Details of the Probe-central Interaction Altas
General Information of Experiment
| Probe Name | DBIA | Probe Info | ||||
|---|---|---|---|---|---|---|
| Probe concentration | 50 mM | |||||
| Criteria | Quantification: Probe vs (Probe+Competitor) | |||||
| Quantitative Method |
TMT
|
|||||
| Competitor Name | BDHI 10 | Competitor Info | ||||
| Competitor Concentration | 50 mM | |||||
| In Vivo Experiment Model | Model Type |
|
Cell lysate | |||
| Derived Tissue |
|
Bone marrow | ||||
| Disease Model | T acute lymphoblastic leukemia [ICD-11:2A90] | |||||
| Model Name | Human T acute lymphoblastic leukemia cell lysate (Jurkat) | |||||
Interaction Altas of This Experiment [1]
Enzyme
| Target ID | Target Name | Binding Sites | Binding Ratio | |||
|---|---|---|---|---|---|---|
| LDTP01803 | Adenosine deaminase (ADA) | C153 | 18.9 | |||
| LDTP01803 | Adenosine deaminase (ADA) | C154 | 18.9 | |||
| LDTP09428 | ATP-dependent RNA helicase DDX54 (DDX54) | C149 | 17.8 | |||
| LDTP13219 | GTPase IMAP family member 2 (GIMAP2) | C98 | 13.8 | |||
| LDTP04183 | Lanosterol synthase (LSS) | C616 | 10.5 | |||
| LDTP14141 | Mannose-1-phosphate guanyltransferase beta (GMPPB) | C306 | 9.8 | |||
| LDTP10612 | Lysophospholipid acyltransferase 7 (MBOAT7) | C280 | 9.7 | |||
| LDTP04265 | Serine--tRNA ligase, cytoplasmic (SARS1) | C395 | 9.2 | |||
| LDTP04265 | Serine--tRNA ligase, cytoplasmic (SARS1) | C398 | 9.2 | |||
| LDTP10698 | E3 ubiquitin-protein ligase UHRF2 (UHRF2) | C14 | 8.4 | |||
| LDTP08891 | Ceramide synthase 5 (CERS5) | C142 | 7.9 | |||
| LDTP10686 | RING finger and CHY zinc finger domain-containing protein 1 (RCHY1) | C62 | 7.4 | |||
| LDTP13574 | E3 ubiquitin-protein ligase HECTD1 (HECTD1) | C369 | 7.0 | |||
| LDTP12233 | Helicase MOV-10 (MOV10) | C938 | 6.7 | |||
| LDTP14142 | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta (PPP2R3B) | C35 | 6.7 | |||
| LDTP13609 | Unconventional myosin-VI (MYO6) | C252 | 5.6 | |||
| LDTP07651 | Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) | C906 | 5.2 | |||
| LDTP05947 | Cullin-2 (CUL2) | C721 | 5.0 | |||
| LDTP04689 | Adenosine kinase (ADK) | C353 | 4.8 | |||
| LDTP04284 | Proteasome subunit beta type-3 (PSMB3) | C19 | 4.0 | |||
| LDTP07561 | Glucose 1,6-bisphosphate synthase (PGM2L1) | C236 | 4.0 | |||
Transporter and channel
| Target ID | Target Name | Binding Sites | Binding Ratio | |||
|---|---|---|---|---|---|---|
| LDTP11873 | Thioredoxin-interacting protein (TXNIP) | C49 | 11.4 | |||
Transcription factor
| Target ID | Target Name | Binding Sites | Binding Ratio | |||
|---|---|---|---|---|---|---|
| LDTP04281 | Transcriptional repressor CTCF (CTCF) | C577 | 9.7 | |||
| LDTP06519 | Transcription factor E2F4 (E2F4) | C148 | 4.2 | |||
Other
| Target ID | Target Name | Binding Sites | Binding Ratio | |||
|---|---|---|---|---|---|---|
| LDTP09699 | MAP kinase-activating death domain protein (MADD) | C1496 | 17.5 | |||
| LDTP08543 | GRIP and coiled-coil domain-containing protein 2 (GCC2) | C798 | 13.0 | |||
| LDTP15421 | Intraflagellar transport protein 70B (IFT70B) | C589 | 12.8 | |||
| LDTP03762 | Glycogen debranching enzyme (AGL) | C399 | 10.9 | |||
| LDTP18918 | MORF4 family associated protein 1 like 2 (MRFAP1L2) | C89 | 10.4 | |||
| LDTP03711 | Catenin alpha-1 (CTNNA1) | C526 | 9.5 | |||
| LDTP18576 | DmX-like protein 1 (DMXL1) | C2618 | 9.5 | |||
| LDTP13507 | BAG family molecular chaperone regulator 5 (BAG5) | C191 | 8.1 | |||
| LDTP12592 | Protein C19orf12 (C19orf12) | C24 | 7.8 | |||
| LDTP17266 | Pre-mRNA-splicing factor 38B (PRPF38B) | C113 | 6.3 | |||
| LDTP00695 | Signal-induced proliferation-associated 1-like protein 1 (SIPA1L1) | C618 | 5.9 | |||
| LDTP09902 | Kinesin-associated protein 3 (KIFAP3) | C78 | 5.4 | |||
| LDTP06261 | Ataxin-7-like protein 3 (ATXN7L3) | C226 | 5.1 | |||