.10); C1451(0.95); C1293(1.03); C107(0.97)  LDD1622  [26]
 LDCM0419  CL30 HEK-293T C2293(1.09); C1451(0.93); C1293(1.02); C107(1.21)  LDD1623  [26]
 LDCM0420  CL31 HEK-293T C2293(1.23); C1451(0.99); C1293(1.38); C107(1.17)  LDD1624  [26]
 LDCM0421  CL32 HEK-293T C2293(1.19); C1451(0.94); C1293(1.05); C107(1.13)  LDD1625  [26]
 LDCM0422  CL33 HEK-293T C2293(1.10); C1451(1.12); C1293(1.24); C107(1.06)  LDD1626  [26]
 LDCM0423  CL34 HEK-293T C2293(1.04); C1451(0.96); C1293(1.13); C107(1.19)  LDD1627  [26]
 LDCM0424  CL35 HEK-293T C2293(1.04); C1451(0.93); C1293(0.91); C107(2.09)  LDD1628  [26]
 LDCM0425  CL36 HEK-293T C2293(1.06); C1451(0.90); C1293(1.15); C1522(1.11)  LDD1629  [26]
 LDCM0426  CL37 HEK-293T C2293(0.96); C1451(0.96); C1293(0.86); C107(1.31)  LDD1630  [26]
 LDCM0428  CL39 HEK-293T C2293(1.01); C1451(0.95); C1293(1.08); C107(1.21)  LDD1632  [26]
 LDCM0429  CL4 HEK-293T C2293(1.04); C1451(0.97); C1293(0.98); C107(1.20)  LDD1633  [26]
 LDCM0430  CL40 HEK-293T C2293(1.06); C1451(0.97); C1293(1.06); C107(1.31)  LDD1634  [26]
 LDCM0431  CL41 HEK-293T C2293(1.07); C1451(1.01); C1293(1.11); C107(1.11)  LDD1635  [26]
 LDCM0432  CL42 HEK-293T C2293(1.04); C1451(0.97); C1293(1.01); C107(1.04)  LDD1636  [26]
 LDCM0433  CL43 HEK-293T C2293(1.07); C1451(0.92); C1293(1.13); C107(1.17)  LDD1637  [26]
 LDCM0434  CL44 HEK-293T C2293(1.07); C1451(1.06); C1293(1.09); C107(1.13)  LDD1638  [26]
 LDCM0435  CL45 HEK-293T C2293(1.24); C1451(1.02); C1293(1.19); C107(1.08)  LDD1639  [26]
 LDCM0436  CL46 HEK-293T C2293(1.03); C1451(0.96); C1293(1.16); C107(1.23)  LDD1640  [26]
 LDCM0437  CL47 HEK-293T C2293(1.01); C1451(1.09); C1293(0.98); C107(0.90)  LDD1641  [26]
 LDCM0438  CL48 HEK-293T C2293(1.03); C1451(0.91); C1293(1.06); C1522(1.16)  LDD1642  [26]
 LDCM0439  CL49 HEK-293T C2293(1.04); C1451(0.99); C1293(0.82); C107(1.23)  LDD1643  [26]
 LDCM0440  CL5 HEK-293T C2293(1.14); C1451(0.96); C1293(1.02); C107(1.15)  LDD1644  [26]
 LDCM0441  CL50 HEK-293T C2293(1.07); C1451(0.92); C1293(0.99); C107(1.22)  LDD1645  [26]
 LDCM0443  CL52 HEK-293T C2293(1.08); C1451(1.01); C1293(1.08); C107(1.03)  LDD1646  [26]
 LDCM0444  CL53 HEK-293T C2293(1.23); C1451(1.02); C1293(1.10); C107(1.07)  LDD1647  [26]
 LDCM0445  CL54 HEK-293T C2293(1.23); C1451(0.93); C1293(1.09); C107(0.91)  LDD1648  [26]
 LDCM0446  CL55 HEK-293T C2293(1.09); C1451(0.97); C1293(1.26); C107(1.10)  LDD1649  [26]
 LDCM0447  CL56 HEK-293T C2293(1.16); C1451(0.97); C1293(1.13); C107(1.14)  LDD1650  [26]
 LDCM0448  CL57 HEK-293T C2293(1.35); C1451(1.06); C1293(1.18); C107(0.90)  LDD1651  [26]
 LDCM0449  CL58 HEK-293T C2293(1.12); C1451(1.02); C1293(1.23); C107(1.14)  LDD1652  [26]
 LDCM0450  CL59 HEK-293T C2293(1.12); C1451(1.06); C1293(0.94); C107(1.41)  LDD1653  [26]
 LDCM0451  CL6 HEK-293T C2293(0.93); C1451(0.99); C1293(1.17); C107(0.99)  LDD1654  [26]
 LDCM0452  CL60 HEK-293T C2293(0.99); C1451(0.95); C1293(1.19); C1522(1.13)  LDD1655  [26]
 LDCM0453  CL61 HEK-293T C2293(1.04); C1451(0.97); C1293(0.90); C107(1.19)  LDD1656  [26]
 LDCM0454  CL62 HEK-293T C2293(1.08); C1451(0.95); C1293(0.97); C107(1.12)  LDD1657  [26]
 LDCM0455  CL63 HEK-293T C2293(1.12); C1451(0.93); C1293(0.94); C107(1.18)  LDD1658  [26]
 LDCM0456  CL64 HEK-293T C2293(1.10); C1451(0.98); C1293(1.04); C107(1.18)  LDD1659  [26]
 LDCM0457  CL65 HEK-293T C2293(1.14); C1451(0.97); C1293(1.10); C107(1.18)  LDD1660  [26]
 LDCM0458  CL66 HEK-293T C2293(1.13); C1451(0.95); C1293(1.10); C107(1.35)  LDD1661  [26]
 LDCM0459  CL67 HEK-293T C2293(1.14); C1451(0.94); C1293(1.13); C107(1.25)  LDD1662  [26]
 LDCM0460  CL68 HEK-293T C2293(1.11); C1451(0.99); C1293(1.11); C107(1.26)  LDD1663  [26]
 LDCM0461  CL69 HEK-293T C2293(1.14); C1451(0.94); C1293(0.99); C107(1.09)  LDD1664  [26]
 LDCM0462  CL7 HEK-293T C2293(1.05); C1451(0.94); C1293(1.06); C107(1.13)  LDD1665  [26]
 LDCM0463  CL70 HEK-293T C2293(1.09); C1451(0.93); C1293(1.16); C107(1.13)  LDD1666  [26]
 LDCM0464  CL71 HEK-293T C2293(1.15); C1451(1.05); C1293(0.95); C107(1.57)  LDD1667  [26]
 LDCM0465  CL72 HEK-293T C2293(1.07); C1451(0.96); C1293(1.25); C1522(1.14)  LDD1668  [26]
 LDCM0466  CL73 HEK-293T C2293(1.00); C1451(1.10); C1293(0.92); C107(1.25)  LDD1669  [26]
 LDCM0467  CL74 HEK-293T C2293(1.11); C1451(1.00); C1293(0.99); C107(1.09)  LDD1670  [26]
 LDCM0469  CL76 HEK-293T C2293(1.18); C1451(0.94); C1293(1.06); C107(1.15)  LDD1672  [26]
 LDCM0470  CL77 HEK-293T C2293(1.16); C1451(1.14); C1293(1.14); C107(0.95)  LDD1673  [26]
 LDCM0471  CL78 HEK-293T C2293(1.11); C1451(0.93); C1293(0.99); C107(1.16)  LDD1674  [26]
 LDCM0472  CL79 HEK-293T C2293(1.15); C1451(0.90); C1293(1.14); C107(1.27)  LDD1675  [26]
 LDCM0473  CL8 HEK-293T C2293(1.00); C1451(1.27); C1293(1.41); C107(1.01)  LDD1676  [26]
 LDCM0474  CL80 HEK-293T C2293(1.09); C1451(1.08); C1293(1.01); C107(1.10)  LDD1677  [26]
 LDCM0475  CL81 HEK-293T C2293(1.19); C1451(0.97); C1293(0.98); C107(1.02)  LDD1678  [26]
 LDCM0476  CL82 HEK-293T C2293(1.12); C1451(0.97); C1293(1.13); C107(0.94)  LDD1679  [26]
 LDCM0477  CL83 HEK-293T C2293(1.02); C1451(1.13); C1293(0.94); C107(1.09)  LDD1680  [26]
 LDCM0478  CL84 HEK-293T C2293(1.03); C1451(0.89); C1293(1.09); C1522(1.17)  LDD1681  [26]
 LDCM0479  CL85 HEK-293T C2293(1.00); C1451(1.07); C1293(0.83); C107(1.17)  LDD1682  [26]
 LDCM0480  CL86 HEK-293T C2293(1.14); C1451(0.94); C1293(1.01); C107(1.48)  LDD1683  [26]
 LDCM0481  CL87 HEK-293T C2293(1.04); C1451(0.96); C1293(1.01); C107(1.12)  LDD1684  [26]
 LDCM0482  CL88 HEK-293T C2293(1.05); C1451(0.90); C1293(1.03); C107(1.33)  LDD1685  [26]
 LDCM0483  CL89 HEK-293T C2293(1.15); C1451(0.96); C1293(1.13); C107(1.15)  LDD1686  [26]
 LDCM0484  CL9 HEK-293T C2293(0.98); C1451(0.94); C1293(0.98); C107(0.72)  LDD1687  [26]
 LDCM0485  CL90 HEK-293T C2293(1.02); C1451(1.20); C1293(1.48); C107(1.17)  LDD1688  [26]
 LDCM0486  CL91 HEK-293T C2293(1.05); C1451(0.91); C1293(1.10); C107(1.16)  LDD1689  [26]
 LDCM0487  CL92 HEK-293T C2293(1.02); C1451(1.07); C1293(1.09); C107(1.36)  LDD1690  [26]
 LDCM0488  CL93 HEK-293T C2293(1.10); C1451(0.94); C1293(1.09); C107(1.11)  LDD1691  [26]
 LDCM0489  CL94 HEK-293T C2293(1.07); C1451(0.96); C1293(1.09); C107(1.24)  LDD1692  [26]
 LDCM0490  CL95 HEK-293T C2293(1.12); C1451(1.18); C1293(1.23); C107(1.58)  LDD1693  [26]
 LDCM0491  CL96 HEK-293T C2293(1.01); C1451(0.94); C1293(1.05); C1522(1.27)  LDD1694  [26]
 LDCM0492  CL97 HEK-293T C2293(0.99); C1451(0.95); C1293(0.83); C107(1.16)  LDD1695  [26]
 LDCM0493  CL98 HEK-293T C2293(1.10); C1451(0.91); C1293(0.96); C107(1.01)  LDD1696  [26]
 LDCM0494  CL99 HEK-293T C2293(1.06); C1451(0.90); C1293(0.97); C107(1.01)  LDD1697  [26]
 LDCM0634  CY-0357 Hep-G2 C1797(2.11); C107(0.65); C2293(0.46)  LDD2228  [22]
 LDCM0027  Dopamine HEK-293T 4.25  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C2293(1.13); C1451(0.95); C1293(0.99); C107(1.19)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1451(1.82); C2293(1.50)  LDD1702  [8]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [12]
 LDCM0625  F8 Ramos C1293(2.51)  LDD2187  [27]
 LDCM0573  Fragment11 Ramos C1293(3.73)  LDD2190  [27]
 LDCM0576  Fragment14 Ramos C1293(1.23)  LDD2193  [27]
 LDCM0468  Fragment33 HEK-293T C2293(1.04); C1451(0.94); C1293(0.99); C107(1.02)  LDD1671  [26]
 LDCM0427  Fragment51 HEK-293T C2293(1.05); C1451(0.93); C1293(0.96); C107(1.08)  LDD1631  [26]
 LDCM0569  Fragment7 Ramos C1293(2.07)  LDD2186  [27]
 LDCM0116  HHS-0101 DM93 Y489(1.44); Y1209(1.63)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y1209(0.74); Y489(1.10)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y1209(0.29); Y489(0.70)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y1209(0.55); Y489(0.71)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y1209(1.17); Y489(1.49)  LDD0268  [14]
 LDCM0107  IAA HeLa N.A.  LDD0221  [20]
 LDCM0022  KB02 HEK-293T C1451(0.95); C1293(0.91); C107(0.98); C1522(0.96)  LDD1492  [26]
 LDCM0023  KB03 Jurkat CAmbiguous(11.06); C1293(49.02)  LDD0209  [13]
 LDCM0024  KB05 COLO792 C1451(2.75)  LDD3310  [28]
 LDCM0030  Luteolin HEK-293T 10.61  LDD0182  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [20]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1451(1.45)  LDD2093  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1451(1.16)  LDD2099  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1451(1.04)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1451(0.88)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1451(1.72)  LDD2111  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1451(1.16)  LDD2123  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1451(1.19)  LDD2129  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1451(1.25)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1451(0.92)  LDD2137  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1451(0.74)  LDD2140  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1451(2.07)  LDD2144  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1451(0.88)  LDD2146  [8]
 LDCM0014  Panhematin HEK-293T 4.32  LDD0062  [11]
 LDCM0029  Quercetin HEK-293T 7.69  LDD0181  [2]
 LDCM0003  Sulforaphane MDA-MB-231 1.94  LDD0160  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dedicator of cytokinesis protein 7 (DOCK7) DOCK family Q96N67
Neurobeachin-like protein 2 (NBEAL2) WD repeat neurobeachin family Q6ZNJ1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
12 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
13 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
14 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
24 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840