Details of the Target

General Information of Target

Target ID LDTP13507
Target Name BAG family molecular chaperone regulator 5 (BAG5)
Gene Name BAG5
Gene ID 9529
Synonyms
KIAA0873; BAG family molecular chaperone regulator 5; BAG-5; Bcl-2-associated athanogene 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASLSRALRVAAAHPRQSPTRGMGPCNLSSAAGPTAEKSVPYQRTLKEGQGTSVVAQGPS
RPLPSTANVVVIGGGSLGCQTLYHLAKLGMSGAVLLERERLTSGTTWHTAGLLWQLRPSD
VEVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESH
VLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGI
RVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTER
IEGIQNMPNVRDHDASVYLRLQGDALSVGGYEANPIFWEEVSDKFAFGLFDLDWEVFTQH
IEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGC
GQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRERSHESYAKNYSVVFPHDEPLAG
RNMRRDPLHEELLGQGCVFQERHGWERPGWFHPRGPAPVLEYDYYGAYGSRAHEDYAYRR
LLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR
PPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLAPAFEGDGYYLAMGGAVAQHNWSHI
TTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADLSNEAFPFSTHKLLRAAGH
LVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRAIDSLSIEKGYRHW
HADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVCFTMEDKVPMFGLE
AIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDPSGGPVSLDFVKSGDYALERMGVTYGAQ
AHLKSPFDPNNKRVKGIY
Target Bioclass
Other
Function
Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding. Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding. Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN.
Uniprot ID
Q9UL15
Ensemble ID
ENST00000299204.6
HGNC ID
HGNC:941

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A158V DBIA    Probe Info 
HCT15 SNV: p.C157Y DBIA    Probe Info 
MOLT4 SNV: p.C233Y IA-alkyne    Probe Info 
TOV21G SNV: p.Q432R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P2
 Probe Info  		7.64  LDD0348  [2]
HRP
 Probe Info  		4.68  LDD0347  [2]
STPyne
 Probe Info  		K138(4.22)  LDD0277  [3]
P11
 Probe Info  		20.00  LDD0201  [4]
BTD
 Probe Info  		C420(0.68)  LDD2099  [5]
DA-P3
 Probe Info  		4.22  LDD0180  [2]
AHL-Pu-1
 Probe Info  		C327(2.17); C218(4.00)  LDD0169  [6]
DBIA
 Probe Info  		C191(8.06)  LDD0205  [7]
Acrolein
 Probe Info  		N.A.  LDD0222  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C191(0.00); C118(0.00); C327(0.00); C213(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C118(0.00); C213(0.00); C233(0.00); C218(0.00)  LDD0036  [9]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [10]
Lodoacetamide azide
 Probe Info  		C213(0.00); C233(0.00); C218(0.00); C118(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [11]
NAIA_4
 Probe Info  		C118(0.00); C327(0.00)  LDD2226  [12]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
Compound 11
 Probe Info  		C327(0.00); C360(0.00)  LDD2213  [13]
IPM
 Probe Info  		N.A.  LDD0005  [14]
PF-06672131
 Probe Info  		N.A.  LDD0017  [15]
TFBX
 Probe Info  		N.A.  LDD0148  [11]
Phosphinate-6
 Probe Info  		C233(0.00); C360(0.00); C218(0.00); C327(0.00)  LDD0018  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
AOyne
 Probe Info  		15.00  LDD0443  [17]
NAIA_5
 Probe Info  		C118(0.00); C213(0.00); C327(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C169
 Probe Info  		20.53  LDD1849  [18]
C177
 Probe Info  		8.17  LDD1856  [18]
C305
 Probe Info  		11.00  LDD1974  [18]
C314
 Probe Info  		15.67  LDD1981  [18]
C403
 Probe Info  		13.83  LDD2061  [18]
FFF probe13
 Probe Info  		20.00  LDD0475  [19]
FFF probe2
 Probe Info  		20.00  LDD0463  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C327(2.98); C218(2.54); C360(2.50)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C327(2.17); C218(4.00)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C360(1.07); C191(0.92); C213(1.02); C118(1.01)  LDD1507  [20]
 LDCM0215  AC10 HEK-293T C360(0.99); C191(0.93); C213(1.00); C118(1.19)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C360(1.03); C191(1.05); C213(0.86); C233(0.71)  LDD1509  [20]
 LDCM0237  AC12 HEK-293T C360(0.91); C191(0.89); C213(0.87); C118(1.08)  LDD1510  [20]
 LDCM0259  AC14 HEK-293T C360(0.95); C191(0.93); C213(1.01); C118(1.21)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C360(0.90); C191(0.98); C213(1.04); C118(0.76)  LDD1513  [20]
 LDCM0276  AC17 HEK-293T C360(1.01); C191(0.97); C213(1.01); C118(1.07)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C360(0.95); C191(0.94); C213(0.95); C118(1.03)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C360(1.01); C191(0.95); C213(0.79); C233(0.80)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C360(0.97); C191(0.93); C213(1.00); C118(1.08)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C360(0.94); C191(0.93); C213(0.96); C118(1.00)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C360(0.96); C191(0.95); C213(0.95); C118(0.81)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C360(1.00); C191(0.97); C213(0.99); C118(1.09)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C360(1.00); C191(1.08); C213(0.98); C118(0.91)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C191(0.99); C213(1.04); C118(1.00); C157(0.97)  LDD1523  [20]
 LDCM0285  AC25 HEK-293T C360(1.06); C191(0.95); C213(1.07); C118(1.44)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C360(1.04); C191(0.95); C213(1.02); C118(1.01)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C360(1.04); C191(0.97); C213(0.81); C233(1.00)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C360(0.92); C191(0.97); C213(0.85); C118(1.00)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C360(0.95); C191(1.01); C213(0.99); C118(0.99)  LDD1528  [20]
 LDCM0290  AC3 HEK-293T C360(1.00); C191(0.97); C213(0.90); C233(0.97)  LDD1529  [20]
 LDCM0291  AC30 HEK-293T C360(0.94); C191(0.97); C213(0.98); C118(1.08)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C360(0.96); C191(0.99); C213(0.98); C118(1.03)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C191(0.97); C213(1.08); C118(1.10); C157(0.85)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C360(1.05); C191(0.99); C213(0.96); C118(0.94)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C360(0.96); C191(0.91); C213(1.10); C118(0.88)  LDD1534  [20]
 LDCM0296  AC35 HEK-293T C360(1.02); C191(1.01); C213(0.96); C233(0.92)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C360(0.89); C191(0.92); C213(0.87); C118(0.98)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C360(0.96); C191(0.97); C213(0.97); C118(1.03)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C360(0.92); C191(0.96); C213(1.03); C118(1.15)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C360(1.00); C191(0.93); C213(1.05); C118(0.76)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C360(0.97); C191(0.93); C213(0.79); C118(1.16)  LDD1540  [20]
 LDCM0302  AC40 HEK-293T C191(0.95); C213(1.02); C118(1.11); C157(0.98)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C360(1.01); C191(0.95); C213(1.00); C118(1.18)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C360(0.95); C191(0.92); C213(0.91); C118(1.06)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C360(1.05); C191(1.00); C213(0.93); C233(0.95)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C360(0.85); C191(0.94); C213(0.93); C118(1.06)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C360(0.98); C191(0.95); C213(1.01); C118(1.09)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C360(0.96); C191(0.91); C213(0.95); C118(1.13)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C360(0.92); C191(0.95); C213(1.12); C118(0.98)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C191(0.93); C213(1.10); C118(1.19); C157(0.97)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C360(1.00); C191(0.94); C213(1.10); C118(1.18)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C360(0.97); C191(1.03); C213(0.91); C118(1.23)  LDD1551  [20]
 LDCM0313  AC50 HEK-293T C360(0.98); C191(0.97); C213(0.92); C118(0.97)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C360(1.06); C191(1.02); C213(0.88); C233(0.98)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C360(0.85); C191(0.94); C213(0.79); C118(0.96)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C360(0.98); C191(0.95); C213(1.03); C118(1.09)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C360(0.86); C191(0.92); C213(1.03); C118(1.14)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C360(0.90); C191(1.01); C213(0.95); C118(0.90)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C191(0.93); C213(0.97); C118(1.15); C157(1.05)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C360(0.93); C191(0.92); C213(1.09); C118(1.21)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C360(0.89); C191(0.94); C213(1.02); C118(0.98)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C360(0.96); C191(1.02); C213(1.00); C233(0.83)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C360(0.91); C191(0.94); C213(1.03); C118(1.07)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C360(0.88); C191(0.93); C213(0.95); C118(1.06)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C360(0.88); C191(0.97); C213(1.03); C118(1.15)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C360(0.79); C191(0.95); C213(1.06); C118(1.06)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C360(0.84); C191(0.99); C213(1.07); C118(0.98)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C191(0.95); C213(0.96); C118(1.01); C157(0.97)  LDD1567  [20]
 LDCM0334  AC7 HEK-293T C360(0.92); C191(0.97); C213(0.90); C118(0.96)  LDD1568  [20]
 LDCM0345  AC8 HEK-293T C191(0.93); C213(1.10); C118(1.01); C157(0.95)  LDD1569  [20]
 LDCM0248  AKOS034007472 HEK-293T C360(0.93); C191(0.95); C213(1.01); C118(1.01)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C360(1.01); C191(0.88); C213(0.98); C118(1.05)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C191(0.93); C213(1.13); C118(1.04); C157(0.98)  LDD1514  [20]
 LDCM0156  Aniline NCI-H1299 12.18  LDD0403  [1]
 LDCM0103  BDHI 10 Jurkat C191(8.06)  LDD0205  [7]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [4]
 LDCM0087  Capsaicin HEK-293T 16.36  LDD0185  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0632  CL-Sc Hep-G2 C191(2.27); C420(1.82); C157(0.94); C327(0.90)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C360(0.95); C191(0.91); C213(0.87); C118(1.62)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C360(1.10); C191(0.92); C213(0.96); C118(1.12)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C360(0.99); C191(0.87); C213(0.95); C157(0.88)  LDD1573  [20]
 LDCM0370  CL101 HEK-293T C360(0.97); C191(0.90); C213(0.93); C118(1.30)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C360(0.90); C191(0.79); C213(0.77); C118(1.11)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C360(0.94); C191(0.93); C213(1.02); C218(0.70)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C360(0.93); C191(0.90); C213(0.89); C157(0.92)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C360(0.97); C191(0.98); C213(0.94); C118(0.88)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C360(1.03); C191(0.94); C213(0.91); C118(0.79)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C360(1.06); C191(0.95); C213(0.95); C218(0.94)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C360(1.07); C191(0.97); C213(0.91); C157(0.97)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C360(0.98); C191(0.94); C213(0.99); C118(1.10)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C360(1.03); C191(0.95); C213(0.99); C118(0.94)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C360(1.03); C191(0.82); C213(0.92); C118(0.83)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C360(1.04); C191(0.95); C213(0.98); C218(1.06)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C360(1.12); C191(0.94); C213(0.95); C157(0.74)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C360(1.01); C191(0.94); C213(0.96); C118(1.22)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C360(1.04); C191(0.84); C213(0.86); C118(0.95)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C360(1.02); C191(0.95); C213(1.00); C218(0.95)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C360(1.06); C191(0.94); C213(0.98); C157(1.05)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C360(0.94); C191(0.94); C213(0.93); C118(0.92)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C360(0.94); C191(0.89); C213(0.94); C118(0.95)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C360(0.99); C191(0.95); C213(1.01); C218(1.23)  LDD1593  [20]
 LDCM0390  CL12 HEK-293T C191(1.03); C213(1.10); C118(1.05); C157(1.01)  LDD1594  [20]
 LDCM0391  CL120 HEK-293T C360(0.99); C191(0.95); C213(0.99); C157(0.84)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C360(0.95); C191(0.97); C213(0.99); C118(1.25)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C360(0.92); C191(0.89); C213(0.91); C118(1.40)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C360(0.98); C191(0.88); C213(0.94); C218(0.90)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C360(0.86); C191(0.92); C213(0.98); C157(0.94)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C360(0.74); C191(0.96); C213(1.14); C118(1.09)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C360(0.79); C191(0.94); C213(1.05); C118(0.78)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C360(0.80); C191(0.99); C213(0.92); C218(0.79)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C360(0.82); C191(0.94); C213(1.01); C157(0.87)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C360(0.99); C191(0.88); C213(1.00); C118(1.53)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C360(1.06); C191(0.87); C213(0.92); C118(0.92)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C360(0.93); C191(0.84); C213(0.91); C218(0.83)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C360(0.96); C191(0.92); C213(0.92); C157(0.95)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C360(0.91); C191(0.84); C213(0.91); C118(0.79)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C360(0.93); C191(0.97); C213(1.02); C118(0.93)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C360(1.04); C191(0.98); C213(0.94); C233(1.11)  LDD1610  [20]
 LDCM0407  CL2 HEK-293T C360(1.08); C191(0.89); C213(0.99); C118(0.93)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C360(0.87); C191(0.94); C213(0.83); C118(1.12)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C360(0.96); C191(0.93); C213(1.00); C118(1.74)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C360(1.16); C191(1.03); C213(1.18); C118(1.00)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C360(1.08); C191(1.02); C213(1.08); C118(0.90)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C191(1.04); C213(1.12); C118(0.78); C157(1.09)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C360(0.84); C191(0.91); C213(0.93); C118(1.10)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C360(1.04); C191(0.92); C213(0.95); C118(1.12)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C360(1.08); C191(0.97); C213(0.93); C218(1.30)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C360(1.03); C191(0.92); C213(0.96); C157(0.90)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C360(1.09); C191(0.95); C213(1.12); C118(0.87)  LDD1621  [20]
 LDCM0418  CL3 HEK-293T C360(0.89); C191(0.94); C213(1.01); C218(0.77)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C360(0.99); C191(0.97); C213(0.95); C118(1.15)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C360(1.05); C191(0.98); C213(0.81); C233(0.83)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C360(0.95); C191(0.96); C213(0.89); C118(1.28)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C360(0.91); C191(0.89); C213(0.81); C118(0.81)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C360(1.05); C191(1.06); C213(1.11); C118(1.03)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C360(1.12); C191(1.12); C213(0.99); C118(0.84)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C191(1.02); C213(1.06); C118(0.88); C157(1.02)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C360(0.90); C191(0.93); C213(0.97); C118(1.41)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C360(0.97); C191(0.93); C213(0.88); C218(0.86)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C360(0.86); C191(0.86); C213(0.94); C157(0.93)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C360(1.02); C191(0.91); C213(0.97); C157(0.93)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C360(1.04); C191(0.95); C213(1.04); C118(0.85)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C360(0.91); C191(1.00); C213(0.90); C118(1.08)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C360(1.03); C191(0.95); C213(0.91); C233(0.84)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C360(1.03); C191(0.95); C213(0.82); C118(0.97)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C360(1.02); C191(0.94); C213(1.01); C118(1.21)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C360(1.02); C191(0.99); C213(1.04); C118(1.12)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C360(1.00); C191(0.92); C213(1.00); C118(0.90)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C191(1.08); C213(1.02); C118(0.89); C157(1.05)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C360(0.87); C191(0.88); C213(0.91); C118(1.11)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C360(0.89); C191(0.94); C213(1.08); C118(1.06)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C360(1.02); C191(0.86); C213(0.97); C118(1.00)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C360(0.94); C191(0.90); C213(1.02); C157(0.92)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C360(0.94); C191(0.84); C213(0.84); C118(0.99)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C360(0.85); C191(0.73); C213(0.95); C118(1.01)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C360(1.07); C191(1.00); C213(0.91); C233(0.86)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C360(0.94); C191(0.88); C213(0.84); C118(0.85)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C360(0.95); C191(0.87); C213(1.00); C118(0.91)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C360(0.91); C191(0.97); C213(1.14); C118(1.21)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C360(1.03); C191(0.94); C213(0.93); C118(0.89)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C360(0.93); C191(0.88); C213(0.98); C118(0.66)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C191(0.93); C213(1.18); C118(0.91); C157(1.04)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C360(0.85); C191(0.94); C213(0.93); C118(1.47)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C360(1.01); C191(0.85); C213(0.91); C118(0.95)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C360(0.99); C191(0.94); C213(0.98); C218(1.15)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C360(0.96); C191(0.84); C213(0.87); C157(0.90)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C360(1.04); C191(0.96); C213(1.06); C118(1.31)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C360(0.96); C191(0.85); C213(0.92); C118(0.91)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C360(1.06); C191(1.00); C213(0.87); C233(0.93)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C360(0.85); C191(0.92); C213(0.75); C118(0.94)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C360(0.90); C191(0.94); C213(1.11); C118(0.71)  LDD1664  [20]
 LDCM0462  CL7 HEK-293T C360(0.99); C191(1.01); C213(0.93); C233(1.01)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C360(1.05); C191(1.07); C213(1.05); C118(1.01)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C360(0.95); C191(0.99); C213(1.03); C118(0.78)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C191(1.01); C213(1.13); C118(1.07); C157(1.03)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C360(0.93); C191(0.91); C213(0.99); C118(0.99)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C360(0.96); C191(0.90); C213(1.00); C118(1.05)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C360(0.98); C191(0.92); C213(0.97); C157(0.89)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C360(0.92); C191(0.85); C213(0.85); C118(0.81)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C360(1.03); C191(0.95); C213(1.09); C118(0.90)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C360(1.03); C191(1.00); C213(0.94); C233(0.90)  LDD1675  [20]
 LDCM0473  CL8 HEK-293T C360(0.69); C191(0.68); C213(0.75); C118(0.86)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C360(0.89); C191(0.94); C213(0.92); C118(0.98)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C360(0.93); C191(0.98); C213(1.06); C118(0.85)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C360(0.99); C191(1.00); C213(0.99); C118(1.25)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C360(0.96); C191(0.95); C213(0.95); C118(0.77)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C191(1.00); C213(1.06); C118(1.04); C157(0.96)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C360(0.78); C191(0.90); C213(0.95); C118(1.15)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C360(0.72); C191(0.87); C213(1.01); C118(0.83)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C360(0.77); C191(0.92); C213(0.90); C218(0.93)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C360(0.74); C191(0.91); C213(0.94); C157(0.85)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C360(0.79); C191(0.94); C213(0.92); C118(1.07)  LDD1686  [20]
 LDCM0484  CL9 HEK-293T C360(0.91); C191(0.98); C213(1.10); C118(1.20)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C360(0.74); C191(0.73); C213(0.89); C118(0.83)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C360(0.84); C191(1.01); C213(0.94); C233(0.72)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C360(0.75); C191(0.83); C213(0.74); C118(0.95)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C360(0.84); C191(0.93); C213(0.97); C118(0.97)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C360(0.97); C191(1.03); C213(1.10); C118(1.05)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C360(0.80); C191(0.83); C213(1.03); C118(0.72)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C191(0.86); C213(1.10); C118(1.26); C157(0.83)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C360(0.99); C191(0.91); C213(1.02); C118(0.80)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C360(0.99); C191(0.92); C213(0.92); C118(0.84)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C360(0.95); C191(0.95); C213(0.97); C218(1.07)  LDD1697  [20]
 LDCM0634  CY-0357 Hep-G2 C360(1.83); C191(1.14)  LDD2228  [12]
 LDCM0028  Dobutamine HEK-293T 4.22  LDD0180  [2]
 LDCM0495  E2913 HEK-293T C360(0.81); C191(0.89); C213(1.05); C218(0.95)  LDD1698  [20]
 LDCM0625  F8 Ramos C191(1.20); C360(2.24); C327(0.48)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C191(0.79); C360(1.75)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C191(0.32); C360(2.12); C327(0.77)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C191(0.91); C360(0.81); C327(0.58)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C191(1.08); C360(1.70); C327(0.88)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C191(1.08); C360(0.62); C327(0.74)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C191(0.91); C360(1.97); C327(1.81)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C191(1.16); C360(0.87); C327(1.14)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C191(0.83); C360(1.39); C327(1.16)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C191(1.26); C360(1.21); C327(0.75)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C191(0.89); C360(0.68); C327(0.40)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C191(0.97); C360(0.88); C327(1.00)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C191(1.27); C360(1.27); C327(1.19)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C191(0.77); C360(1.25); C327(0.79)  LDD2201  [21]
 LDCM0468  Fragment33 HEK-293T C360(0.98); C191(0.94); C213(0.96); C218(0.84)  LDD1671  [20]
 LDCM0596  Fragment38 Ramos C191(0.91); C360(0.96); C327(0.59)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C191(1.14); C360(0.98); C327(1.07)  LDD2184  [21]
 LDCM0427  Fragment51 HEK-293T C360(0.98); C191(0.86); C213(0.95); C118(1.14)  LDD1631  [20]
 LDCM0610  Fragment52 Ramos C191(1.16); C327(0.63)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C191(1.16); C360(0.88); C327(0.50)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C191(0.85); C360(1.50); C327(0.77)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C191(0.90); C327(1.55)  LDD2188  [21]
 LDCM0022  KB02 HEK-293T C360(1.19); C191(0.94); C157(1.02); C166(0.93)  LDD1492  [20]
 LDCM0023  KB03 Jurkat C118(16.13); C191(5.40); C157(23.98)  LDD0209  [7]
 LDCM0024  KB05 COLO792 C232(2.22)  LDD3310  [22]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C420(0.68)  LDD2099  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C420(1.02)  LDD2127  [5]
 LDCM0029  Quercetin HEK-293T 9.48  LDD0181  [2]
 LDCM0170  Structure8 Ramos 5.86  LDD0433  [23]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Leucine-rich repeat serine/threonine-protein kinase 1 (LRRK1) TKL Ser/Thr protein kinase family Q38SD2
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Protein FAM118B (FAM118B) FAM118 family Q9BPY3
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) Fibulin family Q12805
Golgin subfamily A member 6A (GOLGA6A) GOLGA6 family Q9NYA3
Desmin (DES) Intermediate filament family P17661
Keratin-associated protein 5-4 (KRTAP5-4) KRTAP type 5 family Q6L8H1
Late cornified envelope protein 2C (LCE2C) LCE family Q5TA81
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) MAD1 family Q9Y6D9
Cell division cycle-associated 7-like protein (CDCA7L) . Q96GN5
Protein KASH5 (KASH5) . Q8N6L0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
23 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.